Alzheimer's & Dementia最新文献_第3页

Technology that CARES: Enhancing dementia care through everyday technologies 关爱技术：通过日常技术加强痴呆症护理

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2024-11-07 DOI: 10.1002/alz.14192

Andrew M. Kiselica, Greta E Hermann, Michael K. Scullin, Jared F. Benge

{"title":"Technology that CARES: Enhancing dementia care through everyday technologies","authors":"Andrew M. Kiselica, Greta E Hermann, Michael K. Scullin, Jared F. Benge","doi":"10.1002/alz.14192","DOIUrl":"https://doi.org/10.1002/alz.14192","url":null,"abstract":"“Everyday technologies” have long been suggested as digital tools to improve life for and enhance care of persons with Alzheimer's disease and related dementias (ADRD). Within this realm, there is a need to balance potential drawbacks of technologies with their ability to positively impact patient and care partner centered outcomes. To facilitate this goal, we endeavored to provide a common language and conceptual structure to understand digital technology use in ADRD care. Specifically, we describe the pathways by which researchers might develop and deploy technology, including via Cognitive offloading, Automation, Remote monitoring, Emotional/social support, and Symptom treatment (CARES). In addition, we highlight emerging issues in technology‐based care research and provide relevant caveats regarding application of digital technologies in the real world. This discussion provides a framework to organize science on the application of technologies to ADRD care in the future.Highlights “Everyday technologies” have long been suggested as digital tools to improve life for and enhance care of persons with Alzheimer's disease and related dementias (ADRD). However, the potential benefits of digital technologies must be balanced against their possible drawbacks. We describe the pathways by which researchers might develop and deploy technology that CARES, including via Cognitive offloading, Automation, Remote monitoring, Emotional/social support, and Symptom treatment. This discussion provides a framework to organize science on the application of digital technologies to ADRD care in the future. ","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology 全脑活动及其与脑脊液流动的耦合与 tau 病理学有关

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2024-11-07 DOI: 10.1002/alz.14296

Feng Han, JiaQie Lee, Xi Chen, Jacob Ziontz, Tyler Ward, Susan M. Landau, Suzanne L. Baker, Theresa M. Harrison, William J. Jagust

引用次数: 0

Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project) 在非洲减少痴呆症风险：多国实施多模式战略，促进非洲大脑健康老龄化（非洲-FINGERS 项目）

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2024-11-07 DOI: 10.1002/alz.14344

Chinedu T. Udeh-Momoh, Rachel Maina, Udunna C. Anazodo, Rufus Akinyemi, Lukoye Atwoli, Laura Baker, Darina Bassil, Karen Blackmon, Edna Bosire, Gloria Chemutai, Lucia Crivelli, Laz U. Eze, Agustin Ibanez, Dimitra Kafetsouli, Thomas K. Karikari, Linda Khakali, Manasi Kumar, Imre Lengyel, Celeste A. de Jager Loots, Francesca Mangialasche, Sylvia Mbugua, Zul Merali, Michelle Mielke, Cyprian Mostert, Eunice Muthoni, Olivera Nesic-Taylor, Anthony Ngugi, Samuel Nguku, Adesola Ogunniyi, Adedoyin Ogunyemi, Ozioma C. Okonkwo, Njideka Okubadejo, Robert Perneczky, Tunde Peto, Roselyter M. Riang'a, Mansoor Saleh, Shaheen Sayed, Jasmit Shah, Sheena Shah, Alina Solomon, Thomas Thesen, Dominic Trepel, Valentine Ucheagwu, Victor Valcour, Sheila Waa, Tamlyn Watermeyer, Jennifer Yokoyama, Henrik Zetterberg, Miia Kivipelto

