American Journal of Ophthalmology最新文献

{"title":"Negative Pressure Application by the Ocular Pressure Adjusting Pump to Lower IOP in Normal-Tension Glaucoma: Hercules Study.","authors":"Tanner J Ferguson, Thomas W Samuelson, Leon Herndon, Daniel C Terveen, Jason Bacharach, Jacob W Brubaker, John P Berdahl, Nathan M Radcliffe","doi":"10.1016/j.ajo.2025.03.030","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.03.030","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the safety and IOP-lowering efficacy of the Ocular Pressure Adjusting Pump in subjects with normal-tension glaucoma.</p><p><strong>Design: </strong>Prospective, multi-center, masked, randomized, fellow-eye controlled trial.</p><p><strong>Subjects, participants and/or controls: </strong>Subjects with normal-tension glaucoma (NTG) with an IOP ≥12 mmHg and ≤21 mmHg were enrolled. One eye of each subject was randomized to receive negative pressure application; the fellow eye served as a control.</p><p><strong>Methods: </strong>Subjects wore the device overnight for 1 year and the applied negative pressure was programmed by subtracting a reference IOP of 6 mmHg from the baseline IOP.</p><p><strong>Main outcome measures: </strong>The primary effectiveness endpoint was the proportion of eyes achieving an IOP reduction ≥20% at Week 52 during the day. The secondary endpoint was the proportion of eyes achieving a nocturnal IOP reduction ≥20% at Week 52. Exploratory endpoints included mean IOP reduction in clinic and in the sleep lab.</p><p><strong>Results: </strong>186 eyes were randomized across 11 sites. 120 eyes successfully completed all visits across 52 weeks without protocol deviations. At Week 52, 88.3% (n=53) of study eyes versus 1.7% (n=1) of control eyes met the primary endpoint. For the secondary endpoint, 96.7% (n=58) of study eyes versus 5.0% (n=3) met the endpoint. For exploratory IOP analysis, the mean nocturnal IOP reduction at Week 52 was 8.0 mmHg (39.1%) from a baseline of 20.4 ± 2.5 mmHg to 12.4 ± 2.7 mmHg. There were no serious adverse events (AEs). The most commonly reported adverse events were lid (11.8% study, 1.1% control) and periorbital edema (12.9%, 1.1%).</p><p><strong>Conclusions: </strong>The Ocular Pressure Adjusting Pump safely and effectively lowers both daytime and nocturnal IOP in patients with normal-tension glaucoma.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colour Doppler and Contrast-Enhanced Ultrasound Characteristics in Degenerative Retinoschisis and Retinal Detachment.","authors":"Jai Paris, Carmelo Macri, Yong Min Lee, Matthew Le, Fady Sammouh, Meegan Gun, WanYin Lim, Weng Onn Chan","doi":"10.1016/j.ajo.2025.03.029","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.03.029","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate and compare the characteristics of colour Doppler ultrasound (CDUS) and contrast-enhanced ultrasound (CEUS) in degenerative retinoschisis (RS) and rhegmatogenous retinal detachment (RD) .</p><p><strong>Design: </strong>Prospective, observational case series METHODS: We prospectively enrolled patients with degenerative RS, acute RD, or chronic RD at two tertiary centres from January 2024 to January 2025. Patients underwent clinical examination, ultrawide field photography and optical coherence tomography (OCT) , and CDUS, followed by CEUS with Definity® microbubbles. Ultrasound characteristics between groups were compared.</p><p><strong>Results: </strong>We included 65 eyes from 47 patients (25 male, median age 61.8) . There were 51 eyes with RS, 6 eyes with acute RD, and 6 eyes with chronic RD. CDUS revealed no pre-contrast doppler flow in any RS, while all acute RD cases demonstrated doppler flow. CEUS displayed mild microbubble uptake in 18 RS cases (median bubble count of 2) , whereas all RD cases exhibited florid uptake (median bubble count of 48.2) . Compared to RS, acute RD cavities had significantly higher elevation from sclera (by 6.0 CI 2.8 - 9.2 mm) , longer cavity lengths (by 9.8 CI 7.2 - 12.5) , and greater membrane thickness (by 0.89 CI 0.6 - 1.2 mm) . Chronic RD were significantly thicker than RS membranes (by 0.40 CI 0.2 - 0.6 mm) but were no longer or with greater elevation. Pixelated image analysis showed compared to RS, acute RD showed a higher average total particle count (by 45.83 units) , larger particle size (by 66.3 pixels) , and greater total particle area (by 3138 pixels) . Chronic RD cases had mixed CDUS and CEUS findings.