American Journal of Ophthalmology最新文献

{"title":"Ophthalmological and Genetic Profile in Knobloch Syndrome","authors":"Sengul Ozdek ,&nbsp;Ece Ozdemir Zeydanli ,&nbsp;Gulsum Kayhan ,&nbsp;Ebru Yalcin ,&nbsp;Huseyin Baran Ozdemir ,&nbsp;Mehmet Ali Ergun ,&nbsp;Kenan Sonmez ,&nbsp;Arif O. Khan ,&nbsp;Nicola G. Ghazi","doi":"10.1016/j.ajo.2025.05.003","DOIUrl":"10.1016/j.ajo.2025.05.003","url":null,"abstract":"<div><h3>Purpose</h3><div>To analyze the clinical and genetic characteristics of Knobloch syndrome (KNO) in a large cohort, with a focus on retinal detachment (RD) characteristics, surgical outcomes, and variants in the COL18A1 gene.</div></div><div><h3>Design</h3><div>Retrospective, multicenter interventional/observational case series.</div></div><div><h3>Subjects</h3><div>Thirty-four patients (68 eyes) with clinically and genetically confirmed KNO were included.</div></div><div><h3>Methods, Intervention, or Testing</h3><div>Data were collected from three institutions, including demographics, clinical findings, surgical techniques, and outcomes, and genetic testing results. Surgical success was defined as retinal reattachment after silicone oil removal. Genetic testing was performed for the COL18A1 gene to identify pathogenic variants.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcomes included the prevalence and characteristics of RD, surgical success rates, and the identification of pathogenic variants in COL18A1.</div></div><div><h3>Results</h3><div>The median age at diagnosis was 24 months, with consanguinity noted in 76% of cases. RD occurred in 50% of eyes, with a median onset of 2.5 years. Macular hole (MH)-related RD accounted for 57% of cases and presented early (median age: 11 months). Surgical success after the first procedure was 54%, improving to 69% after reoperation. The use of Tenon’s capsule or amniotic membrane grafts in 69% of MH-RD cases doubles the reattachment rate (82% vs 40%). Genetic testing identified 14 COL18A1 variants, including nine novel variants.</div></div><div><h3>Conclusions</h3><div>KNO presents significant diagnostic and surgical challenges: early-onset RD, small flap-shaped MHs that are easily overlooked, and an abnormally adherent vitreoretinal interface. Early recognition of MH-RD and the use of grafts during surgery can improve anatomical outcomes. While the ocular phenotype is often pathognomonic, genetic testing aids in confirming the diagnosis and guiding counseling. Understanding these clinical and surgical challenges may improve outcomes in patients with this rare disorder.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"277 ","pages":"Pages 87-95"},"PeriodicalIF":4.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and Facilitators of Implementing a Community and Faith-Based Intervention to Increase Eye Care Utilization in Black Americans.","authors":"Dominique A Alexis,Olivia L Johnson,Charles E Williams,Paula Anne Newman-Casey,Gretchen A Piatt,Angela R Elam","doi":"10.1016/j.ajo.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.05.006","url":null,"abstract":"Purpose To identify the determinants to successfully implement a community-based intervention to increase eye care utilization in individuals at high-risk for glaucoma. Design Qualitative study with semi-structured interviews Methods Semi-structured qualitative interviews were conducted with community members in Detroit, Michigan at a trusted community site. Participants were Black Americans at least 40 years of age. A codebook of themes was developed through an iterative process and analyzed using Dedoose. Results Narrative themes emerged under two overarching categories: barriers and facilitators. The number of themes identified were 15 and 14 for barriers and facilitators, respectively. All perceived barriers and facilitators fell into one or more domains of the social determinants of health model. Conclusion Identifying facilitators and eliminating barriers to eye care in Black and low-income communities is essential to successful implementation of interventions to increase eye care utilization. Understanding how these determinants align with social determinants of health may be helpful in designing community-based interventions. Community-based participatory research methods are critical to achieving equity in eye care.