Alzheimer's & Dementia最新文献

Activities of daily living and their neural correlates across the Alzheimer's disease continuum: Evidence from a Latin American cohort. 日常生活活动及其在阿尔茨海默病连续体中的神经相关性：来自拉丁美洲队列的证据

IF 11.1 1区医学

Alzheimer's & Dementia Pub Date : 2026-05-01 DOI: 10.1002/alz.71445

Fernando Henríquez, Patricio Riquelme, Gonzalo Forno, Joaquín Migeot, Rodrigo Henríquez, Patricia Lillo, Daniela Thumala-Dockendorff, Cecilia Okuma, Cecilia González Campo, Michael Hornberger, Francisco Aboitiz, Andrea Slachevsky

{"title":"Activities of daily living and their neural correlates across the Alzheimer's disease continuum: Evidence from a Latin American cohort.","authors":"Fernando Henríquez, Patricio Riquelme, Gonzalo Forno, Joaquín Migeot, Rodrigo Henríquez, Patricia Lillo, Daniela Thumala-Dockendorff, Cecilia Okuma, Cecilia González Campo, Michael Hornberger, Francisco Aboitiz, Andrea Slachevsky","doi":"10.1002/alz.71445","DOIUrl":"10.1002/alz.71445","url":null,"abstract":"Introduction: Functional decline in activities of daily living (ADL)-advanced (AADL), instrumental (IADL), and basic (BADL)-is a hallmark of Alzheimer's disease (AD). However, integrated clinical-neuroanatomical evidence on progression across the AD continuum remains limited, particularly in Latin American populations.Methods: We studied 138 older adults with subjective cognitive complaints (SCCs), mild cognitive impairment (MCI), and Alzheimer's disease dementia (ADD). ADL domains were assessed using the Technology-Activities of Daily Living Questionnaire. Structural magnetic resonance imaging data were analyzed using voxel-based morphometry (VBM) to identify gray matter (GM) correlates of ADL performance.Results: A hierarchical decline from AADL to IADL to BADL differentiated clinical stages. SCC and MCI differed mainly in AADL performance, whereas ADD showed decline across all domains. VBM revealed GM correlates consistent with this hierarchy, with distinct but partially overlapping substrates for each ADL domain.Discussion: These findings underscore a diagnostically informative and anatomically organized progression of ADL decline.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 5","pages":"e71445"},"PeriodicalIF":11.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging. α-突触核蛋白病理对正常老年人突触功能障碍及临床预后的影响。

IF 11.1 1区医学

Alzheimer's & Dementia Pub Date : 2026-05-01 DOI: 10.1002/alz.71455

Joseph R Winer, Melanie J Plastini, America Romero, Hillary Vossler, Isha Sai, Divya Channappa, Carla Abdelnour, Marian Shahid-Besanti, Edward N Wilson, Hamilton Se-Hwee Oh, Christina B Young, Alexandra Trelle, Maya Yutsis, Sharon J Sha, Veronica Ramirez, Ryan Taylor, Kyan Younes, Tony Wyss-Coray, Michael D Greicius, Victor W Henderson, Anthony D Wagner, Kathleen L Poston, Elizabeth C Mormino

