Alzheimer's & Dementia最新文献

{"title":"Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression.","authors":"Michael C B David,Magdalena A Kolanko,Thomas D Parker,Ramin Nilforooshan,Karl A Zimmerman,Cristina Bonet Olivares,Karen Hoang,Johanna Brandt,Charikleia Triantafyllou,Peter J Lally,Gregory Scott, ,David J Sharp,Paresh A Malhotra","doi":"10.1002/alz.70749","DOIUrl":"https://doi.org/10.1002/alz.70749","url":null,"abstract":"BACKGROUNDThe noradrenergic locus coeruleus (LC) accumulates pathology early in Alzheimer's disease (AD), with LC dysfunction contributing to symptoms and disease progression. We investigated LC and substantia nigra (SN) integrity in healthy controls and AD participants.METHODSNinety-three AD participants and 29 controls underwent neuromelanin magnetic resonance imaging. LC and SN contrast, reflecting nucleus integrity, related to cognitive and neuropsychiatric symptoms, as well as cognitive decline and atrophy rates.RESULTSLC - but not SN - integrity was reduced in AD versus controls (b = -0.39, p = 0.001) and within AD was associated with global cognition (b = 8.53, p = 0.04) and neuropsychiatric symptoms, accounting for SN. An AD subgroup with reduced SN integrity had worse cognition. LC integrity predicted plasma phosphorylated tau protein 217 (b = -0.30, p = 0.03). Lower LC and SN integrities were both related to faster cognitive decline (LC: b = -4.74, p = 0.048; SN: b = -2.27, p = 0.03), accounting for one another.DISCUSSIONCatecholaminergic nucleus integrity plays an important role in AD. Both systems are relevant to cognitive performance and decline. LC, in particular, relates closely to symptoms, pathology, and rate of progression.HIGHLIGHTSIn symptomatic AD, LC integrity reflects cortical AD pathology, measured by pTau217. LC integrity predicts cognitive function in AD, independent of cortical atrophy. LC and SN integrity independently relate to attentional performance. Symptoms of anxiety, depression, and apathy are associated with lower LC integrity. LC and SN relate to cognitive decline rate and left LC predicts atrophy rate.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"11 1","pages":"e70749"},"PeriodicalIF":14.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-caloric intake rescues early symptomatic AD-induced hippocampal neurovascular coupling deficits.","authors":"Dustin Loren V Almanza,Andrea Trevisiol,Margaret M Koletar,Aaron Y Lai,Jessica A Ribeiro,Mary E Hill,Greg J Stanisz,JoAnne McLaurin,Bojana Stefanovic","doi":"10.1002/alz.70708","DOIUrl":"https://doi.org/10.1002/alz.70708","url":null,"abstract":"INTRODUCTIONAlzheimer's disease (AD) involves progressive hippocampal dysfunction and atrophy. Obesity, common in AD patients, is a known dementia risk factor. Studying their interaction is difficult in humans due to AD's slow progression. Experimental AD models comorbid with obesity are needed for translational insights. This study examined the effects of a high-carbohydrate, high-fat (HCHF) diet in 12-month-old TgF344-AD rats.METHODSNontransgenic (nTg) and TgAD rats received CHOW or CHOW and HCHF diet items from 9 to 12 months of age. Hippocampal neurovascular function was assessed using pseudo continuous arterial spin labeling (pCASL)-MRI during forepaw stimulation. Neuronal activity was recorded with Neuropixels probes.RESULTSCHOW-fed TgAD rats showed reduced hippocampal cerebral blood flow (CBF), CBF changes spread, and neuronal power responses to somatosensory stimulation; all of these deficits were improved on the HCHF diet.DISCUSSIONThis approach provides a sensitive, task-free assay of hippocampal neurovascular coupling. The transiently improved neurovascular and electrophysiological metrics in HCHF-fed TgAD rats may be a manifestation of metabolically dysregulated AD brain benefitting from increased metabolite availability.HIGHLIGHTSPseudo-continuous arterial spin labeling (pCASL) magnetic resonance imaging (MRI) -based characterization of hippocampal functional hyperemia. Hippocampal functional hyperemia is attenuated in symptomatic Alzheimer's disease (AD) pathology. A high-carbohydrate, high-fat (HCHF) diet transiently restores hippocampal functional hyperemia in symptomatic AD pathology.