Advances in Traditional Medicine最新文献_第3页

Retraction Note: Curcumin and 2-DG synergistically target the glio-oncogenesis trigger IL-6 and down-regulate the stemness in glioblastoma model in-vitro 注：姜黄素和2-DG协同作用于胶质母细胞瘤模型中，靶向胶质肿瘤发生触发因子IL-6，下调其干性

IF 1.3

Advances in Traditional Medicine Pub Date : 2026-01-02 DOI: 10.1007/s13596-025-00879-x

Kavita Peter, Puneet Gandhi, Santosh Kumar Kar

引用次数: 0

Myrcene suppressed fever by downregulating systemic TNF-α levels in acute LPS-induced systemic inflammation in rats 月桂素通过下调lps诱导的大鼠全身TNF-α水平抑制发烧

IF 1.4

Advances in Traditional Medicine Pub Date : 2025-12-23 DOI: 10.1007/s13596-025-00878-y

Maycon T. Emilio-Silva, Vinicius P. Rodrigues, Mariana M. Fioravanti, Luiz G. S. Branco, Clelia A. Hiruma-Lima

{"title":"Myrcene suppressed fever by downregulating systemic TNF-α levels in acute LPS-induced systemic inflammation in rats","authors":"Maycon T. Emilio-Silva, Vinicius P. Rodrigues, Mariana M. Fioravanti, Luiz G. S. Branco, Clelia A. Hiruma-Lima","doi":"10.1007/s13596-025-00878-y","DOIUrl":"10.1007/s13596-025-00878-y","url":null,"abstract":"<div><p>Myrcene is a dietary monoterpene found in many plant species, mainly cannabis and citrus fruits. It is a food additive and pharmaceutical that serves as a flavoring and fragrance ingredient for the food and cosmetics industries. This monoterpene has been described as having anti-inflammatory properties. However, its activity against systemic inflammation (SI)-associated syndromes, which cause high mortality worldwide, remains unclear. In this study, we aimed to assess the activity of myrcene on thermoregulatory responses and inflammatory mediators against lipopolysaccharide (LPS)-induced SI. Male Wistar rats (230–280 g) were treated with myrcene (7.5 mg/kg, oral gavage) or vehicle (1% Tween 80, 10 ml/kg) 30 min before LPS (100 μg/kg) or saline (1 ml/kg). Deep body temperature was monitored using implanted data loggers, and blood samples were analyzed for systemic and central inflammatory markers using ELISA and multiplex assays. Statistical analysis was performed using two-way ANOVA, followed by Tukey's test (<i>p</i>< 0.05). Myrcene treatment did not alter the temperature of saline-treated rats. In LPS-treated animals, myrcene significantly attenuated fever and reduced systemic tumor necrosis factor-α (TNF-α) levels. Acute myrcene treatment modulated the immune response to LPS challenge by preventing fever and reducing TNF-α levels, suggesting its potential as an anti-inflammatory agent.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"669 - 678"},"PeriodicalIF":1.4,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the preventive effects of turmeric–ginger–oregano supplementation on DMBA-induced breast cancer in Sprague-Dawley rats 姜黄-姜-牛至对dba诱导的Sprague-Dawley大鼠乳腺癌预防作用的评价

IF 1.4

Advances in Traditional Medicine Pub Date : 2025-12-17 DOI: 10.1007/s13596-025-00874-2

