Alzheimer's & Dementia最新文献

{"title":"Dual-stream algorithms for dementia detection: Harnessing structured and unstructured electronic health record data, a novel approach to prevalence estimation","authors":"Taya A. Collyer, Ming Liu, Richard Beare, Nadine E. Andrew, David Ung, Alison Carver, Jenni Ilomaki, J. Simon Bell, Amanda G. Thrift, Walter A. Rocca, Jennifer L. St Sauver, Alicia Lu, Kristy Siostrom, Chris Moran, Helene Roberts, Trevor T.-J. Chong, Anne Murray, Tanya Ravipati, Bridget O'Bree, Velandai K. Srikanth","doi":"10.1002/alz.70132","DOIUrl":"https://doi.org/10.1002/alz.70132","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Identifying individuals with dementia is crucial for prevalence estimation and service planning, but reliable, scalable methods are lacking. We developed novel set algorithms using both structured and unstructured electronic health record (EHR) data, applying Diagnostic and Statistical Manual of Mental Disorders criteria for dementia case identification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>Our cohort (<i>n</i> = 1082) included individuals aged ≥ 60 with dementia identified through specialist clinics and a comparison group without dementia. Clinicians from Australia and the United States informed predictor selection. We developed algorithms through a biostatistics stream for structured data and a natural language processing (NLP) stream for text, synthesizing results via logistic regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The final structured model retained 16 variables (area under the receiver operating characteristic curve [AUC] 0.853, specificity 72.2%, sensitivity 80.6%). NLP classifiers (logistic regression, support vector machine, and random forest models) performed comparably. The final, combined model outperformed all others (AUC = 0.951, <i>P</i> < 0.001 for comparison to structured model).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Embedding text-derived insights within algorithms trained on structured medical data significantly enhances dementia identification capacity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>Algorithmic tools for detection of individuals with dementia are available; however, previous work has used heterogeneous case definitions which are not clinically meaningful, and has relied on proxies such as diagnostic codes or medications for case ascertainment.</li>\u0000 \u0000 <li>We used a novel, dual-stream algorithmic development approach, simultaneously and separately modeling a clinically meaningful outcome (diagnosis of dementia according to specialized clinical impression) using structured and unstructured electronic health record datasets.</li>\u0000 \u0000 <li>Our clinically grounded case definition supported the inclusion of key structured variables (such as dementia International Classification of Disease codes and medications) as modeling predictors rather than outcomes.</li>\u0000 \u0000 ","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apigenin mitigates oxidative stress, neuroinflammation, and cognitive impairment but enhances learning and memory in aluminum chloride-induced neurotoxicity in rats","authors":"Ademola Adetokunbo Oyagbemi,&nbsp;Omowumi Moromoke Femi-Akinlosotu,&nbsp;Adedunsola Adewunmi Obasa,&nbsp;Moses Semilore Ojo,&nbsp;Adeola Temitope Salami,&nbsp;Temitayo Olabisi Ajibade,&nbsp;Charles Etang Onukak,&nbsp;Olumayowa Olawumi Igado,&nbsp;Oluwaseun Olarenwaju Esan,&nbsp;Taiwo Olaide Oyagbemi,&nbsp;Adewumi Victoria Adeogun,&nbsp;Omolola Victoria Awoyomi,&nbsp;Joseph E. Ikokide,&nbsp;Ishmael Festus Jaja,&nbsp;Olufunke Eunice Ola-Davies,&nbsp;Temidayo Olutayo Omobowale,&nbsp;Adebowale Bernard Saba,&nbsp;Oluwafemi Omoniyi Oguntibeju,&nbsp;Evaristus Nwulia,&nbsp;Momoh Audu Yakubu","doi":"10.1002/alz.70223","DOIUrl":"https://doi.org/10.1002/alz.70223","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Aluminum chloride (AlCl₃) exposure has been linked to neurotoxicity in various animal models, presenting significant concern to human health due to its potential implications in neurodegenerative diseases. Aluminum chloride is a widely recognized neurotoxin and has been used as an animal model of Alzheimer's disease via mechanisms linked with oxidative stress and inflammation. The study investigated the potential ameliorative effect of apigenin on AlCl₃-induced neurotoxicity in rats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>Forty adult male Wistar rats were randomly divided into four different groups – control, AlCl₃ (100 mg/kg), apigenin (50 mg/kg) plus AlCl₃, and apigenin (50 mg/kg) alone administered orally for 14 days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Our findings revealed AlCl₃ exposure induced significant neurobehavioral deficits, oxidative stress, neuroinflammation, and loss of the Purkinje cell layer of the cerebellum. Treatment with apigenin attenuated neuroinflammation and enhanced learning and memory with significant improvement in recognition index.