Alzheimer's & Dementia最新文献

{"title":"Individualized, cross-validated prediction of future dementia using cognitive assessments in people with mild cognitive symptoms","authors":"Emma Borland, Niklas Mattson-Carlgren, Pontus Tideman, , Erik Stomrud, Oskar Hansson, Sebastian Palmqvist","doi":"10.1002/alz.14305","DOIUrl":"https://doi.org/10.1002/alz.14305","url":null,"abstract":"We aimed to develop an algorithm to predict the individualized risk of future dementia using brief cognitive tests suitable for primary care.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"1 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker pathway heterogeneity of amyloid-positive individuals","authors":"Lloyd Prosser, Carole H. Sudre, Neil P. Oxtoby, Alexandra L. Young, Ian B. Malone, Emily N. Manning, Hugh Pemberton, Phoebe Walsh, Frederik Barkhof, Geert Jan Biessels, David M. Cash, Josephine Barnes","doi":"10.1002/alz.14287","DOIUrl":"https://doi.org/10.1002/alz.14287","url":null,"abstract":"In amyloid-positive individuals, disease-related biomarker heterogeneity is understudied.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"73 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the feasibility of 18F-flortaucipir PET imaging in the antemortem diagnosis of primary age-related tauopathy (PART): An observational imaging-pathological study.","authors":"Anna Lavrova,Ryota Satoh,Nha Trang Thu Pham,Aivi Nguyen,Clifford R Jack,Ronald C Petersen,Reichard R Ross,Dennis W Dickson,Val J Lowe,Jennifer L Whitwell,Keith A Josephs","doi":"10.1002/alz.14301","DOIUrl":"https://doi.org/10.1002/alz.14301","url":null,"abstract":"INTRODUCTIONPrimary age-related tauopathy (PART) is characterized by neurofibrillary tangles and minimal β-amyloid deposition, diagnosed postmortem. This study investigates 18F-flortaucipir (FTP) PET imaging for antemortem PART diagnosis.METHODSWe analyzed FTP PET scans from 50 autopsy-confirmed PART and 13 control subjects. Temporal lobe uptake was assessed both qualitatively and quantitatively. Demographic and clinicopathological characteristics and voxel-level uptake using SPM12 were compared between FTP-positive and FTP-negative cases. Intra-reader reproducibility was evaluated with Krippendorff's alpha.RESULTSMinimal/mild and moderate FTP uptake was seen in 32% of PART cases and 62% of controls, primarily in the left inferior temporal lobe. No demographic or clinicopathological differences were found between FTP-positive and FTP-negative cases. High intra-reader reproducibility (α = 0.83) was noted.DISCUSSIONFTP PET imaging did not show a specific uptake pattern for PART diagnosis, indicating that in vivo PART identification using FTP PET is challenging. Similar uptake in controls suggests non-specific uptake in PART.HIGHLIGHTS18F-flortaucipir (FTP) PET scans were analyzed for diagnosing PART antemortem. 32% of PART cases had minimal/mild FTP uptake in the left inferior temporal lobe. Similar to PART FTP uptake was found in 62% of control subjects. No specific uptake pattern was found, challenging in vivo PART diagnosis.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"40 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AAIC 2024 previewed the future of Alzheimer's and dementia prevention, care, and treatment","authors":"","doi":"10.1002/alz.14325","DOIUrl":"https://doi.org/10.1002/alz.14325","url":null,"abstract":"<p>Every year, the Alzheimer's Association International Conference (AAIC) provides a forum for the world's leading scientists in the field of Alzheimer's disease and dementia research to come together and share their findings on the state of the science. In July 2024, individuals ranging from the globe's most experienced dementia investigators to those new to Alzheimer's and dementia research converged in Philadelphia, Pennsylvania, USA, to hear the latest discoveries in risk factors, diagnosis, treatment, care, and more at AAIC 2024.</p><p>AAIC is the world's largest gathering of dementia researchers, and clinicians AAIC 2024 broke records with the largest number of in-person attendees – over 8600. An additional 5700-plus joined online, for a total of over 14,400 attendees. More than half (57%) were women, and 38% were first-time participants. One-third were under the age of 35.</p><p>Attendees in Philadelphia and online had the opportunity to choose from more than 800 podium presentations and scientific sessions, as well as more than 3500 in-person poster presentations and nearly 900 virtual poster presentations. Among the topics explored were the biological underpinnings of dementia, clinical study recruitment, diversification of the clinical trial pipeline, health disparities, and factors that contribute to dementia risk across the life course.