Nadeem Anwar, Salma Sultana, Muhammad Ashir Zia

{"title":"Evaluation of the preventive effects of turmeric–ginger–oregano supplementation on DMBA-induced breast cancer in Sprague-Dawley rats","authors":"Nadeem Anwar, Salma Sultana, Muhammad Ashir Zia","doi":"10.1007/s13596-025-00874-2","DOIUrl":"10.1007/s13596-025-00874-2","url":null,"abstract":"<div><p>Breast cancer is most prevalent cancer among women causing high mortality and morbidity. Conventional therapeutic approaches possess significant challenges such as high cost and potential side effects. Alternatively, herbal combinations with dietary products have been proved to exert promising anti-cancer properties due to safety and less toxicity. In this study, the herbal combinations of <i>Curcuma longa</i> L<i>.</i> (Turmeric), <i>Zingiber officinale</i> Roscoe (Ginger), and <i>Origanum vulgare</i> L<i>.</i> (Oregano) extracts in modified diets were tested against the mammary carcinoma induced by 7,12-Dimethylbenz[a]anthracene (DMBA) in Sprague-Dawley rats for 14 weeks. Following tumor induction, evaluation of body weights, tumor related parameters along with histopathological investigations of mammary tissues were performed. Results indicated the turmeric, ginger, and oregano extracts showed normal body weight gain after DMBA induction. While significant decreases in tumor parameters such as tumor volume (<i>p</i> < 0.01), weight (<i>p</i> < 0.01), burden (<i>p</i> < 0.001), incidence (<i>p</i> < 0.01), and increase in latency (<i>p</i> < 0.001) were observed upon comparing with DMBA group. Moreover, histopathological analysis revealed the typical mammary tissue structures with reduced cell proliferation which suggest the synergistic effect of these compounds to inhibit the tumor progression in chemically induced mammary carcinoma. In conclusion, the modified diets supplemented with turmeric, ginger and oregano proved successful to impart anti-tumor effects against breast cancer.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"707 - 717"},"PeriodicalIF":1.4,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neuroprotective effects and related mechanisms of paeoniflorin on nervous system diseases: a review 芍药苷对神经系统疾病的神经保护作用及其机制研究进展

IF 1.4

Advances in Traditional Medicine Pub Date : 2025-12-15 DOI: 10.1007/s13596-025-00876-0

Maohui Yang, Yuntao Dai, Xuemei Qin

{"title":"The neuroprotective effects and related mechanisms of paeoniflorin on nervous system diseases: a review","authors":"Maohui Yang, Yuntao Dai, Xuemei Qin","doi":"10.1007/s13596-025-00876-0","DOIUrl":"10.1007/s13596-025-00876-0","url":null,"abstract":"<div><p><i>Paeonia lactiflora</i>, a member of the genus <i>Paeonia</i>, is a perennial herbaceous plant, and its roots have been utilized as herbal medicine in traditional Chinese medicine for over 2000 years. <i>Paeonia lactiflora</i> shows therapeutic potential in autoimmune disorder, dermatological disorder, liver disorder, metabolic syndromes as well as disorders related to the heart and brain systems. The total glucosides of paeony serve as one of the fundamental components responsible for the pharmacological properties. Among the components of total paeony glucosides, paeoniflorin, a monoterpenoid glycoside, has demonstrated neuroprotective effects. Currently, paeoniflorin has been widely used in nervous system diseases, including depression, Alzheimer, Parkinson, neuropathic pain, etc. The related mechanisms of paeoniflorin on nervous system diseases are involved in anti-inflammatory, antioxidant, immune regulation and autophagy effects. Certain research of paeoniflorin on neuroprotective effects has attracted increasing attention, yet the specific mechanisms are still unclear. Hence, the review systematically elaborates on the neuroprotective effects of paeoniflorin. Although preclinical studies have confirmed the neuroprotective potential of paeoniflorin, its clinical transformation still faces challenges. Future research needs to focus on human clinical trials, solve its pharmacokinetic bottlenecks, and use multi-omics technology to reveal its mechanism of action. In addition, exploring the synergistic treatment strategy of paeoniflorin and existing drugs will provide a key direction for promoting its practical application.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"519 - 532"},"PeriodicalIF":1.4,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytopharmacological insights into the endodermis and exodermis of Terminalia chebula fruits: antioxidant, antihyperlipidemic, and antidiabetic activities 药用植物药理学研究：抗氧化、抗高脂血症和抗糖尿病活性

IF 1.4

Advances in Traditional Medicine Pub Date : 2025-12-15 DOI: 10.1007/s13596-025-00875-1

Murugan Muthuvel, Annadurai Subramanian, Sujatha Kuppusamy, Vijey Aanandhi Muthukumar