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Apigenin demonstrates promising ameliorative effects against AlCl₃-induced neurotoxicity in rats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>Aluminum chloride toxicity caused significant reduction in learning, exploration, and memory.</li>\u0000 \u0000 <li>Aluminum chloride toxicity induced neurotoxicity, increased biomarkers of oxidative stress, neuroinflammation, and precipitated cognitive impairment.</li>\u0000 \u0000 <li>Apigenin improved brain antioxidant, enhanced learning, exploration, and memory.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep trajectories across three cognitive-aging pathways in community older adults","authors":"Afsara B. Zaheed,&nbsp;Amanda L. Tapia,&nbsp;Nina Oryshkewych,&nbsp;Bradley J. Wheeler,&nbsp;Meryl A. Butters,&nbsp;Daniel J. Buysse,&nbsp;Yue Leng,&nbsp;Lisa L. Barnes,&nbsp;Andrew Lim,&nbsp;Lan Yu,&nbsp;Adriane M. Soehner,&nbsp;Meredith L. Wallace","doi":"10.1002/alz.70159","DOIUrl":"https://doi.org/10.1002/alz.70159","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Comparing sleep and rest–activity rhythms across different cognitive aging pathways can identify novel risk factors and potential mechanisms. However, our current understanding is restricted by differences in sleep measurement, limited longitudinal data, and heterogeneous cognitive aging processes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We applied cubic splines to longitudinal self-reported sleep and actigraphy data from 1449 participants in the Rush Memory and Aging Project and quantified differences in the levels and trajectories of sleep amount, regularity, and timing within and between three cognitive aging pathways: normal, stable mild cognitive impairment, dementia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Sleep amount was lowest in the dementia pathway prior to cognitive impairment but increased with age, most rapidly after dementia. Regularity declined across all pathways, most rapidly after cognitive diagnoses. Timing advanced across all pathways.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Shorter sleep amount in cognitively healthy older adults may be a risk factor or prodromal indicator of dementia, while longer sleep amounts and decreasing regularity may reflect neurodegeneration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>We quantified longitudinal changes in sleep across three cognitive-aging pathways.</li>\u0000 \u0000 <li>We incorporated both subjective and objective measures of sleep health.</li>\u0000 \u0000 <li>Self-report duration increased noticeably from before to after cognitive diagnosis.</li>\u0000 \u0000 <li>Sleep irregularity increased most prominently after cognitive diagnosis.</li>\u0000 \u0000 <li>Advances in sleep timing occurred in both normal and pathological aging.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced myelin contributes to cognitive impairment in patients with monogenic small vessel disease","authors":"Jannis Denecke,&nbsp;Anna Dewenter,&nbsp;Jongho Lee,&nbsp;Nicolai Franzmeier,&nbsp;Carolina Valentim,&nbsp;Anna Kopczak,&nbsp;Martin Dichgans,&nbsp;Lukas Pirpamer,&nbsp;Benno Gesierich,&nbsp;Marco Duering,&nbsp;Michael Ewers","doi":"10.1002/alz.70127","DOIUrl":"https://doi.org/10.1002/alz.70127","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Myelin is pivotal for signal transfer and thus cognition. Cerebral small vessel disease (cSVD) is primarily associated with white matter (WM) lesions and diffusion changes; however, myelin alterations and related cognitive impairments in cSVD remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We included 64 patients with familial cSVD (i.e., cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [CADASIL]) and 20 cognitively unimpaired individuals. χ separation applied to susceptibility weighted imaging was used to assess myelin and iron within WM hyperintensities, normal appearing WM, and two strategic fiber tracts. Diffusion-based mean diffusivity and free water were analyzed for comparisons. Cognitive impairment was assessed by the