Impact of kidney function on biomarkers of neurodegeneration, white matter hyperintensities, and cognition in older adults

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-10-14 DOI:10.1002/alz.70397

Anisa Dhana, Charles S. DeCarli, Klodian Dhana, Pankaja Desai, Kristin Krueger, Kyle Dennis, Ted K. S. Ng, Denis Evans, Kumar B. Rajan

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引用次数: 0

Abstract

BACKGROUND

We evaluated the association between kidney function, neurodegenerative biomarkers (i.e., neurofilament light chain [NfL], total tau [t-tau], and glial fibrillary acidic protein [GFAP]), white matter hyperintensities, and global cognition.

METHODS

The study consisted of 1207 participants living on the south side of Chicago, Illinois, enrolled in the Chicago Health and Aging Project, a population-based cohort since 1993. Kidney function was assessed using the estimated glomerular filtration rate (eGFRcr), calculated according to the 2021 Chronic Kidney Disease Epidemiology (CKD-EPI) based on age, sex, and serum creatinine levels.

RESULTS

In a multivariable-adjusted model, lower levels of eGFRcr were associated with higher levels of biomarkers of neurodegeneration. Specifically, for a 1-SD decrease of eGFRcr, there was a 22% increase in NfL levels in serum. eGFRcr levels were not associated with white matter hyperintensities or global cognition.

DISCUSSION

Kidney function may be considered when interpreting NfL, GFAP, and t-tau levels for risk stratification in research and clinical applications.

Highlights

Kidney function is associated with higher neurfilament light chain (NfL), total tau (t-tau), and glial fibrillary acidic protein (GFAP) serum concentrations, while there was no association with white matter hyperintensities or global cognition.
Individuals with severely impaired kidney function had 146.7% higher serum concentrations of NfL when compared to people with normal kidney function.
This study suggests assessing kidney function in older adults when interpreting NfL, GFAP, and t-tau levels in the serum for risk stratification.

Abstract Image

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肾功能对老年人神经退行性变、白质高信号和认知的生物标志物的影响

我们评估了肾功能、神经退行性生物标志物（即神经丝轻链[NfL]、总tau [t‐tau]和胶质纤维酸性蛋白[GFAP]）、白质高信号和全局认知之间的关系。方法：该研究包括1207名生活在伊利诺伊州芝加哥市南部的参与者，他们加入了芝加哥健康与老龄化项目，这是一个自1993年以来以人口为基础的队列。根据2021年慢性肾脏疾病流行病学（CKD‐EPI）基于年龄、性别和血清肌酐水平计算的肾小球滤过率（eGFRcr）评估肾功能。结果在多变量调整模型中，eGFRcr水平较低与神经变性生物标志物水平较高相关。具体来说，eGFRcr降低1‐SD，血清中NfL水平增加22%。eGFRcr水平与白质高信号或整体认知无关。在研究和临床应用中，在解释NfL、GFAP和t - tau水平进行风险分层时，可以考虑肾功能。肾功能与较高的神经丝轻链（NfL）、总tau （t - tau）和胶质纤维酸性蛋白（GFAP）血清浓度有关，而与白质高信号或全局认知无关。与肾功能正常的人相比，肾功能严重受损的人血清NfL浓度高146.7%。该研究建议在解释血清中NfL、GFAP和t - tau水平时评估老年人的肾功能，以进行风险分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.