{"title":"Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging.","authors":"Joseph R Winer, Melanie J Plastini, America Romero, Hillary Vossler, Isha Sai, Divya Channappa, Carla Abdelnour, Marian Shahid-Besanti, Edward N Wilson, Hamilton Se-Hwee Oh, Christina B Young, Alexandra Trelle, Maya Yutsis, Sharon J Sha, Veronica Ramirez, Ryan Taylor, Kyan Younes, Tony Wyss-Coray, Michael D Greicius, Victor W Henderson, Anthony D Wagner, Kathleen L Poston, Elizabeth C Mormino","doi":"10.1002/alz.71455","DOIUrl":"10.1002/alz.71455","url":null,"abstract":"Introduction: α-Synuclein is the hallmark pathology of Parkinson's disease and dementia with Lewy bodies, described together as Lewy body disease (LBD). We investigated effects of α-syn biomarker positivity in clinically unimpaired (CU) individuals.Methods: We assessed α-syn status (α-syn ±) in 269 CU individuals using a cerebrospinal fluid (CSF) seed amplification assay (SAA). Fifty-six participants with AD and 85 LBD spectrum participants were included for comparison. We compared α-syn SAA results with demographics, fluid biomarkers, cognitive performance, and clinical measures.Results: α -Syn positivity was detected in 9% of CU individuals, a lower rate than in clinically impaired participants with AD (16%) and LBD diagnoses (81%). Compared to α-syn-, α-syn+ CU individuals were older, showed lower synaptic integrity, performed worse on tests of executive function and working memory, and reported more LBD-related non-motor symptoms.Discussion: Further work is needed to understand the timeline of neural and clinical changes in α-syn+ CU individuals and heterogeneity in disease progression.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 5","pages":"e71455"},"PeriodicalIF":11.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring "third places": Comparing neighborhood data for cognitive health research. 测量“第三位”：比较认知健康研究的邻里数据。

IF 11.1 1区医学

Alzheimer's & Dementia Pub Date : 2026-05-01 DOI: 10.1002/alz.71412

Jessica M Finlay, David Rigby, Amber DeJohn, Yue Sun, Brigette A Davis, Arwa Aldulaimy, Desiree Alvarez-McNelis, Ainsley Bowie, Karis Hawkins, Zhe Lin, Weining Kan, Taylor S Ketterhagen, Xinyu Lin, Stephen B Liwur, Mallory Sagehorn, Laine Sullivan, Lucy Vaughan, Shangrui Zhu, Ania Berry, Margaret T Hicken, Michael H Esposito

{"title":"Measuring \"third places\": Comparing neighborhood data for cognitive health research.","authors":"Jessica M Finlay, David Rigby, Amber DeJohn, Yue Sun, Brigette A Davis, Arwa Aldulaimy, Desiree Alvarez-McNelis, Ainsley Bowie, Karis Hawkins, Zhe Lin, Weining Kan, Taylor S Ketterhagen, Xinyu Lin, Stephen B Liwur, Mallory Sagehorn, Laine Sullivan, Lucy Vaughan, Shangrui Zhu, Ania Berry, Margaret T Hicken, Michael H Esposito","doi":"10.1002/alz.71412","DOIUrl":"10.1002/alz.71412","url":null,"abstract":"Introduction: Neighborhood \"third places\" are increasingly studied as contextual determinants of cognitive health, yet the reliability of geospatial datasets is poorly understood.Methods: We evaluated Advan Research, Data Axle, FourSquare, and the National Establishment Time Series (NETS) across five categories: cafes/coffee shops, civic/social organizations, libraries, performing arts/museums, and recreation centers/gyms. Bayesian multilevel logistic regression models estimated locational accuracy and categorical validity for 13,168 coder ratings of 4876 unique businesses. Qualitative content analysis examined reflections from 18 coders.Results: Advan showed high locational accuracy (≥95%), with Data Axle and FourSquare performing well for most categories and NETS the lowest. Inaccuracies stemmed from outdated or incorrect addresses and non-fixed locations. Advan, Data Axle, and FourSquare performed moderately well for categorization (70% to 97%) and NETS the worst. Misclassification reflected ambiguous purposes, misleading names, and uncertainty around third places.Discussion: Study-specific dataset selection, triangulation, cleaning, error calibration, and clearer third place conceptualization are critical to strengthen neighborhood-based dementia research.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 5","pages":"e71412"},"PeriodicalIF":11.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive reserve and longitudinal changes in brain and cognition in semantic variant primary progressive aphasia. 语义变异原发性进行性失语症的认知储备和脑认知纵向变化。