</p><p><strong>Conclusions: </strong>CDUS features differentiating between degenerative RS and RD included the lack of doppler flow in RS, higher and longer cavities in acute RD, and thicker membranes in acute and chronic RD. CEUS features differentiating RS and RD included florid microbubble contrast enhancement in acute RD. These findings could aid in the investigation of cases with diagnostic uncertainty.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-Based Performance of Inflammatory Markers in Giant Cell Arteritis.","authors":"Clara M Castillejo Becerra, Cynthia S Crowson, Hannah E Langenfeld, Deena Tajfirouz, Kevin D Chodnicki, Matthew J Koster, Kenneth J Warrington, John J Chen","doi":"10.1016/j.ajo.2025.03.022","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.03.022","url":null,"abstract":"<p><strong>Objective: </strong>To determine the population-based sensitivities and specificities of various inflammatory markers for the diagnosis of GCA.</p><p><strong>Design: </strong>Retrospective population-based cross-sectional study.</p><p><strong>Participants: </strong>Patients who underwent temporal artery biopsy (TAB) from 01/01/1995 through 12/31/2019 in Olmsted County, Minnesota were identified using the Rochester Epidemiology Project (REP). Subjects were categorized as GCA or non-GCA using the 1990 American College of Rheumatology classification criteria for GCA.</p><p><strong>Testing: </strong>Sensitivity and specificity of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and platelets for a positive GCA diagnosis were calculated.</p><p><strong>Main outcome measures: </strong>GCA diagnosis.</p><p><strong>Results: </strong>There were 553 patients who underwent TAB, 143 with GCA and 410 without GCA. Median age at time of TAB was 75 years (IQR 69-81) and 372 (67%) were female. Patients with GCA had higher CRP (91.1 vs 49.1 mg/L, p<0.001), ESR (66.4 vs 52.0 mm/hr, p<0.001), and platelets (370.5 vs 283.1 × 10⁹/L, p<0.001) than patients in the non-GCA cohort. Sensitivity was 96% for CRP, 80% for ESR, and 49% for platelets. Specificity was 21% for CRP, 43% for ESR, and 79% for platelets. Combined ESR and CRP had a sensitivity of 77% and specificity of 54% while combined ESR, CRP, and platelets had a sensitivity of 41% and specificity of 84%. Normal inflammatory markers, including ESR, CRP, and platelets, were observed in 2 (3%) GCA patients.</p><p><strong>Conclusions: </strong>This population-based study evaluated the performance of various inflammatory markers in the diagnosis of GCA. Inflammatory markers are helpful in the diagnosis of GCA, but normal values do not exclude the diagnosis.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomere Biology Disorders: Microvascular Abnormalities on Optical Coherence Tomography.","authors":"Natasha F S da Cruz, Jesse D Sengillo, Catherin I Negron, Audina M Berrocal","doi":"10.1016/j.ajo.2025.03.027","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.03.027","url":null,"abstract":"<p><strong>Background and objective: </strong>Telomere biology disorders (TBDs) are inherited conditions caused by telomere dysfunction, impacting systemic and ocular health. We aim to explore the role of optical coherence tomography angiography (OCTA) in identifying retinal microvascular abnormalities in TBDs.</p><p><strong>Design: </strong>Retrospective case series.</p><p><strong>Methods: </strong>The electronic medical records of pediatric patients with TBD at a tertiary referral eye center were reviewed from January 2019 to July 2023. OCTA images were reviewed for anomalies of the retinal vasculature.</p><p><strong>Results: </strong>In total, 13 eyes of 7 patients were included in the study. All patients were genetically confirmed to have TBD. The most common genetic variants were CTC1 (5 patients; 71.4%), ACD (1 patient; 14.3%) and RTEL1 (1 patient; 14.3%). On OCTA, all 13 eyes showed some degree of macular microvascular abnormality in both the SVC and DVC. The most common microvascular abnormality seen in the SVC was blood vessels anastomosis (11; 84.6%), and in the DVC was decreased vessel density (9; 69.2%).