Advances in Traditional Medicine最新文献

{"title":"Apoptotic and combinatorial potential of processed Mica via inhibition of CCR4-NOT transcription complex subunit 2/c-Myc and production of reactive oxygen species in non-small cell lung cancer cells","authors":"Woohee Park,&nbsp;Su-Yeon Park,&nbsp;Deok Yong Sim,&nbsp;Bum-Sang Shim,&nbsp;Bonglee Kim,&nbsp;Sung-Hoon Kim","doi":"10.1007/s13596-025-00869-z","DOIUrl":"10.1007/s13596-025-00869-z","url":null,"abstract":"<div><p>Though Mica has been used for dysentery, bleeding and inflammation in Ayurveda medicine along with recent evidence on antimicrobial and antitumor effect, the underlying antitumor mechanism of Mica is not fully understood to date. Thus, the antitumor mechanism of processed Mica (PMC) was explored in non-small cell lung cancer cells. Herein PMC showed cytotoxicity and increased sub G1 population in H460 and A549 non-small cell lung cancer cells (NSCLCs). Also, PMC attenuated the expression of pro-PARP, pro-Caspase 3, cdk2, Cyclin A, NRF2, β-catenin, CCR4-NOT transcription complex subunit 2 (CNOT2), c-Myc and s-phase kinase-associated protein 2 (Skp2) compared to untreated control in H460 and A549 cells. Interestingly, CNOT2 was highly expressed at mRNA level in tumor tissues more than in normal tissues with poor prognosis in the patients with lung cancer. Also, TCGA reveals that CNOT2 closely interacts with c-Myc with spearman score of 0.28. Consistently, CNOT2 was bound to c-Myc in H460 cells by Immunoprecipitation and CNOT2 overexpression disturbed the ability of PMC to reduce c-Myc in A549 cells. Also, PMC significantly increased production of reactive oxygen species (ROS) in H460 and A549 cells. Conversely, ROS inhibitor, N-acetyl-<span>l</span>-cysteine (NAC), disturbed the capacity of PMC to reduce pro-PARP, pro-caspase 3, CNOT2 and c-Myc in A549 cells. Furthermore, PMC showed synergistic apoptotic potential with doxorubicin in H460 cells compared to doxorubicin alone by using CompuSyn analysis and SynergyFinder. Overall, these findings suggest that PMC induces apoptosis in lung cancers via inhibition of CNOT2/c-Myc and production of ROS with combinatorial potential with doxorubicin.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"631 - 643"},"PeriodicalIF":1.4,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13596-025-00869-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharbitis nil (L.) Choisy seed extract attenuates cyclophosphamide-induced immunosuppression via regulation of Th2-type immune and humoral immune responses","authors":"Nguyen Thi Kim Oanh,&nbsp;Ly Hai Trieu,&nbsp;Le Van Minh,&nbsp;Nguyen Manh Khoa,&nbsp;Nguyen Thi Hang,&nbsp;Vu Huong Thuy,&nbsp;Nguyen Huy Van,&nbsp;Tran Quang Luc,&nbsp;Nguyen Thi Vinh Hue,&nbsp;Do Thi Ha","doi":"10.1007/s13596-025-00859-1","DOIUrl":"10.1007/s13596-025-00859-1","url":null,"abstract":"<div><p>This study aimed to investigate the immunostimulatory activities of herbal extract, focusing on <i>Pharbitis nil</i> (L.) Choisy seed (PN) extract, known for its several pharmacological effects in traditional and modern medicine. The immunomodulating effect of PN extract was evaluated in cyclophosphamide (CY)-induced immunosuppression mice. The results revealed that PN extract could directly modulate the immune activity of CY in mice by attenuating its damage to spleen and thymic tissues. PN extract could significantly promote the level of serum cytokines such as IL-4 and IL-10, thus modulating the immune function of immunosuppressed mice possibly by the main mechanism of Th2 type immune response. In addition, PN extract had the effect of enhancing humoral immune response by markedly increasing the level of serum immunoglobulins such as IgM and IgG. Therefore, PN extract may be a potential immunomodulator to ameliorate CY-induced immunosuppression. These findings demonstrate that <i>Pharbitis nil</i> seed extract is a promising immunomodulator that attenuates immunosuppression by selectively enhancing Th2-mediated and humoral immune pathways.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"375 - 390"},"PeriodicalIF":1.3,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148061088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction To: Tripterygium wilfordii attenuates IgE-mediated type I allergy by regulating Th1/Th2 balance","authors":"Xueran Xiao,&nbsp;Fei Li,&nbsp;Tongyun Long,&nbsp;Feng Xu,&nbsp;Chengyan Zhou,&nbsp;Yanfen Zhang,&nbsp;Zhongcheng Liu","doi":"10.1007/s13596-025-00861-7","DOIUrl":"10.1007/s13596-025-00861-7","url":null,"abstract":"","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 1","pages":"277 - 279"},"PeriodicalIF":1.