American Journal of Ophthalmology最新文献

{"title":"Response to letter of Michael Marmor MD.","authors":"David J Browning,Donnie R Koonce,Akshay Mentreddy,Omar Punjabi","doi":"10.1016/j.ajo.2025.09.023","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.09.023","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"1078 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal versus Monofocal Intraocular Lens Implantation in Children with Cataracts.","authors":"Yichao Ding,Xiaomei Wan,Ling Kong,Qiuxuan Du,Mingming Jiang,Feijia Xie,Yi Pang,Wenjie Su,Jing Zhang,Yusen Huang","doi":"10.1016/j.ajo.2025.09.017","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.09.017","url":null,"abstract":"PURPOSETo evaluate the efficacy and safety of multifocal versus monofocal intraocular lens (IOL) implantation in children with cataracts in a real-world setting.DESIGNProspective, non-randomized comparative clinical study.METHODSPediatric patients who underwent cataract surgery with multifocal IOL optic implantation in Berger space or monofocal IOL implantation with primary posterior capsulorhexis (PCCC) and anterior vitrectomy (AV) were recruited for this study. The efficacy outcome was postoperative visual acuity (corrected distance visual acuity (CDVA), distance-corrected intermediate visual acuity (DCIVA), and distance-corrected near visual acuity (DCNVA)), modulation transfer function (MTF), Strehl ratio (SR), ocular scatter index (OSI) and stereopsis. The safety outcomes were postoperative complications.RESULTSA total of 571 eyes of 402 children were included in our study. Multifocal IOLs were implanted in 219 children (311 eyes) and monofocal IOLs in 183 children (260 eyes). Visual results in bilateral or unilateral patients were better after multifocal IOL implantation than after monofocal IOL implantation, regardless of CDVA and DCNVA (P < 0.05). More patients developed postoperative Titmus stereopsis ≤100 arcseconds after multifocal IOL implantation compared to monofocal IOL implantation (both P < 0.05). The MTF and SR values showed a significant increase, and the OSI values showed a significant decrease after surgery (both P < 0.001). MTF cut-off, Strehl ratio, and OSI values showed no significant differences between unilateral and bilateral patients with multifocal or monofocal IOLs (P > 0.05). Multifocal IOL patients achieved higher spectacle independence than monofocal IOL patients (51.67% vs 37.31%, P = 0.033). IOL optic implantation in Berger space was achieved in 93.25% of the eyes with the multifocal IOL implantation (290/311). After surgery, the incidences of corneal edema, transient intraocular hypertension and visual axis opacification (VAO) of children after multifocal IOL implantation in Berger space were lower (2.28% vs. 9.84%, P = 0.017; 2.28% vs. 12.02%, P = 0.006; 0% vs. 6.56%, P = 0.014).CONCLUSIONSDuring the follow-up period of this study, multifocal intraocular lens optic implantation in Berger space demonstrated favorable safety and efficacy in improving visual function for rigorously screened pediatric cataract patients.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"39 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Mydriatic Ocular Fundus Imaging in a General Emergency Department: Feasibility and Novel Considerations for Systematic Screening.","authors":"Nithya Shanmugam,Mung Yan Lin,Jessica G McHenry,Kevin Yan,Stuart Duffield,Andrew M Pendley,George Alencastro Landim,Daniel V Adamkiewicz,Duyen T Vo,Jordan Prosky,Matthew Keadey,David W Wright,Michael Dattilo,Nancy J Newman,Valérie Biousse","doi":"10.1016/j.ajo.2025.09.016","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.09.016","url":null,"abstract":"OBJECTIVETo investigate the feasibility of systematic ocular imaging of consecutive patients presenting to our emergency department (ED) with chief complaints for which ocular funduscopic examination is standard of care.DESIGNProspective quality improvement feasibility project.SUBJECTSConsecutive patients presented to our general ED fulfilling one or more of the following criteria: