American Journal of Ophthalmology最新文献

{"title":"Corrigendum to Peripapillary Retinoschisis: The Expanded Spectrum and New Insights From Multimodal Imaging. Am J Ophthalmol. 2026;282:26-40.","authors":"Lucy Yi Yang, Andrew W Kam, Fred K Chen, Rachael C Heath Jeffery, Andrew Farag, Ananda Kalevar, Jay Chhablani, Marco Lupidi, Michael Chilov, Michael Branley, Jenny Ip, David Kalatzis, Shanil Dhanji, Devin Bestch, R Rishi Gupta, Netan Choudhry, Diogo Cabral, Caroline R Baumal, K Bailey Freund, Adrian T Fung","doi":"10.1016/j.ajo.2026.04.012","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.012","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"TFOS DEWS III: Digest\" Am J Ophthalmol. 2025; 279:451-553.","authors":"Fiona Stapleton, Pablo Argüeso, Penny Asbell, Dimitri Azar, Charles Bosworth, Wei Chen, Joseph B Ciolino, Jennifer P Craig, Juana Gallar, Anat Galor, José A P Gomes, Isabelle Jalbert, Ying Jie, Lyndon Jones, Kenji Konomi, Yang Liu, Jesus Merayo-Lloves, Fabiola R Oliveira, Victor L Perez, Eduardo M Rocha, Benjamin D Sullivan, David A Sullivan, Jelle Vehof, Susan Vitale, Mark Willcox, James S Wolffsohn, Murat Dogru","doi":"10.1016/j.ajo.2026.04.007","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.007","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Biomarkers for Early Differentiation of Candida and Aspergillus Endogenous Fungal Endophthalmitis: Multicenter Optical Coherence Tomography-Based Analysis.","authors":"Aniruddha Agarwal, Nitin Kumar Menia, Alessandro Invernizzi, Prithvi Ramtohul, Alessandro Marchese, Alex Fonollosa, Francesco Pichi, Mudit Tyagi, Abhilasha Baharani, Dina Baddar, Salil Mehta","doi":"10.1016/j.ajo.2026.04.027","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.027","url":null,"abstract":"<p><strong>Purpose: </strong>Endogenous fungal endophthalmitis (EFE) is a rare, sight-threatening intraocular infection with heterogeneous clinical presentations. Candida and Aspergillus species are the most common etiologic agents and may manifest with retinochoroiditis lesions that can be challenging to differentiate clinically. Accurate identification of the causative organism is essential for targeted antifungal therapy, anticipating disease progression, and optimizing outcomes. This study aimed to differentiate the etiology of EFE-associated retinochoroiditis using detailed clinical and optical coherence tomography (OCT) analysis.</p><p><strong>Design: </strong>International, multicenter, retrospective comparative case series.</p><p><strong>Methods: </strong>Demographic information, clinical characteristics, fundus photography, and OCT scans of patients with culture-proven Candida or Aspergillus EFE presenting with retinochoroiditis lesions were collected from eight tertiary-care centers worldwide. Lesion morphology (size, location, multifocality, and associated features) and OCT patterns (vitreal changes, vitreoretinal interface abnormalities, inner/outer retinal infiltration, and choroidal involvement) were compared between groups. Student's t-tests were used for continuous variables and Fisher's exact tests for categorical variables. Multivariable logistic regression and a random forest classifier were applied to identify the features most predictive of fungal species.</p><p><strong>Results: </strong>Thirty-eight eyes of 30 patients (mean age: 64.7±15 years) were included: 28 with Candida and 10 with Aspergillus EFE. Foveal involvement occurred only in Candida cases (28.6% eyes). Compared with Aspergillus, Candida EFE showed significantly more multifocal lesions (p=0.008), mid-peripheral/peripheral involvement (p=0.004), satellite lesions (p=0.001), and \"string-of-pearls\" vitreous exudates (p=0.05). Aspergillus eyes had larger lesions (2.4 vs. 1.2 disc-diameters; p=0.001), more pre-/subretinal hemorrhage (p=0.03), and higher rates of occlusive vasculitis (p=0.008). On OCT, Candida eyes demonstrated more vitreous condensations/rain-cloud sign (p=0.03), preretinal aggregates (p=0.02), and intraretinal fluid (IRF) (p=0.04). Aspergillus infections more commonly exhibited full-thickness involvement with dense shadowing (p=0.001) and choriocapillaris alteration (p=0.008). Multivariable regression and random forest analysis identified lesion size, multifocality, satellite lesions, hemorrhage/vasculitis, IRF, and choriocapillaris alteration as the most discriminative features. These features allowed species differentiation with ∼85% accuracy using machine-learning classification.