利用多模态成像技术评估feevr患者黄斑发展的细胞水平:一项前瞻性队列研究。

IF 4.2 1区 医学 Q1 OPHTHALMOLOGY
Yarou Hu,Xinyu Zhao,Yaling Liu,Zhen Yu,Kaixuan Cui,Zhenquan Wu,Ziying Zhou,Ruiheng Zhang,Li Dong,Wenbin Wei,Shaochong Zhang,Wei Chi,Jie Zhang,Peiquan Zhao,Guoming Zhang
{"title":"利用多模态成像技术评估feevr患者黄斑发展的细胞水平:一项前瞻性队列研究。","authors":"Yarou Hu,Xinyu Zhao,Yaling Liu,Zhen Yu,Kaixuan Cui,Zhenquan Wu,Ziying Zhou,Ruiheng Zhang,Li Dong,Wenbin Wei,Shaochong Zhang,Wei Chi,Jie Zhang,Peiquan Zhao,Guoming Zhang","doi":"10.1016/j.ajo.2025.09.036","DOIUrl":null,"url":null,"abstract":"PURPOSE\r\nTo investigate the multimodal characteristics of macula in patients with familial exudative vitreoretinopathy (FEVR) at a cellular level.\r\n\r\nDESIGN\r\nProspective cohort study.\r\n\r\nPARTICIPANTS\r\nA total of 46 FEVR-affected and healthy eyes were enrolled from July to October 2024 and underwent multimodal examinations. Participants with conditions such as foveal hypoplasia (FH), a history of ocular surgery or trauma in both the control and FEVR groups were excluded.\r\n\r\nMETHODS AND MAIN OUTCOME MEASURES\r\nAll participants were underwent examinations of scanning laser ophthalmoscopy (SLO), ultra-wide-field swept source optical coherence tomography angiography (UWF SS-OCTA), and adaptive optics (AO)-SLO to acquire metrics of multimodal macular characteristics such as macular appearance, layered structure, vasculature and photoreceptor distribution. The baseline information such as best-corrected visual acuity (BCVA), spherical equivalent (SE), and axial length (AL) were also measured.\r\n\r\nRESULTS\r\nComparing to age (9.76 years on average), gender (52% femal), SE (-1.01D on average) and AL (23.66mm on average)-matched healthy eyes, FEVR-affected eyes without FH had increased foveal avascular zone (FAZ) perimeter in deep capillary plexus (DCP), partly thickening inner retina layers and thinning outer nuclear layer, as well as partly lower vessel density of DCP (P<0.05). In cellular-level, eyes with FEVR showed numerically lower cone density and larger cone spacing in fovea, but significantly higher cone density (P=0.03) and smaller cone spacing (P=0.02) in parafovea, as well as higher cone dispersion and lower regularity (P<0.05). Foveal and parafoveal cone density in participants with low BCVA were numerically higher.\r\n\r\nCONCLUSIONS\r\nPatients with FEVR without FH may be characterized by irregular FAZ morphology and cone distribution, exhibiting lower foveal and higher parafoveal cone densities, which was not correlated with their BCVA and may serve as clinical biomarkers for diagnostic assistance in FEVR. Participants with low BCVA but morphologically normal macular structure may harbor underlying cone abnormalities, underscoring the necessity for more thorough assessment, warranting greater caution in diagnosing amblyopia until excluding the influence of cellular-level abnormalities.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"28 1","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cellular-Level Assessment of Macular Development in Patients with FEVR Using Multimodal Imaging: A Prospective Cohort Study.\",\"authors\":\"Yarou Hu,Xinyu Zhao,Yaling Liu,Zhen Yu,Kaixuan Cui,Zhenquan Wu,Ziying Zhou,Ruiheng Zhang,Li Dong,Wenbin Wei,Shaochong Zhang,Wei Chi,Jie Zhang,Peiquan Zhao,Guoming Zhang\",\"doi\":\"10.1016/j.ajo.2025.09.036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"PURPOSE\\r\\nTo investigate the multimodal characteristics of macula in patients with familial exudative vitreoretinopathy (FEVR) at a cellular level.\\r\\n\\r\\nDESIGN\\r\\nProspective cohort study.\\r\\n\\r\\nPARTICIPANTS\\r\\nA total of 46 FEVR-affected and healthy eyes were enrolled from July to October 2024 and underwent multimodal examinations. Participants with conditions such as foveal hypoplasia (FH), a history of ocular surgery or trauma in both the control and FEVR groups were excluded.\\r\\n\\r\\nMETHODS AND MAIN OUTCOME MEASURES\\r\\nAll participants were underwent examinations of scanning laser ophthalmoscopy (SLO), ultra-wide-field swept source optical coherence tomography angiography (UWF SS-OCTA), and adaptive optics (AO)-SLO to acquire metrics of multimodal macular characteristics such as macular appearance, layered structure, vasculature and photoreceptor distribution. The baseline information such as best-corrected visual acuity (BCVA), spherical equivalent (SE), and axial length (AL) were also measured.