{"title":"Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project)","authors":"Chinedu T. Udeh-Momoh, Rachel Maina, Udunna C. Anazodo, Rufus Akinyemi, Lukoye Atwoli, Laura Baker, Darina Bassil, Karen Blackmon, Edna Bosire, Gloria Chemutai, Lucia Crivelli, Laz U. Eze, Agustin Ibanez, Dimitra Kafetsouli, Thomas K. Karikari, Linda Khakali, Manasi Kumar, Imre Lengyel, Celeste A. de Jager Loots, Francesca Mangialasche, Sylvia Mbugua, Zul Merali, Michelle Mielke, Cyprian Mostert, Eunice Muthoni, Olivera Nesic-Taylor, Anthony Ngugi, Samuel Nguku, Adesola Ogunniyi, Adedoyin Ogunyemi, Ozioma C. Okonkwo, Njideka Okubadejo, Robert Perneczky, Tunde Peto, Roselyter M. Riang'a, Mansoor Saleh, Shaheen Sayed, Jasmit Shah, Sheena Shah, Alina Solomon, Thomas Thesen, Dominic Trepel, Valentine Ucheagwu, Victor Valcour, Sheila Waa, Tamlyn Watermeyer, Jennifer Yokoyama, Henrik Zetterberg, Miia Kivipelto","doi":"10.1002/alz.14344","DOIUrl":"https://doi.org/10.1002/alz.14344","url":null,"abstract":"Dementia prevention in Africa is critically underexplored, despite the continent's high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to implement evidence-based strategies that could significantly reduce future dementia cases and mitigate its economic impact. The multinational Africa-FINGERS program offers an innovative solution, pioneering culturally sensitive, multidomain interventions tailored to the unique challenges of the region. Leveraging insights from landmark global studies such as Worldwide-FINGERS and Alzheimer's Disease Neuroimaging Initiative, the program employs a multideterminant precision prevention framework, grounded in community based systems dynamics. Africa-FINGERS further integrates cutting-edge state-of-the-art multimodal biomarker evaluations tailored to regional contexts, with the goal of advancing brain health and establishing a global standard for dementia prevention. This groundbreaking initiative highlights the potential for scalableand sustainable interventions, thus is poised to transform dementia risk reduction efforts across the continent.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142597081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes SV2A PET 显示认知功能未受损的 APOE ε4/ε4 同源基因携带者海马突触缺失

IF 14 1区医学

Alzheimer's & Dementia Pub Date : 2024-10-30 DOI: 10.1002/alz.14327

Anniina Snellman, Jouni Tuisku, Mikko Koivumäki, Saara Wahlroos, Richard Aarnio, Johan Rajander, Mira Karrasch, Laura L. Ekblad, Juha O. Rinne

引用次数: 0

Neurophysiological biomarkers of Alzheimer's disease: In vivo evaluation of synaptic dysfunction. 阿尔茨海默病的神经生理学生物标志物：突触功能障碍的体内评估

IF 13 1区医学

Alzheimer's & Dementia Pub Date : 2024-10-29 DOI: 10.1002/alz.14341

Francesco Motolese, Raffaele Dubbioso, Federico Ranieri, Vincenzo Di Lazzaro

引用次数: 0

Impact of skilled nursing facility quality on Medicare beneficiaries with dementia: Evidence from vacancies. 专业护理机构质量对老年痴呆症医疗保险受益人的影响：来自空缺职位的证据。

IF 13 1区医学

Alzheimer's & Dementia Pub Date : 2024-10-29 DOI: 10.1002/alz.14251

Cyrus M Kosar, Vincent Mor, Amal N Trivedi, Momotazur Rahman

{"title":"Impact of skilled nursing facility quality on Medicare beneficiaries with dementia: Evidence from vacancies.","authors":"Cyrus M Kosar, Vincent Mor, Amal N Trivedi, Momotazur Rahman","doi":"10.1002/alz.14251","DOIUrl":"10.1002/alz.14251","url":null,"abstract":"Introduction: People living with dementia are less likely to be admitted to high-rated nursing homes than people without dementia, despite their increased care needs. We investigated the effect of admission to nursing homes with higher staffing ratings on adverse outcomes for individuals with and without dementia post-hospitalization.Methods: Among Traditional Medicare beneficiaries discharged to nursing homes between 2011 and 2017, we examined the relationship between facility staffing star-ratings and short-term readmission and mortality using an instrumental variables approach to account for selection bias. The instrumental variables were the number of nearby vacant beds in high-rated facilities.Results: Admission to a higher-rated nursing home lowered post-discharge mortality risk at 90 days and reduced 30- and 90-day readmission. Point estimates were larger for people with dementia.Discussion: Findings underscore the need for enhancing direct care staffing in nursing homes and addressing access disparities, particularly for individuals with dementia who benefit significantly from high-quality care.Highlights: We assessed how admission to nursing homes with higher staffing ratings impacted outcomes for individuals with and without dementia by exploiting variation in local bed vacancies as a source of quasi-random assignment. For both persons with and without dementia, adjusted short-term mortality and readmission rates were lower among those discharged to nursing homes with higher staffing ratings. Effects were larger for persons with dementia, indicating welfare loss from inequitable access to higher-rated nursing homes. Increasing staffing in nursing homes and reducing disparities for persons with dementia is essential for enhancing both equity and value.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A short version of the Everyday Cognition scale can predict clinical progression and cognitive decline. 简版日常认知量表可预测临床进展和认知能力下降。