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147339071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of Potentilla discolor Bunge: ethnomedicinal uses, phytochemistry, and pharmacology","authors":"Tong Shen,&nbsp;Jia-Cheng Xie,&nbsp;Yi-Lin He,&nbsp;Hong-Ying Yang","doi":"10.1007/s13596-025-00864-4","DOIUrl":"10.1007/s13596-025-00864-4","url":null,"abstract":"<div><p><i>Potentilla discolor</i> Bunge (common name: “Fanbaicao”, “Jizhuashen”, “Yexiabai”, “Tianou”, “Fanbaiweilingca”) is a traditional Chinese medicinal (TCM) herb, and has attracted significant attention due to its diverse chemical profile and substantial medicinal potential. This paper presents a comprehensive review of <i>P. discolor</i>, systematically summarizing its traditional medicinal uses in TCM clinical practice, detailed phytochemical composition (with a focus on key bioactive components), and the latest advances in its pharmacological studies, aiming to provide a holistic reference for subsequent research and development of this valuable medicinal herb. Furthermore, it also examines recent advances in the biological activities of <i>P. discolor</i> extracts and their bioactive compounds. Overall, we believe this review will serve as a comprehensive documentation of <i>P. discolor</i> for researchers to facilitate further studies.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 1","pages":"1 - 15"},"PeriodicalIF":1.3,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147338695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial properties of Ziziphus spina-christi, Z. mucronata, Balanites aegyptiaca, and B. rotundifolia against pathogenic bacteria","authors":"Mohammed Adefa Seid,&nbsp;Alemtshay Teka,&nbsp;Haile Alemayehu,&nbsp;Tigist Wondimu","doi":"10.1007/s13596-025-00867-1","DOIUrl":"10.1007/s13596-025-00867-1","url":null,"abstract":"<div><p>Plant species of the genera Ziziphus and Balanites are widely used in Ethiopian traditional medicine, particularly for the treatment of infectious diseases. Commonly utilized species include <i>Ziziphus spina-christi</i> (L.) Willd., <i>Z. mucronata</i> Willd., <i>Balanites aegyptiaca</i> (L.) Del., and <i>B. rotundifolia</i> (Tiegh.) Blatt. However, their antimicrobial properties remain inadequately explored from a scientific perspective. This study evaluated the antibacterial activity, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of leaf extracts from these species. Extraction with ethanol and methanol produced variable yields ranging from 5.4 to 42% and 5.7–23.4%, respectively. The extracts were tested against six clinically important bacterial strains: <i>Enterococcus faecalis</i>, <i>Pseudomonas aeruginosa</i>, <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Salmonella typhimurium</i>, and <i>Klebsiella pneumoniae</i>. Antibacterial activity was assessed using the agar well diffusion method, while MIC and MBC values were determined by broth macro-dilution across 15.625–500 mg/mL. All assays were performed in triplicate to ensure reproducibility. The methanol extract of <i>Z. spina-christi</i> exhibited strong antibacterial activity against all strains, with MIC values as low as 15.625 mg/mL. <i>Balanites aegyptiaca</i> showed moderate activity against <i>S. typhimurium</i> and <i>K. pneumoniae</i>, whereas <i>Z. mucronata</i> and <i>B. rotundifolia</i> showed no detectable effects even at 500 mg/mL. One-way ANOVA revealed significant differences among extract concentrations and controls (<i>P</i> &lt; 0.05). Variations in activity may be attributed to solvent polarity or phytochemical composition. As a limitation, solvent-only wells (10% DMSO) and in vivo tests were not included in the main dataset. These findings support traditional uses of <i>Z. spina-christi</i> and <i>B. aegyptiaca</i>, highlighting them as promising antibacterial candidates.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 3","pages":"679 - 692"},"PeriodicalIF":1.4,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of Citrullus lanatus seed powder against Ehrlich Ascites carcinoma induced cancer growth in Swiss albino mice","authors":"Most. Nurafruz Nipa,&nbsp;M. Matakabbir Hossain,&nbsp;Md. Abu Raihan¹,&nbsp;Abdul Auwal,&nbsp;K. M. Rashel,&nbsp;Tasfik Ul Haque Pronoy,&nbsp;Tasnima Kamal,&nbsp;Azmin Akter,&nbsp;Asmaulhusna Biswas,&nbsp;Sharmin Akter,&nbsp;Nitai Roy,&nbsp;Farhadul Islam","doi":"10.1007/s13596-025-00863-5","DOIUrl":"10.1007/s13596-025-00863-5","url":null,"abstract":"<div><p><i>Citrullus lanatus</i> (watermelon) is widely cultivated for its large, round fruits with juicy pulp. While the pulp is consumed as a dietary staple, the seeds, peels, and rind are often discarded or used as animal feed. However, the protective effect of the seed powder against Ehrlich ascites carcinoma (EAC) has yet to be studied. Thus, the current study