Alzheimer's & Dementia最新文献_第9页

Synergistic association of insomnia and anxiety with cognitive impairment and dementia in older adults 老年人失眠和焦虑与认知障碍和痴呆的协同关联

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2026-09-23 DOI: 10.1002/alz.71853

Yan Chen, Qianxi Wang, Ling Li, Shixing Qian, Li Bai, Tih Shih Lee, Shaowei Zhang, Yaping Li, Qianqian Guo, Yang Yang, Feng Yan, Lei Feng, Xia Li

{"title":"Synergistic association of insomnia and anxiety with cognitive impairment and dementia in older adults","authors":"Yan Chen, Qianxi Wang, Ling Li, Shixing Qian, Li Bai, Tih Shih Lee, Shaowei Zhang, Yaping Li, Qianqian Guo, Yang Yang, Feng Yan, Lei Feng, Xia Li","doi":"10.1002/alz.71853","DOIUrl":"https://doi.org/10.1002/alz.71853","url":null,"abstract":"INTRODUCTION We investigated the synergistic effects of comorbid insomnia and anxiety on cognitive impairment and dementia and explored the underlying plasma biomarker mechanisms. METHODS We included adults ≥ 60 years from the cross‐sectional cohort named The Shanghai Action to Prevent Dementia in the Elderly (SHAPE) and used data from the longitudinal United Kingdom (UK) Biobank for validation. Regression models and additive interactions were used to evaluate the associations between comorbid insomnia and anxiety and cognitive outcomes. Biomarker mediation effects (tau phosphorylated at threonine 217 [p‐tau217], glial fibrillary acidic protein [GFAP], and neurofilament light chain [NfL]) were assessed in a SHAPE subcohort. RESULTS Comorbid insomnia and anxiety were synergistically associated with incident cognitive impairment in the SHAPE cohort. This vulnerability was validated longitudinally in individuals with incident dementia in the UK Biobank cohort. Additionally, p‐tau217 and GFAP mediated this association, predominantly driven by p‐tau217, with GFAP showing a modest but significant independent contribution. DISCUSSION Comorbid insomnia and anxiety are synergistically associated with a higher prevalence of cognitive impairment and incidence of dementia. This vulnerability is partially mediated by amyloid pathology, with astrogliosis providing a modest but significant contribution. These findings underscore the need for combined screening and targeted interventions to mitigate dementia risk.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"192 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney function and brain health: cognitive and structural signatures across cohorts 肾脏功能和大脑健康：跨队列的认知和结构特征

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2026-09-23 DOI: 10.1002/alz.71840

Min Li, Wenbo Yang, Ying Hui, Huijing Shi, Yuntao Wu, Li Yu, Lijun Song, Yanfang Tan, Xintian Ren, Xiaoyan Bai, Xiaoshuai Li, Zhenghan Yang, Weikang Guo, Shouling Wu, Jing Li, Zhenchang Wang, Han Lv, Hao Wang

{"title":"Kidney function and brain health: cognitive and structural signatures across cohorts","authors":"Min Li, Wenbo Yang, Ying Hui, Huijing Shi, Yuntao Wu, Li Yu, Lijun Song, Yanfang Tan, Xintian Ren, Xiaoyan Bai, Xiaoshuai Li, Zhenghan Yang, Weikang Guo, Shouling Wu, Jing Li, Zhenchang Wang, Han Lv, Hao Wang","doi":"10.1002/alz.71840","DOIUrl":"https://doi.org/10.1002/alz.71840","url":null,"abstract":"INTRODUCTION Chronic kidney disease (CKD) is linked to cognitive decline, yet the roles of estimated glomerular filtration rate (eGFR) and its variability remain unclear. METHODS We analyzed 6847 adults from two population‐based cohorts (the Multimodality MEdical imaging sTudy bAsed on KaiLuan Study [META‐KLS], UK Biobank) and 426 CKD patients from Beijing Friendship Hospital (BFH)‐CKD. Exposures included eGFR level and variability. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and brain structure by magnetic resonance imaging (MRI). RESULTS In META‐KLS, higher cumulative eGFR was associated with higher MoCA scores ( β = 0.350; 95% confidence interval [CI]: 0.148 to 0.552), whereas greater eGFR variability was associated with lower MoCA scores ( β = −0.454; 95% CI: −0.659 to −0.250). Across cohorts, higher eGFR was associated with white matter, superior frontal, and middle temporal volumes. In META‐KLS, greater variability showed nominal inverse associations with inferior parietal and middle temporal volumes and reduced rostral anterior cingulate cortex thickness. DISCUSSION Lower eGFR and greater eGFR variability were associated with lower MoCA scores and region‐specific structural brain alterations.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"18 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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AAIC ® Advancements: Reducing Disparities in Brain Health convenes October 30 to 31, 2026 AAIC®进展：减少脑健康差异于2026年10月30日至31日召开

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2026-09-23 DOI: 10.1002/alz.71881

引用次数: 0

Mendelian randomization evidence refines retinal alterations in Alzheimer's disease 孟德尔随机化证据细化了阿尔茨海默病的视网膜改变