</p><p><strong>Conclusions: </strong>Candida and Aspergillus EFE presenting with retinochoroiditis exhibit distinct features that allow reliable differentiation between these fungal etiologies. These OCT-based biomarkers may inform early organism-specific management while","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unsuccessful Clinical Trials in Retina: Lessons Learned.","authors":"Julie Tran, Jay Chhablani","doi":"10.1016/j.ajo.2026.04.028","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.028","url":null,"abstract":"<p><strong>Objective: </strong>To analyze patterns of non-success in phase 2 and 3 interventional retinal clinical trials conducted in the United States between 2015 and 2025.</p><p><strong>Design: </strong>Perspective based on retrospective analysis of unsuccessful clinical trials.</p><p><strong>Methods: </strong>Unsuccessful trials that were terminated, withdrawn, or completed without meeting primary endpoints were evaluated across indications, trial phases, intervention classes, and mechanisms of action to identify recurring design, feasibility, and operational challenges.</p><p><strong>Results: </strong>High attrition rates were observed across diabetic macular edema, diabetic retinopathy, neovascular age-related macular degeneration, and geographic atrophy. Phase 2 trials were more frequently discontinued following interim analyses, whereas phase 3 trials more often failed to meet primary efficacy endpoints. Later-phase studies were associated with increased sample size, geographic dispersion, follow-up duration, and assessment burden. Differences in endpoint selection, comparator choice, and population heterogeneity may contribute to attenuation of treatment effects. Operational and sponsor-level factors, including strategic and financial considerations, were also associated with trial discontinuation.</p><p><strong>Conclusion: </strong>Translating early-stage findings into successful late-phase outcomes remains challenging in retinal drug development. Improved alignment of biological rationale, endpoint selection, and operational feasibility may enhance trial success.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AUTO MACHINE LEARNING FOR DIABETIC RETINOPATHY SCREENING: A HEAD-TO-HEAD MULTI-PLATFORM COMPARISON AGAINST HUMAN GRADERS AND IDX-DR.","authors":"Tomasz Krzywicki, Ceren Durmaz Engin, Andrzej Grzybowski","doi":"10.1016/j.ajo.2026.04.030","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.030","url":null,"abstract":"<p><strong>Purpose: </strong>To benchmark multiple automated machine learning (AutoML) platforms for diabetic retinopathy (DR) screening from fundus photographs using a unified training and evaluationframework, with human consensus grading and an FDA-approved autonomous system (IDx-DR) as reference standards.</p><p><strong>Design: </strong>Retrospective, diagnostic performance and benchmarking study METHODS: Image classifiers were trained on large public datasets labeled according to the International Clinical Diabetic Retinopathy (ICDR) scale (APTOS, n = 5,590; DDR, n = 12,524; EyePACS, n = 31,557) after automated image-quality filtering. Performance was evaluated on an independent, institutionally collected patient-level test cohort (n = 726) using the highest DR grade across all images for patient-level classification. The evaluated platforms included Google Vertex AI, Amazon Rekognition, Amazon SageMaker