</p><p>This year, more than 500 conference fellowships were awarded, by the Alzheimer's Association covering expenses such as travel, housing, or registration for those selected. The fellowships prioritize early career researchers and those from low- and middle-income countries, helping them build their careers and professional connections in Alzheimer's and dementia research, care, and treatment and ensuring their representation in all discussions of scientific discovery. Conference attendees represented 101 countries from around the world.</p><p>In her welcome remarks, Alzheimer's Association President and CEO Joanne Pike, DrPH, emphasized global accomplishments and global challenges.</p><p>“Thanks to you and your peers in the global scientific community, we are making progress across the entire continuum of this disease,” said Pike. “In every year that goes by, you are building more and more understanding about how we can prevent this disease, diagnose it early, treat it, and care for those experiencing it. This progress is indeed incredible, but with progress comes the potential for significant inequities in who can benefit from the latest knowledge or latest innovation.”</p><p>Pike continued; “The Alzheimer's Association is working in partnership with global leaders and our peers in countries around the world to develop public health solutions to meet the challenges of this moment, including how we translate your work and implement it not just in countries that have the most access, but in every country around the world, so that no one is left behind.”</p><p>“As Dr. Pike mentioned, our field's evo","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"20 10","pages":"7427-7431"},"PeriodicalIF":13.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.14325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontoparietal network integrity supports cognitive function in pre-symptomatic frontotemporal dementia: Multimodal analysis of brain function, structure, and perfusion","authors":"Xulin Liu, Peter Simon Jones, Maurice Pasternak, Mario Masellis, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster, Eve Ferry-Bolder, John van Swieten, Lize Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Sandro Sorbi, Markus Otto, Florence Pasquier, Simon Ducharme, Chris Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Jonathan D. Rohrer, Kamen A. Tsvetanov, James B. Rowe","doi":"10.1002/alz.14299","DOIUrl":"https://doi.org/10.1002/alz.14299","url":null,"abstract":"Genetic mutation carriers of frontotemporal dementia can remain cognitively well despite neurodegeneration. A better understanding of brain structural, perfusion, and functional patterns in the pre-symptomatic stage could inform accurate staging and potential mechanisms.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"7 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and clinical significance of post-stroke incident ischemic lesions.","authors":"Rong Fang,Marco Duering,Felix J Bode,Sebastian Stösser,Julius N Meißner,Peter Hermann,Thomas G Liman,Christian H Nolte,Lucia Kerti,Benno Ikenberg,Kathleen Bernkopf,Wenzel Glanz,Daniel Janowitz,Michael Wagner,Katja Neumann,Oliver Speck,Emrah Düzel,Benno Gesierich,Anna Dewenter,Annika Spottke,Karin Waegemann,Michael Görtler,Silke Wunderlich,Inga Zerr,Gabor C Petzold,Matthias Endres,Marios K Georgakis,Martin Dichgans,","doi":"10.1002/alz.14274","DOIUrl":"https://doi.org/10.1002/alz.14274","url":null,"abstract":"INTRODUCTIONWhile incident ischemic lesions (IILs) are not unusual on follow-up magnetic resonance imaging (MRI) following stroke, their risk factors and prognostic significance remain unknown.METHODSIn a prospective multicenter study of 503 acute stroke patients, we assessed IILs on registered MRI images at baseline and 6 months, analyzing risk factors and clinical outcomes across 36 months.RESULTSAt 6 months, 78 patients (15.5%) had IILs, mostly diffusion-weighted imaging-positive (72%) and clinically covert (91%). Older age and small vessel disease (SVD) lesions were baseline risk factors for IILs. IILs were associated with worse cognitive (beta for global cognition: -0.31, 95% confidence interval [CI]: -0.48 to -0.14) and functional outcomes (beta for modified Rankin scale [mRS]: 0.36, 95% CI: 0.14 to 0.58), and higher recurrent stroke risk (hazard ratio: 3.81, 95% CI: 1.35 to 10.69). IILs partially explained the relationship between SVD and poor cognition.DISCUSSIONIILs are common and are associated with worse cognitive and functional outcomes and stroke recurrence risk. Assessing IILs following stroke might aid prognostication.HIGHLIGHTSIncident ischemic lesions (IILs) were assessed with registered baseline and 6-month magnetic resonance imaging (MRI) scans in a stroke cohort. IILs 6 months after stroke are present in one-sixth of patients and are mostly clinically silent. Small vessel disease burden is the main baseline risk factor for IILs. IILs are associated with cognitive and functional impairment and stroke recurrence. Assessing IILs by follow-up MRI aids long-term prognostication for stroke patients.