Stress biology最新文献

{"title":"Insulin-like growth factor 1 in heat stress-induced neuroinflammation: novel perspective about the neuroprotective role of chromium.","authors":"Songlin Wang,&nbsp;Kanghui Hou,&nbsp;Siqi Gui,&nbsp;Yue Ma,&nbsp;Shuai Wang,&nbsp;Shanting Zhao,&nbsp;Xiaoyan Zhu","doi":"10.1007/s44154-023-00105-1","DOIUrl":"https://doi.org/10.1007/s44154-023-00105-1","url":null,"abstract":"<p><p>Heat stress (HS) can cause a series of stress responses, resulting in numerous negative effects on the body, such as the diminished food intake, carcass quality and reproductive capacity. In addition to the negative effects on the peripheral system, HS leads to central nervous system (CNS) disorders given its toll on neuroinflammation. This neuroinflammatory process is mainly mediated by microglia and astrocytes, which are involved in the activation of glial cells and the secretion of cytokines. While the regulation of inflammatory signaling has a close relationship with the expression of heat shock protein 70 (Hsp70), HS-induced neuroinflammation is closely related to the activation of the TLR4/NF-κB pathway. Moreover, oxidative stress and endoplasmic reticulum (ER) stress are key players in the development of neuroinflammation. Chromium (Cr) has been widely shown to have neuroprotective effects in both humans and animals, despite the lack of mechanistic evidence. Evidence has shown that Cr supplementation can increase the levels of insulin-like growth factor 1 (IGF-1), a major neurotrophic factor with anti-inflammatory and antioxidant effects. This review highlights recent advances in the attenuating effects and potential mechanisms of Cr-mediated IGF-1 actions on HS-induced neuroinflammation, providing presently existing evidence supporting the neuroprotective role of Cr.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"3 1","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10539081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome editing enables defense-yield balance in rice.","authors":"Yiwen Deng,&nbsp;Zuhua He","doi":"10.1007/s44154-023-00102-4","DOIUrl":"https://doi.org/10.1007/s44154-023-00102-4","url":null,"abstract":"<p><p>This brief article highlights the key findings of the study conducted by Sha et al. (Nature, doi:10.1038/s41586-023-06205-2, 2023), focusing on the cloning of the RBL1 gene from rice, which is associated with lesion mimic mutant (LMM) traits. The RBL1 gene encodes a cytidine diphosphate diacylglycerol (CDP-DAG) synthase and plays a crucial role in regulating cell death and immunity by controlling phosphatidylinositol biosynthesis. The rbl1 mutant shows autoimmunity with multi-pathogen resistance but with severe yield penalty. Using genome editing techniques, the research team successfully generated an elite allele of RBL1 that not only restores rice yield but also provides broad-spectrum resistance against both bacterial and fungal pathogens. These findings demonstrate the potential of utilizing genome editing to enhance crop productivity and pathogen resistance.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"3 1","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10177222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute hyperthermia and hypoxia tolerance of two improved strains of nile tilapia (Oreochromis niloticus).","authors":"Kwasi Adu Obirikorang,&nbsp;Richard Appiah-Kubi,&nbsp;Daniel Adjei-Boateng,&nbsp;Wonder Sekey,&nbsp;Collins Prah Duodu","doi":"10.1007/s44154-023-00099-w","DOIUrl":"https://doi.org/10.1007/s44154-023-00099-w","url":null,"abstract":"<p><p>Tilapia production in Ghana has been hit with episodes of stress and pathogen-induced mass fish kills which have anecdotally been linked to the culture of illegally imported Genetically Improved Farmed Tilapia (GIFT) strains of Nile tilapia, Oreochromis niloticus. This study was thus set up to comprehensively assess the stress tolerance of the GIFT strain and a native strain of Nile tilapia (the Akosombo strain) following exposures to hyperthermic and hypoxic stressors. In a series of experiments, oxygen consumption (MO₂), aquatic surface respiration (ASR), thermal limits and hypoxia tolerance were assessed. The effects of these stressors on haematological parameters were also assessed. The GIFT strain was less tolerant of hypoxia and performed ASR at higher O₂ levels than the Akosombo strain. Under progressive hypoxia, the GIFT strain exhibited higher gill ventilations frequencies (fV) than the Akosombo strain. The thermal tolerance trial indicated that the Akosombo strain of O. niloticus has higher thermotolerance than the GIFT strain and this was reflective in the higher LT₅₀ (45.1℃) and LT_max (48℃), compared to LT₅₀ and LT_max of 41.5℃ and 46℃ respectively. These results imply that it is crucial to consider how the GIFT strain performs under various environmental conditions and changes during culture. Particularly, raising the GIFT strain of Nile tilapia in earthen ponds rich in phytoplankton and subject to protracted episodes of extreme hypoxia may have a detrimental physiological impact on its growth and welfare.