American Journal of Ophthalmology最新文献

{"title":"Exudative AMD Risk Following Blue Light-Filtering IOL Implantation: A Population-Based Study According to Non-Exudative AMD Status","authors":"Jin Yeong Kim, Sunyeup Kim, Jin Cho, Jihei Sara Lee, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Seung Won Lee, Yong Joon Kim","doi":"10.1016/j.ajo.2025.07.007","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.07.007","url":null,"abstract":"To evaluate whether blue light-filtering (BLF) intraocular lenses (IOLs) reduce the risk of exudative age-related macular degeneration (AMD).","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"23 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review of Clinical Utility of Multimodal Imaging in Non-Infectious Posterior Uveitis: MUV Project Report 3","authors":"Massimo Accorinti, Meghan Berkenstock, Maria Vittoria Cicinelli, Janet L. Davis, Alejandra de-la-Torre, Claudia Fabiani, Sapna Gangaputra, Vishali Gupta, Timothy M. Janetos, Ines Leal, John Reynolds, Ariel Schlaen","doi":"10.1016/j.ajo.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.07.002","url":null,"abstract":"The clinical utility of multimodal imaging for diagnosis and management of non-infectious posterior uveitis.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"109 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Pterygium Beheading Procedure","authors":"Minas T. Coroneo","doi":"10.1016/j.ajo.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.07.006","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inefficacy of Longitudinal Cup-to-Disc Ratio Measurements in Identifying Glaucoma Progression","authors":"Amey Kamdar MBBS MHA, Felipe A. Medeiros MD PhD, Swarup S. Swaminathan MD","doi":"10.1016/j.ajo.2025.07.005","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.07.005","url":null,"abstract":"To assess whether longitudinal change in cup-to-disc ratio (ΔCDR) is predictive of glaucoma progression on optical coherence tomography (OCT) or standard automated perimetry (SAP).","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"13 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Striking Iris Transillumination with Visible Ciliary Processes in Ocular Albinism","authors":"Dr. Mohammad Ali MBBS, Dr. Mehul Singh Thakur MBBS, Dr. Mansi Sarwate MBBS MS","doi":"10.1016/j.ajo.2025.07.004","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.07.004","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"696 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Metagenomic Sequencing on Patient Clinical Outcomes for Intraocular Infections: A Multicenter Randomized Controlled Trial","authors":"Jessica G. Shantha, Kareem Moussa, Wipada Laovirojjanakul, Steven Yeh, Edmund Tsui, Judy L. Chen, Albert T. Vitale, Akbar Shakoor, Marissa Larochelle, Katherine Niemeyer, Akshay Mentreddy, Itamar Livnat, Myra Safo, Wendy Ao, Charlene Choo, Daisy Yan, Lina Zhong, Cindi Chen, Kirsten Da Silva, Amit K. Reddy, Jennifer Lee, Amol Sura, Eric L. Crowell, Ying Qian, Yael Sharon, Armin Hinterwirth, Travis Porco, Benjamin F. Arnold, John Gonzales, Nisha R. Acharya, Thomas M. Lietman, Thuy Doan, OPTICS Study Group","doi":"10.1016/j.ajo.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.07.003","url":null,"abstract":"To determine whether the addition of an unbiased test, metagenomic sequencing of intraocular fluid, compared to standard-of-care diagnostics alone, leads to better patient outcomes in presumed infectious intraocular inflammatory eye diseases.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"83 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial growth and meridian modulation of cornea power in children wearing orthokeratology lenses of different back optic zone diameters.","authors":"Muhan Sun,Mengdi Li,Hua Bi,Ting Wang,Shuxian Zhang,Xiaoyan Yang,Bin Zhang,Lihua Li","doi":"10.1016/j.ajo.2025.07.009","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.07.009","url":null,"abstract":"PURPOSETo evaluate the effect of orthokeratology lenses with different back optical zone diameters (BOZD) on relative corneal refraction power shift (RCRPS) and explore its association with axial length growth (ALG).DESIGNA randomized, double-blinded, controlled clinical trial.METHODSSubjects aged between 8 and 15 years, with the refraction of -1.0 to -4.00 D. Participants were randomly assigned to two groups, wearing a BOZD_5.0mm or a BOZD_6.2mm lenses. Axial length (AL) was measured at baseline and 12 months after lens wear, and ALG and age-adjusted ALG (aALG) were calculated. A differential map comparing the 12-month and baseline corneal topography was used to analyze the RCRPS, summed within the central 4 mm diameter. The RCRPS subset was divided into eight meridians at 45-degree intervals. Linear and stepwise multiple linear regression were performed to assess the associations between ALG and RCRPS.RESULTSThere was no significant difference in baseline parameters, including age, spherical equivalent, and AL (all P > 0.05). Over 12 months, children wearing BOZD_5.0mm lens demonstrated significantly slower ALG (0.15 ± 0.13 mm) than those wearing BOZD_6.2mm lenses (0.24 ± 0.17 mm, P = 0.04). aALG was also significantly slower in BOZD_5.0mm group (-0.10 ± 0.12 mm vs. -0.001 ± 0.16 mm, P = 0.01). The summed RCRPS within the central 4mm area was significantly greater in children wearing BOZD_5.0mm lenses (92.31 ± 43.21 D) when compared to children wearing BOZD_6.2mm lenses (70.04 ± 41.64 D, P = 0.04). The summed RCRPS only demonstrated significant differences between the groups on 0-, 45-, and 90-degree meridians (all P < 0.01). The association between aALG and summed RCRPS was analyzed on eight different meridians. Only the 0-,45-, and 90-degree meridians demonstrated significant associations.CONCLUSIONSChildren wearing orthokeratology lenses with smaller BOZD had slower ALG. This difference in ALG was associated with greater RCRPS in the nasal-superior quadrant of the cornea.