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"28 1","pages":"e70708"},"PeriodicalIF":14.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration.","authors":"Guilherme Povala,Bruna Bellaver,Marco Antônio De Bastiani,João Pedro Ferrari-Souza,Cristiano S Aguzzoli,Douglas T Leffa,Pamela C L Ferreira,Firoza Z Lussier,Andreia Rocha,Hussein Zalzale,Carolina Soares,Guilherme Bauer-Negrini,Joseph Therriault,Nesrine Rahmouni,Jenna Stevenson,Stijn Servaes,Cécile Tissot,Bruno Zatt,Thomas K Karikari,Milos D Ikonomovic,Victor L Villemagne,Serge Gauthier,Eduardo R Zimmer,Dana L Tudorascu,Andrea L Benedet,Pedro Rosa-Neto,Tharick A Pascoal","doi":"10.1002/alz.70746","DOIUrl":"https://doi.org/10.1002/alz.70746","url":null,"abstract":"INTRODUCTIONCurrent literature presents conflicting results regarding the impact of neuroinflammation on Alzheimer's disease (AD)-related neurodegeneration. While some studies suggest that neuroinflammation potentiates neurodegeneration, others indicate a protective effect.METHODSWe evaluated 145 individuals with positron emission tomography (PET) for amyloid beta (Aβ), tau, and translocator protein (TSPO), a proxy of neuroinflammation, to test the hypothesis that Aβ and tau are associated with the dual effect of neuroinflammation on neurodegeneration across the AD continuum.RESULTSThe detrimental effects of neuroinflammation on gray matter density occurred in two waves. The first neuroinflammation-related detrimental wave was associated with brain Aβ deposition, while the second was with widespread tau tangle pathology. Furthermore, the concomitant presence of neuroinflammation, Aβ, and tau was associated with faster cognitive decline over 2 years.CONCLUSIONSOur results support a model in which Aβ- and tau-associated neuroinflammation are related to two waves of deleterious effects on AD-related neurodegeneration.HIGHLIGHTSTwo waves of detrimental neuroinflammation effects on brain density associated with Aβ or tau. Aβ associated with deleterious effect of neuroinflammation on brain density in early AD. Tau associated with deleterious effect of neuroinflammation on brain density in late AD. Interactions of Aβ, tau, and neuroinflammation are associated with cognitive decline.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"1 1","pages":"e70746"},"PeriodicalIF":14.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Tenascin-R aggravates Aβ production in the perforant pathway by regulating Nav1.6 activity in APP/PS1 mice\".","authors":"","doi":"10.1002/alz.70759","DOIUrl":"https://doi.org/10.1002/alz.70759","url":null,"abstract":"","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"65 1","pages":"e70759"},"PeriodicalIF":14.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonal hematopoiesis of indeterminate potential and the risk of cognitive impairment in the Women's Health Initiative Memory Study.","authors":"Yasminka A Jakubek, Aaron P Smith, Xiaoyan I Leng, Megan E Hall, Daniel Ezzat, Yash Pershad, Jason M Collins, Md Mesbah Uddin, David W Fardo, Pradeep Natarajan, Alexander G Bick, Jacob O Kitzman, Michael C Honigberg, Kathleen M Hayden, JoAnn E Manson, Siddhartha Jaiswal, Eric A Whitsel, Alexander P Reiner","doi":"10.1002/alz.70737","DOIUrl":"10.1002/alz.70737","url":null,"abstract":"<p><strong>Introduction: </strong>Clonal hematopoiesis of indeterminate potential (CHIP) confers an increased risk of several chronic aging-related diseases. Paradoxically, CHIP was associated with lower risk of dementia in recent studies.</p><p><strong>Methods: </strong>We examined associations between baseline CHIP and incident mild cognitive impairment (MCI) and/or probable dementia in the Women's Health Initiative Memory Study. CHIP was detected using blood-based targeted sequencing. Cox proportional hazards models examined time to onset of cognitive impairment, adjusting for traditional risk factors.