Alzheimer's & Dementia最新文献

{"title":"Mixed methods feasibility study of Music Attuned Technology Care via eHealth (MATCH) for people with complex behavioral and psychological symptoms of dementia within an acute psychogeriatric ward","authors":"Ajay Castelino,&nbsp;Suzanne Dawson,&nbsp;Peixuan Li,&nbsp;Zara Thompson,&nbsp;Jeanette Tamplin,&nbsp;Bec Watt,&nbsp;Jessica Archbold,&nbsp;Karen Elaine Lamb,&nbsp;Sabine Braat,&nbsp;Tanara Vieira Sousa,&nbsp;Felicity Anne Baker","doi":"10.1002/alz.70124","DOIUrl":"https://doi.org/10.1002/alz.70124","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Music-based strategies can reduce distress, agitation, and promote wellbeing in people with dementia. Research in specialized dementia care units is limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>Mixed-methods pre-post study evaluated the feasibility and preliminary effects of Music Attuned Technology Care via eHealth (MATCH) in a dementia-specialized inpatient ward. Staff completed MATCH training and administered MATCH strategies over 8 weeks with enrolled patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Twenty-four staff and 14 patients were recruited. Severity of dementia symptoms, measured by the Neuropsychiatric Inventory Questionnaire, was reduced (median change: −3.0, 95% CI: −9.5, 0.5), especially agitation (median change −3.0, 95% confidence interval −5.5, −0.5). Staff reported high acceptability of MATCH (median score: 13 [interquartile range: 12–14]) and implementing strategies enhanced person-centered care. Patients’ positive responses to music motivated increased use. No changes in staff knowledge or patient depression were found.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>MATCH was acceptable to staff and showed potential to reduce agitation symptoms and medication use, warranting further trials to determine effectiveness.</p>\u0000 \u0000 <p>Clinical trial registration: The clinical trial is registered with the Australia New Zealand Clinical Trials Registry (ACTRN12623001134617).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>MATCH decreased the severity of dementia symptoms, measured by the <i>NPI-Q</i>.</li>\u0000 \u0000 <li>Staff reported high acceptability of MATCH.</li>\u0000 \u0000 <li>Personalized music enhanced person-centered care.</li>\u0000 \u0000 <li>Patients’ positive responses to music motivated increased use.</li>\u0000 \u0000 <li>No changes in staff knowledge or patient depression were found.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological imprint of education and rights-based brain capital","authors":"Agustin Ibanez,&nbsp;Temitope Farombi","doi":"10.1002/alz.70222","DOIUrl":"https://doi.org/10.1002/alz.70222","url":null,"abstract":"<p>Recent findings on the biological embedding of educational disparities in aging and dementia, evidence that access to high-quality education is both a human rights imperative and a critical public health strategy. Education quantity and quality and related factors shape cognitive health and vulnerability to dementia. These factors are particularly salient in low- and middle-income countries, where austerity policies and systemic disparities frequently compromise brain capital. We advocate for a transdisciplinary approach linking education, social justice, and neuroscience within a rights-based framework. Addressing structural determinants through education policy can promote healthy brain aging and reduce inequities.</p><p>TF is supported by an Atlantic Fellowship at the Global Brain Health Institute (GBHI) at Trinity College Dublin. AI is supported by grants from CONICET; ANID/FONDECYT Regular (1210195 and 1210176 and 1220995); ANID/FONDAP/15150012; ANID/PIA/ANILLOS ACT210096; FONDEF ID20I10152, ANID/FONDAP 15150012; Takeda CW2680521 and the MULTI-PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA [ReDLat, supported by Fogarty International Center (FIC), National Institutes of Health, National Institutes of Ageing (AG075775, AG057234, AG082056 and AG083799, CARDS-NIH 75N95022C00031), Alzheimer's Association (SG-20-725707), Rainwater Charitable Foundation – The Bluefield project to cure FTD, and Global Brain Health Institute)]. The views expressed are those of the authors and not necessarily those of the stakeholders. Author disclosures are available in the Supporting Information.