IF 11.1 1区医学

Alzheimer's & Dementia Pub Date : 2026-05-01 DOI: 10.1002/alz.71440

Lauren A Grebe, Brittany T Morin, Janhavi Pillai, David Paul Galang Baquirin, Buddhika Ratnasiri, Rian Bogley, Zoe Ezzes, Lisa D Wauters, Maria Luisa Mandelli, Zachary A Miller, Boon Lead Tee, Jessica de Leon, Kaitlin B Casaletto, Howard J Rosen, Maria Luisa Gorno Tempini, Elizabeth E Galletta, Mira Goral, Jet M J Vonk

{"title":"Cognitive reserve and longitudinal changes in brain and cognition in semantic variant primary progressive aphasia.","authors":"Lauren A Grebe, Brittany T Morin, Janhavi Pillai, David Paul Galang Baquirin, Buddhika Ratnasiri, Rian Bogley, Zoe Ezzes, Lisa D Wauters, Maria Luisa Mandelli, Zachary A Miller, Boon Lead Tee, Jessica de Leon, Kaitlin B Casaletto, Howard J Rosen, Maria Luisa Gorno Tempini, Elizabeth E Galletta, Mira Goral, Jet M J Vonk","doi":"10.1002/alz.71440","DOIUrl":"10.1002/alz.71440","url":null,"abstract":"Introduction: Cognitive reserve (CR) refers to the brain's ability to maintain cognitive performance despite neurodegeneration. Studying CR in semantic variant primary progressive aphasia (svPPA) may clarify variability in disease progression and identify protective factors.Methods: We examined whether education and occupational attainment-two common CR proxies-moderated relationships between gray matter brain volume and cognitive performance in 58 individuals with svPPA. Multiple linear regression models assessed baseline and longitudinal change across five semantic and non-semantic tasks.Results: Greater brain volume related to better cognitive performance across all tasks. However, CR moderated this relationship only for semantic tasks. At baseline, higher education/occupation was linked to better semantic performance when brain volume was lower. Longitudinally, higher education/occupation was associated with faster decline in semantic performance when brain volume was lower.Discussion: CR influences language performance in svPPA, suggesting its effects are domain-specific and aligned with the progression pattern of this syndrome.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 5","pages":"e71440"},"PeriodicalIF":11.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal amyloid PET usually represents intermediate/high Alzheimer's disease neuropathologic change. 淀粉样蛋白PET异常通常代表中重度阿尔茨海默病的神经病理改变。

IF 11.1 1区医学

Alzheimer's & Dementia Pub Date : 2026-05-01 DOI: 10.1002/alz.71449

Brian J Burkett, Heather J Wiste, Derek R Johnson, Bradley F Boeve, Kejal Kantarci, Ronald C Petersen, David S Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, Val Lowe, Petrice M Cogswell, Jay Pillai, Christopher G Schwarz, Aivi T Nguyen, Melissa E Murray, Dennis W Dickson, Clifford R Jack

{"title":"Abnormal amyloid PET usually represents intermediate/high Alzheimer's disease neuropathologic change.","authors":"Brian J Burkett, Heather J Wiste, Derek R Johnson, Bradley F Boeve, Kejal Kantarci, Ronald C Petersen, David S Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, Val Lowe, Petrice M Cogswell, Jay Pillai, Christopher G Schwarz, Aivi T Nguyen, Melissa E Murray, Dennis W Dickson, Clifford R Jack","doi":"10.1002/alz.71449","DOIUrl":"10.1002/alz.71449","url":null,"abstract":"Introduction: Alzheimer's disease neuropathologic change (ADNC) classification identifies not/low and intermediate/high levels of neuropathology. Our goal was to assess how frequently a positive amyloid positron emission tomography (PET) scan indicates not/low ADNC and whether this autopsy finding can occur >10 years after a positive amyloid PET.Methods: Participants with positive amyloid PET scans were categorized by levels of ADNC at autopsy, grouped by time from initial positive amyloid PET to time of death (<5 years, 5 to <10 years, or 10+ years).Results: Among those with a positive amyloid PET scan, the majority had intermediate/high ADNC at autopsy (234/259, 90%). In the group with 10+ years between a positive amyloid PET and death (n = 39) not/low ADNC occurred in 3/39 (8%).Discussion: Not/low ADNC is uncommon among those with positive amyloid PET scans. After 10+ years, it is possible but rare for a positive amyloid PET scan to represent an indolent state of neuropathology.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 5","pages":"e71449"},"PeriodicalIF":11.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to rethinking Alzheimer's disease susceptibility and heterogeneity. Comment on Miller et al. 对重新思考阿尔茨海默病易感性和异质性的反应。评论米勒等人。

