Advances in Traditional Medicine最新文献_第6页

Validation of the constitution in Chinese medicine questionnaires with the newly developed blood-vacuity category: a rare Taiwanese case study 用新开发的血虚类别验证中医问卷中的体质：一项罕见的台湾案例研究

IF 1.8

Advances in Traditional Medicine Pub Date : 2024-07-01 DOI: 10.1007/s13596-024-00769-8

Ting-Yu Huang, Shi-Chen Ou, Wei-Te Huang, Yu-Chuan Lin, Hao-Hsiu Hung, Chin-Wei Chang, Kai-Yuan Hsiao, Yi-Wei Kao, Chien-Hua Wu, Wei-Shan Chang, Ben-Chang Shia, Sheng-Teng Huang

{"title":"Validation of the constitution in Chinese medicine questionnaires with the newly developed blood-vacuity category: a rare Taiwanese case study","authors":"Ting-Yu Huang, Shi-Chen Ou, Wei-Te Huang, Yu-Chuan Lin, Hao-Hsiu Hung, Chin-Wei Chang, Kai-Yuan Hsiao, Yi-Wei Kao, Chien-Hua Wu, Wei-Shan Chang, Ben-Chang Shia, Sheng-Teng Huang","doi":"10.1007/s13596-024-00769-8","DOIUrl":"10.1007/s13596-024-00769-8","url":null,"abstract":"<div><p>The concept of body constitution (BC) is a core notion in traditional Chinese medicine, used in diagnosis, treatment, and prevention; however, there is little standardization in terms of definitions and measurements. To improve standardization, constructive questionnaires have been developed to classify the various BC types. One of the most commonly used is the Constitution in Chinese Medicine Questionnaire (CCMQ). Despite including nine BCs, CCMQ lacks the blood-vacuity constitution, although it is often noted in clinical practice. In this study, we have modified the original CCMQ to include the blood-vacuity constitution and amended the language to better suit the Taiwan population. The revised questionnaire was given to a panel of experts to check for content validity, and then distributed to volunteers for completion. The reliability analysis, based on 512 valid questionnaires, achieved a Cronbach’s alpha value of 0.65–0.86. The content validity index scores ranged from 60 to 100. In addition, we collected demographic data from our volunteers and found that BMI, gender, exercise frequency, disease status, allergies, and psychiatric disorder status may impact the body constitution. Collectively, our study presents an expanded version of the CCMQ which includes the blood-vacuity constitution, and has been validated among the Taiwanese population. Demographic data also demonstrates possible relationships among BC, lifestyle and diseases.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 4","pages":"1205 - 1213"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141711017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phyto-chemical, analytical evaluation and biological attributes of rare medicinal species of flowering shrub Bauhinia racemosa L. 稀有药用花灌木洋紫荆（Bauhinia racemosa L.）的植物化学、分析评价和生物属性

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Advances in Traditional Medicine Pub Date : 2024-07-01 DOI: 10.1007/s13596-024-00761-2

Mary Shamya Arokiarajan, J. John Christopher, S.A. Wasim Akram, N. Zaheer Ahmed, Rampratap Meena, K. Kabiruddin Ahmed

