American Journal of Ophthalmology最新文献

{"title":"Corrigendum to Interferon Alpha-2a as Treatment for Primary Acquired Melanosis With Atypia and for Primary Acquired Melanosis With Atypia Surrounding Conjunctival Melanoma. Am J Ophthalmol. 2026;285:318–323","authors":"Daniela Vaisman, Jacob Pe’er, Maya Eiger-Moscovich, Michal Lotem, Sharon Merims, Shahar Frenkel","doi":"10.1016/j.ajo.2026.07.024","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.07.024","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"60 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy Phenotypes and Treatment Outcomes Across Singaporean, Canadian Asian, and Canadian Caucasian Populations.","authors":"Antoine Huang, Jennifer Ling, Noa Gilead, Mohamed Sherif, Kelvin Teo, Wai-Ching Lam, Chui Ming Gemmy Cheung","doi":"10.1016/j.ajo.2026.08.018","DOIUrl":"10.1016/j.ajo.2026.08.018","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the frequency of polypoidal choroidal vasculopathy (PCV) features, treatment patterns, and 1-year outcomes across Singaporean Asian, Canadian Asian, and Canadian Caucasian populations with neovascular age-related macular degeneration (nAMD) using optical coherence tomography (OCT)-based diagnostic criteria.</p><p><strong>Design: </strong>Retrospective, multicenter, comparative study.</p><p><strong>Participants: </strong>A total of 327 treatment-naïve patients with nAMD: 181 from Singapore National Eye Centre and 146 from Vancouver, Canada (89 Caucasian, 57 Asian).</p><p><strong>Methods: </strong>PCV was diagnosed using modified Asia-Pacific Ocular Imaging Society nonindocyanine green angiography OCT-based criteria (sharp-peaked pigment epithelial detachment and subretinal pigment epithelium ring-like lesion). Baseline OCT features, treatment patterns, and 12-month outcomes were compared across the three ethnic groups.</p><p><strong>Main outcome measures: </strong>PCV prevalence, OCT-based morphological features, treatment patterns, and change in best-corrected visual acuity (BCVA) at 12 months.</p><p><strong>Results: </strong>PCV prevalence was similar between Singaporean Asian (42.5%) and Canadian Asian (42.1%) groups, both significantly higher than Canadian Caucasians (13.5%, P < .01). OCT features in PCV eyes were consistent across ethnic groups, including macular predominance (79.2%-83.3%), double-layer sign (83.3%-93.5%), low soft drusen prevalence (4.2%-8.3%), and subfoveal choroidal thickness >200 µm. Treatment patterns differed: bevacizumab predominated in Canada (65.0%-70.0% for PCV), while Singapore used varied agents, with photodynamic therapy in 31.1%. At 12 months, BCVA improved in Singaporean PCV eyes (-0.22 logMAR, P < .01). In typical nAMD, BCVA improved significantly across all three groups.</p><p><strong>Conclusions: </strong>Ethnic differences in PCV prevalence persist regardless of geographic location, supporting a predominant genetic basis for PCV susceptibility. OCT-based PCV features are consistent across ethnicities, while treatment patterns vary substantially between healthcare systems. Noninvasive OCT-based diagnostic criteria enable reliable cross-ethnic PCV comparison when indocyanine green angiography is unavailable.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":"163-174"},"PeriodicalIF":4.7,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148766548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the Corneal Posterior-to-Anterior Radius Ratio on IOL Power Prediction Using Standard and Total Keratometry","authors":"Zhongxiu Yang, Fu-man Yang, Zi-qi Meng, Hongzhe Li, Yi-kuan Liang, Yun-E Zhao, Pingjun Chang","doi":"10.1016/j.ajo.2026.08.020","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.08.020","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"67 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to Interferon Alpha-2a as Treatment for Primary Acquired Melanosis With Atypia and for Primary Acquired Melanosis With Atypia Surrounding Conjunctival Melanoma. Am J Ophthalmol. 2026;285:318-323.","authors":"Daniela Vaisman, Jacob Pe'er, Maya Eiger-Moscovich, Michal Lotem, Sharon Merims, Shahar Frenkel","doi":"10.1016/j.ajo.2026.07.024","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.07.024","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment on An Artificial Intelligence-Based Prognostic Model for Prediction of Functional Glaucoma Progression From Clinical and Structural Data","authors":"Vahid Mohammadzadeh, Sean Wu, Sajad Besharati, Mahshad Rafiee, Yasamin Banaei, Arthur Martinyan, Jane Zou, Evelyn Kung, Kiumars Edalati, Esteban Morales, Fabien Scalzo, Joseph Caprioli, Kouros Nouri-Mahdavi","doi":"10.1016/j.ajo.2026.08.015","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.08.015","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"5 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conflicts of Interest Transparency, Study Outcomes, and Risk of Bias in Myopia Controlled Trials: A Systematic Review and Meta-Analysis.","authors":"Jia-Yan Kai, Ming-Yan Jin, Yue Peng, Dan-Lin Li, Xing-Xuan Dong, Carla Lanca, Andrzej Grzybowski, Chen-Wei Pan","doi":"10.1016/j.ajo.2026.08.019","DOIUrl":"10.1016/j.ajo.2026.08.019","url":null,"abstract":"<p><strong>Topic: </strong>To determine whether the transparency of conflicts of interest (COI) declarations is associated with study outcomes and methodological quality in randomized controlled trials (RCTs) of myopia controlled interventions.