IF 13 1区医学

Alzheimer's & Dementia Pub Date : 2024-10-29 DOI: 10.1002/alz.14309

Manchumad Manjavong, Adam Diaz, Miriam T Ashford, Anna Aaronson, Melanie J Miller, Jae Myeong Kang, Scott Mackin, Rachana Tank, Michael Weiner, Rachel Nosheny

{"title":"A short version of the Everyday Cognition scale can predict clinical progression and cognitive decline.","authors":"Manchumad Manjavong, Adam Diaz, Miriam T Ashford, Anna Aaronson, Melanie J Miller, Jae Myeong Kang, Scott Mackin, Rachana Tank, Michael Weiner, Rachel Nosheny","doi":"10.1002/alz.14309","DOIUrl":"10.1002/alz.14309","url":null,"abstract":"Background: The Everyday Cognition scale (ECog-39) scores are associated with future cognitive decline. We investigated whether the 12-item ECog (ECog-12), which is being collected in Alzheimer's Disease Neuroimaging Initiative (ADNI)4, can predict progression.Methods: Baseline self (PT)- and study partner (SP)-ECog-12 data were extracted from the 39-item version collected in the ADNI. Weibull analysis examined the relationship between baseline ECog-12 and future clinical progression (change in Clinical Dementia Rating Sum of Boxes [CDR-SB] scores and diagnostic conversion).Results: Higher PT- and SP-ECog-12 scores were associated with faster CDR-SB worsening, with hazard ratios in cognitively unimpaired (CU) 3.34 and 9.61, mild cognitive impairment (MCI) 1.44 and 2.82, and dementia 0.93 and 1.82. They were associated with conversion from CU to MCI 3.01 and 6.24 and MCI to dementia 1.61 and 3.07.Discussion: SP-ECog-12 provided a higher prognostic value for predicting clinical progression, so this can help identify and monitor patients at risk in research and health-care settings.Highlights: The 12-item Everyday Cognition scale (ECog-12) data obtained from both raters increased diagnostic conversion risk from cognitively unimpaired to mild cognitive impairment (MCI) and from MCI to dementia. ECog-12, rated by study partners, was associated with an increased risk of Clinical Dementia Rating Sum of Boxes worsening in all diagnostic groups. Our results provide novel information about the specific scoring outputs and rater types (participant vs. study partner) of ECog-12 that can facilitate screening, prioritization, and longitudinal monitoring of the clinical progression of participants in Alzheimer's Disease Neuroimaging Initiative 4 and other Alzheimer's disease clinical studies, clinical trials, and in health-care settings.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2024 AA criteria for Alzheimer's disease diagnosis: Mainly anchored at Aβ not tau. 2024 AA 阿尔茨海默病诊断标准：主要锚定于 Aβ 而非 tau。

IF 13 1区医学

Alzheimer's & Dementia Pub Date : 2024-10-29 DOI: 10.1002/alz.14340

Alexis Moscoso, Nicolas Villain

引用次数: 0

Retrosplenial hypometabolism precedes the conversion from mild cognitive impairment to Alzheimer's disease. 从轻度认知障碍转变为阿尔茨海默氏症之前，脾后叶代谢功能减退。