</p>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70222","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Dementia Council: Brain health and dementia awareness, Latin America and Caribbean series","authors":"","doi":"10.1002/alz.70272","DOIUrl":"https://doi.org/10.1002/alz.70272","url":null,"abstract":"","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intimate partner violence and cognitive functioning – toward quantifying dementia risk","authors":"Audrey R. Murchland,&nbsp;Sebastien Haneuse,&nbsp;Rebecca B. Lawn,&nbsp;Lisa Berkman,&nbsp;Karen Jakubowski,&nbsp;M. Maria Glymour,&nbsp;Karestan C. Koenen","doi":"10.1002/alz.70029","DOIUrl":"https://doi.org/10.1002/alz.70029","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Intimate partner violence (IPV) victimization is highly common among women and associated with adverse health consequences that may be linked to dementia risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>Nurses’ Health Study II participants (<i>N</i> = 14,771) reported adult (age ≥ 18) emotional, physical, and sexual IPV in 2001/2008 and completed the Cogstate Brief Battery 2014–2019 (4/6 maximum assessments). Any versus no IPV and IPV subtypes were used to predict cognition in confounder-adjusted generalized estimating equation models weighted to account for attrition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Mean age at baseline was 61.0 years (standard deviation = 4.6); 46.5% reported any IPV (42.3% emotional, 22.6% physical, and 11.3% sexual). IPV victimization was associated with 0.029 SD unit (95% confidence interval [CI]: −0.068, 0.009) lower global cognitive score but not rate of cognitive change. Among IPV types, emotional IPV had the strongest association (β = −0.048; 95% CI: −0.075, −0.020) with cognitive scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Gendered social experiences such as IPV may influence dementia risk. Further assessment of IPV in aging cohorts is needed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>IPV predicted lower average cognitive score over follow-up.</li>\u0000 \u0000 <li>Emotional abuse had the largest associations with cognitive score among subtypes.</li>\u0000 \u0000 <li>We found no differences in rate of cognitive score change by violence exposure.</li>\u0000 \u0000 <li>Even modest impacts of violence would translate to large population effects.</li>\u0000 \u0000 <li>Gendered experiences warrant additional research in understanding dementia risk.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted proteomic biomarker profiling using NULISA in a cohort enriched with risk for Alzheimer's disease and related dementias","authors":"Ramiro Eduardo Rea Reyes,&nbsp;Rachael E. Wilson,&nbsp;Rebecca E. Langhough,&nbsp;Rachel L. Studer,&nbsp;Erin M. Jonaitis,&nbsp;Julie E. Oomens,&nbsp;Elizabeth M. Planalp,&nbsp;Barbara B. Bendlin,&nbsp;Nathaniel A. Chin,&nbsp;Sanjay Asthana,&nbsp;Henrik Zetterberg,&nbsp;Sterling C. Johnson","doi":"10.1002/alz.70166","DOIUrl":"https://doi.org/10.1002/alz.70166","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; INTRODUCTION&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Targeted proteomic assays may be useful for diagnosing and staging Alzheimer's disease and related dementias (ADRD). We evaluated the performance of a 120-marker central nervous system (CNS) NUcleic acid Linked Immuno-Sandwich Assay (NULISA) panel in samples spanning the Alzheimer's disease (AD) spectrum.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; METHODS&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Cross-sectional plasma samples (&lt;i&gt;n&lt;/i&gt; = 252) were analyzed using NULISAseq CNS panel from Alamar Biosciences. Receiver-operating characteristic (ROC) analyses demonstrated the accuracy from NULISAseq-tau phosphorylated at threonine 217 (pTau217) in detecting amyloid (A) and tau (T) positron emission tomography (PET) positivity. Differentially expressed proteins were identified using volcano plots.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; RESULTS&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;NULISAseq-pTau217 accurately classified A/T PET status with ROC areas under the curve of 0.92/0.86; pTau217 was upregulated in A+, T+, and impaired groups with log&lt;sub&gt;2&lt;/sub&gt;-fold changes of 1.21, 0.57, and 4.63, respectively, compared to A−. Of interest, TAR DNA-binding protein 43 (TDP-43) phosphorylated at serine 409 (pTDP43-409) was also upregulated in the impaired group and correlated with declining hippocampal volume and cognitive trajectories.