Trail Making Test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>CADASIL patients showed reduced myelin within WM hyperintensities and its penumbra in the normal appearing WM. Myelin was moderately correlated with diffusion and iron changes and associated with slower processing speed controlled for diffusion and iron alterations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Myelin constitutes WM alterations distinct from diffusion changes and substantially contributes to explaining cognitive impairment in cSVD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>χ-negative magnetic resonance signal was reduced within white matter hyperintensities and normal appearing white matter in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, suggesting widespread myelin decreases due to cerebral small vessel disease (cSVD).</li>\u0000 \u0000 <li>χ-negative values were only moderately associated with diffusion tensor imaging derived indices including free water and mean diffusivity, suggesting that χ separation depicts distinct microstructural changes in cSVD.</li>\u0000 \u0000 <li>Alterations in χ-negative values made a unique contribution to explain processing speed impairment, even when controlled for diffusion and iron changes.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmonized cognitive performance in an older adult cohort of Vietnamese American immigrants: The VIP study","authors":"Brandon E. Gavett,&nbsp;Sarah Tomaszewski Farias,&nbsp;Quyen Q. Tiet,&nbsp;Van T. Park,&nbsp;Danielle Harvey,&nbsp;Quyen Vuong,&nbsp;Ladson Hinton,&nbsp;Alka M. Kanaya,&nbsp;Rachel A. Whitmer,&nbsp;Lauren Mai,&nbsp;Oanh L. Meyer","doi":"10.1002/alz.70097","DOIUrl":"https://doi.org/10.1002/alz.70097","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Vietnamese Americans represent an understudied population with unique risk factors relevant to cognitive aging. The current study sought to model global cognition in the Vietnamese Insights into Cognitive Aging Program (VIP) study and harmonize ability estimates with the National Alzheimer's Coordinating Center (NACC) Uniform Data Set.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>Cognitive data from VIP (<i>N</i> = 548) and NACC (<i>N</i> = 15,923) were analyzed using item response theory. Seven common items were assessed for differential item functioning (DIF); items without salient DIF were used to harmonize the cognitive composite score across the two cohorts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Although five of the seven common items showed evidence of DIF, the magnitude of this DIF was negligible, affecting the factor score estimates of only 12 (2.19%) VIP participants by more than one standard error.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Global cognitive functioning can be estimated in Vietnamese American immigrants with minimal bias and psychometrically matched to one of the largest studies of cognitive aging and dementia worldwide.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>This is the first known study to model cognition in older Vietnamese Americans.</li>\u0000 \u0000 <li>Global cognition was harmonized with minimal bias across two diverse cohorts.</li>\u0000 \u0000 <li>Differential item functioning was found in five of seven items, but the impact was not salient.</li>\u0000 \u0000 <li>Results create new opportunities to study health disparities in an underrepresented group.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed methods feasibility study of Music Attuned Technology Care via eHealth (MATCH) for people with complex behavioral and psychological symptoms of dementia within an acute psychogeriatric ward","authors":"Ajay Castelino,&nbsp;Suzanne Dawson,&nbsp;Peixuan Li,&nbsp;Zara Thompson,&nbsp;Jeanette Tamplin,&nbsp;Bec Watt,&nbsp;Jessica Archbold,&nbsp;Karen Elaine Lamb,&nbsp;Sabine Braat,&nbsp;Tanara Vieira Sousa,&nbsp;Felicity Anne Baker","doi":"10.1002/alz.70124","DOIUrl":"https://doi.org/10.1002/alz.70124","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Music-based strategies can reduce distress, agitation, and promote wellbeing in people with dementia. Research in specialized dementia care units is limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>Mixed-methods pre-post study evaluated the feasibility and preliminary effects of Music Attuned Technology Care via eHealth (MATCH) in a dementia-specialized inpatient ward. Staff completed MATCH training and administered MATCH strategies over 8 weeks with enrolled patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Twenty-four staff and 14 patients were recruited. Severity of dementia symptoms, measured by the Neuropsychiatric Inventory Questionnaire, was reduced (median change: −3.0, 95% CI: −9.5, 0.5), especially agitation (median change −3.0, 95% confidence interval −5.5, −0.5). Staff reported high acceptability of MATCH (median score: 13 [interquartile range: 12–14]) and implementing strategies enhanced person-centered care. Patients’ positive responses to music motivated increased use. No changes in staff knowledge or patient depression were found.