{"title":"Phyto-chemical, analytical evaluation and biological attributes of rare medicinal species of flowering shrub Bauhinia racemosa L.","authors":"Mary Shamya Arokiarajan, J. John Christopher, S.A. Wasim Akram, N. Zaheer Ahmed, Rampratap Meena, K. Kabiruddin Ahmed","doi":"10.1007/s13596-024-00761-2","DOIUrl":"10.1007/s13596-024-00761-2","url":null,"abstract":"<div><p>The current investigation compared the efficacy of an ethanol extract of <i>B. racemosa</i> L. leaf against standard bacterial and fungal cultures. Quantitative phytochemical analysis of Phenol, Flavonoid and Tanin was studied by the appropriate methods; Heavy metal test was done by Atomic Absorption Spectrometer; Antimicrobial activity was done by disc diffusion and agar well diffusion method; MIC through 96 well method and antioxidant assay was performed by DPPH and ABTS. Ethanol extract of <i>B. racemosa</i> L. showed significantly higher inhibitory effect against <i>E. coli</i>, <i>S. aureus</i> and <i>B. cereus</i>, and moderate antimicrobial activity against <i>K. pneumoniae</i>, but it was inactive on fungal strain at lower concentrations. The minimum bactericidal concentration of <i>B. racemosa</i> L. extract against the pathogenic bacteria tested was 1.25 mg/ml for <i>P. aeruginosa</i>, 2.5 mg/ml for <i>E. coli</i> and 5 mg/ml for <i>B. cereus</i>, <i>K. pnuemoniae</i>, and <i>S. aureus</i>. The extract has exhibited antioxidant activity which was evaluated by DPPH and ABTS as 61.61 ± 0.61 and 64.45 ± 0.49% of inhibition in 250 µg/ml concentration. Prominent phytochemical bioconstituents, as determined by phytochemical investigation, comprise flavonoids (8.712 ± 0.7 mg/g Rutin equivalents), tannins (2.930 ± 0.73 mg/g Tannic acid equivalents) and phenol (12.06 ± 0.25 mg/g Gallic acid equivalents) etc. Lethality experiment was performed by using brine shrimp to determine the cytotoxicity of plant extract and the substantial mortality rate observed as LC50 = 22.8435 µg/mL. The result of fluorescence analysis showed various shades of green and brown fluorescence in visible light and various shades of green, blue and brown were found under UV light. HPTLC, FTIR and GCMS were done to find out the bioactive phytocompounds.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 4","pages":"1181 - 1203"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of the efficacy of herbal medicines in the treatment of acute diarrhea 草药治疗急性腹泻疗效的系统综述

IF 1.8

Advances in Traditional Medicine Pub Date : 2024-06-26 DOI: 10.1007/s13596-024-00766-x

Emmanuel Prempeh, Lennox Akwetey, Samuel Ankamah, Naomi Amofah-Serwaa, Emelia Bekoe

{"title":"A systematic review of the efficacy of herbal medicines in the treatment of acute diarrhea","authors":"Emmanuel Prempeh, Lennox Akwetey, Samuel Ankamah, Naomi Amofah-Serwaa, Emelia Bekoe","doi":"10.1007/s13596-024-00766-x","DOIUrl":"10.1007/s13596-024-00766-x","url":null,"abstract":"<div><p>Acute diarrhea is a global health challenge, especially in developing regions. It accounted for 444,000 child mortalities in 2021, and indiscriminate use of antibiotics in its management is reported to contribute significantly to increase in antibiotic resistance. The objective of this study was to identify herbal drugs which are efficacious in acute diarrhea treatment. This systematic review assessed the efficacy of herbal medicines in treating acute diarrhea through the analysis of randomized controlled trials. The review followed PRISMA and the Cochrane Handbook guidelines. Literature search was performed in PubMed, CINAHL, Web of Science, Scopus, Cochrane Central, and a clinical trial registry for studies involving human subjects with acute diarrhea and herbal medicine (HM) interventions. Primary outcome measures included stool consistency, stool frequency, duration of diarrhea, abdominal pain, nausea and vomiting, and pyrexia. The search found 2581 articles, of which 9 involving 916 participants (72% children, 27% adults) were analyzed. The studies span 1976–2022, and assessed: <i>Boswellia serrata</i> (Indian frankincense), <i>Rheum ribes </i>L. (rhubarb)<i>, Camellia sinensis</i> (black tea)<i>, Potentilla tormentilla</i> (Septfoil), apple pectin-chamomile extract, kaolin-pectin, Dirasif (multi-herbal preparation), <i>Psidium guajava</i> (guava folia), and Dowdo (wheat and milk herbal feed). The studies had varying participant age ranges, diarrhea causes, and risks of bias. Only <i>C. sinensis</i> was able to reduce stool consistency, while R<i>. ribes</i> and <i>B. serrata</i> reduced diarrhea duration significantly. Other HMs had positive effects on abdominal pain, nausea and vomiting, and pyrexia. Studies on <i>C. sinensis B. serrata</i> extract, <i>R. ribes</i>, and <i>P. tormentilla</i> extract demonstrated significant efficacy and, low to moderate risk of bias.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"25 2","pages":"371 - 384"},"PeriodicalIF":1.8,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Unveiling the potential antibacterial mechanism of Melaleuca cajuputi leaf extract by cell morphology studies and molecular docking analysis 更正为通过细胞形态学研究和分子对接分析揭示 Melaleuca cajuputi 叶提取物的潜在抗菌机制

