American Journal of Ophthalmology最新文献

{"title":"What Should Patients with Age-Related Macular Degeneration Eat?","authors":"Tiarnán D.L. Keenan, Mélanie Hébert, Emily Y. Chew, Mark W. Johnson","doi":"10.1016/j.ajo.2026.04.003","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.003","url":null,"abstract":"To summarize relevant data on what individuals with age-related macular degeneration (AMD) should eat and to propose simple, evidence-based, dietary and micronutrient supplement guidelines that can be shared with patients and physicians.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"52 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147681470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease","authors":"Zhang Hao, Weimin He","doi":"10.1016/j.ajo.2026.04.004","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.004","url":null,"abstract":"To characterize clinicopathologic and imaging differences between ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) and IgG4-related ophthalmic disease (IgG4-ROD) and to evaluate clinical and artificial intelligence–assisted approaches for differentiating these entities.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"19 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147681102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between PDE-5 Inhibitor Therapy and the Hazard of Open-Angle Glaucoma.","authors":"Abdelrahman M Elhusseiny,Ibrahim Abboud,Amr Almobayed,Felipe A Medeiros","doi":"10.1016/j.ajo.2026.04.009","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.009","url":null,"abstract":"PURPOSETo evaluate the association between phosphodiesterase type-5 inhibitor (PDE-5i) therapy and the development of glaucoma suspect (GS) status or open-angle glaucoma (OAG) in men with erectile dysfunction (ED).DESIGNMulticenter, retrospective cohort study using deidentified electronic health records.SUBJECTSMale adults aged ≥40 years with ED, with or without chronic PDE-5i exposure.METHODSWe used propensity score matching (PSM) to balance demographics, systemic and ophthalmic comorbidities, medications, laboratory measures. Additionally, we applied Cox proportional models on the unmatched cohorts to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs).MAIN OUTCOME MEASURESDevelopment of GS or OAG at 1, 2, and 3-years following PDE-5i exposure.RESULTSBefore matching, 40,676 men received PDE-5i therapy and 32,415 had no exposure. After PSM, the development of GS status was less frequent among PDE-5i users at 1 year (6.49% vs 9.73%, p<0.01), 2 years (9.27% vs 10.86%, p<0.01), and 3 years (11.17% vs 12.06%, p=0.01). Similarly, the development of OAG was less frequent among PDE-5i users at 1 year (2.13% vs 3.22%, p<0.01), 2 years (3.00% vs 3.80%, p<0.01), and 3 years (3.88% vs 4.28%, p=0.04). Cox proportional models demonstrated reduced hazards for GS at 1 year (aHR 0.78; 95% CI, 0.75-0.81; p<0.01), 2 years (0.89; 0.86-0.93; p<0.01), and 3 years (0.94; 0.90-0.97; p=0.01), and for OAG at 1 year (0.76; 0.71-0.81; p<0.01), 2 years (0.79; 0.75-0.83; p<0.01), and 3 years (0.84; 0.79-0.88; p=0.01).CONCLUSIONChronic PDE-5i use was associated with a lower hazard of developing GS and OAG over 1-, 2-, and 3-years of follow-up. These findings suggest a potential protective association between PDE-5i and glaucoma development that requires confirmation in prospective studies.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"17 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altitude-Specific IOP Risks After Vitrectomy with Gas Tamponade: Modeling and Travel Guidance based on calculated elevation profiles.","authors":"Ruiwen Teng,Jia Luo,Peiquan Zhao,Ping Fei","doi":"10.1016/j.ajo.2026.04.005","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.005","url":null,"abstract":"PURPOSETo develop a globally applicable, theoretical mathematical construct for predicting altitude-related intraocular pressure (IOP) elevation following pars plana vitrectomy (PPV) with intraocular gas tamponade, enabling personalized travel risk assessment through route-specific elevation profiling and bedside computational tools.DESIGNSingle-center retrospective observational case series integrated with computational modeling and clinical illustrative scenarios.SUBJECTSTwelve patients (12 eyes) who underwent standard PPV with 14% C₃F₈ tamponade at Xinhua Hospital (altitude 0 m), failed to follow postoperative travel restrictions, and subsequently developed symptomatic IOP elevation during high-altitude travel (≥1,000 m).METHODSA mathematical model was developed integrating Boyle-Mariotte's law with first-order gas absorption kinetics, incorporating surgical center altitude correction. Clinical application employs a binary safety threshold (ΔIOP ≤6 mmHg: proceed; >6 mmHg: defer). The framework was applied to four gases (14% C₃F₈, 16% C₂F₆, 20% SF₆ and 100% air). A Google Earth Pro-based elevation profiling protocol and web-based calculator were developed for bedside risk estimation.MAIN OUTCOME MEASURESPredicted ΔIOP, binary safety determination, and minimum safe air travel intervals by gas type.RESULTSTheoretical safety intervals varied by half-life: air travel (2,400 m cabin) safe after day 35 for C₃F₈, day 22 for both SF₆ and C₂F₆, and day 13 for air. The 12 cases illustrated clinical utility.CONCLUSIONSThis theoretical construct provides a reproducible, globally applicable binary decision-support tool for post-vitrectomy travel risk assessment. Route-specific elevation profiling and web-based calculation enable personalized bedside risk estimation. Altitude-Specific IOP Risks After Vitrectomy with Gas Tamponade: Modeling and Travel Guidance based on calculated elevation profiles.