current vision complaints, headaches, neurologic/neurosurgical disorders, hypertensive crisis, diabetes mellitus, or end-stage renal disease.METHODSStudy personnel acquired table-top non-mydriatic ocular fundus photographs with optical coherence tomography of the posterior pole (NMFP-OCT) on consecutive patients presenting to our ED over 16 consecutive days/nights with complaints that would warrant an ophthalmology evaluation, including vision complaints, headaches, neurologic/neurosurgical disorders, hypertensive crisis, diabetes mellitus, or end-stage renal disease.MAIN OUTCOME MEASURESDemographic information, indication for NMFP-OCT, findings, quality of NMFP/OCT, number of NMFP-OCT, and reasons why NMFP-OCT were not taken were documented.RESULTSAmong 1838 ED visits over 16 days, orders for NMFP-OCT were placed for 801 patients (43.6%). 410/801 patients (51%) received NMFP-OCT in the ED; 391/801 patients (49%) did not. 93/410 with NMFP-OCT (22.7%) versus 23/391 without NMFP-OCT (5.9%) had vision complaints (p<0.001), 99/410 (24.1%) versus 35/391 (9%) had headaches (p<0.001), 125/410 (30.5%) versus 164/391 (41.9%) had neurological/neurosurgical disorders (p<0.05), 4/410 (1%) versus 4/391 (1%) had hypertensive crisis, and 76/410 (18.5%) versus 132/391 (33.8%) had diabetes. Demographics were similar in both groups. 220/391 patients (56.3%) did not have NMFP-OCT for medical reasons (47.3% too sick/unable to sit, 9% infectious precautions); 171/391 (43.7%) did not have NMFP-OCT because of process problems in the ED. Few ocular imaging studies (6.7%) was uninterpretable.CONCLUSIONDespite 24/7 coverage of the ED by our team, 49% of patients did not have NMFP-OCT for reasons related to underlying patient illness or specific to the ED setting. Realistic expectations are needed when considering the feasibility of implementation of new ophthalmic technology in the ED.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"76 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145078050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Sensory and Motor Outcomes for the Treatment of Abnormal Head Posture Secondary to Nystagmus.","authors":"Alvaro Morgado,Eric D Gaier,Gena Heidary,Ryan Gise,Steven J Staffa,Linda Dagi","doi":"10.1016/j.ajo.2025.09.015","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.09.015","url":null,"abstract":"PURPOSEPatients with nystagmus often develop an abnormal head posture (AHP) to optimize fixation at the null point. While certain strabismus procedures have been shown to effectively reduce AHP by shifting the null point closer to primary gaze, the sustainability of these outcomes and impact on vision remains poorly understood. This study evaluates long-term motor and sensory outcomes of extraocular muscle surgery targeting AHP in patients with nystagmus, and reports on the impact of best corrected visual acuity, and surgery to address concurrent strabismus, on these outcomes.DESIGNRetrospective, interventional case series SUBJECTS: Diagnostic and procedural coding queries were used to identify all patients with nystagmus and torticollis treated from 2014-2023. Patients confirmed to have a history of extraocular muscle surgery targeting AHP and complete sensorimotor examinations were included. Surgery modified to address concurrent strabismus did not result in exclusion.INTERVENTIONStrabismus surgery to reduce anomalous head posture.PRIMARY OUTCOMEMotor success was defined as a post-surgical AHP ≤ 10°, and sensory alteration defined as change of ≥2 octaves (≥0.6 log arcsec).RESULTSForty patients met inclusion criteria with a median follow-up of 38 months (interquartile range [IQR], 12-56 months). AHP decreased from a median of 30° (IQR 20-40°) pre-operatively to 5° (IQR 0-10°) postoperatively (p<0.001). A successful motor outcome was achieved in 73% of patients at 3 months, 71.4% at 2 years, and 77.5% at the last evaluation, with no significant change over time (p=0.663). Simultaneous strabismus repair did not alter the likelihood of a successful reduction in AHP (p=0.697). Pre-operative