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"109 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Myopia Management: The Therapeutic Potential of Microbiota-Targeted Interventions.","authors":"Liting Zhao,Yuanhua Xie,Wen Chen,Yanni Zhang,Ying Lu,Yuanjun Li,Yewei Yin,Tu Hu,Dan Wen","doi":"10.1016/j.ajo.2025.07.008","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.07.008","url":null,"abstract":"OBJECTIVEMyopia is a growing global health concern, particularly in East Asia. Recent studies suggest that ocular surface microbiota may play a key role in regulating local immune homeostasis in the eye. This study aims to investigate the relationship between ocular surface microbiota and high myopia (HM), with the goal of identifying potential microbiota targets for controlling myopia progression.METHODS16S rRNA sequencing was used to analyze ocular surface microbiota in HM and NC groups. Microbial diversity and composition were compared, focusing on the abundance of Lactobacillus vini (L. vini). The correlation analysis explores potential factors influencing the distribution of differentially abundant bacterial species. In vivo and in vitro experiments assessed its role in Collagen-1 synthesis, scleral remodeling, and ocular inflammation.RESULTSSignificant differences in microbial diversity were found between the HM and NC groups. L. vini was enriched in the NC group and suggested potential in inhibiting myopia progression. Dysbiosis of L. vini in myopic individuals may also be mediated by parental myopia background. In vivo and in vitro experiments further confirmed that L. vini downregulated ocular surface inflammatory markers IL-6 and TNF-α in form deprivation myopic mice, inhibited scleral remodeling, and reduced myopic phenotypic changes.CONCLUSIONL. vini may help mitigate myopia progression, potentially through regulating ocular surface inflammation. Future studies using genomic techniques are needed to further understand the mechanisms and therapeutic potential of microbiota-targeted interventions in myopia management.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"6 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Explantation of Revakinagene Taroretcel Capsule Due to Non-Clearing Vitreous Hemorrhage Secondary to Fixation Loop Extrusion.","authors":"Avery W Zhou,Thomas M Aaberg,Charles C Wykoff","doi":"10.1016/j.ajo.2025.06.048","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.06.048","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"21 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Macular Burden of Calcified Drusen and the Onset of Large Choroidal Hypertransmission Defects in Intermediate AMD.","authors":"Omar S El-Mulki,Alessandro Berni,James Kastner,Mengxi Shen,Yuxuan Cheng,Gissel Herrera,Sara Beqiri,Omer Trivizki,Viet-Hoan Le,Bhagavath Sivathanu Kumar,Maura Di Nicola,Robert O'Brien,Nadia K Waheed,Giovanni Gregori,Ruikang K Wang,Philip J Rosenfeld","doi":"10.1016/j.ajo.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.07.001","url":null,"abstract":"PURPOSEThis study used en face swept-source optical coherence tomography (SS-OCT) imaging to follow eyes with intermediate age-related macular degeneration (iAMD) in the presence and absence of calcified drusen (CaD) to determine if the presence and size of CaD increased the risk of forming large choroidal hypertransmission defects (hyperTDs).DESIGNPost hoc subgroup analysis of a prospective cohort study.METHODSEyes with iAMD were enrolled in a prospective SS-OCT study, and the onset of large hyperTDs was retrospectively analyzed. Imaging was performed using 6×6 mm SS-OCT angiography (SS-OCTA) scans at baseline and follow-up. Large hyperTDs were defined as bright lesions ≥250 µm in greatest linear dimension (GLD) on en face sub-retinal pigment epithelium (subRPE) slabs positioned 64-400 µm beneath Bruch's membrane (BM). CaD were identified as drusen with heterogeneous internal reflectivity projecting choroidal hypotransmission defects (hypoTDs) on the same subRPE slabs. CaD were distinguished from hyperreflective foci (HRF) by analyzing corresponding B-scans. Two independent graders used a semiautomated algorithm to refine CaD outlines and reach consensus, with disagreements adjudicated by a senior grader. CaD area, HRF area, and drusen volume were measured within 5-mm fovea-centered circles.RESULTSMedian follow-up time for the 171 eyes from 121 patients followed in this study was 59.1 months (95% CI: 52.0-67.8 months), and 82 eyes developed at least one large hyperTD during follow-up. The mean baseline CaD area measurement was 0.037 mm² [range: 0-0.567 mm²] in eyes that developed hyperTDs, while in eyes that did not, it was 0.008 mm² [range: 0-0.360 mm²] (P = 0.01). Drusen volume, HRF area, and CaD area were predictors for hyperTD onset when considered alone, but only HRF area (P < 0.001) and CaD area (P =.008) remained significant predictors for hyperTD onset when using a multivariable Cox regression analysis. Regardless of area, the presence of any CaD increased the risk of hyperTD formation (P < 0.001).CONCLUSIONSIn a multivariable Cox regression analysis, the area measurements of CaD and HRF in eyes with iAMD were significant predictors of hyperTD onset, and the presence of any CaD increased the risk of hyperTD formation.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"21 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}