IF 13 1区医学

Alzheimer's & Dementia Pub Date : 2024-10-29 DOI: 10.1002/alz.14258

Dylan J Terstege, Liisa A M Galea, Jonathan R Epp

{"title":"Retrosplenial hypometabolism precedes the conversion from mild cognitive impairment to Alzheimer's disease.","authors":"Dylan J Terstege, Liisa A M Galea, Jonathan R Epp","doi":"10.1002/alz.14258","DOIUrl":"10.1002/alz.14258","url":null,"abstract":"Introduction: Not all individuals who experience mild cognitive impairment (MCI) transition through progressive stages of cognitive decline at the same rate, if at all. Previous observational studies have identified the retrosplenial cortex (RSC) as an early site of hypometabolism in MCI which seems to be predictive of later transition to Alzheimer's disease (AD).Methods: We examined N = 399 MCI subjects with baseline 18F-fluorodeoxyglucose positron emission tomography. Subjects were classified based on whether their diagnosis converted from MCI to AD.Results: Whole-brain metabolism was decreased in converters (MCI-AD). This effect was more prominent at the RSC, where MCI-AD subjects showed even greater hypometabolism. Observations of RSC hypometabolism and its utility in predicting transition from MCI-AD withstood statistical analyses in a large retrospective study.Discussion: These results point to the utility of incorporating RSC hypometabolism into predictive models of AD progression risk and call for further examination of mechanisms underlying this relationship.Highlights: Not all individuals who develop MCI will progress to AD. Individuals with MCI who progress to AD show early whole-brain hypometabolism. Early hypometabolism is particularly prominent at the RSC.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Latent change-on-change between amyloid accumulation and cognitive decline. 淀粉样蛋白积累与认知能力下降之间的潜伏变化。

IF 13 1区医学

Alzheimer's & Dementia Pub Date : 2024-10-29 DOI: 10.1002/alz.14326

Hannah M Klinger, Brian C Healy, Bernard J Hanseeuw, Rich N Jones, Rory Boyle, Diana L Townsend, Michael J Properzi, Gillian T Coughlan, Mabel Seto, Colin Birkenbihl, Michelle E Farrell, Kathryn V Papp, Jasmeer P Chhatwal, Hyun-Sik Yang, Aaron P Schultz, Rebecca E Amariglio, Heidi I L Jacobs, Julie C Price, Keith A Johnson, Dorene M Rentz, Reisa A Sperling, Rachel F Buckley

{"title":"Latent change-on-change between amyloid accumulation and cognitive decline.","authors":"Hannah M Klinger, Brian C Healy, Bernard J Hanseeuw, Rich N Jones, Rory Boyle, Diana L Townsend, Michael J Properzi, Gillian T Coughlan, Mabel Seto, Colin Birkenbihl, Michelle E Farrell, Kathryn V Papp, Jasmeer P Chhatwal, Hyun-Sik Yang, Aaron P Schultz, Rebecca E Amariglio, Heidi I L Jacobs, Julie C Price, Keith A Johnson, Dorene M Rentz, Reisa A Sperling, Rachel F Buckley","doi":"10.1002/alz.14326","DOIUrl":"10.1002/alz.14326","url":null,"abstract":"Introduction: While the influence of cross-sectional β-amyloid (Aβ) on longitudinal changes in cognition is well established, longitudinal change-on-change between Aβ and cognition is less explored.Methods: A series of bivariate latent change score models (LCSM) examined the relationship between changes in 11C-Pittsburgh Compound-B (PiB) positron emission tomography (PET) and the Preclinical Alzheimer's Cognitive Composite-5 (PACC-5) while adjusting for covariates, including cross-sectional medial temporal lobe (MTL) tau-PET burden. We selected 352 clinically normal older participants with up to 9 years of PiB-PET and PACC-5 data from the Harvard Aging Brain Study (HABS).Results: Aβ accumulation was associated with subsequent cognitive decline beyond the effects of cross-sectional Aβ burden. Within this model including covariates such as age, sex, and apolipoprotein ε4 (APOEε4) status, we found no evidence supporting previously published associations between cross-sectional tau-PET and cognitive intercept/slope.Discussion: Short-term Aβ changes are significantly associated with cognitive decline in clinically normal older adults and may eclipse the effect of cross-sectional Aβ and MTL tau.Highlights: Aβ accumulation is associated with subsequent cognitive decline. High Aβ burden is not the sole metric signaling impending cognitive decline. Contrary to prior work, MTL tau-PET and cognition were not associated in our models. Models of bivariate latent Aβ and cognitive change may eclipse the effects of MTL tau.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0