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Alzheimer's & Dementia最新文献

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Correction to Prevalent stroke, age of its onset, and post‐stroke lifestyle in relation to dementia: A prospective cohort study
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-12-24 DOI: 10.1002/alz.14384
{"title":"Correction to Prevalent stroke, age of its onset, and post‐stroke lifestyle in relation to dementia: A prospective cohort study","authors":"","doi":"10.1002/alz.14384","DOIUrl":"https://doi.org/10.1002/alz.14384","url":null,"abstract":"","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"25 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision diagnosis of cognitive impairment due to Alzheimer's disease for therapeutic interventions
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-12-24 DOI: 10.1002/alz.14043
David S. Knopman
{"title":"Precision diagnosis of cognitive impairment due to Alzheimer's disease for therapeutic interventions","authors":"David S. Knopman","doi":"10.1002/alz.14043","DOIUrl":"https://doi.org/10.1002/alz.14043","url":null,"abstract":"<jats:label/>With the advent of anti‐amyloid monoclonal antibody (AAMA) therapy, precision diagnosis is necessary for identifying appropriate patients with cognitive disorders due to Alzheimer's disease. Therapy with AAMAs requires that candidates be diagnosed with mild cognitive impairment or mild dementia, have elevated brain amyloid‐β, have good physical, psychiatric, and medical health, and lack clinical or biomarker evidence of potentially impactful non‐Alzheimer brain disorders. The first three diagnostic activities are the core of the Clinical Practice Guidelines, but the last element of the precision diagnosis requires new decision‐making tools for recognizing multi‐etiology cognitive impairment. Within the context of shared decision‐making between clinician, patient, and family, proper diagnosis is essential. In addition to discussing the benefits and risks of AAMA therapy, the experienced clinician must empathetically assist in bridging the gap between expectations of benefit and the patient's overall diagnostic suitability for AAMA therapy.Highlights<jats:list list-type=\"bullet\"> <jats:list-item>In order to prescribe an anti‐amyloid monoclonal antibody (AAMA) to the right patients, those selected for treatment should be diagnosed with mild cognitive impairment or mild dementia, have elevated brain amyloid‐β (Aβ), and have good physical, psychiatric, or medical health.</jats:list-item> <jats:list-item>Persons with Alzheimer's biology as the primary etiology are the ideal AAMA treatment recipients. A novel activity necessary to optimize therapeutic response is to exclude persons with clinical or biomarker evidence of alternative contributory brain disorders.</jats:list-item> <jats:list-item>While mild clinical severity and elevated brain amyloid‐β are essential elements for selecting patients for AAMA treatment, clinical judgment is required to weigh the implications of more advanced disease severity, other medical co‐morbidities, and the presence of other contributory neuropathologies.</jats:list-item></jats:list>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"14 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral risk factors and their role in biomarker-based screening for dementia in the community
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-12-24 DOI: 10.1002/alz.14293
Yi-Han Hu, Osorio Meirelles, Eric J. Shiroma, Claudia L. Satizabal, Sudha Seshadri, Russell P. Tracy, Vilmundur Gudnason, Lenore J. Launer
{"title":"Peripheral risk factors and their role in biomarker-based screening for dementia in the community","authors":"Yi-Han Hu, Osorio Meirelles, Eric J. Shiroma, Claudia L. Satizabal, Sudha Seshadri, Russell P. Tracy, Vilmundur Gudnason, Lenore J. Launer","doi":"10.1002/alz.14293","DOIUrl":"https://doi.org/10.1002/alz.14293","url":null,"abstract":"Peripheral risk factors (PRFs) may correlate with dementia plasma biomarkers, potentially reflecting peripheral rather than brain health. This study explores the associations between PRFs and plasma biomarkers glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and total-tau, and their role in predicting future dementia.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"64 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pivotal legislation to renew US commitment to addressing Alzheimer's signed into law