Canvas, AutoGluon, AutoKeras, and Apple CreateML. Models were assessed for three screening endpoints-any DR, referable DR (RDR), and sight-threatening DR (STDR)-across probability thresholds of 20%, 50%, and 70%. The primary endpoints were the Area Under the Receiver Operating Characteristic Curve (AUC) and sensitivity for RDR at a 50% decision threshold. Secondary endpoints included specificity, positive predictive value, negative predictive value, accuracy, and F1-score with 95% confidence intervals. Pairwise comparisons were performed using bootstrap testing (n=1,000) for AUC differences and McNemar's test (at a 50% threshold) for binary outcomes, both subjects to Bonferroni correction (p<0.0033). Grad-CAM was applied to locally deployable convolutional neural network-based models.</p><p><strong>Results: </strong>Using human consensus grading as the reference standard, Amazon SageMaker Canvas and AutoGluon demonstrated the strongest overall discrimination, achieving AUC values up to0.96 for STDR and 0.93-0.94 for RDR. At the 50% decision threshold, Canvas showed the most balanced performance for RDR (sensitivity 88.3%, specificity 85.5%, accuracy 86.0%), whereasAutoGluon favored sensitivity (any DR sensitivity 95.9%) at the expense of specificity. Vertex AI showed consistently weaker and unstable performance (any DR AUC 0.58; RDR AUC 0.38). Relative to IDx-DR, Amazon Rekognition and Canvas showed the highest agreement, particularly for STDR (AUC up to 0.88-0.90; κ up to ∼0.56). Agreement with human graders was generallylow to moderate (κ ≈ 0.3-0.6) and increased at higher probability thresholds.</p><p><strong>Conclusions: </strong>AutoML platforms can achieve clinically meaningful performance for DR screening. Differences across tools and thresholds reflect their adaptability to diverse clinical settings, underscoring the importance of external validation and threshold calibration.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Interferon Alpha-2a as Treatment for Primary Acquired Melanosis With Atypia and for Primary Acquired Melanosis With Atypia Surrounding Conjunctival Melanoma\".","authors":"Raman Yadav, Varsha Yadav, Sameer Rastogi","doi":"10.1016/j.ajo.2026.03.049","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.03.049","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Strabismus in Children with Retinopathy of Prematurity.","authors":"Amr Almobayed, Qais Dihan, Adam K Cohen, Isdin Oke, Seif E Abdelnaem, Paul H Phillips, Abdelrahman M Elhusseiny","doi":"10.1016/j.ajo.2026.04.025","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.025","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the cumulative incidence of strabismus among children diagnosed with retinopathy of prematurity (ROP).</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Participants: </strong>Children aged ≤18 years with a diagnosis of ROP, with or without treatment exposure.</p><p><strong>Methods: </strong>We defined treated ROP as receipt of laser photocoagulation and/or intravitreal anti-vascular endothelial growth factor (VEGF) injection, while untreated ROP had no record of either intervention. We estimated the cumulative incidence of strabismus at 1, 3, and 5 years after ROP diagnosis using Kaplan-Meier analysis. We used Cox proportional hazards models to calculate adjusted hazard ratios (aHR) and 95% confidence intervals (CIs), adjusting for demographic variables and ocular comorbidities.</p><p><strong>Main outcome measures: </strong>Development of strabismus following ROP diagnosis.</p><p><strong>Results: </strong>The cohort included 27,720 ROP patients: 973 were treated and 26,747 were untreated. Cumulative incidence of strabismus was consistently higher among treated patients. At 5 years, cumulative incidence was 34.78% in treated patients compared with 22.14% in untreated patients, with esodeviations as the most common subtype, occurring in 22.35% of treated patients and 11.87% of untreated patients. Treatment exposure was independently associated with an increased hazard of strabismus (aHR, 1.58; 95% CI, 1.29 to 1.95; P < 0.001). Amblyopia (aHR, 2.58; 95% CI, 2.25-2.96; P < 0.001) and nystagmus (aHR, 1.76; 95% CI, 1.48-2.1; P < 0.001) were also independently associated with increased hazard.