aims to evaluate the protective activity of <i>C. lanatus</i> seed powder against EAC-induced cancer growth in a mouse model. The protective activity of <i>C. lanatus</i> seed powder against EAC cells was assessed through multiple parameters, such as cancer cell growth inhibition, inhibition of angiogenesis, survival time extension in tumor-bearing mice, tumor weight reduction, and hematological profile improvement, followed by pretreatment of mice with 5% seed powder in a normal diet for 60 days. Mice pretreated with <i>C. lanatus</i> seed powder demonstrated a 44.77% inhibition of EAC cell growth (<i>p</i> &lt; 0.05), a 35.29 increase in lifespan (<i>p</i> &lt; 0.05), and a significant reduction in tumor weight in EAC-bearing mice in comparison to that of untreated EAC-bearing animals. The seed powder supplement improved hematological parameters such as RBC, WBC, and Hb in tumor-bearing mice. In normal mice, the supplement had no significant adverse effects on hematological and biochemical parameters such as glucose, SGOT, SGPT, LDL, HDL, TG, cholesterol, and creatinine levels, remaining within normal ranges after the treatment period. These findings suggest that <i>C. lanatus</i> seed powder could provide immunity against the growth and proliferation of cancer cells, however, further research is necessary to identify the active compounds and elucidate the underlying mechanisms of its protective anticancer activity.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"493 - 506"},"PeriodicalIF":1.3,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148060616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine techniques for the management of fibromyalgia: a systematic review of randomized controlled trials","authors":"Helena L. Silva,&nbsp;Andreia V. Santos,&nbsp;Alexandra B. Monteiro,&nbsp;Maria R. Sousa,&nbsp;Jorge Magalhães Rodrigues","doi":"10.1007/s13596-025-00865-3","DOIUrl":"10.1007/s13596-025-00865-3","url":null,"abstract":"<div><p>Fibromyalgia, a chronic condition characterized by widespread pain and a constellation of other symptoms, presents a significant health challenge globally. Its underlying mechanisms remain elusive, and conventional treatments often fail to provide adequate relief. While conventional medications have a role, exploring complementary therapies becomes increasingly important. Traditional Chinese medicine (TCM), with its holistic approach and emphasis on balancing bodily systems, offers potential avenues for fibromyalgia management. This systematic review aims to critically evaluate the effectiveness and underlying mechanisms of TCM techniques in the management of fibromyalgia symptoms, based on recent randomized controlled trials. A systematic review was conducted, searching multiple databases for recent randomized controlled trials. Eighteen studies were included, involving 1595 participants. Techniques studied included acupuncture (manual and scalp), electroacupuncture, cupping, moxibustion, and herbal therapy. Acupuncture is suggested to be effective in reducing pain and fatigue, and improving the quality of life. Mechanisms may involve neurotransmitter modulation and improved brain connectivity. Cupping seems effective in reducing pain and improving quality of life. Its mechanisms may involve enhanced blood circulation and opioid release. Regarding moxibustion, it may be able to reduce pain levels and improve sleep quality. Mechanisms may involve inflammation modulation and brain activity regulation. <i>Qigong</i> also showed benefits in reducing pain, fatigue, and improving the quality of life. Mechanisms may involve nervous system regulation and energy balance. Finally, herbal Therapy’s limited evidence showed conflicting results. Traditional Chinese medicine techniques may be valuable complementary treatments for fibromyalgia. However, efficacy should be further investigated.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"281 - 303"},"PeriodicalIF":1.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148060963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging trends in pharmacological research of herbal-based traditional medicine","authors":"Phu-Tho Nguyen,&nbsp;Huu-Thanh Nguyen","doi":"10.1007/s13596-025-00866-2","DOIUrl":"10.1007/s13596-025-00866-2","url":null,"abstract":"<div><p>Traditional medicine (TM) has been practiced for millennia and remains vital in healthcare. However, its pharmacological mechanisms are not fully understood by modern scientific standards. Emerging research methodologies now allow for a more systematic exploration of TM’s multi-component and multi-target interactions. This review aims to explore emerging trends in pharmacological research of TM, focusing on advanced methodologies like