IF 1.8

Advances in Traditional Medicine Pub Date : 2024-06-24 DOI: 10.1007/s13596-024-00767-w

Musa Isah, Wan‑Nor‑Amilah Wan Abdul Wahab, Hasmah Abdullah, Shajarahtunnur Jamil, Mohd Dasuki Sul’ain, Abdullahi Ibrahim Uba, Gokhan Zengin, Dibyajit Lahiri, Hisham Atan Edinur, Wan Rosli Wan Ishak

引用次数: 0

Unravelling therapeutic potential and nano formulation approaches of farnesol, a bioactive sesquiterpene 一种具有生物活性的倍半萜——法尼醇的治疗潜力和纳米配方方法

IF 1.8

Advances in Traditional Medicine Pub Date : 2024-06-23 DOI: 10.1007/s13596-024-00768-9

Tabasum Ali, Rabiah Bashir, Ifat Jan, Khurshid Iqbal Andrabi, Ghulam Nabi Bader

{"title":"Unravelling therapeutic potential and nano formulation approaches of farnesol, a bioactive sesquiterpene","authors":"Tabasum Ali, Rabiah Bashir, Ifat Jan, Khurshid Iqbal Andrabi, Ghulam Nabi Bader","doi":"10.1007/s13596-024-00768-9","DOIUrl":"10.1007/s13596-024-00768-9","url":null,"abstract":"<div><p>Historically natural compounds and their structural equivalents have significantly contributed to pharmacotherapy. Sesquiterpenes, the C15-terpenoids are the source of many modern pharmaceuticals and therapeutic medications. These are mostly present in higher plants as well as other living systems including fungi and marine animals. They exist naturally as hydrocarbons or in oxygenated forms like lactones, alcohols, acids, aldehydes, and ketones. The sesquiterpene alcohol; farnesol isolated from plants like <i>Cymbopogon nardus, Polianthes tuberosa</i> and <i>Cyclamen persicum</i> is a promising biomolecule having immense pharmacological properties. Various studies have shown its potential as an anti-inflammatory, antioxidant, cardioprotective, antihypertensive, antidiabetic, antianxiety, antimicrobial, hepatoprotective, and anticancer agent. This review summarizes the importance of sesquiterpenes with special reference to pharmacological properties of farnesol, the design and development of its nano formulations such as a nanoparticle, nanogels, nanocomposites, etc., and their efficacy in in vivo and in vitro models.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"25 2","pages":"353 - 370"},"PeriodicalIF":1.8,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological potential Maclura tinctoria （L.）Don ex Steud。（桑科）：民族植物学知识，植物化学成分和药理潜力的进展综述

IF 1.8

Advances in Traditional Medicine Pub Date : 2024-06-20 DOI: 10.1007/s13596-024-00764-z