</p><p><strong>Clinical relevance: </strong>Myopia control practice is guided largely by RCT evidence, much of which involves industry participation. Variability in the transparency of COI disclosures may influence how such evidence is interpreted for clinical decision-making.</p><p><strong>Methods: </strong>PubMed, Embase, Cochrane Library, and Web of Science were systematically searched from inception to October 6, 2025. Eligible studies were RCTs of myopia controlled interventions in children or adolescents with at least 6 months of follow-up and reporting cycloplegic spherical equivalent and/or axial length outcomes. COI declaration transparency was categorized a priori into predefined levels. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Associations between COI transparency and study conclusions, statistical significance, and effect sizes were evaluated using cross-sectional, multiple meta-regression models. The protocol was registered in PROSPERO (CRD420261291949).</p><p><strong>Results: </strong>A total of 134 RCTs were included. Sixteen trials (11.9%) did not report a COI statement, 85 (63.4%) provided simple declarations of no conflicts, 14 (10.4%) reported intermediate disclosures, and 19 (14.2%) provided detailed COI statements. Distributions of overall risk of bias and the domain of selective outcome reporting differed significantly across COI transparency categories, with a higher proportion of low-risk judgments observed in trials with more detailed COI disclosures (both P < .01). Overall, COI transparency was not significantly associated with study outcomes. However, in stratified analyses, greater COI transparency was significantly associated with more favorable study conclusions among trials evaluating optical interventions, even after adjustment for industry funding and other covariates (odds ratio = 2.66, 95% confidence interval: 1.19-5.92, P = .02). Similar patterns were observed in trials with larger sample sizes and those published in higher-impact factor journals, although these associations were attenuated after accounting for industry funding.</p><p><strong>Conclusion: </strong>Transparency in COI declarations demonstrates context-specific relationships with study conclusions and reporting quality in myopia controlled trials. While transparent disclosure is essential for research integrity, its interpretation should be integrated with funding context when evaluating evidence to inform clinical practice.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":"80-90"},"PeriodicalIF":4.7,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment on: Outcomes of minimally invasive glaucoma surgery, trabeculectomy, and tube shunt surgery in secondary glaucoma: IRIS® Registry analysis","authors":"Asahi Fujita, Nazlee Zebardast, Alice C. Lorch, Joan W. Miller, David S. Friedman","doi":"10.1016/j.ajo.2026.08.010","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.08.010","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148715392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Outcomes of Minimally Invasive Glaucoma Surgery, Trabeculectomy, and Tube Shunt Surgery in Secondary Glaucoma: Intelligent Research in Sight Registry Analysis.","authors":"Wanyi Shu, Lin Fu","doi":"10.1016/j.ajo.2026.07.061","DOIUrl":"10.1016/j.ajo.2026.07.061","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Retinal Age Gap as a Biomarker for Patient Satisfaction and Visual Quality After Cataract Surgery.","authors":"Jai Paris, Carmelo Macri, Dinesh Selva, Weng Onn Chan","doi":"10.1016/j.ajo.2026.07.060","DOIUrl":"10.1016/j.ajo.2026.07.060","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment on \"Retinal Age Gap as a Biomarker for Patient Satisfaction and Visual Quality After Cataract Surgery\".","authors":"Koji Komatsu, Yoichiro Masuda, Kei Sano, Ryo Ohira, Shingo Mitooka, Masanobu Iida, Kosuke Ichihara, Euido Nishijima, Tetsutaro Oki, Tadashi Nakano","doi":"10.1016/j.ajo.2026.08.007","DOIUrl":"10.1016/j.ajo.2026.08.007","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}