Susanna Lopez, Harald Hampel, Claudio Del Percio, Giuseppe Noce, Roberta Lizio, Stefan J. Teipel, Martin Dyrba, Gabriel González-Escamilla, Hovagim Bakardjian, Patrizia Andrea Chiesa, Enrica Cavedo, Andrea Vergallo, Pablo Lemercier, Giuseppe Spinelli, Michel J. Grothe, Marie-Claude Potier, Fabrizio Stocchi, Chiara Coletti, Raffaele Ferri, Matteo Pardini, Marie-Odile Habert, Simone Marziali, Bruno Dubois, Claudio Babiloni, and INSIGHT-preAD study group
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Grothe, Marie-Claude Potier, Fabrizio Stocchi, Chiara Coletti, Raffaele Ferri, Matteo Pardini, Marie-Odile Habert, Simone Marziali, Bruno Dubois, Claudio Babiloni, and INSIGHT-preAD study group","doi":"10.1002/alz.70438","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>We investigated whether older adults with subjective memory complaints (SMC) and amyloid-β accumulation may show clinical progression over 2 years, as measured by resting-state electroencephalographic (rsEEG), structural magnetic resonance imaging (sMRI), and cognitive variables, depending on educational attainment.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>We analyzed these markers in 84 SMC participants from INSIGHT-Pre-AD study, grouped by amyloid-β deposition (<sup>18</sup>F-florbetapir positron emission tomography) and educational attainment.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>In amyloid-negative individuals, higher educational attainment was linked to greater posterior rsEEG alpha activity, possibly reflecting neuroprotective effects. Conversely, amyloid-positive individuals with higher educational attainment showed reduced posterior rsEEG alpha rhythms and lower parietal cortical thickness, potentially indicating compensatory mechanisms counteracting early amyloidosis and neurodegeneration. No longitudinal changes were found in either group over 2 years.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Education had a stable influence on rsEEG, sMRI, and cognitive markers over 2 years in SMC individuals. Longer follow-up periods should be used to monitor brain status with those markers.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Education, subjective memory complaint (SMC), and brain amyloid-β deposition.</li>\n \n <li>Stable influence of education on resting-state electroencephalographic (rsEEG), structural magnetic resonance imaging (sMRI), and cognitive markers over 2 years.</li>\n \n <li>Compensatory mechanism of education against early amyloidosis and neurodegeneration.</li>\n \n <li>Longer follow-up periods to monitor brain status in SMC older adults with those markers.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 7","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70438","citationCount":"0","resultStr":"{\"title\":\"Educational attainment, electroencephalographic rhythms, cortical structure, and cognitive performance over 2 years in older adults with subjective memory complaints and brain amyloidosis\",\"authors\":\"Susanna Lopez, Harald Hampel, Claudio Del Percio, Giuseppe Noce, Roberta Lizio, Stefan J. Teipel, Martin Dyrba, Gabriel González-Escamilla, Hovagim Bakardjian, Patrizia Andrea Chiesa, Enrica Cavedo, Andrea Vergallo, Pablo Lemercier, Giuseppe Spinelli, Michel J. Grothe, Marie-Claude Potier, Fabrizio Stocchi, Chiara Coletti, Raffaele Ferri, Matteo Pardini, Marie-Odile Habert, Simone Marziali, Bruno Dubois, Claudio Babiloni, and INSIGHT-preAD study group\",\"doi\":\"10.1002/alz.70438\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>We investigated whether older adults with subjective memory complaints (SMC) and amyloid-β accumulation may show clinical progression over 2 years, as measured by resting-state electroencephalographic (rsEEG), structural magnetic resonance imaging (sMRI), and cognitive variables, depending on educational attainment.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>We analyzed these markers in 84 SMC participants from INSIGHT-Pre-AD study, grouped by amyloid-β deposition (<sup>18</sup>F-florbetapir positron emission tomography) and educational attainment.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>In amyloid-negative individuals, higher educational attainment was linked to greater posterior rsEEG alpha activity, possibly reflecting neuroprotective effects. 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Educational attainment, electroencephalographic rhythms, cortical structure, and cognitive performance over 2 years in older adults with subjective memory complaints and brain amyloidosis
INTRODUCTION
We investigated whether older adults with subjective memory complaints (SMC) and amyloid-β accumulation may show clinical progression over 2 years, as measured by resting-state electroencephalographic (rsEEG), structural magnetic resonance imaging (sMRI), and cognitive variables, depending on educational attainment.
METHODS
We analyzed these markers in 84 SMC participants from INSIGHT-Pre-AD study, grouped by amyloid-β deposition (18F-florbetapir positron emission tomography) and educational attainment.
RESULTS
In amyloid-negative individuals, higher educational attainment was linked to greater posterior rsEEG alpha activity, possibly reflecting neuroprotective effects. Conversely, amyloid-positive individuals with higher educational attainment showed reduced posterior rsEEG alpha rhythms and lower parietal cortical thickness, potentially indicating compensatory mechanisms counteracting early amyloidosis and neurodegeneration. No longitudinal changes were found in either group over 2 years.
DISCUSSION
Education had a stable influence on rsEEG, sMRI, and cognitive markers over 2 years in SMC individuals. Longer follow-up periods should be used to monitor brain status with those markers.
Highlights
Education, subjective memory complaint (SMC), and brain amyloid-β deposition.
Stable influence of education on resting-state electroencephalographic (rsEEG), structural magnetic resonance imaging (sMRI), and cognitive markers over 2 years.
Compensatory mechanism of education against early amyloidosis and neurodegeneration.
Longer follow-up periods to monitor brain status in SMC older adults with those markers.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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