Stress biology最新文献

{"title":"Identification of specific transcripts for plant heat stress tolerance through genome-wide analysis of SIZ1-dependent alternative polyadenylation.","authors":"Jun Wang, Xiujuan Wu, Zhou Zhou, Sitong Zheng, Minghui Hu, Yincui Xiao, Leqian Shi, Cheng Zhang, Jiamei Li, Chengwei Yang, Jianbin Lai, Danlu Han, Zhibo Yu","doi":"10.1007/s44154-026-00340-2","DOIUrl":"https://doi.org/10.1007/s44154-026-00340-2","url":null,"abstract":"<p><p>Heat stress (HS) has emerged as a significant environmental factor affecting plant growth and agricultural productivity. Alternative polyadenylation (APA) is a crucial co-transcriptional process that regulates developmental processes and stress responses in plants. However, the distinct roles of its resultant transcripts in plant HS response remain to be investigated. In this study, we employed poly(A) tag sequencing (PAT-seq) to identify over 1500 transcripts whose expression exhibited significant alterations in response to HS, mediated by SIZ1, a SUMO E3 ligase in Arabidopsis. Further analysis revealed that more than 300 switch genes with varying poly(A) site usages were differentially expressed under HS conditions. Compared to non-canonical poly(A) sites, more genes utilize 3'UTR sites to regulate transcript expression by altering the usage of poly(A) signals. Based on the information of APA genes regulated by SIZ1, we selected two genes, Galactinol synthase enzyme (GolS2) and Tetratricopeptide repeat (TPR) like 3 (TTL3), for characterizing their novel functions. Overexpression of the distal transcript of GolS2 or the proximal transcript of TTL3 enhanced heat tolerance in Arabidopsis. Collectively, our current study elucidates the regulation of APA mediated by SIZ1 during HS response and establishes a strategy for identifying specific transcripts arising from APA for plant heat tolerance.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary supplementation of Acer truncatum leaf extract alleviates oxidative-stress induced impairment of ovarian function in laying hens via Nrf2-mediated antioxidant defense and VEGF-mediated angiogenesis.","authors":"Kailong Qin, Junjie Ma, Minglu Gao, Yanli Liu, Xiaojun Yang","doi":"10.1007/s44154-026-00329-x","DOIUrl":"10.1007/s44154-026-00329-x","url":null,"abstract":"<p><p>This study aimed to evaluate the potential of Acer truncatum leaf extract (ATLE) to mitigate oxidative-stress-induced impairment of reproductive function in laying hens, with a focus on mechanisms involving antioxidant defense, angiogenesis, and ovarian microenvironment homeostasis. Oxidative stress was induced by tert-butyl hydroperoxide (tBHP) injection. Hens were randomly assigned to a control group (CON), an oxidative stress group (BCON), and an oxidative stress group supplemented with 0.6% ATLE (BATLE). Egg-laying performance, ovarian morphology, reproductive hormones, oxidative stress markers, and angiogenesis indicators were evaluated and integrated with transcriptomic analysis. The results were as follows: 1) Production and Morphology: ATLE supplementation alleviated (P < 0.05) the tBHP-induced decrease in egg laying rate and elevation in feed conversion ratio (FCR). It also mitigated (P < 0.05) reductions in the number of hierarchical follicles and the ovarian stroma index while restoring (P < 0.05) serum concentrations of LH and GH, thereby re-establishing reproductive endocrine balance. 2) Antioxidant Defense: ATLE activated (P < 0.05) Nrf2 and increased (P < 0.05) transcription of downstream antioxidant genes, including SOD3, GPX3, PRDX4, GSR and CAT, thereby enhancing (P < 0.05) the SOD and CAT activities and reducing (P < 0.05) MDA concentrations within both serum and ovarian tissues. 3) Vascular Network Support: ATLE attenuated (P < 0.05) the tBHP-induced downregulation of angiogenic factors, including protein levels of VEGF, ANGPT1, and HIF-1α and mRNA expression levels of VEGFA, ANGPT1, ANGPT2, ITGA5, and MMP9. 