阿尔茨海默病协会发布了首个基于血液的生物标志物测试临床实践指南

IF 11.1 1区 医学 Q1 CLINICAL NEUROLOGY
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Adoption of these recommendations will lead to quicker, more accessible, more accurate diagnoses — and better outcomes for individuals and families affected by Alzheimer's.”</p><p>The guideline cautions that there is significant variability in diagnostic test accuracy and many commercially available BBM tests do not meet these thresholds.</p><p>“Not all BBM tests have been validated to the same standard or tested broadly across patient populations and clinical settings, yet patients and clinicians may assume these tests are interchangeable; they are not,” said Rebecca M. Edelmayer, PhD, Alzheimer's Association vice president of scientific engagement and a co-author of the guideline. “This guideline helps clinicians apply these tools responsibly, avoid overuse or inappropriate use, and ensure that patients have access to the latest scientific advancements.”</p><p>Compared to standard-of-care PET imaging and CSF tests, BBM tests are typically less costly, more accessible, and more acceptable to patients. The guideline emphasizes that BBM tests do not substitute for a comprehensive clinical evaluation by a health care professional, and should be ordered and interpreted by a health care professional in the context of clinical care.</p><p>This is the first evidence-based guideline in the Alzheimer's space that uses Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The use of GRADE ensures a transparent, structured, and evidence-based process for evaluating the certainty of evidence and formulating recommendations. This strengthens the credibility and reproducibility of the guideline and allows for explicit linkage between evidence and recommendations.</p><p>This guideline's primary audience is specialists involved in the diagnostic evaluation of cognitive impairment in specialized care settings. A specialist is defined as a health care provider, typically in neurology, psychiatry, or geriatrics, who cares for adults with cognitive impairment or dementia. It also applies to primary care providers, nurse practitioners, and physician assistants in specialized care settings.</p><p>A panel of 11 clinicians convened by the Alzheimer's Association — including clinical neurologists, geriatricians, nurse practitioners, physician assistants, and subject-matter experts — conducted a systematic review and formulated evidence-based recommendations for using BBM tests in individuals with objective cognitive impairment, including those with mild cognitive impairment (MCI) or dementia. Final recommendations were informed by public comments and input from the Association's National Early-Stage Advisory Group, which includes people living with early-stage Alzheimer's.</p><p>For this initial iteration of the guideline, the BBMs included plasma phosphorylated-tau (p-tau) and amyloid-beta (Aβ) tests measuring the following analytes: p-tau217, ratio of p-tau217 to non-p-tau217 ×100 (%p-tau217), p-tau181, p-tau231, and ratio of Aβ42 to Aβ40. The various BBM tests measure abnormal forms of either amyloid beta or tau protein, the two biomarkers associated with Alzheimer's disease. Forty-nine (49) observational studies were reviewed and 31 BBM tests were evaluated.</p><p>The panel determined that endorsing specific tests was premature, opting for a brand-agnostic, performance-based approach that blinded panel members to the tests they were evaluating to minimize bias. This ensures the guideline's credibility, durability, and actionability. According to the panel: “Ranking or endorsing specific tests is premature at this time. Instead, test accuracy data and accuracy judgments reported in this guideline are meant to serve as a resource for clinicians … to aid them in choosing which test(s) to order.”</p><p>This CPG is part of ALZPro, the Alzheimer's Association's comprehensive hub of resources to promote best practices, empowering health professionals across disciplines to reduce risk, advance early detection, improve care, and expand equitable access for all communities. ALZPro unites care resources, relevant scientific findings, clinical guidelines and insights, continuing education and implementation tools on one platform.</p><p>Upcoming CPGs will address cognitive assessment tools, clinical implementation of staging criteria and treatment, and prevention of Alzheimer's and other dementias.</p><p>This CPG was convened and funded by the Alzheimer's Association, but the Association was not involved in formulating the clinical questions or recommendations.</p><p>The Alzheimer's Association Center for Dementia Respite Innovation (CDRI) is awarding more than $4 million in grants to 41 community-based service providers to drive innovative models of quality dementia-specific respite care. The CDRI is administered through a partnership of the Alzheimer's Association, the University of Minnesota School of Public Health and USAging.</p><p>The 41 grant recipients are the second-year recipients of a 5-year, $25 million grant program to enhance respite services for the nearly 12 million dementia caregivers nationwide. Respite care provides caregivers with a temporary rest from caregiving, while the person living with Alzheimer's continues to receive person-centered care in a supportive environment. Respite care can be provided at home — by a friend, other family member, volunteer or paid service — or in a professional or community-based care setting, such as adult day care or a faith-based organization.</p><p>“Caring for someone living with dementia is often a 24/7 responsibility,” said Sam Fazio, PhD, vice president, Care and Support Programs and Research at the Alzheimer's Association. “These grants are aimed at creating dementia-specific respite programs that give caregivers a break, while ensuring the person living with dementia gets high-quality care in a safe, caring environment. There is a tremendous need for these programs across the country, and we hope these grants can start bridging current gaps.”</p><p>The 41 grant recipients span 26 states from Alaska to Florida and include new pilot and start-up programs to bring or expand dementia-specific respite programs in these communities. Several of the service providers selected serve communities at higher risk for Alzheimer's or other dementia — an important objective of the 5-year program. See a complete list of this year's grant recipients.</p><p>In conjunction with the grant, the CDRI will also provide online training and ongoing technical assistance to the grant recipients focusing on improving person-centered care efforts to support program sustainability after the grant period and to ensure that respite services are dementia-capable, especially in communities at higher risk for Alzheimer's or other dementia. The CDRI will also collect data and evaluate the impact of these innovative projects over the 5 years to inform public policy.</p><p>“In our second year, we have incorporated insights and experiences from our first year of programming. We've strategically enhanced our education resources to provide more comprehensive support, doubled the number of grants awarded to extend our national reach, and introduced a 2-year start-up award option,” said Isabella Marini, associate director, Center for Dementia Respite Innovation. “This allows grant recipients more flexibility and stability as they develop critical respite programs that provide much-needed relief to families navigating the challenging journey of dementia care. Our goal is not just to fund programs, but to create meaningful, sustainable support systems that recognize the incredible dedication of caregivers across the country.”</p><p>According to the 2022 National Strategy to Support Family Caregivers, gaps in the availability of and access to respite can be significant, adding to the stress and burden of unpaid caregivers. 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Edelmayer, PhD, Alzheimer's Association vice president of scientific engagement and a co-author of the guideline. “This guideline helps clinicians apply these tools responsibly, avoid overuse or inappropriate use, and ensure that patients have access to the latest scientific advancements.”</p><p>Compared to standard-of-care PET imaging and CSF tests, BBM tests are typically less costly, more accessible, and more acceptable to patients. The guideline emphasizes that BBM tests do not substitute for a comprehensive clinical evaluation by a health care professional, and should be ordered and interpreted by a health care professional in the context of clinical care.</p><p>This is the first evidence-based guideline in the Alzheimer's space that uses Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The use of GRADE ensures a transparent, structured, and evidence-based process for evaluating the certainty of evidence and formulating recommendations. This strengthens the credibility and reproducibility of the guideline and allows for explicit linkage between evidence and recommendations.</p><p>This guideline's primary audience is specialists involved in the diagnostic evaluation of cognitive impairment in specialized care settings. A specialist is defined as a health care provider, typically in neurology, psychiatry, or geriatrics, who cares for adults with cognitive impairment or dementia. It also applies to primary care providers, nurse practitioners, and physician assistants in specialized care settings.</p><p>A panel of 11 clinicians convened by the Alzheimer's Association — including clinical neurologists, geriatricians, nurse practitioners, physician assistants, and subject-matter experts — conducted a systematic review and formulated evidence-based recommendations for using BBM tests in individuals with objective cognitive impairment, including those with mild cognitive impairment (MCI) or dementia. 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According to the panel: “Ranking or endorsing specific tests is premature at this time. Instead, test accuracy data and accuracy judgments reported in this guideline are meant to serve as a resource for clinicians … to aid them in choosing which test(s) to order.”</p><p>This CPG is part of ALZPro, the Alzheimer's Association's comprehensive hub of resources to promote best practices, empowering health professionals across disciplines to reduce risk, advance early detection, improve care, and expand equitable access for all communities. ALZPro unites care resources, relevant scientific findings, clinical guidelines and insights, continuing education and implementation tools on one platform.</p><p>Upcoming CPGs will address cognitive assessment tools, clinical implementation of staging criteria and treatment, and prevention of Alzheimer's and other dementias.</p><p>This CPG was convened and funded by the Alzheimer's Association, but the Association was not involved in formulating the clinical questions or recommendations.</p><p>The Alzheimer's Association Center for Dementia Respite Innovation (CDRI) is awarding more than $4 million in grants to 41 community-based service providers to drive innovative models of quality dementia-specific respite care. 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引用次数: 0

