American Journal of Ophthalmology最新文献

{"title":"Comment on: Association Between Glucagon-Like Peptide 1 Receptor Agonists Exposure and Intraocular Pressure Change.","authors":"Wei-Zhen Tang, Hao-Wen Chen, Tai-Hang Liu","doi":"10.1016/j.ajo.2024.09.038","DOIUrl":"10.1016/j.ajo.2024.09.038","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":"273-274"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Ophthalmic Immune-Related Adverse Events and Association With Survival: Results From a Real-World Database.","authors":"Flora Lum","doi":"10.1016/j.ajo.2024.10.034","DOIUrl":"10.1016/j.ajo.2024.10.034","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":"277"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment on Ophthalmic Immune-Related Adverse Events and Association With Survival: Results From a Real-World Database.","authors":"Lee Quiruz, Negin Yavari, Bijal Kikani, Ankur Sudhir Gupta, Karen Michelle Wai, Andrea Lora Kossler, Chase Ludwig, Eubee Baughn Koo, Ehsan Rahimy, Prithvi Mruthyunjaya","doi":"10.1016/j.ajo.2024.11.001","DOIUrl":"10.1016/j.ajo.2024.11.001","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":"278-279"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: \"Comment on: Association between Glucagon-Like Peptide 1 Receptor Agonists Exposure and Intraocular Pressure Change\".","authors":"Shahin Hallaj, William Halfpenny, Benton G Chuter, Robert N Weinreb, Sally L Baxter, Qi N Cui","doi":"10.1016/j.ajo.2024.10.021","DOIUrl":"10.1016/j.ajo.2024.10.021","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":"275-276"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features, Risk Factors and Outcomes following Surgery for Late Intraocular Lens Decentration in the Dead Bag Syndrome.","authors":"Vandana Nath,Abhay R Vasavada,Suchi Dholu,Shail Vasavada,Shyamal Dwivedi,Bharti Shivnani,Vaishali Vasavada,Sankaranarayanan Rajkumar,Samaresh Srivastava","doi":"10.1016/j.ajo.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.01.008","url":null,"abstract":"PURPOSETo evaluate demographic profile, risk factors and outcomes following intraocular lens (IOL) exchange surgery for late decentration of IOLs in the dead bag syndrome DESIGN: Prospective, interventional case series PARTICIPANTS: 46 eyes (43 patients) with late decentration/dislocation of IOLs and spontaneous posterior capsule rupture in a clear and relatively intact capsular bag. None of the eyes had significant zonular weakness.METHODSStudy conducted at Raghudeep Eye Hospital, India. Explantation of the decentered/dislocated IOL along with pars plana vitrectomy and intrascleral fixation of a three-piece foldable IOL using the Yamane technique was performed for all eyes.MAIN OUTCOME MEASURESDemographic profile, associated risk factors, visual outcomes and postoperative complications following IOL exchange in dead bag syndrome.RESULTSThirty eyes had in-the-bag IOL decentration and 16 had total dislocation of the IOL into the vitreous cavity. The mean age was 68.7 ± 8.9 (standard deviation, SD) years and 91% patients were males. 36 patients had unilateral IOL disease, whereas 7 had bilateral dead bag syndrome, with or without clinically significant IOL decentration. The mean duration from primary cataract surgery to re-surgery was 16.8 years. More than 50% eyes had axial myopia (axial length > 24mm). Only 4 eyes (9.3%) had associated pseudoexfoliation. Mean followup after IOL exchange surgery was 10.9 + 9.8 (SD) months. The single piece hydrophobic acrylic IOL was the most commonly explanted IOL. Intraoperatively, Soemmering's ring was seen in 71.7% (31) eyes. Eighty-seven % eyes had an improvement in corrected distance visual acuity (CDVA) following surgery, with 95% eyes having a CDVA of ≤0.3 LogMAR. Postoperatively, following complications were seen - transient IOP spike in 8 (17%) eyes and cystoid macular edema in 6 eyes (13%). Three eyes had a pre-existing glaucoma, which remained controlled at final followup.CONCLUSIONThe major risk factors for the dead bag syndrome are male gender, axial myopia and the duration of posterior capsule rupture event from the cataract surgery. Bilaterality and presence of Soemmering's ring in majority of the cases are new observations, warranting further research. Outcomes following surgery are satisfactory.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"32 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Accuracy of Toric Intraocular Lens Formulas With Measured Posterior Corneal Astigmatism of Different Orientations.","authors":"Alejandro Tello, Virgilio Galvis, Ana Maria Amaya","doi":"10.1016/j.ajo.2024.11.026","DOIUrl":"https://doi.org/10.1016/j.ajo.2024.11.026","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Cataract Surgery Complications in Patients with Prior Intravitreal Injection Therapy.","authors":"Cindy S Zhao,Kacper Chwialkowski,Karen M Wai,Prithvi Mruthyunjaya,Ehsan Rahimy,Eubee B Koo","doi":"10.1016/j.ajo.