best-corrected visual acuity (BCVA) of ≥20/40 was associated with successful reduction in AHP in 95% compared to only 58% for patients with BCVA <20/40 (p=0.007). Stereoacuity assessment, available for 29/40 (72.5%) of patients, showed stability in 27 (93%) and improvement in 2 (7%).CONCLUSIONSStrabismus surgery effectively and durably reduced AHP for at least 3 years with stable sensory function. Concurrent strabismus repair did not compromise reduction in AHP. BCVA < 20/40 significantly reduced the likelihood of a successful outcome and should be discussed at the time of pre-operative counselling of all affected patients.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"15 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Capsular Tension Ring on Rotational Stability of Loop-Haptic Intraocular Lens in Highly Myopic Patients","authors":"Hongzhe Li ,&nbsp;Wentao Tong ,&nbsp;Yiwen Hu ,&nbsp;Pingjun Chang ,&nbsp;Yun-e Zhao","doi":"10.1016/j.ajo.2025.09.012","DOIUrl":"10.1016/j.ajo.2025.09.012","url":null,"abstract":"<div><h3>PURPOSE</h3><div>To compare the rotational stability, tilt and decentration of loop-haptic intraocular lenses (IOLs) in highly myopic patients with and without capsular tension ring (CTR) implantation.</div></div><div><h3>DESIGN</h3><div>Randomized controlled trial.</div></div><div><h3>METHODS</h3><div>Consecutive highly myopic patients (axial length ≥ 26.00 mm) scheduled to undergo phacoemulsification with loop-haptic IOL implantation were randomly assigned to receive either CTR implantation or no CTR. The axial orientation of the IOL was measured at the end of surgery (EOS), and at 1 day, 1 week, 1 month, and 3 months postoperatively. Swept-source optical coherence tomography was performed at each follow-up visit to evaluate the tilt and decentration of IOL.</div></div><div><h3>RESULTS</h3><div>A total of 36 eyes with CTR implantation and 36 eyes without CTR were included. Absolute IOL rotation was significantly lower in the CTR group than in the Non-CTR group from EOS to 1 day (<em>P</em> = .039) and from EOS to 3 months (<em>P</em> = .018). Subgroup analysis demonstrated that CTR implantation significantly reduced IOL rotation in eyes with thick crystalline lenses (<em>P</em> = .041). Although the CTR group consistently exhibited slightly lower values of tilt and decentration at each follow-up visit, the differences were not statistically significant (All <em>P</em> &gt; .05).</div></div><div><h3>CONCLUSIONS</h3><div>CTR implantation improves the postoperative rotational stability of loop-haptic IOLs and mitigates the effect of thick crystalline lenses in highly myopic patients, while having no significant impact on IOL tilt or decentration.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"281 ","pages":"Pages 63-71"},"PeriodicalIF":4.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Lactic Acid Levels in the Aqueous Humor May Be an Indicator of Uveal Melanoma.","authors":"Sarah Miller,Marisol Cano,Ryan Kawalerski,Michan Daisy Shi,Akrit Sodhi,Shannath L Merbs,Fatemeh Rajaii,Dan-Ning Hu,Charles G Eberhart,James T Handa","doi":"10.1016/j.ajo.2025.09.014","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.09.014","url":null,"abstract":"PURPOSETo determine if aqueous humor lactic acid levels, a surrogate marker for tumor cell metabolic activity, are elevated in uveal melanoma (UM) and whether L-lactate levels correlate with clinical, pathological, and molecular tumor characteristics.DESIGNCase-control study SUBJECTS: Eyes with UM and control eyes undergoing cataract surgery METHODS: L-lactate levels were measured from aqueous taken at the time of enucleation for UM (n=34) or controls (n=13). 