\\r\\n\\r\\nRESULTS\\r\\nComparing to age (9.76 years on average), gender (52% femal), SE (-1.01D on average) and AL (23.66mm on average)-matched healthy eyes, FEVR-affected eyes without FH had increased foveal avascular zone (FAZ) perimeter in deep capillary plexus (DCP), partly thickening inner retina layers and thinning outer nuclear layer, as well as partly lower vessel density of DCP (P<0.05). In cellular-level, eyes with FEVR showed numerically lower cone density and larger cone spacing in fovea, but significantly higher cone density (P=0.03) and smaller cone spacing (P=0.02) in parafovea, as well as higher cone dispersion and lower regularity (P<0.05). Foveal and parafoveal cone density in participants with low BCVA were numerically higher.\\r\\n\\r\\nCONCLUSIONS\\r\\nPatients with FEVR without FH may be characterized by irregular FAZ morphology and cone distribution, exhibiting lower foveal and higher parafoveal cone densities, which was not correlated with their BCVA and may serve as clinical biomarkers for diagnostic assistance in FEVR. Participants with low BCVA but morphologically normal macular structure may harbor underlying cone abnormalities, underscoring the necessity for more thorough assessment, warranting greater caution in diagnosing amblyopia until excluding the influence of cellular-level abnormalities.\",\"PeriodicalId\":7568,\"journal\":{\"name\":\"American Journal of Ophthalmology\",\"volume\":\"28 1\",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ajo.2025.09.036\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajo.2025.09.036","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的从细胞水平探讨家族性渗出性玻璃体视网膜病变(FEVR)患者黄斑的多模态特征。前瞻性队列研究。2024年7月至10月,共招募了46只受发热热影响的健康眼睛,并进行了多模式检查。在对照组和FEVR组中,有中央凹发育不全(FH)、眼部手术史或外伤史的参与者被排除在外。方法和主要观察指标:所有受试者均接受扫描激光眼底镜(SLO)、超宽视场扫描源光学相干断层血管造影(UWF SS-OCTA)和自适应光学(AO)-SLO检查,以获得黄斑外观、分层结构、血管和光感受器分布等多模态黄斑特征指标。同时测量最佳矫正视力(BCVA)、球面等效视力(SE)、眼轴长度(AL)等基线信息。结果与年龄(平均9.76岁)、性别(女性占52%)、SE(平均-1.01D)和AL(平均23.66mm)匹配的健康眼相比,无FH的fevr感染眼在深毛细血管丛(DCP)中央凹无血管带(FAZ)周长增加,视网膜内层部分增厚,外核层部分变薄,DCP血管密度部分降低(P<0.05)。在细胞水平上,FEVR组眼底中央凹锥体密度较低,锥体间距较大,而副中央凹锥体密度较高(P=0.03),锥体间距较小(P=0.02),锥体弥散度较高,规整性较差(P<0.05)。低BCVA的参与者的中央凹和旁中央凹锥密度在数值上更高。结论无FH的FEVR患者FAZ形态和锥体分布不规则,中央凹较低,旁中央凹较高,与BCVA无关,可作为FEVR诊断辅助的临床生物标志物。低BCVA但黄斑结构形态正常的参与者可能存在潜在的视锥异常,强调需要进行更彻底的评估,在诊断弱视时需要更加谨慎,直到排除细胞水平异常的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cellular-Level Assessment of Macular Development in Patients with FEVR Using Multimodal Imaging: A Prospective Cohort Study.
PURPOSE To investigate the multimodal characteristics of macula in patients with familial exudative vitreoretinopathy (FEVR) at a cellular level. DESIGN Prospective cohort study. PARTICIPANTS A total of 46 FEVR-affected and healthy eyes were enrolled from July to October 2024 and underwent multimodal examinations. Participants with conditions such as foveal hypoplasia (FH), a history of ocular surgery or trauma in both the control and FEVR groups were excluded. METHODS AND MAIN OUTCOME MEASURES All participants were underwent examinations of scanning laser ophthalmoscopy (SLO), ultra-wide-field swept source optical coherence tomography angiography (UWF SS-OCTA), and adaptive optics (AO)-SLO to acquire metrics of multimodal macular characteristics such as macular appearance, layered structure, vasculature and photoreceptor distribution. The baseline information such as best-corrected visual acuity (BCVA), spherical equivalent (SE), and axial length (AL) were also measured. RESULTS Comparing to age (9.76 years on average), gender (52% femal), SE (-1.01D on average) and AL (23.66mm on average)-matched healthy eyes, FEVR-affected eyes without FH had increased foveal avascular zone (FAZ) perimeter in deep capillary plexus (DCP), partly thickening inner retina layers and thinning outer nuclear layer, as well as partly lower vessel density of DCP (P<0.05). In cellular-level, eyes with FEVR showed numerically lower cone density and larger cone spacing in fovea, but significantly higher cone density (P=0.03) and smaller cone spacing (P=0.02) in parafovea, as well as higher cone dispersion and lower regularity (P<0.05). Foveal and parafoveal cone density in participants with low BCVA were numerically higher. CONCLUSIONS Patients with FEVR without FH may be characterized by irregular FAZ morphology and cone distribution, exhibiting lower foveal and higher parafoveal cone densities, which was not correlated with their BCVA and may serve as clinical biomarkers for diagnostic assistance in FEVR. Participants with low BCVA but morphologically normal macular structure may harbor underlying cone abnormalities, underscoring the necessity for more thorough assessment, warranting greater caution in diagnosing amblyopia until excluding the influence of cellular-level abnormalities.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
9.20
自引率
7.10%
发文量
406
审稿时长
36 days
期刊介绍: The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信