IF 11.1 1区医学

Alzheimer's & Dementia Pub Date : 2026-05-01 DOI: 10.1002/alz.71454

Zachary A Miller, Bruce L Miller, Gil D Rabinovici, Maria Luisa Gorno-Tempini

引用次数: 0

Correlation between in vivo ¹⁸F-flortaucipir PET and whole-brain postmortem histological tau signals in Alzheimer's disease. 体内18F-flortaucipir PET与阿尔茨海默病全脑死后组织学tau信号的相关性

IF 11.1 1区医学

Alzheimer's & Dementia Pub Date : 2026-05-01 DOI: 10.1002/alz.71453

Yishu Chao, Yuheng Chen, Trevor A Chadwick, Theresa M Harrison, Leonardo Iaccarino, Helmut Heinsen, Daniela Ushizima, Duygu Tosun, William J Jagust, Lea T Grinberg

{"title":"Correlation between in vivo 18F-flortaucipir PET and whole-brain postmortem histological tau signals in Alzheimer's disease.","authors":"Yishu Chao, Yuheng Chen, Trevor A Chadwick, Theresa M Harrison, Leonardo Iaccarino, Helmut Heinsen, Daniela Ushizima, Duygu Tosun, William J Jagust, Lea T Grinberg","doi":"10.1002/alz.71453","DOIUrl":"https://doi.org/10.1002/alz.71453","url":null,"abstract":"Introduction: Clinicopathological studies offer crucial interpretations of 18F-flortaucipir (FTP) tau positron emission tomography (PET) signal but are limited by methods. We leveraged whole-brain, quantitative immunohistochemical (IHC) Alzheimer's Disease (AD) tau density maps to comprehensively evaluate the FTP tracer.Methods: We generated IHC maps for three AD-tau antibodies-AT8, AT100, and MC1-using two human brains histologically staged at Braak IV and VI. FTP-PET scans were acquired 6 and 10 weeks prior to death. Using region-wise and voxelwise methods, we correlated FTP-PET with IHC signals.Results: Only AT8 (p-tau Ser202/Thr205; neuronal and neuritic tau pathology) showed a notable correlation with FTP standardized uptake value ratios (SUVRs) in the Braak VI case (Spearman's rank correlation coefficient [rs] = 0.461, p < 0.001). FTP SUVRs failed to capture medial temporal lobe (MTL) tau burden, whereas neocortical regions showed lower IHC burden but more variability in FTP uptake.Discussion: Although FTP signals correlate well with AT8-positive tau in the more advanced case, they underestimate the severity of MTL burden, potentially confounding assessments of tau-targeted therapies.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 5","pages":"e71453"},"PeriodicalIF":11.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disentangling treatment status from disease severity in studies of diabetes and Alzheimer's disease biomarkers. 糖尿病和阿尔茨海默病生物标志物研究中治疗状态与疾病严重程度的分离