23 (68%) UM patients were followed for at least 5 years. Clinical information was gathered by retrospective chart review. Tumor samples were profiled by RT-qPCR and factor analysis to emulate prognostic classification.1 MAIN OUTCOME MEASURE: Aqueous humor lactate levels RESULTS: Aqueous L-lactate concentration in UM eyes was higher than controls (p<0.01). The L-lactate concentration correlated with increasing mitotic activity on pathologic examination (p=0.02), but not with tumor size, prior brachytherapy, predominant histologic cell type, or metastasis. L-lactate levels did not correlate with gene expression profile.CONCLUSIONL-lactate levels in aqueous samples from patients with uveal melanoma were higher than controls, which lays the foundation for future studies into whether this may be helpful for diagnosing suspicious uveal lesions.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"36 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular and Orbital Trauma Correlated with an Increased Risk of Mortality in Female Patients with a History of Intimate Partner Violence.","authors":"Linus Amarikwa,Lynette M Renner,Natalie A Homer,Karen M Wai,Chase A Ludwig,Euna Koo,Ehsan Rahimy,Prithvi Mruthyunjaya,Erin M Shriver,Andrea L Kossler","doi":"10.1016/j.ajo.2025.09.013","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.09.013","url":null,"abstract":"OBJECTIVETo characterize the risk factors for mortality and rates of mortality in female patients with a history of ocular or orbital trauma and intimate partner violence (IPV).DESIGNThis is a retrospective cohort study that included all data from 2005 to 2024.PARTICIPANTSIncluded females aged 18-55 years old with variable history of IPV and orbital trauma.METHODSPatients were identified using the TriNetX Network and were grouped by presence of IPV and orbital trauma. Rates of mortality, hospitalization, and emergency department (ED) visits following trauma were analyzed. Propensity score matching (PSM) was done to control for differences in baseline demographics and medical comorbidities. Cox regression analysis was completed to determine the association between mortality and known risk factors for IPV.MAIN OUTCOME MEASURESHazard ratio (HR) for mortality and rate of 5-year mortality following ocular or orbital trauma.RESULTSAfter matching and assessing for the presence of ocular or orbital trauma, 2,812 patients were included in both the IPV-related ocular or orbital trauma and IPV with no ocular or orbital trauma groups. The analysis found that a history of ocular or orbital trauma increased the risk of mortality in patients with a history of IPV (hazard ratio (HR) = 1.7, 95% CI: 1.3-2.4, p < 0.001).CONCLUSIONSA history of ocular or orbital trauma is a significant risk factor for mortality among female patients with a history of IPV. High risk patients should be identified at the time of presentation and protective measures initiated.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"34 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular Lens Power Calculations in Post-Hyperopic Laser Vision Correction Eyes: Comparing Legacy and New No-History Formulas.","authors":"Sanjana Suraneni,Adam R Bleeker,Abdelrahman M Anter,Sebastian Leal,David A Murphy,Kamran M Riaz,David L Cooke,Rahul S Tonk","doi":"10.1016/j.ajo.2025.09.010","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.09.010","url":null,"abstract":"PURPOSETo compare the refractive accuracy of legacy and new post-refractive formulas in eyes with previous hyperopic laser vision correction (H-LVC).DESIGNRetrospective cohort study.METHODS▒ SETTING: Two academic medical centers.SUBJECTS153 eyes (109 patients) with previous H-LVC that underwent cataract surgery between 2019-2023. An SS-OCT biometer was used to obtain biometric measurements, including standard (K), posterior (PK), and total keratometry (TK) values.MAIN OUTCOME MEASURESRefractive prediction errors were calculated and compared for two legacy H-LVC formulas using K values, six new H-LVC formulas using K values, and four new H-LVC formulas using PK or TK values. All formulas were ranked by root mean square error (RMSE) and percentage of eyes with prediction errors within ±0.50 D. Heteroscedastic (RMSE) testing was used to evaluate relative formula performance.RESULTSWhen ranked by RMSE, newer formulas ranked higher than legacy formulas, and new formulas with PK/TK values ranked higher than versions without PK/TK values. Using heteroscedastic (RMSE) testing, Barrett True K NH-K was superior to Shammas PHL (p<0.001). Shammas-Cooke (Kpost = 0.8977 x K - 0.2976 x AL + 11.7149) and K6-TK were superior to their prior H-LVC versions (Shammas-PHL and K6-K, respectively) (p<0.05).CONCLUSIONSThe top-ranking formulas (Barrett True K-TK, K6-TK, and EVO 2.0-PK) were all new H-LVC formulas. Formula performance may variably improve with PK/TK values. When PK/TK values are unavailable, EVO 2.0-K, Barrett True K NH-K, and Pearl DGS may be the most reliable formulas.