American Journal of Ophthalmology最新文献

{"title":"Reply to Comment on: Influence of the Corneal Posterior-to-Anterior Radius Ratio on IOL Power Prediction Using Standard and Total Keratometry","authors":"Zhongxiu Yang,Yun-E Zhao,Pingjun Chang","doi":"10.1016/j.ajo.2026.09.032","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.09.032","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"11 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional architecture of outer retinal tubulation in Bietti crystalline dystrophy","authors":"Maasa Ogata,Takahiro Kogo,Hanako O. Ikeda,Takuro Kamei,Kazuya Morino,Shogo Numa,Manabu Miyata,Yuki Muraoka,Akitaka Tsujikawa","doi":"10.1016/j.ajo.2026.10.001","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.10.001","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"35 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Noninfectious Uveitis is Associated With Increased Psychiatric Comorbidities: An All of Us Research Program Analysis’. Am J Ophthalmol. 2026 Jul 21;291:243-251","authors":"Priya Marella,Vijay Subramanian,Miriam Habiel","doi":"10.1016/j.ajo.2026.08.035","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.08.035","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"11 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Prevalence and Incidence of Strabismus by Age Group in Japan: A Nationwide Population-Based Cohort Study’. Am J Ophthalmol. 2024;262: 222-228.","authors":"Manabu Miyata,Ai Kido,Masahiro Miyake,Hiroshi Tamura,Takuro Kamei,Saori Wada,Hiroaki Ueshima,Kentaro Kawai,Shinya Nakao,Akinari Yamamoto,Kenji Suda,Eri Nakano,Miho Tagawa,Akitaka Tsujikawa","doi":"10.1016/j.ajo.2026.09.021","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.09.021","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"13 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment on: Evaluation of the Impact of Gamma-aminobutyric Acid on Diabetic Retinopathy in a Large US Population-based Cohort","authors":"Katherine E. Talcott,Sonia B. Kim,Rishi P. Singh","doi":"10.1016/j.ajo.2026.10.008","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.10.008","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"31 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Cost-Effectiveness of Photobiomodulation for Intermediate Dry Age-Related Macular Degeneration: A Model-Based Analysis Using the LIGHTSITE III 24-Month Trial\".","authors":"Dipeng Li, Shengping Hu, Mao Wu","doi":"10.1016/j.ajo.2026.08.051","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.08.051","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Influence of the Corneal Posterior-to-Anterior Radius Ratio on IOL Power Prediction Using Standard and Total Keratometry.","authors":"Wenrui Liu, Tao Peng","doi":"10.1016/j.ajo.2026.09.033","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.09.033","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5-Year Following Up of the Treatment Effects of Plaque Brachytherapy for Circumscribed Choroidal Haemangioma in Pediatric Patients.","authors":"He-Yan Li, Jing-Ying Xiu, Zhi-Xi Zeng, Xu-Han Shi, Jing-Yan Yang, Dong-Jun Li, Wen-Bin Wei, Qiong Yang, Yue-Ming Liu","doi":"10.1016/j.ajo.2026.09.037","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.09.037","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the long-term clinical outcomes and anatomical regression kinetics of pediatric versus adult patients with circumscribed choroidal hemangioma (CCH) following I-125 plaque brachytherapy.</p><p><strong>Design: </strong>Retrospective clinical cohort study.</p><p><strong>Methods: </strong>This retrospective study included pediatric patients and adult controls diagnosed with symptomatic CCH and treated with I-125 plaque brachytherapy. Clinical and imaging data, including best-corrected visual acuity (BCVA), tumor height, and largest basal diameter (LBD), were analyzed at baseline and at 1, 6 months, 1, 2, and 5 years post-treatment. The primary outcome was the rate of tumor height reduction, and secondary outcomes included subretinal fluid (SRF) resolution and functional visual recovery.</p><p><strong>Results: </strong>A total of 50 eyes from pediatric patients and 97 eyes from adults patients were evaluated. At baseline, the pediatric group exhibited significantly greater mean tumor height (6.45 ± 1.87mm) compared to the adult group (4.46 ± 1.46 mm, P < 0.05). Following brachytherapy, the pediatric cohort demonstrated significantly faster anatomical regression, with higher height reduction rates at 1, 6, 12, and 24 months (P < 0.01). By the 5-year following up, the cumulative height reduction was comparable between the two groups. In both cohorts, anatomical regression was characterized by more significant vertical collapse than changes in LBD. Most SRF resolved after 3 months of the surgery, while only 3 SRF cases did not resolve among pediatric patients after brachytherapy. Functional outcomes were favorable, with over 60% of patients achieving a visual improvement of >2 Snellen lines. Although children regressed faster anatomically, the final BCVA at 5 years showed no significant difference between the age groups (P > 0.05).</p><p><strong>Conclusions: </strong>Pediatric CCH demonstrated a more rapid anatomical response to I-125 plaque brachytherapy than adult, although the greater absolute tumor regression in pediatric patients should be interpreted in the context of greater baseline tumor thickness and enhanced radiosensitivity. Despite differences in the timing and magnitude of regression, plaque brachytherapy provided substantial tumor control and visual benefits in both pediatric and adult patients. Timely intervention of brachytherapy in pediatric cases may facilitate resolution of exudation and help preserve visual function.