</p><p><strong>Conclusions: </strong>ROP confers an increased hazard of developing subsequent strabismus, with higher cumulative incidence among children who undergo treatment for ROP.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implantable polypropylene capsular hook(s) for managing subluxated lenses: a prospective study.","authors":"Yiyi Wang, Liangning Cui, Wei Lou, Yao Zhang, Haiying Jin","doi":"10.1016/j.ajo.2026.04.024","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.024","url":null,"abstract":"<p><strong>Purpose: </strong>To report the clinical outcomes of intrascleral fixation of implantable capsular hooks for managing subluxated lenses.</p><p><strong>Design: </strong>Prospective, non-comparative, interventional case series.</p><p><strong>Methods: </strong>Patients with subluxated lenses who underwent in-the-bag intraocular lens (IOL) implantation assisted by capsular tension ring and implantable capsular hook(s) made of 7-0 polypropylene sutures were included. The main postoperative outcome measure was IOL position including IOL decentration, tilt, postoperative anterior chamber depth (ACD), and the distance between IOL and iris. Secondary postoperative outcomes included best-corrected visual acuity (BCVA), spherical equivalent (SE), corneal endothelial cell density (ECD), intraocular pressure (IOP), and complications.</p><p><strong>Results: </strong>Seventy-four eyes of 74 patients were enrolled, with a mean follow-up of 13.2 ± 8.9 months (range: 6-36 months). The IOL position remained stable throughout the follow-up period, with a mean IOL decentration of 0.31 ± 0.24 mm and a mean tilt of 1.83 ± 1.35° at the final follow-up visit. Both postoperative ACD and the distance between IOL and iris remained stable, with values of 3.91 ± 0.33 mm and 0.65 ± 0.26 mm at the final follow-up visit, respectively. The mean BCVA improved from 0.75 ± 0.73 logMAR (Snellen 20/112) preoperatively to 0.24 ± 0.28 logMAR (Snellen 20/35) at the final follow-up visit (P<0.05). The mean SE was -2.37 ± 4.68 D preoperatively and -1.09 ± 1.33 D at the final follow-up visit (P < 0.05). The mean ECD decreased from 2577.64 ± 486.10 cells/mm² preoperatively to 2171.313 ± 707.23 cells/mm² at the final follow-up visit with a mean loss of 14.70 ± 14.60 % (P<0.05). The intraoperative complication was transient mild bleeding during penetration of the scleral wall (n = 4, 5.4 %). Postoperative complications included IOP elevation (n = 9, 12.2 %), hypotony (n = 2, 2.7 %), grade 2 anterior chamber cells (n = 2, 2.7 %), retinal detachment (n = 1, 1.4%), cystoid macular edema (n = 1, 1.4%), and posterior capsule opacification (n = 1, 1.4%).</p><p><strong>Conclusion: </strong>Intrascleral fixation of implantable capsular hooks enables in-the-bag IOL implantation in eyes with subluxated lenses and represents a feasible, stable, and safe approach.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between retinal nerve fiber layer thickness and cardiovascular-kidney-metabolic syndrome: A UK Biobank cohort study.","authors":"Jihei Sara Lee, Seok-Jae Heo, David Myung, Chan Yun Kim, Sang Yeop Lee","doi":"10.1016/j.ajo.2026.04.023","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.023","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association between retinal nerve fiber layer (RNFL) thickness and the severity of cardiovascular-kidney-metabolic (CKM) syndrome in a large community cohort.</p><p><strong>Design: </strong>Retrospective cross-sectional analysis of a community-based cohort.</p><p><strong>Participants: </strong>UK residents 40 to 60 years of age at enrollment of UK Biobank.