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"3 1","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10538672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unbalanced diets enhance the complexity of gut microbial network but destabilize its stability and resistance.","authors":"Penghao Sun,&nbsp;Mengli Wang,&nbsp;Wei Zheng,&nbsp;Shuzhen Li,&nbsp;Xiaoyan Zhu,&nbsp;Xuejun Chai,&nbsp;Shanting Zhao","doi":"10.1007/s44154-023-00098-x","DOIUrl":"https://doi.org/10.1007/s44154-023-00098-x","url":null,"abstract":"<p><p>Stability is a fundamental ecological property of the gut microbiota and is associated with host health. Numerous studies have shown that unbalanced dietary components disturb the gut microbial composition and thereby contribute to the onset and progression of disease. However, the impact of unbalanced diets on the stability of the gut microbiota is poorly understood. In the present study, four-week-old mice were fed a plant-based diet high in refined carbohydrates or a high-fat diet for four weeks to simulate a persistent unbalanced diet. We found that persistent unbalanced diets significantly reduced the gut bacterial richness and increased the complexity of bacterial co-occurrence networks. Furthermore, the gut bacterial response to unbalanced diets was phylogenetically conserved, which reduced network modularity and enhanced the proportion of positive associations between community taxon, thereby amplifying the co-oscillation of perturbations among community species to destabilize gut microbial communities. The disturbance test revealed that the gut microbiota of mice fed with unbalanced diets was less resistant to antibiotic perturbation and pathogenic bacteria invasion. This study may fill a gap in the mechanistic understanding of the gut microbiota stability in response to diet and provide new insights into the gut microbial ecology.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"3 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10556598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rescuing the Golgi from heat damages by ATG8: restoration rather than clean-up.","authors":"Anni Luo,&nbsp;Jian-Xiang Liu","doi":"10.1007/s44154-023-00100-6","DOIUrl":"https://doi.org/10.1007/s44154-023-00100-6","url":null,"abstract":"<p><p>High temperature stress poses significant adverse effects on crop yield and quality. Yet the molecular mechanisms underlying heat stress tolerance in plants/crops, especially regarding the organellar remodeling and homeostasis, are largely unknown. In a recent study, Zhou et al. reported that autophagy-related 8 (ATG8), a famous regulator involved in autophagy, plays a new role in Golgi restoration upon heat stress. Golgi apparatus is vacuolated following short-term acute heat stress, and ATG8 is translocated to the dilated Golgi membrane and interacts with CLATHRIN LIGHT CHAIN 2 (CLC2) to facilitate Golgi restoration, which is dependent on the ATG conjugation system, but not of the upstream autophagic initiators. These exciting findings broaden the fundamental role of ATG8, and elucidate the organelle-level restoration mechanism of Golgi upon heat stress in plants.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"3 1","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10187817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VmPacC-mediated pH regulation of Valsa mali confers to host acidification identified by comparative proteomics analysis.","authors":"Liangsheng Xu,&nbsp;Hailong Liu,&nbsp;Shan Zhu,&nbsp;Yangguang Meng,&nbsp;Yinghao Wang,&nbsp;Jianyu Li,&nbsp;Feiran Zhang,&nbsp;Lili Huang","doi":"10.1007/s44154-023-00097-y","DOIUrl":"https://doi.org/10.1007/s44154-023-00097-y","url":null,"abstract":"<p><p>Apple valsa canker caused by the Ascomycete fungus Valsa mali is one of the most serious diseases of apple, resulting in huge economic losses in the apple-growing area of China. Previous study found that the pathogen could acidify the infected tissues to make lower ambient pH (from 6.0 to 3.5) for their successfully colonization. The pH signaling transcription factor VmPacC is required for acidification of its environment and for full virulence in V. mali. It is known that the functional cooperation of proteins secreted by V. mali plays pivotal role in its successful colonization of host plants. In this study, we used tandem mass tag (TMT) labeling coupled with LC-MS/MS-based quantitative proteomics to analyze the VmPacC-mediated pH regulation in V. mali, focusing on differentially expressed proteins (DEPs). We identified 222 DEPs specific to VmPacC deletion, and 921 DEPs specific to different pH conditions (pH 6.0 and 3.4). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses indicated that these DEPs were mainly involved in pathways associated with carbon metabolism, biosynthesis of antibiotics, citrate cycle (TCA cycle), glycolysis/gluconeogenesis, glutathione metabolism, ribosomes, and pentose phosphate pathways. Additionally, we identified 119 DEPs that were shared among the VmPacC deletion mutant and different pH conditions, which were mainly related to energy metabolism pathways, providing the energy required for the hyphal growth and responses to environmental stresses. A protein-protein interaction (PPI) network analysis indicated that most of the shared proteins were mapped to an interaction network with a medium confidence score of 0.4. Notably, one uncharacterized protein (KUI69106.1), and two known proteins (heat shock protein 60 (KUI73579.1), aspartate aminotransferase (KUI73864.1)) located in the core of the network were highly connected (with ≥ 38 directed edges) with the other shared DEPs. Our results suggest that VmPacC participates in the pathogen's regulation to ambient pH through the regulation of energy metabolism pathways such as the glycolysis/gluconeogenesis pathway and TCA cycle. Finally, we proposed a sophisticated molecular regulatory network to explain pH decrease in V. mali. Our study, by providing insights into V. mali regulating pH, helps to elucidate the mechanisms of host acidification during pathogen infection.