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"9 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foldable capsular buckle as a viable intervention for retinal detachment in late pregnancy.","authors":"Ruxu Sun,Jiangdong Ji,Zizhong Hu","doi":"10.1016/j.ajo.2026.03.039","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.03.039","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"223 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Retinal Non-Perfusion with Ultra-Widefield OCT-A: Correlations with Diabetic Retinopathy Severity and Peripheral Lesions.","authors":"Selin S Gumustop,Xinyi Ding,Yi Stephanie Zhang,Ioanna Ploumi,Ying Zhu,Leiyu Wang,Francesco Romano,Itika Garg,Chong Chen,Kayla N Nodecker,Shivesh H Shah,Sarah L Wagner,Leo A Kim,David M Wu,Nimesh A Patel,Demetrios G Vavvas,Deeba Husain,Joan W Miller,John B Miller","doi":"10.1016/j.ajo.2026.04.006","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.006","url":null,"abstract":"PURPOSETo compare non perfusion area (NPA) and the ischemic index (ISI) between two fields of view using ultra-widefield optical coherence tomography angiography (UWF-OCTA) and evaluate their correlation with diabetic retinopathy (DR) severity and predominantly peripheral lesions (PPL).DESIGNCross-sectional, retrospective study.PARTICIPANTSSixty-two patients (101 eyes) with DR without prior pan-photocoagulation (PRP) treatment, imaged with 12 × 12-mm and 21 × 26-mm scans on UWF-OCTA. Forty-nine patients (79 eyes) with same-day ultra-widefield color fundus photography (UWF-CFP) were included in the PPL analysis.METHODSNPA was calculated from UWF-OCTA scans using a semi-automatic algorithm on FIJI. ISI was determined as NPA divided by total scan area. A subset of eyes with same-day UWF CFP were assessed by two graders for the presence and extent of fields with PPLs - defined as > 50% of diabetic lesions in extended versus Early Treatment of Diabetic Retinopathy Study (ETDRS) fields. Eyes were classified as having PPLs if ≥ 1 field met this criterion.MAIN OUTCOME MEASURESNPA and ISI from 12 × 12-mm and 21 × 26-mm scans and their association with DR severity.RESULTSNPA and ISI were significantly greater in PDR versus NPDR for both scans and the NPA/ISI was significantly higher in the 21 × 26-mm scan (p < 0.001 for all). Both the 12 × 12-mm (OR: 1.26 [95% CI: 1.07-1.48, P = 0.006]) and the 21 × 26-mm ISI (OR: 1.20 [95% CI: 1.10-1.29, P < 0.001]) were significantly associated with increasing DR severity. ROC analysis showed similar performance between both scan ISI at predicting DR severity (AUC: 0.868 vs 0.878, p =0.558). In the sub-analysis, presence of PPL was only significantly associated with ISI on the 21 × 26-mm scan (B = 0.43901, p=0.009). However, the interaction of both presence (B= 0.16, p=0.006) and extent (B= 0.2,5 p=0.044) of PPLs with increasing DR severity was positively associated with increasing ISI on the 21 × 26-mm scan.CONCLUSIONSNPA/ISI on both the 12 × 12-mm and 21 × 26-mm scans is predictive of DR severity, highlighting the importance of OCTA detection of ischemia. The wider scan area of the 21 × 26-mm scan can better assess far peripheral ischemia that correlates with PPLs, supporting its potential role in tracking DR progression.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"23 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment on: Impact of Phacoemulsification on Vitreomacular Traction Release and Complications.","authors":"Suraj Bala, Nitesh Mohan, Victor Bellanda, Andrea Arline, Gabriel Castilho S Barbosa, Matthew J Schulgit, Sumit Sharma, Sunil K Srivastava, Danny A Mammo, Ananth Sastry","doi":"10.1016/j.ajo.2026.03.046","DOIUrl":"10.1016/j.ajo.2026.03.046","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Big Data or Big Bias? Interpreting Large-Scale Ophthalmic Studies","authors":"Swarup S. Swaminathan, Felipe A. Medeiros","doi":"10.1016/j.ajo.2026.03.029","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.03.029","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"29 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotational Stability and Refractive Outcomes of a Toric Hydrophilic Acrylic Intraocular Lens","authors":"Marcus Lisy, Nikolaus Mahnert, Markus Schranz, Victor Danzinger, Claudette Abela-Formanek, Christina Leydolt, Rupert Menapace, Daniel Schartmüller","doi":"10.1016/j.ajo.2026.03.043","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.03.043","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"195 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Gene Therapy Revolutionize Treatment of Neovascular Age-Related Macular Degeneration","authors":"Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan","doi":"10.1016/j.ajo.2026.04.001","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.04.001","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"20 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}