Everyday functioning in young onset dementia: differences between diagnostic groups

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-09-24 DOI:10.1002/alz.70711

Emma Weltings, Merel C. Postema, Maureen van Dam, Mark A. Dubbelman, Mukrabe E. Tewolde, Flora H. Duits, Afina W. Lemstra, The LEADS consortium, Bradford C. Dickerson, Maria C. Carrillo, Gil D. Rabinovici, Dustin B. Hammers, Wiesje M. Van der Flier, Liana G. Apostolova, Yolande A. L. Pijnenburg, Sietske A. M. Sikkes

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引用次数: 0

Abstract

BACKGROUND

The aim of this study was to examine differences in Instrumental Activities of Daily Living (IADL) among young-onset dementia (YOD) diagnoses.

METHODS

Participants were included from Amsterdam Dementia and Longitudinal Early-Onset Alzheimer's Disease (LEADS) cohorts, with diagnoses of typical Alzheimer's disease (AD), behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA), posterior cortical atrophy (PCA), or dementia with Lewy bodies (DLB) established in multidisciplinary meetings. We compared overall IADL scores and item level scores between groups using multiple regression analyses, adjusted for cohort, demographics, and disease severity.

RESULTS

We included 582 YOD patients (58.4 ± 4.2 years; 59%F), with overall moderate IADL problems (47.5 ± 8.57). DLB patients showed the most IADL difficulties (41.8 ± 7.8) compared to PCA, typical AD, bvFTD, and PPA (adjusted β range 4.62 to 14.14, all p < 0.01), whereas PPA patients showed the least IADL difficulties (55.8 ± 9.83), with item-specific differences.

CONCLUSION

We found differences in everyday functioning between YOD types. Understanding IADL in YOD types will assist in care planning.

Highlights

Patients with DLB showed the most IADL difficulties compared to PCA, typical AD, bvFTD, and PPA
Patients with PPA showed the least IADL difficulties compared to DLB, PCA, typical AD, and bvFTD
We identified diagnostic group-specific activity challenges. While ‘working’ was among the most commonly impaired activities across al groups, distinct functional challenges emerged per diagnosis: for example, DLB had high impairment in financial tasks, PCA patients in visual-spatial tasks, and bvFTD with planning and organizational activities (e.g. making appointments).

Abstract Image

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年轻痴呆患者的日常功能：诊断组之间的差异。

背景：本研究的目的是检查年轻发病痴呆（YOD）诊断中日常生活工具活动（IADL）的差异。方法：参与者来自阿姆斯特丹痴呆和纵向早发性阿尔茨海默病（LEADS）队列，诊断为典型阿尔茨海默病（AD）、行为变异性额颞叶痴呆（bvFTD）、原发性进行性失语（PPA）、后皮质萎缩（PCA）或路易体痴呆（DLB）。我们使用多元回归分析比较各组间总体IADL评分和项目水平评分，并根据队列、人口统计学和疾病严重程度进行调整。结果：我们纳入582例YOD患者（58.4±4.2岁；59%F），总体中度IADL问题（47.5±8.57）。与PCA、典型AD、bvFTD和PPA相比，DLB患者表现出最多的IADL困难（41.8±7.8）（调整后的β范围为4.62至14.14，均为p）。了解YOD类型的IADL有助于制定护理计划。重点：与PCA、典型AD、bvFTD和PPA相比，DLB患者表现出最多的IADL困难。与DLB、PCA、典型AD和bvFTD相比，PPA患者表现出最少的IADL困难。虽然“工作”是所有群体中最常见的受损活动之一，但每个诊断都出现了不同的功能挑战：例如，DLB患者在财务任务中受损严重，PCA患者在视觉空间任务中受损严重，而bvFTD患者在计划和组织活动（例如预约）方面受损严重。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.