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"232 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-assisted oculo-gait measurements for cognitive impairment in cerebral small vessel disease.","authors":"Huimin Chen,Hao Du,Fang Yi,Tingting Wang,Shuo Yang,Yuesong Pan,Hongyi Yan,Dandan Liu,Mengyuan Zhou,Yiyi Chen,Mengxi Zhao,Jingtao Pi,Yingying Yang,Xiangmin Fan,Xueli Cai,Ziyu Qiu,Jipeng Zhang,Yawei Liu,Wenping Gu,Yilong Wang","doi":"10.1002/alz.14288","DOIUrl":"https://doi.org/10.1002/alz.14288","url":null,"abstract":"INTRODUCTIONOculomotor and gait dysfunctions are closely associated with cognition. However, oculo-gait patterns and their correlation with cognition in cerebral small vessel disease (CSVD) remain unclear.METHODSPatients with CSVD from a hospital-based cohort (n = 194) and individuals with presumed early CSVD from a community-based cohort (n = 319) were included. Oculo-gait patterns were measured using the artificial intelligence (AI) -assisted 'EyeKnow' eye-tracking and 'ReadyGo' motor evaluation systems. Multivariable linear and logistic regression models were employed to investigate the association between the oculo-gait parameters and cognition.RESULTSAnti-saccade accuracy, stride velocity, and swing velocity were significantly associated with cognition in both patients and community dwellers with CSVD, and could identify cognitive impairment in CSVD with moderate accuracy (area under the curve [AUC]: hospital cohort, 0.787; community cohort, 0.810) after adjusting for age and education.DISCUSSIONThe evaluation of oculo-gait features (anti-saccade accuracy, stride velocity, and swing velocity) may help screen cognitive impairment in CSVD.HIGHLIGHTSOculo-gait features (lower anti-saccade accuracy, stride velocity, and swing velocity) were associated with cognitive impairment in cerebral small vessel disease (CSVD). Logistic model integrating the oculo-gait features, age, and education level moderately distinguished cognitive status in CSVD. Artificial intelligence-assisted oculomotor and gait measurements provide quick and accurate evaluation in hospital and community settings.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"41 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of leukocytes in cognitive impairment due to long-term exposure to fine particulate matter: A large population-based mediation analysis","authors":"Benjamin Aretz, Gabriele Doblhammer, Michael T. Heneka","doi":"10.1002/alz.14320","DOIUrl":"https://doi.org/10.1002/alz.14320","url":null,"abstract":"Our understanding of how fine particulate matter (PM_2.5) impacts cognitive functioning is limited. Systemic inflammation processes may play a role in mediating this effect.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"44 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of MIND diet with cognitive decline among Black and White older adults","authors":"Puja Agarwal, Lisa L. Barnes, Klodian Dhana, Xiaoran Liu, Yanyu Zhang, Todd Beck, Marilyn C. Cornelis, Christy Tangney, Kumar B. Rajan","doi":"10.1002/alz.14277","DOIUrl":"https://doi.org/10.1002/alz.14277","url":null,"abstract":"We examined the Mediterranean–Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet's association with cognitive decline by race among older adults in the Chicago Health and Aging Project.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"30 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"APOE 𝜀4-related blood–brain barrier breakdown is associated with microstructural abnormalities","authors":"Emilie T. Reas, Seraphina K. Solders, Amaryllis Tsiknia, Curtis Triebswetter, Qian Shen, Charlotte S. Rivera, Murray J. Andrews, Austin Alderson-Myers, James B. Brewer","doi":"10.1002/alz.14302","DOIUrl":"https://doi.org/10.1002/alz.14302","url":null,"abstract":"Blood–brain barrier (BBB) dysfunction occurs in Alzheimer's disease (AD). Yet, the stage at which it appears along the AD time course and whether it contributes to neurodegeneration remain unclear.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"93 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}