</p><p><strong>Methods: </strong>The cohort underwent baseline examination from April 2007 to October 2010. We analyzed high-quality optical coherence tomography images and identified the presence of CKM syndrome. We explored associations between RNFL and CKM syndrome severity using multivariable logistic regression.</p><p><strong>Main outcome measures: </strong>Odds ratios (OR) for having advanced CKM syndrome (stage 3 or higher) at baseline were calculated after adjustment for age, sex, ethnicity, intraocular pressure, education and socioeconomic status.</p><p><strong>Results: </strong>A total of 17,082 participants were included (mean age 57.63±7.66 years old, 56.8% females) in the study, and 15,892 participants (93.0%) had CKM syndrome stage 1 or higher at baseline. Advanced CKM syndrome was observed more frequently in the thinnest quintile of RNFL thickness (14.8%) in comparison to the thickest quintile (9.1%). A multivariate regression controlling for potential confounders showed that decrease in RNFL thickness by 1 µm increased the risk of having advanced CKM syndrome by 2.4% (OR 1.024, 95% CI 1.010-1.039, P=0.001) at baseline.</p><p><strong>Conclusions: </strong>Thinner RNFL is associated with advanced CKM syndrome in individuals without a previous neurodegenerative or ocular disease. Our findings suggest that RNFL may serve as a valuable marker for monitoring disease severity of CKM syndrome. Further research, however, is warranted to investigate the pathways linking RNFL and CKM syndrome and to validate RNFL as a prognostic marker for CKM syndrome in larger populations.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-individual Comparison of Two Refractive Extended-Depth-of-Focus Intraocular Lens Designs.","authors":"Johannes Zeilinger,Stefan Palkovits,Manuel Ruiss,Caroline Pilwachs,Philipp Necpal,Ava Elahi,Oliver Findl","doi":"10.1016/j.ajo.2026.04.014","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.014","url":null,"abstract":"PURPOSETo compare intra-individual differences in visual performance of two non-diffractive refractive extended-depth-of-focus (EDF) intraocular lenses (IOLs) targeted for emmetropia.DESIGNProspective, randomized, patient-and examiner-masked intra-individual comparative study.METHODSForty patients (80 eyes) with bilateral age-related cataract underwent phacoemulsification with implantation of refractive EDF IOL in each eye: a wavefront-shaped refractive EDF IOL (DEN00V, Johnson and Johnson Vision) in one eye and a sector-segmented EDF IOL (AN6V, Teleon) in the fellow eye. After 3 months, monocular distance corrected and uncorrected distance (CDVA/UDVA) intermediate (DIVA/UIVA), and near (DNVA/UNVA) visual acuity, refractive outcomes, defocus curves, contrast sensitivity, halometry, and subjective visual quality using questionnaires were compared.RESULTSIn thirty-seven patients (74 eyes) mean UDVA at 4m, DIVA at 66cm and UDNVA at 40cm were 0.05±0.10, 0.17±0.11 and 0.31±0.11 logMAR for the DEN00V and 0.06±0.10, 0.15±0.10 and 0.32±0.11 logMAR for the AN6V respectively with no significant differences. A statistically significant difference was observed for the primary endpoint, UIVA, with 0.18±0.13 logMAR for the DEN00V and 0.12±0.09 logMAR for the AN6V. Nominal differences were observed for CDVA and UNVA with 0.01±0.07 and 0.32±0.12 logMAR for the DEN00V and -0.02±0.07 (p=0.01), and 0.25±0.10 (p=0.01) logMAR for the AN6V, respectively. Further nominal differences could be shown for contrast sensitivity under photopic and mesopic conditions. However, these differences did not remain statistically significant after adjustment for multiple comparisons.CONCLUSIONSBoth IOLs demonstrated and extended range of functional vision, preserved contrast sensitivity, and minimal photopic phenomena. A statistically significant difference was observed for the primary endpoint UIVA, favouring the AN6V.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"144 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}