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teprotumumab for Thyroid Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Real-World Studies.","authors":"Aimin Sun, Xing Wang, Junyu Wang, Nan Yu, Yedi Cao, Yahui Wei, Jizhe Han, Ying Gao, Yuan Wu","doi":"10.1016/j.ajo.2026.09.034","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.09.034","url":null,"abstract":"<p><strong>Topic: </strong>Teprotumumab is the first FDA-approved biologic for moderate-to-severe thyroid eye disease (TED). Although efficacy has been established in randomized controlled trials (RCTs), real-world studies (RWS) have reported different efficacy and safety patterns, supporting an updated synthesis.</p><p><strong>Clinical relevance: </strong>A comprehensive assessment of teprotumumab across trials and routine clinical practice is needed to guide treatment decisions.</p><p><strong>Methods: </strong>This systematic review and meta-analysis included RCTs and RWS evaluating intravenous teprotumumab in adults with TED and reporting at least one prespecified efficacy or safety outcome. Other anti-IGF-1R RCTs were used only in supplementary class analyses. PubMed, Embase, Web of Science, and the Cochrane Library were searched from inception to August 10, 2026. Two reviewers independently screened studies, extracted data, and assessed risk of bias using the Cochrane RoB 2 tool and Joanna Briggs Institute criteria. Fixed- or random-effects models were selected according to heterogeneity. Risk ratios were used for dichotomous outcomes, mean differences for continuous outcomes, and proportions for single-arm RWS. Certainty was evaluated using GRADE. The protocol was registered in PROSPERO (CRD420251152338).</p><p><strong>Results: </strong>Thirty-six studies (6 RCTs and 30 RWS) were included; 4 RCTs evaluated teprotumumab and 2 evaluated other anti-IGF-1R antibodies. Proptosis response favored teprotumumab in RCTs (risk ratio, 4.55; 95% confidence interval, 2.52-8.23) and was achieved by 82% of patients in RWS (95% confidence interval, 0.78-0.86; 11 studies, 482 patients). Diplopia response also favored teprotumumab in RCTs (risk ratio, 2.13; 95% confidence interval, 1.51-2.98), while 60% of patients improved in RWS (95% confidence interval, 0.51-0.68; 6 studies, 204 patients). Hyperglycemia was more frequent with teprotumumab in RCTs (risk ratio, 2.67; 95% confidence interval, 1.04-6.85) and occurred in 17% of patients in RWS (13 studies, 671 patients). Hearing impairment was also increased in RCTs (risk ratio, 4.05; 95% confidence interval, 1.50-10.96) and occurred in 18% of patients in RWS (13 studies, 592 patients).</p><p><strong>Conclusion: </strong>Teprotumumab improves proptosis and diplopia across study designs, but hyperglycemia and hearing impairment in real-world practice warrant appropriate patient selection and monitoring.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital and Periorbital Epithelioid Hemangioma (Angiolymphoid Hyperplasia with Eosinophilia): A multicentre study of 25 cases.","authors":"Ayushi Agarwal, Abdullah Almater, Priyyanca Raghunath, Kaveh Vadani, Geoff Rose, Abdulrahman Alfarhan, Divisha Jain, Dilip K Mishra, Swathi Kaliki, Sahil Agrawal, Neelam Pushker, Rachna Meel, Seema Kashyap, Marco Sales-Sanz, María A Amesty, Dinesh Selva","doi":"10.1016/j.ajo.2026.09.036","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.09.036","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize clinicoradiological features and outcomes of peri-orbital and orbital epithelioid hemangioma (EH).</p><p><strong>Design: </strong>Retrospective, multicentre, observational case series SUBJECTS: Twenty-five (29 eyes) cases of biopsy-proven orbital and peri-orbital EH.</p><p><strong>Methods: </strong>25 cases (29 eyes) of orbital and peri-orbital EH managed across six tertiary centres over a 28-year period were reviewed. Previously reported radiological findings were pooled and compared with the present cohort.</p><p><strong>Main outcome measures: </strong>Clinicoradiological patterns, types of intervention, and treatment outcomes including completeness of excision and presence of tumor residue, in orbital and peri-orbital EH.</p><p><strong>Results: </strong>The median age at presentation was 38 years (IQR: 18-49) with no gender predilection. Of the 21 (25 eyes) cases with imaging, orbital involvement predominated in 20 (80%) eyes, with most lesions located in the superior quadrant (n=14, 70%). Lacrimal gland (LG) was involved in 14/20 (70%) eyes. Extraocular muscles were involved in 10/20 (50%) eyes, the most common being the superior rectus-levator muscle complex (n=7, 35%). A 'hypervascular' phenotype was identified in 9/25 (36%) eyes, characterized by heterogenous contrast enhancement with internal flow voids on magnetic resonance imaging, and an intrinsic vascular blush on angiography. Interventions included excisional biopsy (n=13, 62%), debulking (n=3, 14%), incisional biopsy (n=5, 24%), and primary sclerotherapy (n=1, 5%). Excisional biopsy was curative (p=0.0005) with tumor residue being more common in infiltrative, ill-defined lesions on imaging (p=0.0196).</p><p><strong>Conclusion: </strong>Orbital and periorbital EH demonstrates a radiological fingerprint, characterized by superior orbital tropism with predilection for LG, with a 'hypervascular' radiological phenotype identified in one-third of cases. Complete excision, where feasible, remains curative.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}