</p><p><strong>Conclusions: </strong>OCTA imaging reveals a high prevalence of microvascular abnormalities in patients with TBD, highlighting its potential role in assessing retinal vascular changes associated with the disease.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence and Persistence on Prostaglandin Analogues for Glaucoma: A Systematic Review and Meta-Analysis.","authors":"Christophe Baudouin, Jonathan S Myers, Sarah H Van Tassel, Nina A Goyal, Jose Martinez-de-la-Casa, Alvin Ng, Jennifer S Evans","doi":"10.1016/j.ajo.2025.03.025","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.03.025","url":null,"abstract":"<p><strong>Purpose: </strong>To systematically review, synthesize and quantify studies reporting patterns of adherence and persistence with prostaglandin analogues (PGAs) in order to comprehensively understand real-world treatment behavior among patients with glaucoma who are prescribed PGAs. These data can inform the decision between a glaucoma therapy based on either topical PGA medications or procedural PGA-based intervention.</p><p><strong>Design: </strong>Systematic literature review (SLR) and meta-analysis (MA) METHODS: We updated a 2011 SLR using electronic database searches (MEDLINE, Embase and the Cochrane Database of Systematic Reviews [CDSR]), supplemented by hand searches of SLR and MA bibliographies. We included observational studies conducted in adult glaucoma patients treated with PGAs that reported objective measures of persistence or adherence. In addition to estimated rates of adherence and persistence, adherence among patients on any/unspecified PGA was characterized by mean MPR/PDC (medication possession ratio/proportion of days covered, where values >80% indicate good adherence). Duration of therapy was defined as the time period between initial therapy prescription and time of therapy discontinuation or switch.</p><p><strong>Results: </strong>The SLR included 50 publications reporting on 47 unique studies and involving 961,000 patients. The subsequent MA included all but four studies which did not report the age distribution of patients. The mean proportion of patients on any/unspecified PGA who were adherent at Year 1 was 44% (95% CI: 31-58%). Among patients on any/unspecified PGA, the mean MPR/PDC was 54% (95% CI: 38-75%) at Year 1 and 60% at Year 2 (95% CI: 39-94%). The mean proportion of patients on any/unspecified PGA who were persistent fell from 75% (95% CI: 66-85%) at Month 6 to 31% (95% CI: 12-55%) at Year 3, with a smaller decrease observed between Year 1 (56%; 95% CI: 45-66%) and Year 2 (53%; 95% CI: 45-62%), and a larger decrease between Years 2 and 3. The mean duration on therapy was 315.7 days (95% CI: 190.0-441.5 days).</p><p><strong>Conclusions: </strong>Suboptimal adherence and persistence with PGAs are common, with further decreases as duration lengthens. These findings may underscore the value of procedural glaucoma treatments that do not depend on daily patient engagement with topical medications.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drugs Associated with Floppy Iris Syndrome: A Real-World Population-Based Study: Drugs Associated with Floppy Iris Syndrome.","authors":"Moiz Lakhani, Angela T H Kwan, Andrew Mihalache, Marko M Popovic, Bernard Hurley, Rajeev H Muni","doi":"10.1016/j.ajo.2025.03.023","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.03.023","url":null,"abstract":"<p><strong>Purpose: </strong>Intraoperative floppy iris syndrome (IFIS) is associated with an increased rate of severe intraoperative complications and greater visual morbidity during cataract surgery, particularly in females. To date, no post-marketing pharmacovigilance study has comprehensively examined all FDA-approved drugs for their association with IFIS development or explored potential sex differences. Understanding the risk factors for IFIS allows cataract surgeons to better stratify surgical risks and implement appropriate preoperative and intraoperative measures to ensure adequate pupil dilation in high-risk patients.