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; DISCUSSION&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study shows the potential of a targeted proteomics panel for characterizing brain changes pertinent to ADRD. The promising pTDP43-409 findings require further replication.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Highlights&lt;/h3&gt;\u0000 \u0000 &lt;div&gt;\u0000 &lt;ul&gt;\u0000 \u0000 &lt;li&gt;The NULISAseq pTau217 assay was comparable to the Simoa pTau217 assay, both utilizing the ALZpath antibody, in detecting amyloid positron emission tomography (PET) positivity, each with areas under the curve greater than 90%.&lt;/li&gt;\u0000 \u0000 &lt;li&gt;Nineteen proteins were differentially expressed in participants with mild cognitive impairment (MCI) compared to those who were unimpaired. Markers of non-AD proteinopathies such as pTDP43-409, oligomeric alpha-synuclein, and huntingtin (HTT), were among those upregulated in MCI.&lt;/li&gt;\u0000 \u0000 &lt;li&gt;High levels of plasma pTDP43-409 were associated with worsening hippocampal atrophy and cognitive decline, clinical indicators of limbic-predominant age-related TDP-43 encephalopathy (LATE), compared to those with low pTDP43-409.&lt;/li","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease","authors":"Xu Hou,&nbsp;Michael G. Heckman,&nbsp;Fabienne C. Fiesel,&nbsp;Shunsuke Koga,&nbsp;Alexandra I. Soto-Beasley,&nbsp;Jens O. Watzlawik,&nbsp;Jing Zhao,&nbsp;Rebecca R. Valentino,&nbsp;Patrick W. Johnson,&nbsp;Launia J. White,&nbsp;Zachary S. Quicksall,&nbsp;Joseph S. Reddy,&nbsp;Jose Bras,&nbsp;Rita Guerreiro,&nbsp;Na Zhao,&nbsp;Guojun Bu,&nbsp;Dennis W. Dickson,&nbsp;Owen A. Ross,&nbsp;Wolfdieter Springer","doi":"10.1002/alz.70198","DOIUrl":"https://doi.org/10.1002/alz.70198","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Phosphorylated ubiquitin (p-S65-Ub) is generated during PINK1-PRKN mitophagy as a specific marker of mitochondrial damage. Despite the widespread deposition of p-S65-Ub in aged and diseased human brain, the genetic contribution to its accumulation remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>To identify novel mitophagy regulators, we performed a genome-wide association study using p-S65-Ub level as a quantitative trait in 1012 autopsy-confirmed Lewy body disease (LBD) samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>We identified a significant genome-wide association with p-S65-Ub for rs429358 (<i>apolipoprotein E ε4</i> [<i>APOE</i>4]) and a suggestive association for rs6480922 (<i>ZMIZ1</i>). <i>APOE</i>4 was associated with higher p-S65-Ub levels and greater neuropathological burden. Functional validation in mouse and human induced pluripotent stem cell (iPSC) models confirmed <i>APOE</i>4-mediated mitophagy alterations. Intriguingly, <i>ZMIZ1</i> rs6480922 was associated with lower p-S65-Ub levels, reduced neuropathological load, and increased brain weight, indicating a potential protective role.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Our findings underscore the importance of mitochondrial quality control in LBD pathogenesis and nominate regulators that may contribute to disease risk or resilience.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>p-S65-Ub levels were used as a quantitative marker of mitochondrial damage.</li>\u0000 \u0000 <li>A GWAS identified two genetic variants that modify mitophagy in LBD autopsy brain.</li>\u0000 \u0000 <li><i>APOE</i>4 was associated with increased p-S65-Ub accumulation and neuropathology.</li>\u0000 \u0000 <li><i>APOE</i>4 altered mitophagy via pathology-dependent and pathology-independent mechanisms.</li>\u0000 \u0000 <li><i>ZMIZ1</i> was linked to reduced p-S65-Ub and neuropathology indicative of protection.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Alzheimer's disease blood biomarker stability: Implications for the use of tau/amyloid ratios","authors":"Daniel J. Figdore,&nbsp;Bethany J. Schuder,&nbsp;Susan Ashrafzadeh-Kian,&nbsp;Tina Gronquist,&nbsp;Joshua A. Bornhorst,&nbsp;Alicia Algeciras-Schimnich","doi":"10.1002/alz.70173","DOIUrl":"https://doi.org/10.1002/alz.70173","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>We compare the stability of phosphorylated tau (p-tau)217, amyloid beta (Aβ)42, Aβ40, Aβ42/40, and p-tau217/Aβ42 at different storage temperatures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>Ten ethylenediaminetetraacetic acid–plasma sample aliquots stored at frozen, refrigerated, and ambient temperatures were tested at various timepoints up to 30 days. The mean percent change from baseline was calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Aβ42 and Aβ40 concentrations decreased by &gt;15% after 6 hours at ambient temperature and after 24 hours refrigerated, while p-tau217 remained stable over 72 hours with &lt; 10% deviation from baseline at either storage temperature. The Aβ42/40 ratio remained relatively constant as each analyte concentration decreased concurrently, while the p-tau217/Aβ42 ratio deviated from baseline over time. All biomarkers were stable up to 30 days frozen.