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"53 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IOL Power Calculation Project: Accuracy of 36 Formulas","authors":"Oleksiy V. Voytsekhivskyy ,&nbsp;Kenneth J. Hoffer ,&nbsp;David L. Cooke ,&nbsp;Giacomo Savini","doi":"10.1016/j.ajo.2025.05.004","DOIUrl":"10.1016/j.ajo.2025.05.004","url":null,"abstract":"<div><h3>PURPOSE</h3><div>To ascertain the refractive accuracy of 36 intraocular lens (IOL) power calculation formulas in unoperated eyes.</div></div><div><h3>DESIGN</h3><div>Retrospective accuracy and validity analysis.</div></div><div><h3>PARTICIPANTS</h3><div>Six hundred fifty-five patients undergoing phacoemulsification and implantation of the Tecnis 1 ZCB00 IOL (Johnson &amp; Johnson Vision, Jacksonville, FL, USA).</div></div><div><h3>METHODS</h3><div>Thirty-six formulas were evaluated including some that have never been tested, such as 3C 2.0, Eom, Hoffer H, Hoffer H-5, Fam adjusted methods, Norrby Regression Formula (Norrby RF), Norrby thin lens paraxial Ray-Tracing (Norrby RT), and VRF Cooke modified axial length (VRF CMAL). Optical biometry with the IOLMaster 700 (Carl Zeiss Meditec AG) was performed preoperatively. All descriptive statistics and the percentage of eyes within prediction error thresholds were evaluated with optimized lens constants.</div></div><div><h3>MAIN OUTCOME MEASURES</h3><div>The Formula Performance Index (FPI) and Formula Performance Index for subgroup (FPI sub) were used as the primary formula outcomes.</div></div><div><h3>RESULTS</h3><div>The highest FPI indexes were yielded by the VRF-G (0.590), Hoffer QST (0.575), VRF CMAL (0.574), Eom (0.572), EVO 2.0 (0.569), and Kane (0.568) formulas. The heteroscedastic test revealed statistically significant differences (<em>P</em> &lt; .05) among formulas. The standard deviation (SD) of VRF-G (0.353 D), EVO 2.0 (0.362 D), Kane (0.366 D), Hoffer QST (0.371 D), and Eom (0.372 D) were lower than other methods (<em>P</em> &lt; .05). The highest percentage of eyes with a PE within ±0.50 D was achieved by VRF-G (87.48%), Kane (86.41%), Hoffer QST (86.26%), and PEARL-DGS (86.26%).</div></div><div><h3>CONCLUSION</h3><div>Contemporary IOL power calculation formulas (Eom, EVO 2.0, Hoffer QST, VRF CMAL, and VRF-G) improved accuracy in all axial length ranges compared to traditional and updated methods. The CMAL method raised the accuracy of the VRF formula.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"277 ","pages":"Pages 45-56"},"PeriodicalIF":4.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular Pressure Monitoring Using An Implantable Sensor Detects Structural Glaucoma Progression in the EYEMATE-IO Trial.","authors":"Eleonora Micheletti,Harsha Rao,Robert N Weinreb,Kaweh Mansouri,","doi":"10.1016/j.ajo.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.05.010","url":null,"abstract":"OBJECTIVE AND PURPOSETo evaluate the association between intraocular pressure (IOP) measurements and concurrent rates of retinal nerve fiber layer (RNFL) thinning in primary open-angle glaucoma (POAG) eyes previously implanted with a sulcus-based IOP sensor.DESIGNThis case series is part of the prospective, open-label, multicenter interventional EYEMATE-SC trial.SUBJECTS, PARTICIPANTS, AND/OR CONTROLSPatients implanted with the EYEMATE-IO sensor system (Implandata, Hanover, Germany) were enrolled in the 3 years' ARGOS-03 follow-up study.METHODS, INTERVENTION, OR TESTINGAll patients enrolled had at least five optical coherence tomography (OCT) examinations six-months apart with minimum two years follow-up. A minimum of 4 IOP