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"3 1","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10556992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the precision redox map during fasting-refeeding and satiation in C. elegans.","authors":"Xinhua Qiao,&nbsp;Lu Kang,&nbsp;Chang Shi,&nbsp;Aojun Ye,&nbsp;Dongli Wu,&nbsp;Yuyunfei Huang,&nbsp;Minghao Deng,&nbsp;Jiarui Wang,&nbsp;Yuzheng Zhao,&nbsp;Chang Chen","doi":"10.1007/s44154-023-00096-z","DOIUrl":"https://doi.org/10.1007/s44154-023-00096-z","url":null,"abstract":"<p><p>Fasting is a popular dietary strategy because it grants numerous advantages, and redox regulation is one mechanism involved. However, the precise redox changes with respect to the redox species, organelles and tissues remain unclear, which hinders the understanding of the metabolic mechanism, and exploring the precision redox map under various dietary statuses is of great significance. Twelve redox-sensitive C. elegans strains stably expressing genetically encoded redox fluorescent probes (Hyperion sensing H₂O₂ and Grx1-roGFP2 sensing GSH/GSSG) in three organelles (cytoplasm, mitochondria and endoplasmic reticulum (ER)) were constructed in two tissues (body wall muscle and neurons) and were confirmed to respond to redox challenge. The H₂O₂ and GSSG/GSH redox changes in two tissues and three organelles were obtained by confocal microscopy during fasting, refeeding, and satiation. We found that under fasting condition, H₂O₂ decreased in most compartments, except for an increase in mitochondria, while GSSG/GSH increased in the cytoplasm of body muscle and the ER of neurons. After refeeding, the redox changes in H₂O₂ and GSSG/GSH caused by fasting were reversed in most organelles of the body wall muscle and neurons. In the satiated state, H₂O₂ increased markedly in the cytoplasm, mitochondria and ER of muscle and the ER of neurons, while GSSG/GSH exhibited no change in most organelles of the two tissues except for an increase in the ER of muscle. Our study systematically and precisely presents the redox characteristics under different dietary states in living animals and provides a basis for further investigating the redox mechanism in metabolism and optimizing dietary guidance.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"3 1","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10242500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid alkalinization factor: function, regulation, and potential applications in agriculture.","authors":"Ran Zhang,&nbsp;Peng-Tao Shi,&nbsp;Min Zhou,&nbsp;Huai-Zeng Liu,&nbsp;Xiao-Jing Xu,&nbsp;Wen-Ting Liu,&nbsp;Kun-Ming Chen","doi":"10.1007/s44154-023-00093-2","DOIUrl":"https://doi.org/10.1007/s44154-023-00093-2","url":null,"abstract":"<p><p>Rapid alkalinization factor (RALF) is widespread throughout the plant kingdom and controls many aspects of plant life. Current studies on the regulatory mechanism underlying RALF function mainly focus on Arabidopsis, but little is known about the role of RALF in crop plants. Here, we systematically and comprehensively analyzed the relation between RALF family genes from five important crops and those in the model plant Arabidopsis thaliana. Simultaneously, we summarized the functions of RALFs in controlling growth and developmental behavior using conservative motifs as cues and predicted the regulatory role of RALFs in cereal crops. In conclusion, RALF has considerable application potential in improving crop yields and increasing economic benefits. Using gene editing technology or taking advantage of RALF as a hormone additive are effective way to amplify the role of RALF in crop plants.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"3 1","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10242508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple and universal function of acetic acid to overcome the drought crisis.","authors":"Toru Kudo,&nbsp;Taiko Kim To,&nbsp;Jong-Myong Kim","doi":"10.1007/s44154-023-00094-1","DOIUrl":"https://doi.org/10.1007/s44154-023-00094-1","url":null,"abstract":"<p><p>Acetic acid is a simple and universal compound found in various organisms. Recently, acetic acid was found to play an essential role in conferring tolerance to water deficit stress in plants. This novel mechanism of drought stress tolerance mediated by acetic acid via networks involving phytohormones, genes, and chromatin regulation has great potential for solving the global food crisis and preventing desertification caused by global warming. We highlight the functions of acetic acid in conferring tolerance to water deficit stress.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"3 1","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10184392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune receptor mimicking hormone receptors: a new guarding strategy.","authors":"Xueru Liu,&nbsp;Josh Li,&nbsp;Tony ShengZhe Peng,&nbsp;Xin Li","doi":"10.1007/s44154-023-00095-0","DOIUrl":"https://doi.org/10.1007/s44154-023-00095-0","url":null,"abstract":"<p><p>Plant intracellular nucleotide-binding domain leucine-rich repeat (NLR) receptors play crucial roles in immune responses against pathogens. How diverse NLRs recognize different pathogen effectors remains a significant question. A recent study published in Nature uncovered how pepper NLR Tsw detects phytohormone receptors' interference caused by tomato spotted wilt virus (TSWV) effector, triggering a robust immune response, showcasing a new manner of NLR guarding.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"3 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10177224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}