Visual Impairment and Risk of All-Cause and Cause-Specific Mortality: Results from Two Prospective Cohort Studies.

IF 4.2 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology Pub Date : 2025-10-04 DOI:10.1016/j.ajo.2025.09.053

Xing-Xuan Dong,Jia-Yan Kai,Dan-Lin Li,Carla Lanca,Andrzej Grzybowski,Chaofu Ke,Chen-Wei Pan

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Abstract

PURPOSE To elucidate the association of visual impairment (VI) on both all-cause and cause-specific mortality. DESIGN Population based cohort study METHODS: 12,510 US adults aged 40 years or older from the US National Health and Nutrition Examination Survey (1999-2008) and 95,477 UK adults aged 40 years or older from the UK Biobank (2006-2010). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Competing risk models were used to investigate the influence of VI on cause-specific mortality. RESULTS After adjusting for socio-demographic information, lifestyle factors and health status, the HR for all-cause mortality was significantly elevated among individuals with VI (US NHANES: HR = 1.63, 95% CI: 1.39-1.91; UK Biobank: HR = 1.25, 95% CI: 1.08-1.44). A significant association between VI and heart disease-specific mortality was observed in the US NHANES (HR = 1.76, 95% CI: 1.33-2.32), which was confirmed in the competing risk analysis (HR = 1.34, 95% CI: 1.12-1.61). CONCLUSIONS VI is associated with elevated hazards of all-cause and heart disease-specific mortality. Early detection and management of VI, integrated with comprehensive cardiovascular risk prevention, may have significant public health implications.

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视力损害与全因和特定原因死亡的风险：两项前瞻性队列研究的结果。

目的探讨视力障碍（VI）与全因死亡率和病因特异性死亡率的关系。设计：基于人群的队列研究方法：12510名来自美国国家健康与营养调查（1999-2008）的40岁及以上的美国成年人和95477名来自英国生物银行（2006-2010）的40岁及以上的英国成年人。Cox比例风险模型用于估计风险比（hr）和95%置信区间（ci）。竞争风险模型用于研究VI对病因特异性死亡率的影响。结果在调整了社会人口统计学信息、生活方式因素和健康状况后，VI患者的全因死亡率HR显著升高（US NHANES: HR = 1.63,95% CI: 1.39 ~ 1.91; UK Biobank: HR = 1.25,95% CI: 1.08 ~ 1.44）。在美国NHANES中观察到VI与心脏病特异性死亡率之间存在显著关联（HR = 1.76,95% CI: 1.33-2.32），这在竞争风险分析中得到证实（HR = 1.34,95% CI: 1.12-1.61）。结论svi与全因死亡率和心脏病特异性死亡率风险升高相关。VI的早期发现和管理，结合全面的心血管风险预防，可能具有重大的公共卫生意义。

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来源期刊

American Journal of Ophthalmology 医学-眼科学

CiteScore

9.20

自引率

7.10%

发文量

406

审稿时长

36 days

期刊介绍： The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.