4) Microenvironment Remodeling: Transcriptomic integration revealed that ATLE-mediated repair overlapped (> 88%) with oxidative-stress-induced damage across functional modules. By reversing dysregulation of key genes such as VEGFA, KDR, and FN1, ATLE restored core pathways including focal adhesion and ECM-receptor interaction, and coordinated processes such as extracellular matrix, angiogenesis, and response to wounding, driving a systemic remodeling of the ovarian reproductive microenvironment toward homeostasis. In summary, this study demonstrated that ATLE activated multiple signaling axes, notably Nrf2 and VEGF. As a result, ATLE enhanced antioxidant defenses against oxidative damage and promoted vascular health and microenvironmental remodeling in the ovary. Together, these effects preserved the structural integrity and function of the laying hen reproductive system. These findings supported the potential of ATLE as a natural feed additive and provided a scientific rationale for using nutritional strategies to alleviate oxidative stress and improve reproductive health in laying hens.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13462015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress in pigs and opportunities with selenium-containing amino acids.","authors":"Sung Woo Kim, Nathalia de Oliveira Telesca Camargo, Olivier Merdy, Tadele Kiros, Yan Zhao","doi":"10.1007/s44154-026-00328-y","DOIUrl":"10.1007/s44154-026-00328-y","url":null,"abstract":"<p><p>Modern pig farming practices, characterized by highly-productive and fast-growing genetics, early weaning, and uncontrolled factors such as heat stress and various nutritional challenges, impose cumulative stress on the animal. Elevated concentrations of reactive oxygen species within cells can compromise cellular function and decrease reproductive performance of breeding stock and the growth of progeny up to market age, and deteriorate pork quality, ultimately causing economic losses. Antioxidants and micronutrients can be supplemented in animal feed to alleviated the adverse impact of oxidative stress on pig health and production performance. Selenium is an essential micronutrient required for an efficient antioxidant defense system. Se-enriched yeast serves as a natural source of organice selenium. Its effectiveness in improving selenium (Se) assimilation and oxidative status in modern pigs, especially under intensee stress conditions, has been well documented. This review aims to address oxidative stress challenges encountered by pigs during commercial production and elaborate on the capacity of organic Se to mitigate oxidative stress in pigs. Se-enriched yeast provides biologically and nutritionally important amounts of SeMet and SeCys. The review summarizes evidence that, compared wtih inorganic Se, dietary Se-enriched yeast effectively alleviates oxidative stress in pigs while enhancing production performance and pork quality.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13454094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing microRNA regulatory networks for engineering climate resilience and nutritional enhancement in millets.","authors":"Kasanaboina Krishna, Ephrem Habyarimana, Harsha Rayudu Jamedar, Ishwarya Lakshmi Vg, Sonal Chavan, B V Vara Prasad, Y Chandra Mohan, Bandela Edukondalu, Stanislaus Antony Ceasar","doi":"10.1007/s44154-026-00332-2","DOIUrl":"10.1007/s44154-026-00332-2","url":null,"abstract":"<p><p>Millets are increasingly promoted as climate-resilient nutri-cereals that can stabilize production and support nutritious diets under drought, heat, salinity, and low-input farming. MicroRNAs (miRNAs) provide a powerful post-transcriptional regulatory layer that regulates stress signaling, crop development, nutrient homeostasis, and grain filling by targeting key transcription factors and transporter networks. Millet miRNA research remains at an early developmental stage. To date, most studies have focused predominantly on miRNA identification and expression profiling, while rigorous functional characterization and mechanistic dissection of regulatory networks are still limited. Moreover, integration of miRNA dynamics with genotype (G) × environment (E) interactions, particularly under field-relevant stress conditions, remains insufficiently explored. In this review, we synthesize stress- and nutrition-associated miRNAs reported across major cereals, highlighting conserved regulatory modules, and summarize emerging millet-specific candidates linked to drought, salinity, grain quality, and micronutrient accumulation. We critically evaluate methodological gaps, such as incomplete degradome support, inconsistent phenotyping, and limited grain ionomics, that constrain