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2026-09-23 DOI: 10.1002/alz.71879

Shulei Man, Yuzhu Gao, Kefan Mou, Yunxia Gao, Ming Zhang

引用次数: 0

Trajectories of late‐life job insecurity and labor force participation: Associations with cognitive function and impairment in the Health and Retirement Study's harmonized cognitive assessment protocol 晚年工作不安全感和劳动力参与的轨迹：健康与退休研究的统一认知评估协议与认知功能和损害的关系

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2026-09-23 DOI: 10.1002/alz.71863

Erika T. Beidelman, Xuexin Yu, Constance Beaufils, Rachel Donnelly, Mateo Farina, Amanda Sonnega, Lindsay C. Kobayashi, Yuan S. Zhang

{"title":"Trajectories of late‐life job insecurity and labor force participation: Associations with cognitive function and impairment in the Health and Retirement Study's harmonized cognitive assessment protocol","authors":"Erika T. Beidelman, Xuexin Yu, Constance Beaufils, Rachel Donnelly, Mateo Farina, Amanda Sonnega, Lindsay C. Kobayashi, Yuan S. Zhang","doi":"10.1002/alz.71863","DOIUrl":"https://doi.org/10.1002/alz.71863","url":null,"abstract":"INTRODUCTION Continued workforce participation may preserve later‐life cognition, yet many Americans face job insecurity and instability in later life, with potential consequences for cognitive aging. METHODS Using Health and Retirement Study (HRS) Harmonized Cognitive Assessment Protocol data ( n = 2418), we applied gender‐stratified sequence analyses to identify clusters of combined employment and job insecurity trajectories (1998 to 2014). We estimated associations with domain‐specific cognitive scores and impairment status in 2016 using weighted, multivariable‐adjusted regression. RESULTS Six clusters were identified separately for women and men. Among women, self‐employed, early retirement, not in labor force, and secure‐to‐retirement trajectories were significantly associated with lower memory and executive function scores ( β range = −0.13 to −0.32 standard deviation units) compared to secure employment. Among men, inconsistent employment was associated with poorer performance across most cognitive domains compared to secure employment. Employment instability and early retirement were associated with higher odds of cognitive impairment among women. DISCUSSION These results underscore employment security as a potential protective factor for cognitive aging.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"269 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prosocial helping behaviors attenuate accelerated cognitive decline driven by APOE ε4 亲社会帮助行为减弱APOE ε4驱动的加速认知衰退

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2026-09-23 DOI: 10.1002/alz.71877

Sae Hwang Han, Jessica Danielle Faul

{"title":"Prosocial helping behaviors attenuate accelerated cognitive decline driven by APOE ε4","authors":"Sae Hwang Han, Jessica Danielle Faul","doi":"10.1002/alz.71877","DOIUrl":"https://doi.org/10.1002/alz.71877","url":null,"abstract":"INTRODUCTION The apolipoprotein E ( APOE ) ε4 allele accelerates cognitive decline through multiple biological pathways—including neuroinflammatory, vascular, and stress‐regulatory mechanisms—yet few modifiable behaviors counter this genetic vulnerability. Prosocial helping engages these same systems in opposing directions, suggesting it may attenuate APOE ε4–related cognitive decline. METHODS We analyzed more than two decades of longitudinal data from a large, multiethnic US sample ( N = 17,972). Multilevel models that isolate within‐person change tested whether transitions in formal volunteering and informal helping moderate APOE ε4–related cognitive decline, while addressing key sources of endogeneity. RESULTS Adopting and sustaining formal volunteering attenuated the accelerated cognitive decline typically observed among ε4 carriers, with protective associations evident at modest engagement levels (≤ 4 hours/week). Informal helping was uniquely protective among Hispanic older adults, highlighting the role of cultural context in prosocial engagement. DISCUSSION Prosocial helping may be a feasible, scalable strategy for slowing APOE ε4–driven cognitive decline.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"1 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social engagement, formal education, and cognitive outcomes among older adults in India: A longitudinal population‐based study 印度老年人的社会参与、正规教育和认知结果：一项基于人口的纵向研究

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2026-09-23 DOI: 10.1002/alz.71850

Peiyao Zhu, Emma Nichols, Marco Angrisani, Alden L. Gross, Jinkook Lee, Lindsay C Kobayashi

{"title":"Social engagement, formal education, and cognitive outcomes among older adults in India: A longitudinal population‐based study","authors":"Peiyao Zhu, Emma Nichols, Marco Angrisani, Alden L. Gross, Jinkook Lee, Lindsay C Kobayashi","doi":"10.1002/alz.71850","DOIUrl":"https://doi.org/10.1002/alz.71850","url":null,"abstract":"INTRODUCTION We estimated the associations between baseline social engagement and cognitive function and change among older adults in India, overall and by education. METHODS Data were from 3869 adults aged ≥ 60 years from the Longitudinal Aging Study in India—Diagnostic Assessment of Dementia Wave 1 (2017–2019) and Wave 2 (2022–2024). Baseline social engagement was measured using a 12‐point index, dichotomized as higher (< 8) versus lower (≥ 8) engagement. General and domain‐specific cognitive scores were derived at both waves. Multivariable‐adjusted joint models accounted for mortality and evaluated effect modification by education. RESULTS Higher baseline social engagement was associated with higher general cognitive scores at baseline (0.145 standard deviation units; 95% confidence interval: 0.076, 0.214), but not with cognitive change over time. Education attainment did not show a consistent pattern of effect modification across cognitive domains. DISCUSSION Social engagement was associated with cognitive level at baseline but not the rate of cognitive change over time, with no consistent evidence of effect modification by education.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"47 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research satisfaction among participants in a preclinical Alzheimer's disease trial 阿尔茨海默病临床前试验参与者的研究满意度