{"title":"Phytopharmacological insights into the endodermis and exodermis of Terminalia chebula fruits: antioxidant, antihyperlipidemic, and antidiabetic activities","authors":"Murugan Muthuvel, Annadurai Subramanian, Sujatha Kuppusamy, Vijey Aanandhi Muthukumar","doi":"10.1007/s13596-025-00875-1","DOIUrl":"10.1007/s13596-025-00875-1","url":null,"abstract":"<div><p><i>Terminalia chebula Retz</i>., a polyphenol-rich medicinal fruit, exhibits layer-specific bioactivities relevant to metabolic disorders. In vitro antioxidant assays report potent activity for layer-specific extracts, DPPH inhibition up to 96% (ethanolic extract) and IC<sub>50</sub> values as low as 2.08 µg mL<sup>−1</sup> (methanolic fraction) and 3.15 µg mL<sup>−1</sup> (neuroprotective DPPH value) for selected fractions. Enzyme inhibition assays show strong suppression of α-glucosidase and α-amylase (reported IC<sub>50</sub> ≈ 0.19 µg mL<sup>−1</sup> for methanol–water extracts in one study). In vivo rodent models demonstrate dose-dependent glucose lowering (e.g., 200 mg kg<sup>−1</sup> aqueous extract ~ 46.8% reduction in OGTT peak glucose; chronic dosing reduced fasting glucose from 253 ± 9.4 to 123 ± 8.4 mg dL<sup>−1</sup>) and improved lipid parameters (reductions in total cholesterol and LDL-C reported across studies). Comparative analyses suggest the endodermis is relatively enriched in small, highly scavenging polyphenols. In contrast, the exodermis concentrates hydrolyzable tannins (e.g., chebulagic/chebulinic acids) that favor enzyme inhibition and lipid-modulating activity. A randomized, placebo-controlled human trial using an aqueous <i>T. chebula</i> extract (500–1000 mg/day) reported improvements in endothelial function, inflammatory markers (CRP, IL-6) and lipid profile over 12 weeks. We highlight current methodological limitations (heterogeneous extraction protocols, absence of standardized layer sampling, and limited clinical data) and propose standardized reporting (IC<sub>50</sub>, % inhibition, extraction solvent, dose ranges) and layer-specific clinical studies to enable translation of these anatomical phytopharmaceuticals.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"559 - 577"},"PeriodicalIF":1.4,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms and modalities of herbal anti-fertility: toward integrative reproductive health solutions 草药抗生育的机制和方式：迈向综合生殖健康解决方案

IF 1.4

Advances in Traditional Medicine Pub Date : 2025-12-11 DOI: 10.1007/s13596-025-00870-6

Manoj Kumar Mishra, Sumit Sharma, Shivangi Sharma, Sagar Pamu

{"title":"Mechanisms and modalities of herbal anti-fertility: toward integrative reproductive health solutions","authors":"Manoj Kumar Mishra, Sumit Sharma, Shivangi Sharma, Sagar Pamu","doi":"10.1007/s13596-025-00870-6","DOIUrl":"10.1007/s13596-025-00870-6","url":null,"abstract":"<div><p>The main objective of this panoramic review is to examine the herbal medicinal plants that are utilized as anti-fertility activities all over the globe. Traditionally, the herbs were the only source for people to treat any disease, and afterward, as much of the modern method and treatment are introduced, but it cannot replace the requirement of herbal treatment for various diseases. There are various such diseases that are not treated by allopathic medicine but treated by herbal medicine. Many of the modern methods are frequently used as males and females for contraception, which are discussed in this review below, but these methods cause various types of side effects, which are very few or neglected in using medicinal plant-derived products. Herbal contraceptives are the efficient treatment for the exhibition of natural, free toxicity, 100% anti-fertility activity, including anti-implantation, anti-ovulatory, anti-spermatogenic, abortifacient, and estrogenic activities in males and females. People, including both males and females, who are desired for contraception without any side effects prefer herbal methods. Although herbal contraceptive regularity in the time interval of doses. Therefore, this review provides the information according to various recent research conducted using PRISMA for the herbal medicine being used as a potent anti-fertility agent.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"533 - 557"},"PeriodicalIF":1.4,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note: Development of ethosome comprising combined herbal extracts and its effect on hair growth 由草药提取物组成的溶体的开发及其对头发生长的影响

IF 1.3

Advances in Traditional Medicine Pub Date : 2025-12-06 DOI: 10.1007/s13596-025-00873-3

Eswaran Madhunithya, Gunasekaran Venkatesh, Govindarajan Shyamala, Venkatraman Manjari, Santhanam Ramesh, Arjunan Karuppaiah, Veintramuthu Sankar