network pharmacology, metabolomics, artificial intelligence (AI), and molecular docking. It examines how these methods contribute to understanding mechanisms of action, optimizing therapeutic efficacy, and integrating TM into modern medicine. A comprehensive literature review was conducted using major academic databases, including PubMed, Web of Science, and Scopus. Studies relevant to TM pharmacological research, with an emphasis on network pharmacology, metabolomics, AI applications, and molecular docking, were selected. These methodologies have identified multi-target interactions within classical TM formulations, aiding in the optimization of herbal prescriptions. Advances in metabolomics, proteomics, and lipidomics have provided insights into TM-induced biochemical changes. AI-driven techniques like deep learning and big data analytics support virtual screening, herb-drug interaction predictions, and precision medicine in TM. Molecular docking has improved the identification of bioactive compounds and therapeutic targets. Emerging technologies have revolutionized TM pharmacological research, bridging traditional knowledge with modern scientific validation. The integration of computational and experimental methods enhances TM’s applicability in modern healthcare. Further research is necessary to refine these approaches, ensuring wider acceptance of TM in evidence-based medicine.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"305 - 323"},"PeriodicalIF":1.3,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148061242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STIM2 suppressed Anti-tumor immunity in cholangiocarcinoma","authors":"Li-Ping Ying,&nbsp;Zong-Yang Wu,&nbsp;Jin-Bo Wang,&nbsp;Ji-Ye Feng,&nbsp;Kai Lu","doi":"10.1007/s13596-025-00860-8","DOIUrl":"10.1007/s13596-025-00860-8","url":null,"abstract":"<div><p>Stromal interaction molecule 2(STIM2) has been implicated in the progression of various kinds of tumors. Existing researches have not explored its effect on how tumor-associated macrophages (TAMs) are polarized into the M2 phenotype in cholangiocarcinoma. CCA cells underwent co-culture with an M2-like conditioned medium (M2-CM). We established the subcutaneous xenograft model of nude mice. The western blot together with quantitative real-time PCR (qPCR) assisted in the determination of molecule expression. STIM2 suppresses anti-tumor immunity in CCA through inhibiting CD8 + T cell under the mediation of TAM. STIM2 induces TAMs to be transformed into pro-tumorigenic M2-like phenotypes through the activation of cAMP signaling pathway. STIM2 holds a large potential of serving for the immunotherapy targeting CCA by virtue of TAMs. The molecular mechanism regarding its tumor-promoting effect in CCA is elucidated in the study.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 2","pages":"483 - 491"},"PeriodicalIF":1.3,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148060953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the anti-biofilm potential of phytoconstituents of culinary spices against candidiasis","authors":"Khushbu Wadhwa,&nbsp;Hardeep Kaur,&nbsp;Neelam Yadav,&nbsp;Jaya Pandey,&nbsp;Mohd Tariq,&nbsp;Farid Menaa,&nbsp;Neha Kapoor,&nbsp;Tabarak Malik","doi":"10.1007/s13596-025-00858-2","DOIUrl":"10.1007/s13596-025-00858-2","url":null,"abstract":"<div><p>The culinary spices exhibit aromatic flavours, vibrant colour and medicinal properties. Despite the growing interest in the spices-derived phytocompounds (e.g., alkaloids, terpenoids, polyphenols, fatty acids), there is still a paucity of research exploring their mechanism and efficiency as antifungal and antibiofilm agents against candidiasis. Hence, exploring spice-derived nutraceuticals, as potential antibiofilm agents against invasive fungal infections caused by <i>Candida</i> spp. offers promising prospects for the treatment of candidiasis. In this review article, we report 15 naturally occurring spices and their extracts capable of fighting invasive fungal infections caused by <i>Candida</i> spp. We also strove to understand their underlying molecular mechanisms and relative efficacy. This could lead to the development of novel therapeutic antifungal scaffolds. However, the pharmacokinetic assessment and toxicological studies of spice-derived phytocompounds must be critically checked to evaluate their safety profile and to establish their potential in translational medicine.</p><h3>Graphical abstract</h3><p>Culinary spices obtained from different parts of the plant.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"26 1","pages":"17 - 46"},"PeriodicalIF":1.3,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147341093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}