IF 11.1 1区医学

Alzheimer's & Dementia Pub Date : 2026-05-01 DOI: 10.1002/alz.71465

Qifei Fu, Xuan Yin, Shifen Xu

引用次数: 0

Designing a communication strategy to promote Alzheimer's disease prevention: The CULTIVAMENTE campaign. 设计一种促进阿尔茨海默病预防的传播策略：culamente运动。

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2026-05-01 DOI: 10.1002/alz.71448

José M Aravena,Hugo Castro,Ronald Poblete,Gillian Saavedra,Rocio Briceño,Waldo Torres,Mayerling Vecchi,Marilú Budinich,Patricio Fuentes,Cecilia Albala,Becca R Levy

{"title":"Designing a communication strategy to promote Alzheimer's disease prevention: The CULTIVAMENTE campaign.","authors":"José M Aravena,Hugo Castro,Ronald Poblete,Gillian Saavedra,Rocio Briceño,Waldo Torres,Mayerling Vecchi,Marilú Budinich,Patricio Fuentes,Cecilia Albala,Becca R Levy","doi":"10.1002/alz.71448","DOIUrl":"https://doi.org/10.1002/alz.71448","url":null,"abstract":"INTRODUCTIONAwareness of Alzheimer's disease (AD) prevention remains limited in community settings, contributing to low adoption of evidence-based recommendations. This study aimed to design a context-tailored communication strategy for older adults and health-care providers.METHODSA three-phase, multi-method study using a design-thinking framework was conducted in senior centers, including qualitative research, contextual observations, and participatory codesign.RESULTSA total of 101 older adults and 54 health-care providers contributed to the development phase. The resulting strategy, CULTIVAMENTE, uses positive aging imagery and nudge-based cues to deliver evidence-based AD prevention messages through posters, brochures, and websites. After implementation, older adults in intervention centers reported increased knowledge of prevention strategies (32.7%-61.4%) and more frequent discussions with health-care providers (9.9%-21.8%). Health-care providers reported high acceptability and use of campaign materials.DISCUSSIONCULTIVAMENTE is a low-intensity and context-tailored approach that was feasible to implement and supported improvements in AD prevention awareness.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"137 1","pages":"e71448"},"PeriodicalIF":14.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Alzheimer's disease subtypes and biomarkers from human multi-omics data using subspace merging algorithm. 利用子空间合并算法从人类多组学数据中识别阿尔茨海默病亚型和生物标志物

IF 11.1 1区医学

Alzheimer's & Dementia Pub Date : 2026-05-01 DOI: 10.1002/alz.71292

Ziyan Song, Xiaoqing Huang, Asha Jacob Jannu, Travis S Johnson, Jie Zhang, Kun Huang

{"title":"Identification of Alzheimer's disease subtypes and biomarkers from human multi-omics data using subspace merging algorithm.","authors":"Ziyan Song, Xiaoqing Huang, Asha Jacob Jannu, Travis S Johnson, Jie Zhang, Kun Huang","doi":"10.1002/alz.71292","DOIUrl":"10.1002/alz.71292","url":null,"abstract":"Introduction: Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment.Methods: We applied a subspace-merging algorithm to integrate multi-omics data from brain tissues of three large AD cohorts and identify data-driven AD subtypes. Within each cohort, we performed multiple analyses to characterize subtype-specific biology. A Phenome-wide Association Study (PheWAS) of expression quantitative trait loci (eQTLs) targeting differentially expressed genes (DEGs) was conducted to link molecular differences to disease phenotypes.Results: We identified AD subtypes that differed in cognitive and pathological phenotypes in three cohorts. Further analyses highlighted synaptic and neurotransmission pathways, and the PheWAS revealed significant associations with disease phenotypes.Discussion: Our developed integration algorithm successfully merged different data modalities into a common subspace for patient clustering and identified data-driven subtypes. The identified transcriptomic signatures provide valuable insights into the molecular mechanisms underlying AD heterogeneity, paving the way for personalized AD treatment.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 5","pages":"e71292"},"PeriodicalIF":11.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0