measurements daily at different times of the day were obtained with the EYEMATE-IO.MAIN OUTCOME MEASURESMean IOP, peak IOP, and fluctuation of IOP measured by EYEMATE-IO sensor during the period between two consecutive OCT examinations were calculated and the relationship with OCT RNFL thinning was analyzed using mixed effects models. The relationship of mean IOP measured by Goldmann applanation tonometry (GAT) on the day of OCT visit with RNFL thinning was also analyzed.RESULTSEight eyes of 8 patients with the EYEMATE-IO sensor were included in the analysis. The mean number of self-measurements of IOP per patient was 7283 ± 5562 (range 1478 to 17247), with a mean follow-up time of 2.88 ± 0.19 years (range 2.43 to 3.01). The mean number of OCT examinations per patient was 6.38 ± 0.74 (range 5 to 7). Overall, the mean rate of RNFL thinning during the follow-up was -0.62 ± 1.06 um/year (P=0.274). In the linear mixed-effects model analysis, both peak IOP and IOP fluctuations measured using the EYEMATE-IO sensor were significantly associated with RNFL thinning (coefficient [95%CI]: -0.11 [-0.19;-0.34], P=0.005 and -0.76 [-1.31;-0.20], P=0.007, respectively), whereas no association was found for in-office mean IOP measured by GAT (coefficient 95%CI]: 0.04 [-0.12;0.20], P=0.616).CONCLUSIONSPeak IOP and IOP fluctuations in glaucoma patients derived from measurements with the EYEMATE-IO sensor were associated with progression of the disease, whereas GAT measurements were not. These findings suggest that self-measurements of IOP throughout the day with an implantable IOP sensor can predict glaucoma progression.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"76 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Screening Examination for CMV Retinitis among Patients with CMV Viremia.","authors":"Chloe Y Li,Andrew Massa,Maria Krisch,Neha Gupta,Nilesh Raval,Tavish Nanda,James Lin,Mark P Breazzano,Srilaxmi Bearelly","doi":"10.1016/j.ajo.2025.04.039","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.04.039","url":null,"abstract":"PURPOSETo determine utility of cytomegalovirus retinitis (CMVR) screening among patients with CMV bloodstream infection (viremia) in the context of multiple and recently implemented state-wide policies in heightening congenital screening.DESIGNRetrospective diagnostic testing evaluation.STUDY POPULATION- All patients with CMV viremia and ophthalmologic examination during the study period between 2010 and 2023 were included.METHODS- Patients with CMV viremia were identified via International Classification of Diseases (ICD)-10 code. Information regarding their demographics and clinical course were collected from respective electronic health records.MAIN OUTCOME MEASURE(S)- Immunocompromising conditions, CMV testing modality, CMV plasma titer, ophthalmic findings, CD4 count, CMVR diagnosis (presumed or confirmed based on direct ocular tissue confirmation), and visual acuity.RESULTS234 patients with CMV viremia and underwent a screening dilated fundus examination during inpatient hospitalization between 2010 and 2019 were identified. 18 (7.7%) patients with CMV viremia were found to have CMVR. Among 49 pediatric patients, 2 (4.1%) had CMVR; zero neonates with congenital infection had CMVR. Five CMVR patients had confirmed ocular CMV infection by aqueous humor testing, while remaining 13 did not and were classified as presumed CMVR cases. Among all CMVR cases, 14 (78%) were symptomatic, while 2 (11%) were asymptomatic and 2 (11%) were unable to report symptoms. Factors associated with increased risk of CMVR diagnosis included: HIV/AIDS infection (unadjusted OR [uOR]: 4.83, 95% CI: 1.76-12.35) and presence of ocular symptoms (uOR: 14.3, 95% CI: 3.6 to 64.4). After adjusting for race, HIV/AIDS infection status, and presence of ocular symptoms, HIV/AIDS infection (adjusted OR [aOR]: 4.12, 95%CI: 1.33 to 14.22) and ocular symptoms (aOR: 14.88, 95% CI: 3.82 to 99.2) remained