translational application to breeding. Finally, we propose a practical roadmap that combines tissue- and stage-resolved miRNA atlases, target validation using degradome sequencing, RNA Ligase-Mediated Rapid Amplification of cDNA Ends (RLM-RACE), and reporter assays, together with functional intervention platforms such as Short Tandem Target Mimic (STTM), artificial miRNAs (amiRNAs), and CRISPR-mediated editing of miRNA loci or target sites, all integrated with marker-enabled selection and genomic prediction. Advancing from descriptive miRNA catalogues toward experimentally validated regulatory networks will enable miRNA-based breeding and genome editing for climate-smart, micronutrient-dense millet cultivars.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13454096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium tolerance mediated by GhBCAT12 through branched-chain amino acid degradation via vacuolar sequestration in cotton.","authors":"Lei Xiao, Xiugui Chen, Yunxin He, Depei Kong, Junjuan Wang, Jihua Yang, Yupeng Cui, Hui Huang, Kang Zhao, Jing Wang, Hao Lan, Ruize Song, Fange Wu, Xinrui Zhang, Xin Yu, Junshan Zhu, Jinkai Liu, Songyue Zhou, Xiaoyu Tian, Mengru Wei, Shuai Wang, Lixue Guo, Ping Li, Xiaowei Wang, Xue-Rong Zhou, Wuwei Ye","doi":"10.1007/s44154-026-00335-z","DOIUrl":"10.1007/s44154-026-00335-z","url":null,"abstract":"<p><p>Soil Cd²⁺ pollution threatens agricultural safety. Branched-chain amino acid (BCAA) metabolism is involved in stress responses, but its role in cotton Cd²⁺ tolerance remains unclear. Here, 16 GhBCAT genes were identified in Gossypium hirsutum, among which GhBCAT12 was significantly induced by Cd²⁺ stress. Silencing GhBCAT12 increased Cd²⁺ sensitivity, causing growth inhibition, oxidative damage, and cell death. Metabolomic analysis revealed the accumulation of leucine, isoleucine, and valine, with decreased acetyl-CoA, indicating that GhBCAT12 mediates BCAA degradation. This study reveals a novel pathway in which GhBCAT12-mediated BCAA degradation provides acetyl-CoA precursors for the tricarboxylic acid (TCA) cycle, sustaining ATP production, which in turn powers vacuolar Cd²⁺ sequestration. These findings provide a new target for improving heavy metal tolerance in crops.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rumen epithelial functional adaptation in alpine ewes: transcriptomic effects of micronutrient premix and concentrate supplementation levels.","authors":"Jie Cheng, Yan Cheng, Baohui Zhang, Kefyalew Gebeyew, Aifei Yan, Fan Hu, Jinxia Li, Jie Liu, Weihua Zhao, Jinghe Kang, Zhiliang Tan, Zhixiong He","doi":"10.1007/s44154-026-00324-2","DOIUrl":"10.1007/s44154-026-00324-2","url":null,"abstract":"<p><p>Ovine species inhabiting harsh environments frequently develop enhanced functional adaptations. This study aims to (1) characterize rumen epithelial modifications in lactating Hulunbeier ewes under alpine conditions, and (2) elucidate how these adaptive responses are modulated by micronutrient supplementation and varying concentrate feed levels. Thirty lactating Hulunbeier ewes were randomly assigned to one of the three dietary groups and fed the same roughages with one of the following concentrates: 1) 550 g/d of local concentrate (LF) as the control, 2) 550 g/d of formulated concentrate (FF), and 3) 700 g/d of formulated concentrate (FS). Daily feed intake were recorded, and rumen epithelial tissues were collected for transcriptome analysis after slaughter on day 37 of the experiment. Transcriptomic analyses were performed on a subset of 11 ewes (LF, n = 4; FF, n = 4; FS, n = 3). No independent qPCR validation was conducted; results are therefore preliminary. In the exploratory cross-breed comparison, Hulunbeier sheep showed a suggestive trend toward enhanced expression of energy metabolism genes (ATP5MC2, ATP5PO, UQCRH) and genes encoding mitochondrial respiratory chain components relative to lowland Hu sheep. Supplementation with micronutrient premix upregulated key detoxification genes (CYP1A1, LOC101119706) and modulated immune-related pathways. In contrast, high concentrate levels promoted biosynthetic processes while suppressing cellular signaling functions. Gene Set Enrichment Analysis further indicated activation of thermogenesis pathways in the high-concentrate group, accompanied by altered expression of