Patricia Quintero-Rincón, Yina Pájaro-González, Fredyc Diaz-Castillo

{"title":"Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological potential","authors":"Patricia Quintero-Rincón, Yina Pájaro-González, Fredyc Diaz-Castillo","doi":"10.1007/s13596-024-00764-z","DOIUrl":"10.1007/s13596-024-00764-z","url":null,"abstract":"<div><p><i>Maclura tinctoria</i> (Moraceae), commonly known as dinde, is a lactescent tree of significant economic importance with extensive ethnomedicinal and ethnobotanical applications. Among native populations in the Neotropics, dinde is used to address diverse forms of inflammatory arthritis, along with ailments stemming from viral, bacterial, or fungal origins. Its efficacy stands out notably in the treatment of conditions affecting the buccal cavity, respiratory tract, and venereal infections. These medicinal attributes have spurred investigations into their potential for developing nutraceuticals and pharmacological agents. Also, dinde has a commercial appeal intertwined with the remarkable qualities of its wood, which include the resistance to moisture and termites. This review consolidates information encompassing peer-reviewed articles from major scientific databases such as Science Direct, Scopus, Springer, PubMed, and Google Scholar. The review spans fifty-four phytocompounds, characterized by remarkable structural complexity and identified from the year 2000 onward. These compounds are categorized into flavones, isoflavones, flavonols, flavanols, flavanones, chalcones, and xanthones, where a significant portion exhibiting glycosylation or prenylation. Additionally, phenolic acids and condensed tannins contribute to the chemical diversity of this species. This comprehensive review offers updated insights into the potential bioactivity of chemical constituents identified in this plant, elucidating findings derived from different studies employing both in vitro and in vivo assays.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"25 2","pages":"331 - 351"},"PeriodicalIF":1.8,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13596-024-00764-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Larvicidal and antiplasmodial studies of Eucalyptus camaldulensis (Myrtaceae) Leaf 桉树（桃金娘科）叶的杀幼虫剂和抗疟研究

IF 1.8

Advances in Traditional Medicine Pub Date : 2024-06-18 DOI: 10.1007/s13596-024-00765-y

Stephen A. Adesida, Samuel A. Oguntimehin, Funmilayo G. Famuyiwa, Kolade O. Faloye, Seun B. Ogundele, Oyenike I. Bello, Oluyemi J. Oladiran, Ayobami J. Olusola, Adetola H. Adewole, Praise A. Adebayo, Maryam O. Oredola

{"title":"Larvicidal and antiplasmodial studies of Eucalyptus camaldulensis (Myrtaceae) Leaf","authors":"Stephen A. Adesida, Samuel A. Oguntimehin, Funmilayo G. Famuyiwa, Kolade O. Faloye, Seun B. Ogundele, Oyenike I. Bello, Oluyemi J. Oladiran, Ayobami J. Olusola, Adetola H. Adewole, Praise A. Adebayo, Maryam O. Oredola","doi":"10.1007/s13596-024-00765-y","DOIUrl":"10.1007/s13596-024-00765-y","url":null,"abstract":"<div><p><i>Eucalyptus camaldulensis</i> is a medicinal plant used as insect repellant and antimalarial agent in ethnomedicine. This study examined the antiplasmodial and larvicidal potential of <i>E. camaldulensis</i> leaf extract and also identified the plant extract's most active fraction(s). The acute oral toxicity test of the methanol extract was evaluated using Lorke’s method. The larvicidal assay was performed on the extract and partitioned fractions according to the 2005 World Health Organization guidelines, while the 4-day chemosuppressive and curative antimalarial assays were carried out against <i>Plasmodium bergei bergei</i>. Endosulphan and chloroquine (10 mg/kg) was used as the positive controls for the larvicidal and antiplasmodial assays, respectively, while tween 80 in normal saline (1%) was the negative control. The methanol leaf extract of EC showed good larvicidal activity across all tested concentrations (LC<sub>50</sub> 3.79 ± 0.64 mg/mL), while the aqueous fraction with LC<sub>50</sub> of 2.80 ± 0.14 mg/mL was the most active. Its acute toxicity test showed it was safe up to 5000 mg/kg. The extract significantly increased dose-dependent antiplasmodial activity for the chemosuppressive and curative models (<i>p</i> < 0.05) than the negative control. At 800 mg/kg, EC gave chemosuppressive (53.69 ± 1.62%) and curative (81.26 ± 1.87%) activities, which was significantly lower than that of 10 mg/kg chloroquine (82.00 ± 0.57% and 92.51 ± 0.22% respectively). The aqueous partitioned fraction gave the highest chemosuppression (73.84 ± 2.73%) at 80 mg/kg, which was comparable to the positive control. The methanol extract of <i>E. camaldulensis</i> leaf is a promising larvicidal and antimalarial agent that could proffer a solution to vector control and the prevalence of malaria.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 4","pages":"1169 - 1179"},"PeriodicalIF":1.8,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cecropia obtusifolia: phytopharmacology and its potential use in the treatment of diseases Cecropia obtusifolia：植物药理学及其在疾病治疗中的潜在用途