引用次数: 0

Retraction Note: Preventive effect of Gymnema sylvestre homeopathic preparation on streptozotocin-nicotinamide induced diabetic nephropathy in rats 注：匙羹藤顺势疗法制剂对链脲佐菌素-烟酰胺致大鼠糖尿病肾病的预防作用

IF 1.3

Advances in Traditional Medicine Pub Date : 2025-11-21 DOI: 10.1007/s13596-025-00871-5

Lalit Kishore, Randhir Singh

引用次数: 0

Retraction Note: Biosynthesis of silver nanoparticles using Pterorhachis zenkeri: characterization and evaluation of antioxidant, anti-apoptotic, and androgenic properties in TM3 leydig cells exposed to cyclophosphamide 引用本文：利用紫菀生物合成纳米银：暴露于环磷酰胺的TM3 leydig细胞的抗氧化、抗凋亡和雄激素特性的表征和评价

IF 1.3

Advances in Traditional Medicine Pub Date : 2025-11-21 DOI: 10.1007/s13596-025-00872-4

Patrick Brice Defo Deeh, Nagabhishek Sirpu Natesh, Karthik Alagarsamy, Madan Kumar Arumugam, Ramachandran Dasnamoorthy, Tharunkumar Sivaji, Vinita Vishwakarma

引用次数: 0

Chili pepper leaves extract induced antitumor effect via inhibition of NFkB/METTL1 mediated glycolysis in hepatocellular carcinoma cells 辣椒叶提取物通过抑制NFkB/METTL1介导的肝细胞糖酵解诱导抗肿瘤作用

IF 1.4

Advances in Traditional Medicine Pub Date : 2025-11-19 DOI: 10.1007/s13596-025-00862-6

Su-Yeon Park, Deok Yong Sim, Bonglee Kim, Ah Reum Cho, Bum-Sang Shim, Bo-Ram Choi, Dahye Yoon, Dae Young Lee, Hyo Bong Jeong, Hye Eun Lee, Sung-Hoon Kim

{"title":"Chili pepper leaves extract induced antitumor effect via inhibition of NFkB/METTL1 mediated glycolysis in hepatocellular carcinoma cells","authors":"Su-Yeon Park, Deok Yong Sim, Bonglee Kim, Ah Reum Cho, Bum-Sang Shim, Bo-Ram Choi, Dahye Yoon, Dae Young Lee, Hyo Bong Jeong, Hye Eun Lee, Sung-Hoon Kim","doi":"10.1007/s13596-025-00862-6","DOIUrl":"10.1007/s13596-025-00862-6","url":null,"abstract":"<div><p>In the current work, we investigated the antitumor effects of a 30% ethanol extract of chili pepper leaves (<i>Capsicum annum;</i> PLE), in Hep3B and Huh7 hepatocellular carcinoma (HCC) cells. PLE showed significant cytotoxicity and reduced the expression of pro-caspase 3 and pro-poly (ADP-ribose) polymerase (pro-PARP) in Hep3B and Huh7 cells. Also, it also suppressed glycolysis-related proteins, including hexokinase 2 (HK2), pyruvate kinase M2 (PKM2), lactate dehydrogenase (LDH), methyltransferase-like 1 (METTL1), and NF-κB/IκB. Notably, PLE decreased METTL1 and NF-κB subunit RELA expression in both nuclear and cytosolic fractions in Hep3B and Huh7 cells. Furthermore, PLE disturbed the interaction between METTL1 and RELA, while RELA depletion reduced HK2 and LDH expression in Huh7 cells. In contrast, METTL1 depletion did not affect NF-κB phosphorylation, suggesting that METTL1 functions downstream of NFkB. In vivo, PLE treatment significantly inhibited Hep3B tumor growth in BALB/c nude mice without affecting body weight. Immunohistochemistry revealed decreased METTL1, NF-κB, LDH, and proliferating cell nuclear antigen (PCNA) expression, along with increased caspase-3 activation. Collectively, these findings suggest that PLE exerts anticancer effects by inducing apoptosis and suppressing NF-κB/METTL1-mediated glycolysis in HCC, supporting its potential as a dietary anticancer supplement.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><img></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"617 - 629"},"PeriodicalIF":1.4,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13596-025-00862-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0