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2026-09-23 DOI: 10.1002/alz.71852

Marina Ritchie, Kedir Hussen, Oliver Langford, Michael C. Donohue, Mary Sano, Joshua D. Grill, Paul Aisen, Reisa Sperling, Rema Raman

{"title":"Research satisfaction among participants in a preclinical Alzheimer's disease trial","authors":"Marina Ritchie, Kedir Hussen, Oliver Langford, Michael C. Donohue, Mary Sano, Joshua D. Grill, Paul Aisen, Reisa Sperling, Rema Raman","doi":"10.1002/alz.71852","DOIUrl":"https://doi.org/10.1002/alz.71852","url":null,"abstract":"INTRODUCTION Empirical data capturing participants’ experiences in preclinical Alzheimer's disease (AD) trials are limited. We examined participant responses on a Research Satisfaction Survey (RSS) from the Anti‐Amyloid Treatment in Asymptomatic AD Study. METHODS Participants completed the RSS at week 0, 48, 108, 168, and 240. We examined potential differences in responses by baseline participant characteristics and trial completion status. RESULTS RSS scores were high, with > 90% of participants responding positively to all satisfaction items. Across timepoints, altruistic motivations were most frequently affirmed, while study design elements were most frequently disfavored. Affirmation of social motivations increased over time. Participants who responded “not satisfied” at baseline to repeating their decision to enroll had higher odds of study discontinuation than those who responded “satisfied” (1.99; 95% confidence interval [CI]:1.24, 3.19). DISCUSSION An RSS captures participant experiences in a preclinical AD trial, can guide decisions on study design features, and may identify those at risk for loss to follow‐up.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"51 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Human iPSC‐derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer's disease model” 更正“人类iPSC衍生的gaba能间神经元移植可恢复阿尔茨海默病模型中的电路平衡和认知功能”

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2026-09-21 DOI: 10.1002/alz.71875

引用次数: 0

Baseline cerebrospinal fluid complement balance is associated with longitudinal memory decline in relation to plasma p‑tau181 levels in mild cognitive impairment 基线脑脊液补体平衡与轻度认知障碍患者血浆p - tau181水平相关的纵向记忆下降有关

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2026-09-21 DOI: 10.1002/alz.71836

Zhinan Ye, Qihan Zhang, Bo Zhang, Bingxin Teng, Shiyue Wang, Jiaxuan Chen, Bohao Li, Hongjie Jin, Zhexin Zheng, Zhuoyu Yang, Xuanang Hu, Xinyan Zhao, Suwen Huang, Yiyun Weng, Dehao Yang

{"title":"Baseline cerebrospinal fluid complement balance is associated with longitudinal memory decline in relation to plasma p‑tau181 levels in mild cognitive impairment","authors":"Zhinan Ye, Qihan Zhang, Bo Zhang, Bingxin Teng, Shiyue Wang, Jiaxuan Chen, Bohao Li, Hongjie Jin, Zhexin Zheng, Zhuoyu Yang, Xuanang Hu, Xinyan Zhao, Suwen Huang, Yiyun Weng, Dehao Yang","doi":"10.1002/alz.71836","DOIUrl":"https://doi.org/10.1002/alz.71836","url":null,"abstract":"INTRODUCTION The role of complement in Alzheimer's disease (AD) remains unclear, particularly regarding tau pathology and memory decline. METHODS In 123 mild cognitive impairment (MCI) participants from Alzheimer's Disease Neuroimaging Initiative (ADNI), linear mixed‑effects models and Johnson–Neyman analysis examined associations of baseline cerebrospinal fluid (CSF) C3/FH ratio with longitudinal memory decline moderated by time‑varying plasma phosphorylated tau181 (p‑tau181). RESULTS The three‑way interaction was significant ( p = 0.023). A region of statistical significance was identified: the conditional association of C3/FH with memory decline became significant when p‑tau181 exceeded 0.76 SD, with higher C3/FH associated with slower decline at elevated p‑tau181 levels. Cross‐sectionally, no significant C3/FH–memory associations were observed in any diagnostic group (all p > 0.05). DISCUSSION These findings indicate that complement balance is associated with memory decline in MCI in a manner dependent on plasma p‑tau181 levels, suggesting that complement may interact with AD‑related pathophysiology during the prodromal phase. The identified statistical region provides a hypothesis‑generating benchmark for future studies.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"1 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0