significantly associated with increased risk of CMVR.CONCLUSIONPatients with CMV viremia and HIV/AIDS infection or visual symptoms are at significantly elevated risk of CMVR and should undergo ophthalmic examination. Meanwhile, the utility of DFE in neonates with congenital CMV infection but no clinically observable sequelae of infection is debatable, given the rarity of CMVR while undergoing concurrent systemic treatment in this population. Although larger, prospective studies would be informative, retinal screening in neonates with congenital CMV infection without other clinical signs of infection does not appear supported by these and other recent data.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"68 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lawnmower-Related Eye Injuries in the U.S., 2004 to 2023","authors":"Nicholas R. Stange ,&nbsp;Charles A. Jennissen","doi":"10.1016/j.ajo.2025.04.038","DOIUrl":"10.1016/j.ajo.2025.04.038","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the epidemiology, mechanisms, and trends of lawnmower-related eye injuries in the U.S., focusing on national estimates, injury types, and high-risk populations.</div></div><div><h3>Design</h3><div>A retrospective trend study.</div></div><div><h3>Participants</h3><div>Individuals presenting to National Electronic Injury Surveillance System (NEISS) emergency departments.</div></div><div><h3>Methods</h3><div>Lawnmower-related eye injuries from 2004 to 2023 were identified using the NEISS. The database narratives were coded to classify the mechanism of injury and other variables. Periorbital injuries were not included. Descriptive and comparative analyses (chi-square and Fisher’s exact test) were performed of national estimates derived using statistical weights.</div></div><div><h3>Main Outcome Measures</h3><div>Injury mechanisms, demographics, diagnoses, and trends over time.</div></div><div><h3>Results</h3><div>An estimated 120,613 lawnmower-related eye injuries occurred in the U.S. from 2004 to 2023 (<em>N</em> = 2467 NEISS cases). Those injured were 82% males, 95% adults, and 82% non-Hispanic Whites. Ninety-nine percent of injuries occurred at home. Most injuries (77%) were from projectiles (predominately grass, dirt, and rocks), 12% nonprojectile injuries during mowing, 8% maintenance/repair-related, and 2% from chemical exposures (primarily gasoline). Common diagnoses included eye abrasions/contusions (55%) and foreign bodies (27%). Severe injuries included retinal detachment, iris sphincter tear, corneal erosion, lens dislocation, and open globes. Only 2% of projectile injuries were documented in narratives as using eye protection, including eyeglasses. The average annual estimate for lawnmower-related eye injuries was 33% lower when comparing 2018-2023 to 2004-2017 (4502 vs 6686, <em>P</em> &lt; .001). Injuries decreased more in males than in females (35% vs 23%, <em>P</em> &lt; .001), and in adults aged 18 to 65 (35%) as compared to youth &lt;18 yrs (26%) and adults &gt;65 yrs (23%), <em>P</em> &lt; .001. Whereas injuries decreased in non-Hispanic White individuals (41%), they increased in Black individuals (18%) and other racial/ethnic groups, including Hispanic (42%), <em>P</em> &lt; .001. Youth &lt;18 years were a higher proportion of bystander (50%) vs operator (5%) injuries, <em>P</em> &lt; .001. Bystanders, as compared to operators, had higher rates of severe injuries requiring hospital admission, <em>P</em> = .002.</div></div><div><h3>Conclusions</h3><div>Lawnmower-related eye injuries remain a serious risk, especially from projectiles. Interventions designed to increase the use of safety glasses both while operating mowers and when performing maintenance/repair, such as sharpening blades, and prevent bystander presence, especially children, are needed to significantly reduce risk of injury.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"277 ","pages":"Pages 7-16"},"PeriodicalIF":4.