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>MATCH was acceptable to staff and showed potential to reduce agitation symptoms and medication use, warranting further trials to determine effectiveness.</p>\u0000 \u0000 <p>Clinical trial registration: The clinical trial is registered with the Australia New Zealand Clinical Trials Registry (ACTRN12623001134617).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>MATCH decreased the severity of dementia symptoms, measured by the <i>NPI-Q</i>.</li>\u0000 \u0000 <li>Staff reported high acceptability of MATCH.</li>\u0000 \u0000 <li>Personalized music enhanced person-centered care.</li>\u0000 \u0000 <li>Patients’ positive responses to music motivated increased use.</li>\u0000 \u0000 <li>No changes in staff knowledge or patient depression were found.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological imprint of education and rights-based brain capital","authors":"Agustin Ibanez,&nbsp;Temitope Farombi","doi":"10.1002/alz.70222","DOIUrl":"https://doi.org/10.1002/alz.70222","url":null,"abstract":"<p>Recent findings on the biological embedding of educational disparities in aging and dementia, evidence that access to high-quality education is both a human rights imperative and a critical public health strategy. Education quantity and quality and related factors shape cognitive health and vulnerability to dementia. These factors are particularly salient in low- and middle-income countries, where austerity policies and systemic disparities frequently compromise brain capital. We advocate for a transdisciplinary approach linking education, social justice, and neuroscience within a rights-based framework. Addressing structural determinants through education policy can promote healthy brain aging and reduce inequities.</p><p>TF is supported by an Atlantic Fellowship at the Global Brain Health Institute (GBHI) at Trinity College Dublin. AI is supported by grants from CONICET; ANID/FONDECYT Regular (1210195 and 1210176 and 1220995); ANID/FONDAP/15150012; ANID/PIA/ANILLOS ACT210096; FONDEF ID20I10152, ANID/FONDAP 15150012; Takeda CW2680521 and the MULTI-PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA [ReDLat, supported by Fogarty International Center (FIC), National Institutes of Health, National Institutes of Ageing (AG075775, AG057234, AG082056 and AG083799, CARDS-NIH 75N95022C00031), Alzheimer's Association (SG-20-725707), Rainwater Charitable Foundation – The Bluefield project to cure FTD, and Global Brain Health Institute)]. The views expressed are those of the authors and not necessarily those of the stakeholders. Author disclosures are available in the Supporting Information.</p>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70222","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Dementia Council: Brain health and dementia awareness, Latin America and Caribbean series","authors":"","doi":"10.1002/alz.70272","DOIUrl":"https://doi.org/10.1002/alz.70272","url":null,"abstract":"","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intimate partner violence and cognitive functioning – toward quantifying dementia risk","authors":"Audrey R. Murchland,&nbsp;Sebastien Haneuse,&nbsp;Rebecca B. Lawn,&nbsp;Lisa Berkman,&nbsp;Karen Jakubowski,&nbsp;M. Maria Glymour,&nbsp;Karestan C. Koenen","doi":"10.1002/alz.70029","DOIUrl":"https://doi.org/10.1002/alz.70029","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Intimate partner violence (IPV) victimization is highly common among women and associated with adverse health consequences that may be linked to dementia risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>Nurses’ Health Study II participants (<i>N</i> = 14,771) reported adult (age ≥ 18) emotional, physical, and sexual IPV in 2001/2008 and completed the Cogstate Brief Battery 2014–2019 (4/6 maximum assessments). Any versus no IPV and IPV subtypes were used to predict cognition in confounder-adjusted generalized estimating equation models weighted to account