</p><p><strong>Results: </strong>Using a conventional variant allele fraction (VAF) threshold of 2%, CHIP was not associated with incident cognitive impairment. The presence of larger CHIP clone (VAF ≥ 8%) was associated with a lower incidence of adjudicated probable dementia (hazard ratio = 0.62 [95% confidence interval = 0.41 to 0.94], p = 0.025), while the association with the composite outcome MCI/probable dementia was weaker and overlapped 1.0.</p><p><strong>Discussion: </strong>The association of CHIP with lower risk of cognitive impairment in postmenopausal women may be dependent on VAF and impairment severity.</p><p><strong>Highlights: </strong>The WHIMS comprises ∼5000 postmenopausal women, followed for up to 25 years. CHIP was associated with reduced risk of adjudicated probable dementia in WHIMS. Large CHIP clones (> 8% VAF), but not small clones (<8% VAF), showed an association. CHIP was not associated with MCI in the WHIMS cohort.</p>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 10","pages":"e70737"},"PeriodicalIF":11.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dementia prevalence in the Wisconsin Longitudinal Study.","authors":"Victoria J Williams,Ralph Trane,Kamil Sicinski,Carol Roan,Kate Lange,Kerryann DiLoreto,Brittani Strait,Anne Fischer,Grete Wichmann,Garrett Wartenweiler,Nicole Cooke,Emma Henning,Sterling C Johnson,Michal Engelman,Pamela Herd,Sanjay Asthana","doi":"10.1002/alz.70714","DOIUrl":"https://doi.org/10.1002/alz.70714","url":null,"abstract":"INTRODUCTIONWhile there is growing appreciation of the importance of sociobiological determinants of dementia, few lifespan cohorts offer well-characterized dementia outcomes to explore these aims. We sought to identify dementia prevalence in the Wisconsin Longitudinal Study (WLS), one of the most comprehensive lifespan cohort studies in the United States. Highlights We found dementia prevalence in the WLS to be 8.9% when this large population-based cohort was sampled at a mean age of 81. Of the identified dementia cases, 79% were clinically determined to be due to a presumed underlying etiology of AD. The targeted multiphased assessment approach used to classify dementia in WLS will be iteratively repeated over time to capture new dementia incidence, complemented by parallel efforts to link WLS with Medicare claims data to identify additional dementia cases among non-respondents or those not selected into the ILIAD sampling frame. Ongoing data collection efforts include in-home blood collection efforts to characterize plasma levels of AD biomarkers in the WLS cohort. When resultant dementia classifications are combined with the robust prospectively collected life course data covering a wide array of socioeconomic, educational, occupational, social, behavioral, and physical health variables, the WLS dataset offers an unparalleled opportunity to investigate the sociobiological determinants of late-life dementia.METHODSUsing a targeted multiphased assessment approach, participants were first screened for dementia risk using a phone-based cognitive assessment. Those scoring below cut-off underwent additional cognitive/medical assessment to determine a consensus-based cognitive diagnosis and suspected underlying etiology.RESULTSCognitive status was determined for 5414 participants, with a dementia prevalence of 8.9% when assessed at a mean age of 81 years.DISCUSSIONThe WLS offers prospectively collected data covering nearly every facet of participant's lives from high school to late life. When combined with newly defined dementia outcomes, the WLS dataset offers a valuable resource to explore full life course determinants of dementia.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"4 1","pages":"e70714"},"PeriodicalIF":14.