Liset de Boer, Lize C. Jiskoot, Harro Seelaar, John C. van Swieten, Agustin Ibanez, Marcelo Maito, Sol Fittipaldi, Julie F. H. De Houwer, Tine Swartenbroekx, Pam A. Boesjes, Rhian S. Convery, Eve Ferry-Bolder, Phoebe Foster, Arabella Bouzigues, Lucy Chisman-Russell, Esther van den Berg, Janne Papma, Sanne Franzen, Renelle Bourdage, James B. Rowe, Barbara Borroni, Daniela Galimberti, Pietro Tiraboschi, Mario Masellis, Elizabeth Finger, Robert Laforce, Caroline Graff, Alexander Gerhard, Raquel Sanchez-Valle, Alexandre Mendonça, Fermin Moreno, Matthis Synofzik, Rik Vandenberghe, Simon Ducharme, Isabelle Le Ber, Johannes Levin, Thibaud Lebouvier, Benedetta Nacmias, Markus Otto, Christopher R. Butler, Isabel Santana, Maxime Bertoux, M. Carmela Tartaglia, Jonathan D. Rohrer, Jackie M. Poos, the GENFI Consortium
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Poos, the GENFI Consortium","doi":"10.1002/alz.70741","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>We investigated international differences in facial emotion recognition (FER) across stages of frontotemporal dementia (FTD). Previous studies may have missed early decline by combining data and masking variations in FER across countries.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>An FER test was administered to 159 individuals with behavioral variant FTD, 521 presymptomatic pathogenic variant carriers, and 583 controls from 16 countries of residence. Linear mixed models assessed age, sex, education, and country effects on FER. Voxel-based morphometry examined neural correlates across countries.</p>\n </section>\n \n <section>\n \n <h3> REULTS</h3>\n \n <p>Country accounted for 18%–18.3% of FER variance in presymptomatic carriers and controls and 9.9% in individuals with behavioral variant of FTD (bvFTD). Cross-country differences interacted with the effects of sex, age, and education. Neural correlates involving the frontal lobe and basal ganglia were identified in individuals with bvFTD, but no cross-country differences were found.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>These results underscore the need for culturally sensitive FER tools in research and clinical practice, especially as global multinational clinical trials emerge.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Performance on a test for facial emotion recognition (FER) varies between countries.</li>\n \n <li>The percentage of variance is lower in the behavioral variant of frontotemporal dementia (bvFTD) compared to presymptomatic pathogenic variant carriers and healthy controls.</li>\n \n <li>Cross-country differences interacted with the effects of sex, age, and education.</li>\n \n <li>There were no differences in brain correlates of FER across countries.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 10","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519523/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cross-country variance in facial emotion recognition in presymptomatic and symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia\",\"authors\":\"Liset de Boer, Lize C. 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Cross-country variance in facial emotion recognition in presymptomatic and symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia
INTRODUCTION
We investigated international differences in facial emotion recognition (FER) across stages of frontotemporal dementia (FTD). Previous studies may have missed early decline by combining data and masking variations in FER across countries.
METHODS
An FER test was administered to 159 individuals with behavioral variant FTD, 521 presymptomatic pathogenic variant carriers, and 583 controls from 16 countries of residence. Linear mixed models assessed age, sex, education, and country effects on FER. Voxel-based morphometry examined neural correlates across countries.
REULTS
Country accounted for 18%–18.3% of FER variance in presymptomatic carriers and controls and 9.9% in individuals with behavioral variant of FTD (bvFTD). Cross-country differences interacted with the effects of sex, age, and education. Neural correlates involving the frontal lobe and basal ganglia were identified in individuals with bvFTD, but no cross-country differences were found.
DISCUSSION
These results underscore the need for culturally sensitive FER tools in research and clinical practice, especially as global multinational clinical trials emerge.
Highlights
Performance on a test for facial emotion recognition (FER) varies between countries.
The percentage of variance is lower in the behavioral variant of frontotemporal dementia (bvFTD) compared to presymptomatic pathogenic variant carriers and healthy controls.
Cross-country differences interacted with the effects of sex, age, and education.
There were no differences in brain correlates of FER across countries.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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