for attrition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Mean age at baseline was 61.0 years (standard deviation = 4.6); 46.5% reported any IPV (42.3% emotional, 22.6% physical, and 11.3% sexual). IPV victimization was associated with 0.029 SD unit (95% confidence interval [CI]: −0.068, 0.009) lower global cognitive score but not rate of cognitive change. Among IPV types, emotional IPV had the strongest association (β = −0.048; 95% CI: −0.075, −0.020) with cognitive scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Gendered social experiences such as IPV may influence dementia risk. Further assessment of IPV in aging cohorts is needed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>IPV predicted lower average cognitive score over follow-up.</li>\u0000 \u0000 <li>Emotional abuse had the largest associations with cognitive score among subtypes.</li>\u0000 \u0000 <li>We found no differences in rate of cognitive score change by violence exposure.</li>\u0000 \u0000 <li>Even modest impacts of violence would translate to large population effects.</li>\u0000 \u0000 <li>Gendered experiences warrant additional research in understanding dementia risk.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted proteomic biomarker profiling using NULISA in a cohort enriched with risk for Alzheimer's disease and related dementias","authors":"Ramiro Eduardo Rea Reyes,&nbsp;Rachael E. Wilson,&nbsp;Rebecca E. Langhough,&nbsp;Rachel L. Studer,&nbsp;Erin M. Jonaitis,&nbsp;Julie E. Oomens,&nbsp;Elizabeth M. Planalp,&nbsp;Barbara B. Bendlin,&nbsp;Nathaniel A. Chin,&nbsp;Sanjay Asthana,&nbsp;Henrik Zetterberg,&nbsp;Sterling C. Johnson","doi":"10.1002/alz.70166","DOIUrl":"https://doi.org/10.1002/alz.70166","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; INTRODUCTION&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Targeted proteomic assays may be useful for diagnosing and staging Alzheimer's disease and related dementias (ADRD). We evaluated the performance of a 120-marker central nervous system (CNS) NUcleic acid Linked Immuno-Sandwich Assay (NULISA) panel in samples spanning the Alzheimer's disease (AD) spectrum.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; METHODS&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Cross-sectional plasma samples (&lt;i&gt;n&lt;/i&gt; = 252) were analyzed using NULISAseq CNS panel from Alamar Biosciences. Receiver-operating characteristic (ROC) analyses demonstrated the accuracy from NULISAseq-tau phosphorylated at threonine 217 (pTau217) in detecting amyloid (A) and tau (T) positron emission tomography (PET) positivity. Differentially expressed proteins were identified using volcano plots.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; RESULTS&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;NULISAseq-pTau217 accurately classified A/T PET status with ROC areas under the curve of 0.92/0.86; pTau217 was upregulated in A+, T+, and impaired groups with log&lt;sub&gt;2&lt;/sub&gt;-fold changes of 1.21, 0.57, and 4.63, respectively, compared to A−. Of interest, TAR DNA-binding protein 43 (TDP-43) phosphorylated at serine 409 (pTDP43-409) was also upregulated in the impaired group and correlated with declining hippocampal volume and cognitive trajectories.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; DISCUSSION&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study shows the potential of a targeted proteomics panel for characterizing brain changes pertinent to ADRD. The promising pTDP43-409 findings require further replication.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Highlights&lt;/h3&gt;\u0000 \u0000 &lt;div&gt;\u0000 &lt;ul&gt;\u0000 \u0000 &lt;li&gt;The NULISAseq pTau217 assay was comparable to the Simoa pTau217 assay, both utilizing the ALZpath antibody, in detecting amyloid positron emission tomography (PET) positivity, each with areas under the curve greater than 90%.&lt;/li&gt;\u0000 \u0000 &lt;li&gt;Nineteen proteins were differentially expressed in participants with mild cognitive impairment (MCI) compared to those who were unimpaired. Markers of non-AD proteinopathies such as pTDP43-409, oligomeric alpha-synuclein, and huntingtin (HTT), were among those upregulated in MCI.&lt;/li&gt;\u0000 \u0000 &lt;li&gt;High levels of plasma pTDP43-409 were associated with worsening hippocampal atrophy and cognitive decline, clinical indicators of limbic-predominant age-related TDP-43 encephalopathy (LATE), compared to those with low pTDP43-409.&lt;/li","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}