electron transport chain genes. PPARA may be involved in volatile fatty acid metabolism in response to micronutrient supplementation, but this requires direct experimental testing. Collectively, with the caveat of small sample size and lack of qPCR validation, these pilot-scale transcriptomic findings generate hypotheses that may underlie nutritional modulation of rumen function in alpine-adapted sheep; however, further validation with larger sample sizes and correlated phenotypic measurements is warranted. These results provide preliminary insights for developing targeted nutritional strategies to enhance ruminant production in breeds adapted to extreme environments.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When growth becomes risky: stress-driven sporulation and sexual development in fungi.","authors":"Jie Yang, Qinhu Wang, Huiquan Liu","doi":"10.1007/s44154-026-00333-1","DOIUrl":"10.1007/s44154-026-00333-1","url":null,"abstract":"<p><p>Fungi frequently encounter nutrient limitation, osmotic stress, oxidative pressure, light fluctuations, temperature shifts, and host-associated stresses. Rather than responding passively to deteriorating environments, many fungi actively redirect development from vegetative growth toward asexual sporulation, sexual reproduction, or resting structure formation. These transitions promote dispersal, dormancy, stress resistance, or genetic diversification, but they are not governed by a single conserved stress-response pathway. Instead, conserved nutrient- and stress-sensing modules are integrated with lineage-specific developmental circuits. This review synthesizes recent advances in understanding how environmental stress, particularly nutrient limitation, regulates fungal reproductive development. We discuss nutrient limitation as both a physiological constraint and a developmental signal, and compare regulatory mechanisms across yeasts, filamentous ascomycetes, and pathogenic fungi. Major pathways and regulatory layers include cAMP-PKA, TOR, HOG MAPK signaling, light-responsive systems, the Velvet complex, chromatin regulation, diffusible chemical signals, and sexual-stage-specific adenosine-to-inosine (A-to-I) mRNA editing. Together, these mechanisms determine whether fungi remain vegetative or commit to reproduction. We also evaluate why sexual reproduction may be favored under stressful or low-fitness conditions. While asexual spores and resting structures can enhance survival and dispersal, costly meiotic reproduction may be promoted when recombination allows offspring or alleles to escape maladapted genetic backgrounds. Fitness-associated sex and abandon-ship models therefore provide useful evolutionary frameworks for interpreting stress-induced reproduction. Understanding these mechanisms is timely and important because fungal reproductive switching affects industrial spore production, pathogen transmission, disease management, and evolutionary potential. Future progress will require causal, ecologically grounded models linking environmental perception, molecular regulation, reproductive output, and fitness consequences.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13433876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological and molecular processes of plant tolerance to bicarbonate-induced alkaline stress.","authors":"Jiahe Fu, Liangliang Li, Minghui Xing, Wei Xie, Chenbo Zhu, Kaixin Yang, Xiaofan Nie, Xiaojian Yin, Mohammad Golam Mostofa, David Burritt, Lam-Son Phan Tran, Yuanyuan Bu, Weiqiang Li","doi":"10.1007/s44154-026-00325-1","DOIUrl":"10.1007/s44154-026-00325-1","url":null,"abstract":"<p><p>Bicarbonate-dominated alkaline soils represent a major class of salt-affected soils that can severely limit plant growth due to the combined effect of ionic toxicity, osmotic stress, and high pH. These soils exist in many parts of the world and often limit crop productivity due to the so-called alkaline stress in the rhizosphere. Alkaline stress reduces bioavailability of essential nutrients required for plant growth, such as iron, phosphates, and manganese, disrupts proton homeostasis, and perturbs cellular redox balance. Elucidating the mechanisms that enable plants to adapt to and grow in alkaline soils is essential if saline-alkali agriculture, where crops are grown on soils with high salt concentrations and