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in inflammatory markers, mitochondrial function, and synaptic proteins in male and female Alzheimer's disease post mortem brains.","authors":"Alex J T Yang,Ahmad Mohammad,Robert W E Crozier,Lucas Maddalena,Evangelia Tsiani,Adam J MacNeil,Gaynor E Spencer,Aleksandar Necakov,Paula Duarte-Guterman,Jeffery Stuart,Rebecca E K MacPherson","doi":"10.1002/alz.70645","DOIUrl":"https://doi.org/10.1002/alz.70645","url":null,"abstract":"INTRODUCTIONInflammation and mitochondrial impairments are suggested to underlie Alzheimer's disease (AD) development. This study examined whether metabolic, synaptic, and inflammatory markers in AD differed from non-demented brains.METHODSMale and female AD brains were analyzed by immunofluorescence, Western blot, enzyme-linked immunosorbent assay-based cytokine, and mitochondrial respiration analysis.RESULTSAD brains had greater Akt phosphorylation, but only AD males had greater downstream mammalian target of rapamycin phosphorylation. AD females showed lower mitochondrial complex IV respiration. AD brains had greater expression of synaptic markers α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, glutamate receptor 1, and synaptophysin, while AD females had a higher expression ELKS1. Microglial expression was lower in AD gray matter, AD females had higher microglial expression in white matter, while cytokine interleukin 2 content was greater in AD brains.DISCUSSIONMarkers of impaired insulin signaling, impaired mitochondrial function, and greater neuroinflammation were found in AD brains. Female brains had greater differences in metabolic signaling than males and this dysregulation is unique/worse with AD.HIGHLIGHTSNeuroinflammation and metabolic function are worse with Alzheimer's disease (AD). Female brains exhibit more distinct changes in metabolic signaling than males. Female brains have worse metabolic changes with AD. Harmful inflammatory and mitochondrial signaling may promote AD.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"30 1","pages":"e70645"},"PeriodicalIF":14.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cognitive Change Index in the Alzheimer's Disease Research Center setting: Self- and informant-ratings for perceived cognitive decline.","authors":"Yousaf Abughofah,Shannon L Risacher,Frederick W Unverzagt,Martin R Farlow,Liana G Apostolova,Jared R Brosch,David G Clark,Sunu Mathew,Sujuan Gao,Selena Wang,Sophia Wang,Andrew J Saykin","doi":"10.1002/alz.70754","DOIUrl":"https://doi.org/10.1002/alz.70754","url":null,"abstract":"INTRODUCTIONThe Cognitive Change Index (CCI) is a brief questionnaire that assesses self and informant perceptions regarding cognitive function. We examined the ability of the CCI to distinguish between cognitively unimpaired (CU) older adults and those with mild cognitive impairment (MCI) or Alzheimer's disease (AD) dementia.METHODS485 individuals from the Indiana Alzheimer's Disease Research Center (IADRC) and their study partners completed 20-item self and informant versions of the CCI. Receiver operator characteristic (ROC) curves were analyzed to assess differentiation between CU and those with impairment.RESULTSHigh area under the ROC curve (AUC) values were obtained when using the self and informant CCI forms to distinguish CU individuals from those with impairment, with AUC values of 0.803 (95% confidence interval [CI] = 0.761-0.844) and 0.914 (95% CI = 0.886-0.942) for the self and informant forms, respectively.DISCUSSIONThe CCI can serve as a useful screening instrument in the context of a multimodal assessment strategy for MCI and dementia.HIGHLIGHTSNovel research that uses the Cognitive Change Index (CCI) for dementia screening. Our findings suggest that CCI can distinguish those with dementia compared to those without. These findings can be correlated to other screening instruments. Results could see the CCI play a role in early Alzheimer's disease (AD) screening and diagnosis.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"28 1","pages":"e70754"},"PeriodicalIF":14.