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"51 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype-Phenotype Correlations of COL2A1 and COL11A1 Patients","authors":"Antoine Constant ,&nbsp;Alejandra Daruich ,&nbsp;Federico Bernabei ,&nbsp;Matthieu P. Robert ,&nbsp;Cyril Burin-Des-Roziers ,&nbsp;Sophie Valleix ,&nbsp;Dominique Bremond-Gignac ,&nbsp;Antoine P. Brézin ,&nbsp;Pierre-Raphaël Rothschild","doi":"10.1016/j.ajo.2025.09.011","DOIUrl":"10.1016/j.ajo.2025.09.011","url":null,"abstract":"<div><h3>PURPOSE</h3><div>To describe and compare the ophthalmologic and extraophthalmologic features of patients with Stickler syndrome because of pathogenic variants in <em>COL2A1</em> and <em>COL11A1</em>.</div></div><div><h3>DESIGN</h3><div>Retrospective cross-sectional study nested in a multicentric cohort study.</div></div><div><h3>METHODS</h3><div>Records of patients with a confirmed molecular diagnosis of Stickler syndrome followed up in the ophthalmology department at Necker-Enfants Malades and Cochin University hospitals (Paris) between 2016 and 2024 were retrospectively reviewed. Demographic data, clinical findings from ophthalmologic examination, and extraophthalmologic features were recorded. Patients with an incomplete file, lack of genetic evidence despite a compatible clinical phenotype, and those presenting with rare variants were excluded.</div></div><div><h3>RESULTS</h3><div>Among 110 patients with confirmed Stickler syndrome, 90 (82%) had a <em>COL2A1</em> variant and 20 (18%) a <em>COL11A1</em> variant. The median age at last follow-up was 24.4 years (IQR 0.9-77.6), and the median follow-up duration was 10.8 years (IQR 4.2-27.3). Retinal detachment occurred in 50% of patients with <em>COL2A1</em> variants (45/90) and 45% of those with <em>COL11A1</em> variants (9/20), with no statistically significant difference between groups (<em>P</em> = .81). Twenty-four patients (22%) had a bilateral retinal detachment with a median time for a retinal detachment of the fellow eye of 3.0 (IQR 0-25.2) years. The patients with <em>COL11A1</em> variants were significantly different from those with <em>COL2A1</em> variants in terms of deafness frequency (50% [10/20] vs 13% [12/90]; <em>P</em> = .005; 95% CI 13.7%, 59.7%), axial lengths (28.9 ± 3.2 mm vs 26.3 ± 2.3 mm; <em>P</em> &lt; .001; 95% CI +1.20, +4.02), age at retinal detachment onset (9.8 [IQR 5.3-19.7] years vs 13.3 [IQR 0.5-66] years; <em>P</em> = .006; 95% CI –12.44, –2.19), and median time to retinal detachment in the fellow eye (2.0 [IQR 0.2-3] years vs 4.5 [IQR 0-25.2] years; <em>P</em> = .009; 95% CI –7.99, –1.30).</div></div><div><h3>CONCLUSIONS</h3><div>The study highlights phenotypic difference between <em>COL2A1-</em> and <em>COL11A1</em>-related Stickler syndrome, with <em>COL11A1</em> variants potentially associated with more severe ocular phenotype. Such genotype-phenotype correlations may contribute to refining patient management and guiding prophylactic interventions. These findings could support individualized follow-up strategies; however, confirmation in larger cohorts is warranted.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"281 ","pages":"Pages 17-24"},"PeriodicalIF":4.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: OCT and OCTA Features of Optic Disc Melanocytoma: PHOMS, Perfusion Deficits, and Association with Vision Loss.","authors":"Gábor Hollό, Yoshiyuki","doi":"10.1016/j.ajo.2025.09.001","DOIUrl":"10.1016/j.ajo.2025.09.001","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}