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-12-24 DOI: 10.1002/alz.14446
{"title":"Pivotal legislation to renew US commitment to addressing Alzheimer's signed into law","authors":"","doi":"10.1002/alz.14446","DOIUrl":"https://doi.org/10.1002/alz.14446","url":null,"abstract":"","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"27 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interocular retinal asymmetry and cognitive frailty: A prospective cohort study
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-12-23 DOI: 10.1002/alz.14437
Yung-Sung Lee, Yi-Ting Hsieh, Te-Hsuan Huang, Jeng-Min Chiou, Tao-Chun Peng, Yao-Lin Liu, Jen-Hau Chen, Yen-Ching Chen
{"title":"Interocular retinal asymmetry and cognitive frailty: A prospective cohort study","authors":"Yung-Sung Lee, Yi-Ting Hsieh, Te-Hsuan Huang, Jeng-Min Chiou, Tao-Chun Peng, Yao-Lin Liu, Jen-Hau Chen, Yen-Ching Chen","doi":"10.1002/alz.14437","DOIUrl":"https://doi.org/10.1002/alz.14437","url":null,"abstract":"The retinal nerve fiber layer (RNFL) or ganglion cell–inner plexiform layer (GC-IPL) is associated with cognitive impairment. However, the relationship between retinal asymmetry and cognitive frailty (CF) remains unknown.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"59 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomic signatures of Alzheimer's disease and Lewy body dementias: A comparative analysis
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-12-23 DOI: 10.1002/alz.14375
Anna Canal-Garcia, Rui M. Branca, Paul T. Francis, Clive Ballard, Bengt Winblad, Janne Lehtiö, Per Nilsson, Dag Aarsland, Joana B. Pereira, Erika Bereczki
{"title":"Proteomic signatures of Alzheimer's disease and Lewy body dementias: A comparative analysis","authors":"Anna Canal-Garcia, Rui M. Branca, Paul T. Francis, Clive Ballard, Bengt Winblad, Janne Lehtiö, Per Nilsson, Dag Aarsland, Joana B. Pereira, Erika Bereczki","doi":"10.1002/alz.14375","DOIUrl":"https://doi.org/10.1002/alz.14375","url":null,"abstract":"We aimed to identify unique proteomic signatures of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD).","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"24 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ADNI Private Partners Scientific Board (PPSB) Diversity, Equity, and Inclusion (DE&I) Working Group: A new collaboration that crosses boundaries for industry, academia, and under‐represented patients
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-12-23 DOI: 10.1002/alz.14248
Ruth Croney, Emil Fristed, Donna Masterman, Martine Meyer, Pallavi Sachdev, Aparna Vasanthakumar, Christopher J. Weber, Theresa Devins
{"title":"ADNI Private Partners Scientific Board (PPSB) Diversity, Equity, and Inclusion (DE&I) Working Group: A new collaboration that crosses boundaries for industry, academia, and under‐represented patients","authors":"Ruth Croney, Emil Fristed, Donna Masterman, Martine Meyer, Pallavi Sachdev, Aparna Vasanthakumar, Christopher J. Weber, Theresa Devins","doi":"10.1002/alz.14248","DOIUrl":"https://doi.org/10.1002/alz.14248","url":null,"abstract":"<jats:label/>The Alzheimer's Disease Neuroimaging Initiative (ADNI) Private Partners Scientific Board (PPSB) Diversity, Equity, and Inclusion Working Group (DE&amp;I WG) was established to work with the ADNI3 Diversity Task Force to provide an industry perspective on increasing the representation of diverse participants in ADNI3 and to build precompetitive cross‐industry knowledge in engagement and recruitment of under‐represented participants (URPs). In this article, we review and highlight the role and ongoing activities within the ADNI PPSB DE&amp;I WG and provide a cross‐industry perspective on areas where precompetitive collaboration can improve the inclusiveness in clinical trials, drawing on examples from ADNI4.Highlights<jats:list list-type=\"bullet\"> <jats:list-item>New collaboration crosses boundaries to allow PPSB DE&amp;I WG members to work together in a preproprietary way.</jats:list-item> <jats:list-item>When faced with the same challenges required by FDA combined with a growing prevalence of AD, the DE&amp;I WG has drafted a range of initiatives that may benefit ADNI, AD patients, care partners, and respective companies involved in this work.</jats:list-item> <jats:list-item>In order to address the multifactorial problem of successfully enrolling representative populations in clinical trials, it will “take a village” to bring about sustainable changes.</jats:list-item> </jats:list>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"40 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-12-23 DOI: 10.1002/alz.14448