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Differences in the stability of Aβ42 and p-tau217 may lead to altered p-tau217/Aβ42 ratio results if samples are not handled properly during the pre-analytical testing phase. Ideally, samples should be frozen promptly and sent to the laboratory frozen.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>Plasma phosphorylated tau (p-tau)217, amyloid beta (Aβ)42, Aβ40, Aβ42/40, and p-tau217/Aβ42 stability was assessed.</li>\u0000 \u0000 <li>P-tau217 was stable, but Aβ42 and Aβ40 started decreasing by 6 hours at ambient temperature.</li>\u0000 \u0000 <li>The analyte stability differences led to falsely increased p-tau217/Aβ42 ratios.</li>\u0000 \u0000 <li>Increases &gt; 15% were seen in p-tau217/Aβ42 after 6 hours at ambient temperature or 24 hours at 4°C.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity changes during midlife link to brain integrity and amyloid burden","authors":"Muge Akinci,&nbsp;Pablo Aguilar-Domínguez,&nbsp;Eleni Palpatzis,&nbsp;Mahnaz Shekari,&nbsp;Marina García-Prat,&nbsp;Carme Deulofeu,&nbsp;Karine Fauria,&nbsp;Judith García-Aymerich,&nbsp;Juan Domingo Gispert,&nbsp;Marc Suárez-Calvet,&nbsp;Oriol Grau-Rivera,&nbsp;Gonzalo Sánchez-Benavides,&nbsp;Eider M. Arenaza-Urquijo,&nbsp;for the ALFA study","doi":"10.1002/alz.70007","DOIUrl":"https://doi.org/10.1002/alz.70007","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Evidence suggests that midlife physical activity may reduce Alzheimer's disease (AD) risk. In at-risk individuals, we investigated midlife physical activity changes in relation to AD-related pathologies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We included 337 cognitively unimpaired adults with baseline and follow-up physical activity evaluations within 4.07 ± 0.84 years. We performed multiple regressions considering follow-up amyloid-PET burden and MRI-based medial temporal lobe cortical thickness as outcomes. Independent variables encompassed changes in adherence to World Health Organization (WHO)-recommended physical activity levels, activity amounts, and sedentary behavior (no activity reported).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Remaining sedentary was associated with lower cortical thickness compared to doing limited physical activity, maintaining adherence, or becoming adherent to WHO recommendations. Becoming adherent to recommendations was linked to lower amyloid burden compared to becoming non-adherent. Increased activity amounts showed a dose-dependent association with lower amyloid burden.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Increasing physical activity and new adherence to WHO recommendations could be key objectives for preventive strategies during midlife.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CLINICAL TRIAL REGISTRATION INFORMATION</h3>\u0000 \u0000 <p>Registered at Clinicaltrials.gov (identifier: NCT02485730).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>Boosting physical activity in midlife may have beneficial effects in preclinical AD.</li>\u0000 \u0000 <li>Physical activity increases relate to lower Aβ burden in a dose-dependent manner.</li>\u0000 \u0000 <li>Remaining sedentary links to lower cortical thickness in AD-vulnerable structures.</li>\u0000 \u0000 <li>New adherence to WHO-recommended physical activity levels may enhance brain health.