Renée C. Groechel, Albert C. Liu, Pamela L. Lutsey, Priya Palta, Anna M. Kucharska-Newton, Silvia Koton, A. Richey Sharrett, Alden L. Gross, Keenan A. Walker, Rebecca F. Gottesman
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Abstract
INTRODUCTION
This study aimed to assess whether mid-life social relationships are associated with a lower risk of late-life dementia.
METHODS
Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (Visit 2;1990–1992). A composite measure, “social relationships,” was generated. Incident dementia cases were identified following Visit 2 through 2019, using ongoing surveillance. Associations between mid-life social relationships and incident dementia were evaluated with Cox proportional-hazard regression models. Formal interaction tests examined whether sex or race modified this association.
RESULTS
Among 13,070 participants without dementia, those with strong social relationships in mid-life had a lower risk for developing dementia, compared to participants with poor mid-life social relationships. Neither sex nor race significantly modified this association.
DISCUSSION
Stronger mid-life social relationships may have a potentially protective effect on dementia risk. Future studies evaluating psychosocial health at multiple time points in ethnically diverse populations are needed.
Highlights
Psychosocial health is a modifiable risk factor for dementia.
Stronger mid-life social relationships are associated with a lower risk of dementia.
Social relationships may have a potentially protective effect on late-life outcomes.
This study leveraged data collected from nearly 20 years of follow-up in 13,070 participants.
Longitudinal data used in this study were captured in a population that is 24% Black.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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