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.01.004","url":null,"abstract":"OBJECTIVETo compare the rate of cataract surgery complications in patients with and without prior intravitreal injection (IVI) pharmacotherapy.DESIGNA retrospective cohort study was performed using the TriNetX (Cambridge, MA) aggregated electronic health records research network.SUBJECTSPatients with a history of IVI therapy within twenty years of cataract surgery were compared to a control group using propensity score matching (PSM) to balance for baseline demographics, systemic, and ocular co-morbidities. Patients with a history of lensectomy or pars plana vitrectomy (PPV) prior to cataract surgery were excluded.INTERVENTIONIVI therapy within twenty years of cataract surgery.MAIN OUTCOME MEASURESRate of retinal detachment (RD), RD repair, anterior vitrectomy, retained lens, dislocated intraocular lens (IOL), need for a secondary lens procedure, and endophthalmitis within 14, 30, and 90 days of cataract surgery.RESULTSPrior to PSM, 16,356 and 512,152 patients did and did not, respectively, have IVI pharmacotherapy prior to cataract surgery. After PSM, both groups had 14,240 patients. A higher rate (RR 1.34; 95% CI, 1.16-1.54; p<0.0005) of aggregate complications within 90 days of cataract surgery was found in the group with prior IVI (447/13,719 = 3.3%) relative to controls (340/13,945=2.4%). The exposure group saw an increased risk of RD repair at 30 days (RR 1.84; 95% CI, 1.27-2.66; p=0.001) and 90 days (RR 2.05; 95% CI, 1.65-2.54; p<0.0005). No other complications were associated with IVI. In particular, IVI was not associated with higher rates of anterior vitrectomy except in patients with diabetic retinopathy (DR) at 90 days (RR 1.24; 95% CI, 0.85-1.79; p=0.001). Patients with DR and prior IVI had a higher risk of lensectomy, RD repair, and secondary procedures (p < 0.0005 for all) compared to DR patients without prior IVI.CONCLUSIONSPatients with prior IVI saw more complications following cataract surgery, primarily for RD. IVI treatment history should be considered in pre-operative planning.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"26 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Ageing in the Clinical Presentation of Uveitis.","authors":"Priya Samalia,Joanne Sims,Rachael Niederer","doi":"10.1016/j.ajo.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.01.007","url":null,"abstract":"PURPOSEThe primary aim of this study was to determine age-related patterns of uveitis entities. Secondary aims included age-related patterns of uveitic treatments and complications.DESIGNRetrospective clinical cohort study Methods: 4,395 participants presenting with uveitis to a single center from January 2009 to December 2023 were included.RESULTSThe median age at presentation was 45.1 years (IQR 32.2-60.3). Infections were more frequent in both younger (0-19 years) and older (≥60 years) participants. Toxoplasmosis was the most frequent cause of infectious uveitis in younger (0-19 years; 12.5%) participants and herpes zoster virus was the most prevalent cause of uveitis in adults 40+ years of age (40-59 years, 7.1%; 60-79 years, 20.5%; 80+years, 38.6%). Tumor-related uveitic masquerades demonstrated a significant association with increasing age (p<0.001). Younger individuals were more likely to require steroid-sparing immunosuppression (p<0.001) and more likely to require a switch from initial DMARD therapy (p<0.001). Older subjects were more likely to develop cystoid macular edema, raised intraocular pressure and cataract (p<0.001), while younger subjects were more likely to develop posterior synechiae (P=0.001), papillitis (p<0.001) and choroidal neovascular membrane (p=0.002).CONCLUSIONSAge appears to be a key factor influencing the underlying etiology and clinical course of uveitis. Investigations should be tailored to the clinical presentation and consideration of the individuals presenting age may provide clues as to the underlying cause of disease and to guide treatment.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"9 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Subretinal Gene Therapy for Treatment of Retinal and Choroidal Vascular Diseases.","authors":"Gary D Novack","doi":"10.1016/j.ajo.2024.12.032","DOIUrl":"https://doi.org/10.1016/j.ajo.2024.12.032","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"98 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment on Accuracy of Toric Intraocular Lens Formulas With Measured Posterior Corneal Astigmatism of Different Orientations.","authors":"Stephen Stewart, Tun Kuan Yeo, Salissou Moutari, Richard McNeely, Jonathan E Moore","doi":"10.1016/j.ajo.2025.01.010","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.01.010","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}