Juan-Camilo Vargas-Gonzalez, Nico Dimal, Kasey Cortez, Hilary Heuer, Leah K. Forsberg, Brian S. Appleby, Sami Barmada, Andrea Bozoki, David Clark, Yann Cobigo, R. Ryan Darby, Bradford C. Dickerson, Kimiko Domoto-Reilly, Douglas R. Galasko, Daniel H. Geschwind, Nupur Ghoshal, Neill R. Graff-Radford, Ian M. Grant, David Irwin, Ging-Yuek Robin Hsiung, Lawrence S. Honig, Kejal Kantarci, Gabriel C. Léger, Irene Litvan, Ian R. Mackenzie, Joseph C. Masdeu, Mario F. Mendez, Chiadi U. Onyike, Belen Pascual, Peter Pressman, Eliana Marisa Ramos, Erik D. Roberson, Emily Rogalski, Brad F. Boeve, Adam L. Boxer, Howie J. Rosen, Maria Carmela Tartaglia
{"title":"Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia","authors":"Juan-Camilo Vargas-Gonzalez, Nico Dimal, Kasey Cortez, Hilary Heuer, Leah K. Forsberg, Brian S. Appleby, Sami Barmada, Andrea Bozoki, David Clark, Yann Cobigo, R. Ryan Darby, Bradford C. Dickerson, Kimiko Domoto-Reilly, Douglas R. Galasko, Daniel H. Geschwind, Nupur Ghoshal, Neill R. Graff-Radford, Ian M. Grant, David Irwin, Ging-Yuek Robin Hsiung, Lawrence S. Honig, Kejal Kantarci, Gabriel C. Léger, Irene Litvan, Ian R. Mackenzie, Joseph C. Masdeu, Mario F. Mendez, Chiadi U. Onyike, Belen Pascual, Peter Pressman, Eliana Marisa Ramos, Erik D. Roberson, Emily Rogalski, Brad F. Boeve, Adam L. Boxer, Howie J. Rosen, Maria Carmela Tartaglia","doi":"10.1002/alz.14448","DOIUrl":"https://doi.org/10.1002/alz.14448","url":null,"abstract":"Psychotropic medication (PM) use in behavioral-variant frontotemporal dementia (bvFTD) is higher than in other dementias. However, no information exists on whether PM use differs between sporadic and genetic bvFTD.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"111 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuropathological correlates of vulnerability and resilience in the cerebellum in Alzheimer's disease
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-12-23 DOI: 10.1002/alz.14428
Colby L. Samstag, Nicola H. Chapman, Laura E. Gibbons, Julianne Geller, Nicholas Loeb, Siddhant Dharap, Mayumi Yagi, David G. Cook, Kathleen F. Pagulayan, Paul K. Crane, Eric B. Larson, Ellen M. Wijsman, Caitlin S. Latimer, Thomas D. Bird, C. Dirk Keene, Erik S. Carlson
{"title":"Neuropathological correlates of vulnerability and resilience in the cerebellum in Alzheimer's disease","authors":"Colby L. Samstag, Nicola H. Chapman, Laura E. Gibbons, Julianne Geller, Nicholas Loeb, Siddhant Dharap, Mayumi Yagi, David G. Cook, Kathleen F. Pagulayan, Paul K. Crane, Eric B. Larson, Ellen M. Wijsman, Caitlin S. Latimer, Thomas D. Bird, C. Dirk Keene, Erik S. Carlson","doi":"10.1002/alz.14428","DOIUrl":"https://doi.org/10.1002/alz.14428","url":null,"abstract":"We investigated whether the cerebellum develops neuropathology that correlates with well-accepted Alzheimer's disease (AD) neuropathological markers and cognitive status.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"4 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with care-resistant behavior in the National Alzheimer's Coordinating Center's Uniform Data Set
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-12-23 DOI: 10.1002/alz.14451
Reed W. R. Bratches, Tamara Backhouse, Paul J. Barr, Cheryl Lee, Frank Puga, Rita A. Jablonski
{"title":"Factors associated with care-resistant behavior in the National Alzheimer's Coordinating Center's Uniform Data Set","authors":"Reed W. R. Bratches, Tamara Backhouse, Paul J. Barr, Cheryl Lee, Frank Puga, Rita A. Jablonski","doi":"10.1002/alz.14451","DOIUrl":"https://doi.org/10.1002/alz.14451","url":null,"abstract":"Little is known about the factors associated with care-resistant behavior in community-dwelling persons living with dementia.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"83 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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