Examination of metabolic syndrome in Down syndrome and association with dementia

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-10-17 DOI:10.1002/alz.70799

Dina Dass, Lam-Ha T. Dang, Laura Xicota, Sharon Krinsky-McHale, Balaji Kannappan, Adam M. Brickman, Bradley T. Christian, Elizabeth Head, Sid E. O'Bryant, Mark Mapstone, Benjamin Handen, Karen Marder, Joseph H. Lee, Alzheimer Biomarker Consortium – Down syndrome (ABC-DS)

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Abstract

INTRODUCTION

In the neurotypical population, metabolic syndrome (MetS) is associated with Alzheimer's disease (AD). However, this has not been well studied in adults with Down syndrome (DS).

METHODS

The prevalence of MetS and its subcomponents was examined in adults with DS using the Alzheimer Biomarkers Consortium – Down Syndrome data (ABC-DS, N = 389). Logistic regression was used to examine the relationship between MetS and AD at baseline visits.

RESULTS

Prevalence of MetS, diabetes, hypertension, and hyperlipidemia was low with DS, even though the prevalence of obesity was elevated. Obesity was positively associated with AD in adults with DS (odds ratio = 2.79, P = 0.021), but there was no association between MetS and AD in DS.

DISCUSSION

The prevalence of MetS was low in adults with DS. Although MetS was not associated with AD, obesity, a subcomponent of MetS, was associated with AD in adults with DS. This may inform targeted treatments in the future.

Highlights

There was a low prevalence of metabolic syndrome (MetS) in adults with Down syndrome (DS).
Overall MetS was not associated with dementia in adults with DS.
Obesity, a subcomponent of MetS, had a high prevalence in adults with DS.
Obesity was positively associated with dementia in adults with DS.

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唐氏综合征代谢综合征的检查及其与痴呆的关系

在神经典型人群中，代谢综合征（MetS）与阿尔茨海默病（AD）有关。然而，这在患有唐氏综合症（DS）的成人中还没有得到很好的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.