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 5","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of the EAT-Lancet diet and the Mediterranean diet in relation to neuroimaging biomarkers and cognitive performance","authors":"Jessica Samuelsson,&nbsp;Anna Stubbendorff,&nbsp;Anna Marseglia,&nbsp;Olof Lindberg,&nbsp;Caroline Dartora,&nbsp;Sara Shams,&nbsp;Nira Cedres,&nbsp;Silke Kern,&nbsp;Johan Skoog,&nbsp;Lina Rydén,&nbsp;Eric Westman,&nbsp;Ingmar Skoog","doi":"10.1002/alz.70191","DOIUrl":"https://doi.org/10.1002/alz.70191","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>The impact of the sustainable EAT-Lancet planetary health diet on brain and cognitive health remains unclear. This study compared the impact of the EAT-Lancet diet with the well-established cognitive-beneficial Mediterranean diet (MeDi) in relation to neuroimaging biomarkers and cognitive performance among older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>The study included 615 dementia-free 70-year-olds from the Swedish population-based Gothenburg H70 Birth Cohort study. Dietary adherence was measured with EAT-Lancet diet and MeDi scores. Neuroimaging measures included cortical thickness, hippocampal volume, small vessel disease, and deep learning-derived brain age. Cognitive performance was assessed with a global cognitive composite score.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>In multi-adjusted models, higher adherence to the EAT-Lancet diet was associated with higher total mean cortical thickness, and thicker cortex in Alzheimer's disease-signature regions, while a higher adherence to the MeDi was associated with better cognitive performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>The results indicate the beneficial effects of both the EAT-Lancet and the MeDi on brain health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> HIGHLIGHTS</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>There were no indications of detrimental effects of adhering to the EAT-Lancet diet.</li>\u0000 \u0000 <li>Adhering to the EAT-Lancet planetary health diet was associated with thicker cortex.</li>\u0000 \u0000 <li>Results confirm links between the Mediterranean diet and better cognitive function.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial-temporal interactions between white matter hyperintensities and multiple pathologies across the Alzheimer's disease continuum","authors":"Li Liang,&nbsp;Wei Liu,&nbsp;Youping Zhong,&nbsp;Tengfei Guo,&nbsp;Chenfei Ye,&nbsp;Ting Ma","doi":"10.1002/alz.70098","DOIUrl":"https://doi.org/10.1002/alz.70098","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>The interactive relationships between Alzheimer's disease (AD) and white matter hyperintensities (WMHs) in multiscale brain structural networks still need to be clarified.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>Based on subjects enrolled from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, regional WMHs, amyloid beta (Aβ) accumulation, and microstructural changes detected by diffusion weighted imaging (DWI) in multiscale brain networks were modeled by time-evolving graphs; their interactive relationships were further investigated using Granger causality after constructing pseudo-time subject sequences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>In up to 86% of the extracted pseudo-time subject sequences, Aβ was determined to be the Granger cause of WMHs in the structural connectivity of the inferior longitudinal fasciculus (ILF). Meanwhile WMHs were significantly correlated with microstructural changes measured by reduced fractional anisotropy in the inferior fronto-occipital fasciculus, ILF, and cingulum, which Granger causality pathways detected in 91%, 94%, and 93% of pseudo-time subject sequences, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>These findings provide novel insights for understanding the multiscale space-time interactions between WMHs and AD pathologies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Highlights</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>This study proposed time-evolving graph modeling of heterogeneous disease markers (amyloid beta [Aβ], white matter hyperintensities [WMHs], and microstructural changes of white matter tracts) across the Alzheimer's disease (AD) continuum to investigate their complex interactions in multiscale brain structural networks.</li>\u0000 \u0000 <li>Regional accumulation of Aβ promoted WMH progression in subnetworks connected by the inferior longitudinal fasciculus (ILF).</li>\u0000 \u0000 <li>Regional WMHs were strongly associated with bundle-specific microstructural changes in the ILF, inferior fronto-occipital fasciculus, and cingulum.</li>\u0000 \u0000 <li>These results might provide novel insights for understanding the interactive relationship between cerebral small vessel disease and AD.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}