IF 1.8

Advances in Traditional Medicine Pub Date : 2024-06-13 DOI: 10.1007/s13596-024-00756-z

Yolotl Moreno-Hernandez, Zendy Evelyn Olivo-Vidal, Xariss Miryam Sánchez-Chino, Angel Betanzos-Reyes, Benito Salvatierra-Izaba

{"title":"Cecropia obtusifolia: phytopharmacology and its potential use in the treatment of diseases","authors":"Yolotl Moreno-Hernandez, Zendy Evelyn Olivo-Vidal, Xariss Miryam Sánchez-Chino, Angel Betanzos-Reyes, Benito Salvatierra-Izaba","doi":"10.1007/s13596-024-00756-z","DOIUrl":"10.1007/s13596-024-00756-z","url":null,"abstract":"<div><p>Chronic non-communicable diseases are the primary cause of death globally, with infectious diseases following closely behind. Therefore, efforts are being made worldwide to combat and manage these diseases through the discovery of new treatments, including the exploration of natural products. <i>Cecropia obtusifolia</i> has gained attention due to its pharmacological properties, including hypotensive, hypoglycemic, hypolipidemic, and antimalarial effects. These properties have been attributed to the secondary metabolites present, such as chlorogenic acid, isoorientin, and flavonolignans. The plant has demonstrated the ability to lower blood glucose and lipids, reduce blood pressure, and exhibit antiplasmodial activity. Therefore, this report comprehensively reviews the pharmacological effects and potential applications in treating various illnesses. It aims to serve as a reference for further research and the use of this compound as a therapeutic agent.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><img></picture></div></div></figure></div></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"25 1","pages":"57 - 67"},"PeriodicalIF":1.8,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141347291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the potential antibacterial mechanism of Melaleuca cajuputi leaf extract by cell morphology studies and molecular docking analysis 通过细胞形态学研究和分子对接分析揭示 Melaleuca cajuputi 叶提取物的潜在抗菌机制

IF 1.8

Advances in Traditional Medicine Pub Date : 2024-06-04 DOI: 10.1007/s13596-024-00763-0

Musa Isah, Wan-Nor-Amilah Wan Abdul Wahab, Hasmah Abdullah, Shajarahtunnur Jamil, Mohd Dasuki Sul’ain, Abdullahi Ibrahim Uba, Gokhan Zengin, Dibyajit Lahiri, Hisham Atan Edinur, Wan Rosli Wan Ishak