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation From Ophthalmic Research to Ophthalmic Products","authors":"Gary D. Novack ,&nbsp;William J. Brock ,&nbsp;Audrey R. Schupp","doi":"10.1016/j.ajo.2025.05.001","DOIUrl":"10.1016/j.ajo.2025.05.001","url":null,"abstract":"<div><h3>Purpose</h3><div>To provide guidance primarily for the academic researcher for the translation from research of novel ophthalmic drugs for improved patient treatment to early-stage development including clinical trials.</div></div><div><h3>Methods</h3><div>Based upon available guidelines and the authors’ extensive experience in developing novel products, the authors present the requirements for chemistry (both drug substance and formulated drug product), nonclinical (pharmacology, pharmacokinetics, and toxicology), clinical and regulatory development.</div></div><div><h3>Conclusion</h3><div>Development of successful novel ophthalmic products is a structured, sequential, and interactive scientific process.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"276 ","pages":"Pages 365-373"},"PeriodicalIF":4.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postreceptor Neural Loss in Patients With Chronic Central Serous Chorioretinopathy","authors":"Beatrice Ghezzo ,&nbsp;Andrea Ghilardi ,&nbsp;Maria Chiara Marena ,&nbsp;Pasquale Viggiano ,&nbsp;Francesco Boscia ,&nbsp;Sonia Serafino ,&nbsp;Paola Marolo ,&nbsp;Michele Reibaldi ,&nbsp;Enrico Borrelli","doi":"10.1016/j.ajo.2025.04.040","DOIUrl":"10.1016/j.ajo.2025.04.040","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the relationship between ganglion cell layer (GCL) thickness and photoreceptor alterations in eyes with resolved chronic central serous chorioretinopathy (CSC).</div></div><div><h3>Design</h3><div>Retrospective, cross-sectional “case-control” comparison study.</div></div><div><h3>Methods</h3><div>We collected data from 70 eyes from 70 male individuals with chronic CSC, pachychoroid pigment epitheliopathy, and healthy controls. Optical coherence tomography imaging was used to assess ellipsoid zone (EZ) reflectivity as a marker of photoreceptor integrity and GCL thickness as an indicator of inner retinal loss. Normalized EZ reflectivity and GCL thickness were compared among groups, and a regression analysis was performed to evaluate the relationship between photoreceptor damage and inner retinal thinning.</div></div><div><h3>Results</h3><div>CSC eyes exhibited significantly reduced EZ reflectivity compared to pachychoroid pigment epitheliopathy and healthy controls (<em>P</em> &lt; .05). GCL thickness was also reduced in CSC eyes, particularly in the ETDRS inner ring. A significant association was found between EZ reflectivity and GCL thickness in CSC patients (<em>P</em> = .046), suggesting a link between photoreceptor and ganglion cell loss.</div></div><div><h3>Conclusions</h3><div>Photoreceptor damage in chronic CSC is associated with inner retinal thinning, supporting the hypothesis of postreceptor neural loss. These findings provide further insights into the broader retinal involvement in CSC and may have implications for visual function in affected patients.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"277 ","pages":"Pages 26-32"},"PeriodicalIF":4.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment on Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration.","authors":"David A Eichenbaum, Nancy Holekamp, Arshad M Khanani, Dante Pieramici, Vrinda Hershberger, Veeral Sheth, Flavia Brunstein, Ling Ma, Yixuan Zou, Vahan B Indjeian, Randall Dere, Mauricio Maia, Joy C Hsu, Simon S Gao, Brian Yaspan, Jeffrey R Willis, Henry Wiley, Phillip Lai, Hao Chen","doi":"10.1016/j.ajo.2025.04.042","DOIUrl":"10.1016/j.ajo.2025.04.042","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration\".","authors":"Tiarnán D L Keenan","doi":"10.1016/j.ajo.2025.04.044","DOIUrl":"10.1016/j.ajo.2025.04.044","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}