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of neurodegenerative proteins with brain iron deposition and cognition in cerebral small vessel disease: a quantitative susceptibility mapping and plasma biomarker study","authors":"Yiwen Chen, Meng Li, Jing Li, Pengcheng Liang, Zhenyu Cheng, Na Wang, Xinyue Zhang, Yuanyuan Wang, Nan Zhang, Yena Che, Wenwen Gao, Lingfei Guo, Changhu Liang","doi":"10.1002/alz.70710","DOIUrl":"https://doi.org/10.1002/alz.70710","url":null,"abstract":"INTRODUCTIONCerebral small vessel disease (CSVD) is a common neurological disorder with limited pathology on conventional magnetic resonance imaging. This study uses quantitative susceptibility mapping (QSM) to investigate links among brain iron, plasma neurodegenerative proteins, and cognition in CSVD.METHODSThis study enrolled 319 CSVD patients, grouped into CSVD‐M and CSVD‐S. Plasma proteins were measured in 178 participants, with 80 being followed up after 2 years. QSM‐based voxel‐wise analysis assessed brain iron, CSVD severity, and protein correlations. A cross‐lagged panel model was used to analyze the temporal association between plasma protein levels and brain iron levels.RESULTSIn CSVD‐S, elevated QSM values in the right Rolandic operculum/superior temporal gyrus negatively correlated with plasma Aβ42 and executive function. Aβ42 also negatively correlated with QSM in cortical regions, tied to episodic memory decline. Higher baseline Aβ40 predicted increased QSM in the left putamen at follow‐up.DISCUSSIONPlasma Aβ42 and Aβ40 may drive brain iron deposition and cognitive impairment in CSVD, serving as potential early biomarkers for disease progression.Highlights<jats:list list-type=\"bullet\"> <jats:list-item>QSM reveals brain iron links to Aβ42, cognition in CSVD.</jats:list-item> <jats:list-item>Plasma Aβ42 correlates with iron in motor and frontal areas.</jats:list-item> <jats:list-item>High Aβ40 predicts putamen iron increase in CSVD follow‐up.</jats:list-item> <jats:list-item>Iron deposition is tied to executive, memory deficits in CSVD.</jats:list-item> </jats:list>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"53 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a virtual iSupport Program on carers and people with dementia","authors":"Lily Xiao, Shahid Ullah, Ying Yu, Claudia Meyer, Michael Chapman, Langduo Chen, Kai Ping TAN, Sue McKechnie, Mel Ottaway, Andre Queiroz De Andrade, Julie Ratcliffe, Craig Whitehead, Kam Tran, Yao Wang, Alison Kitson","doi":"10.1002/alz.70747","DOIUrl":"https://doi.org/10.1002/alz.70747","url":null,"abstract":"INTRODUCTIONWe conducted a virtual iSupport Program intervention for carers of people living with dementia (PLWD).METHODSWe applied a pragmatic randomized controlled trial to evaluate a multicomponent program delivered virtually in four organizations (July 2022 to December 2024). The primary outcome was quality of life (QoL) of carers and PLWD at 12 months post‐baseline, and the secondary outcomes were carers’ self‐efficacy, social support, reactions to behavior, PLWD's behavior frequency, hospital admissions, and emergency department presentations.RESULTSOne hundred forty‐nine carers enrolled in the study. The intervention group reported increased mental‐health‐related QoL points of 12.0 (<jats:italic>p</jats:italic> &lt; 0.001), self‐efficacy points of 14.8 to 18.5 (<jats:italic>p</jats:italic> &lt; 0.001), social support points of 0.25 (<jats:italic>p</jats:italic> &lt; 0.028), reduced reactions to behavior points of ‐0.25 (<jats:italic>p</jats:italic> &lt; 0.028), and a 60% lower hospital admission rate (<jats:italic>p</jats:italic> = 0.045) at 12 months compared with the usual care group.DISCUSSIONThe virtual iSupport Program showed benefits for both carers and PLWD in a 12‐month intervention.TRIAL REGISTRATIONAustralia New Zealand Clinical Trials Registry: ACTRN12622000199718.Highlights<jats:list list-type=\"bullet\"> <jats:list-item>A total of 149 dementia carers participated in the virtual iSupport program intervention trial.</jats:list-item> <jats:list-item>The program included skills training, peer support, and access to care services.</jats:list-item> <jats:list-item>The program improved mental health‐related quality of life for carers.</jats:list-item> <jats:list-item>The program improved self‐efficacy, social support, and reduced distress for carers.</jats:list-item> <jats:list-item>The program reduced 60% hospital admission rate for people with dementia.</jats:list-item> </jats:list>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"64 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}