</p><p><strong>Design: </strong>Retrospective pharmacovigilance clinical cohort study.</p><p><strong>Methods: </strong>This population-based, observational study analyzed IFIS cases reported to the Food and Drug Administration Adverse Event Reporting System (FAERS) from October 2003 to March 2024 using OpenVigil 2.1. Disproportionality metrics, including reporting odds ratios (RORs), proportional reporting ratios (PRRs), and relative risk reductions (RRRs), were used to assess signals for positive adverse reactions (n>2, χ²>4, PRR>2), compared to all other drugs. Subgroup analyses were also conducted by sex.</p><p><strong>Results: </strong>Of 12,345,128 adverse event (AE) reports, 649 (0.0053%) involved IFIS. The majority of cases were reported by healthcare professionals (75.75%, n=203), followed by consumers (12.69%, n=34) and unknown sources (11.57%, n=31). Drugs with the highest disproportionality for IFIS included imipramine (ROR=251.66, 95% CI=157.53-402.02), tamsulosin (ROR=171.44, 95% CI=143.12-205.36), and chlorpromazine (ROR=91.30, 95% CI=49.91-167.03) (all p<0.0001, IC₀₂₅>0). Over-reported drug classes included α1-blockers, tricyclic antidepressants, atypical antipsychotics, carbonic anhydrase inhibitors, corticosteroids, 5α-reductase inhibitors, β-blockers, prostaglandin analogs, and β2-agonists. Among females, brinzolamide (ROR=409.63, 95% CI=196.78-852.73) and salbutamol (ROR=67.12, 95% CI=28.37-158.80) were disproportionately associated with IFIS (both p<0.0001, IC₀₂₅>0), whereas these associations were not observed in males.</p><p><strong>Conclusions: </strong>This analysis of over 20,000 drugs and 12 million reports highlights that, in addition to α1-blockers and atypical antipsychotics, tricyclic antidepressants are among the key agents most disproportionately associated with IFIS, with notable sex differences. These findings are crucial for informing perioperative counseling and surgical planning for cataract surgery.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Eye Curvature as a Biomarker for Differentiating Pathologic Myopia from High Myopia.","authors":"Haichao Chen, Zhe Pan, Xinyu Liu, Hui Xie, Fahim Ahmed Zaman, Xiaodong Wu, Yuxin Fang, Can Can Xue, Yu Mao, Xiaofei Wang, Zhuxin Xiong, Yingxiang Han, Jost B Jonas, Tien Yin Wong, Ya Xing Wang","doi":"10.1016/j.ajo.2025.03.024","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.03.024","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize posterior eye curvature and to assess its diagnostic performance in differentiating pathologic myopia (PM) from simple high myopia (SHM).</p><p><strong>Design: </strong>Population-based, cross-sectional study.</p><p><strong>Participants: </strong>A total of 790 eyes from 790 participants (mean age: 60.6 ± 8.3 years; 59% female) were randomly selected from the Beijing Eye Study, including 406 non-myopic eyes, 175 eyes with mild myopia, 102 eyes with moderate myopia, 76 eyes with simple SHM, and 31 eyes with PM.</p><p><strong>Methods: </strong>Posterior eye curvature was calculated using the outer boundary of the retinal pigment epithelium layer, derived from automatically segmented spectral-domain optical coherence tomography images. Three curvature parameters were computed: curvature^mean, curvature^max and curvature^macula.</p><p><strong>Main outcome measures: </strong>The values and spatial distribution of curvature parameters across different myopia groups, and their diagnostic performance in distinguishing PM from SHM.