high pH, is to contribute to global food security. Here, we summarize recent advances in the physiological, biochemical, and molecular processes that enable plants to tolerate and grow in alkaline soils. Key physiological mechanisms reviewed include plasma membrane H⁺-ATPase-driven proton extrusion, regulation of ion transporters, secretion of organic acids to acidify the rhizosphere, vacuolar sequestration of sodium and associated anions, and accumulation of compatible solutes for osmotic adjustment. At the molecular level, we also review and evaluate the genes, signaling pathways, and transcription factor networks underlying alkaline stress tolerance, with an emphasis on modules governing ion/redox homeostasis and root development. We also summarize emerging evidence on root-microbe interactions and their contributions to enhanced alkaline tolerance in plants. Finally, we discuss key requirements and future research directions for translating alkaline-tolerance mechanisms into crop improvement for alkaline soils.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13407812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population genomics reveals gene flow and positive selection patterns in the wine-related yeast Hanseniaspora uvarum.","authors":"Ruiqi Ma, Hui Wang, Yue Wei, Yue Sun, Jie Xue, Yi Qin, Shiheng Tao, Yanlin Liu","doi":"10.1007/s44154-026-00319-z","DOIUrl":"10.1007/s44154-026-00319-z","url":null,"abstract":"<p><p>Hanseniaspora uvarum is a representative non-Saccharomyces species that plays a significant role in fermentation processes such as winemaking. In recent years, this species has gained attention in food engineering and evolutionary biology. However, the population genomic signatures in this species remain poorly understood. In this study, a population genomics analysis was conducted on 151 H. uvarum strains (45 from Ningxia, China; 21 from other regions of China; 67 from Australia; and 18 from other regions or of unspecified origin), and a pangenome analysis was performed on 159 strains, incorporating eight additional genome assemblies. Phylogenetic analysis, ancestry coefficient analysis, and principal component analysis generally distinguished Chinese strains from those sampled on other continents. However, substantial post-divergence gene flow and introgression were inferred between intercontinentally paired clades. Positively selected candidate genes exhibited region-specific patterns: GO terms related to the positive regulation of filamentous growth in response to external stimuli were significantly enriched in the Ningxia strains; the stress-related GO term \"cytoplasmic stress granule\" was significantly enriched in both the Ningxia and Australian strains, but with distinct sets of associated genes. Although the samples were primarily isolated from anthropogenic environments, H. uvarum exhibited an open pangenome, indicating substantial adaptive potential to diverse stresses. This study advances our understanding of the evolutionary dynamics of H. uvarum and establishes a genomic foundation for future ecological and industrial research on this yeast.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13407411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An NLR-VOZ seesaw: from asymmetric selection to synthetic broad-spectrum resistance.","authors":"Yachun Su, Shoujian Zang, Tingting Sun, Chuihuai You, Youxiong Que","doi":"10.1007/s44154-026-00334-0","DOIUrl":"10.1007/s44154-026-00334-0","url":null,"abstract":"<p><p>A recent study in Nature identified the rice (Oryza sativa) nucleotide-binding site and leucine-rich repeat (NLR) receptor XA48, which recognized the ancient bacterial effector XopG and triggered immunity by promoting degradation of the negative regulators OsVOZ1/2. Population genomics revealed an asymmetric selection, with Xa48 retained in indica but lost in japonica due to a reproductive penalty. By stacking XA48-mediated effector-triggered immunity (ETI) with XA21-mediated pattern-triggered immunity (PTI) and introducing the compatible OsVOZ1^S allele, broad-spectrum bacterial blight resistance from wild rice was reconstituted. This work provides a design strategy that helps break the growth-defence trade-off.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13388620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}