{"title":"Unveiling the potential antibacterial mechanism of Melaleuca cajuputi leaf extract by cell morphology studies and molecular docking analysis","authors":"Musa Isah, Wan-Nor-Amilah Wan Abdul Wahab, Hasmah Abdullah, Shajarahtunnur Jamil, Mohd Dasuki Sul’ain, Abdullahi Ibrahim Uba, Gokhan Zengin, Dibyajit Lahiri, Hisham Atan Edinur, Wan Rosli Wan Ishak","doi":"10.1007/s13596-024-00763-0","DOIUrl":"10.1007/s13596-024-00763-0","url":null,"abstract":"<div><p>The antimicrobial properties of the <i>Melaleuca cajuputi</i> plant have been documented. However, the underlying antimicrobial mechanisms remain relatively unexplored. Thus, this study aimed to investigate the antibacterial effects of <i>M. cajuputi</i> leaf extract against selected bacterial strains and unveil the potential antibacterial mechanisms of the most potent sub-fraction through time-kill assay, cell morphology studies, and molecular docking analysis. The fractions and sub-fractions were obtained from the methanolic extract of <i>M. cajuputi</i> leaf by bioassay-guided fractionation. The antibacterial activity was tested against <i>Staphylococcus aureus, Streptococcus agalactiae, Klebsiella pneumoniae,</i> and <i>Escherichia coli</i> using broth microdilution assay. The most potent sub-fraction, Melaleuca fraction 2d (MF2d), demonstrated remarkable antibacterial activity with MIC values ranging from 0.063 to 0.25 mg/mL and induced significant cellular damage against the tested bacteria. The chemical characterization of the most potent sub-fraction (MF2d) from methanolic extract of <i>M. cajuputi</i> leaf identified five (5) compounds with 2-isopropyl-10-methyl phenanthrene (83.09%) as the major component. <i>In-silico</i> molecular docking analysis revealed that all the docked ligands showed strong binding propensity towards target bacterial proteins, including DNA gyrase (PDB ID: 1ZI0), dihydropteroate synthase (PDB ID: 1AD1), and D-alanyl transferase (PDB ID: 6O93) with the binding energy ranging from − 6.0 to − 8.4 kcal/mol. The overall findings demonstrated the potential of the <i>M. cajuputi</i> plant as a valuable source of novel antibacterial agents.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 4","pages":"1157 - 1168"},"PeriodicalIF":1.8,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survey the change of skin surface temperature at the face when using tonifying or dispersing acupuncture manipulations at dazhui acupoint in healthy volunteers 调查健康志愿者在大椎穴使用补法或散法针刺时面部皮肤表面温度的变化

IF 1.8

Advances in Traditional Medicine Pub Date : 2024-06-03 DOI: 10.1007/s13596-024-00762-1

Dieu-Thuong Thi Trinh, Phuong-Quynh Ngoc Le, Minh-Man Pham Bui, Nguyen Lam Vuong

{"title":"Survey the change of skin surface temperature at the face when using tonifying or dispersing acupuncture manipulations at dazhui acupoint in healthy volunteers","authors":"Dieu-Thuong Thi Trinh, Phuong-Quynh Ngoc Le, Minh-Man Pham Bui, Nguyen Lam Vuong","doi":"10.1007/s13596-024-00762-1","DOIUrl":"10.1007/s13596-024-00762-1","url":null,"abstract":"<div><p>In addition to stimulating specific acupoints, acupuncture uses manipulations with varying effects. For Dazhui acupoint, tonifying acupuncture clears heat, while dispersing acupuncture dissipates it. This study aims to compare changes in facial skin temperature caused by these techniques in healthy volunteers. The single-blinded, randomized controlled trial involved 57 healthy volunteers aged 18–30, undergoing three sessions of acupuncture with a one-week interval. Participants were randomly assigned to three groups with different acupuncture sequences: sham-tonifying-dispersing, tonifying-dispersing-sham, and dispersing-sham-tonifying. Acupuncture sessions lasted 30 min, and facial skin temperatures were measured at five time points using a FLIR C5 thermal camera. We recorded that tonifying acupuncture at the Dazhui acupoint led to a significant increase from 34.30 °C (33.65–35.20 °C) to 35.40 °C (34.85–35.85 °C) in facial skin temperature while dispersing acupuncture led to a significant decrease from 34.90 °C (33.95–35.65 °C) to 34.00 °C (33.00–34.75 °C). Compared to the sham group, both tonifying and dispersing acupuncture showed significant differences in skin temperature. The variation in skin temperature between tonifying and dispersing acupuncture was also statistically significant. These results show that acupuncture at the Dazhui acupoint can influence facial skin temperature, establishing a relationship between this acupoint and facial physiology. Moreover, the contrasting skin temperature responses to tonifying and dispersing acupuncture techniques at Dazhui validate their distinct physiological effects.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 4","pages":"1147 - 1155"},"PeriodicalIF":1.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141268717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0