</p><p><strong>Results: </strong>Higher curvature parameters were significantly associated with older age, longer axial length (AL), more myopic refractive error (RE), lower best-corrected visual activity, and smaller subfoveal choroidal thickness (all P<0.001). These parameters increased progressively with myopia severity (all P<0.001). Unlike traditional metrics such as AL, which demonstrated a steady increase across the entire spectrum of myopia, curvature parameters showed a significantly sharper increase between SHM and PM, compared to other pairwise comparisons (non-myopia vs. mild myopia, mild vs. moderate myopia, and moderate myopia vs. SHM) (all P<0.001). After adjusting for age, AL, and RE, the curvature parameters remained significantly associated with the occurrence of PM (all P≤0.003). In distinguishing PM from SHM, curvature^max achieved the highest diagnostic performance, with an area under the receiver operating characteristic curve (AUROC) of 0.92 (95%CI, 0.87-0.98), followed by 0.86 (95%CI, 0.78-0.94) for curvature^mean, 0.84 (95%CI, 0.76-0.93) for curvature^macula, 0.75 (95%CI, 0.62-0.89) for AL, and 0.76 (95%CI, 0.66-0.86) for RE. The performance of curvature^max was significantly higher than AL (P=0.020) and RE (P=0.006).</p><p><strong>Conclusions: </strong>Posterior eye curvature increased with myopia severity and outperformed traditional AL and RE, suggesting its potential as a desirable biomarker in differentiating PM from SHM. Further research, particularly longitudinal studies, is warranted to evaluate whether the curvature can predict myopia prognosis and the development of pathologic changes.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Differences in Patient-Physician Communication in Ophthalmic Practice, Pre- and Post-Covid 19.","authors":"Jasmine S Brown, Sunni Mumford, Dominique A Alexis, Ahmara G Ross, Eve J Higginbotham","doi":"10.1016/j.ajo.2025.03.020","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.03.020","url":null,"abstract":"<p><strong>Purpose: </strong>Physician communication patterns can increase patient satisfaction and adherence to therapy in the primary care setting. This study investigated gender differences in ophthalmologist communication patterns before and after the Covid-19 pandemic.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>Messages sent by ophthalmic patients at Penn Medicine from 2017-2022 were collected. Differences in the number of physician messages sent for a given patient, median response length and response time to patient inquiries and messages were examined based on year and physician gender.</p><p><strong>Results: </strong>Female ophthalmologists sent longer response messages to their patients (median [25^th, 75^th percentiles] response length for women vs. men; 672 [492-965] characters vs. 637 [460, 918] characters; P < .0001) and a higher number of response messages per patient compared to their male counterparts (mean [SD] for women vs. men; 5.5 [2.9] vs. 3.0 [1.5]; P = .04). There was an increase in this gender difference in the peri- and post-Covid 19 period (i.e. 2020-2022) (P = .007). Male ophthalmologists sent a higher percentage of same-day responses from 2017-2020 (P < .0001), while female ophthalmologists sent a higher percentage of same-day responses from 2021-2022 (P < .0001). The largest gender difference in same day responses occurred in 2020 (34% for men vs. 30% for women; (P < .0001).</p><p><strong>Conclusions: </strong>Gender differences exist in ophthalmologist communication patterns and the Covid-19 pandemic impacted these differences. Future studies will be helpful in determining the potential association of these specific communication patterns with patient satisfaction assessments, eye health outcomes and physician burnout.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment on: Multifocal Vitelliform Paravascular Retinopathy (MVPR): A New Disorder in the Vitelliform Spectrum.","authors":"Weilin Song, David Sarraf","doi":"10.1016/j.ajo.2025.03.018","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.03.018","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The Glaucoma Intensive Treatment Study (GITS): A Randomized Controlled Trial Comparing Intensive and Standard Treatment on 5 Years Visual Field Development” [Am J Ophthalmol 2024;266:274-288]","authors":"Boel Bengtsson ,&nbsp;Anders Heijl ,&nbsp;Johan Aspberg ,&nbsp;Gauti Jóhannesson ,&nbsp;Sabina Andersson-Geimer ,&nbsp;Christina Lindén","doi":"10.1016/j.ajo.2025.02.023","DOIUrl":"10.1016/j.ajo.2025.02.023","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"273 ","pages":"Page 264"},"PeriodicalIF":4.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}