摘要

在2025年阿尔茨海默病协会国际会议上,该协会发布了首个关于使用基于血液的生物标志物(BBM)测试的临床实践指南(CPG)CPG提供了明确的、基于证据的、与品牌无关的建议,以支持使用BBM测试更准确和更容易诊断阿尔茨海默氏症。这些建议与采用稳健和透明方法的系统审查相关联,并将随着证据的发展定期更新。“这是阿尔茨海默病治疗的关键时刻,”阿尔茨海默病协会首席科学官和医疗事务负责人、该指南的合著者玛丽亚·c·卡里略博士说。“我们第一次有了严格的循证指南,使临床医生能够自信和一致地使用血液生物标志物测试。采纳这些建议将导致更快、更容易获得、更准确的诊断,并为受阿尔茨海默病影响的个人和家庭带来更好的结果。”新CPG的建议(这两项建议均仅适用于因记忆障碍而接受专门护理的认知障碍患者)是:灵敏度≥90%、特异性≥75%的BBM检测可作为分诊检测,阴性结果极有可能排除阿尔茨海默病的病理。阳性结果也应通过其他方法确认,如脑脊液(CSF)或淀粉样正电子发射断层扫描(PET)测试。BBM检测灵敏度和特异性≥90%,可替代PET淀粉样蛋白成像或脑脊液阿尔茨海默病生物标志物检测。该指南警告说,诊断测试的准确性存在显著差异,许多市售的BBM测试不符合这些阈值。“并非所有的BBM检测都按照相同的标准进行了验证,或者在患者群体和临床环境中进行了广泛的测试,但患者和临床医生可能认为这些检测是可互换的;阿尔茨海默氏症协会科学参与副主席、该指南的合著者丽贝卡·m·埃德尔迈耶博士说。“该指南有助于临床医生负责任地应用这些工具,避免过度使用或不当使用,并确保患者能够获得最新的科学进展。”与标准的PET成像和CSF测试相比,BBM测试通常成本更低,更容易获得,并且更容易被患者接受。该指南强调,BBM测试不能替代由卫生保健专业人员进行的全面临床评估,而应由卫生保健专业人员在临床护理的背景下订购和解释。这是阿尔茨海默氏症领域第一个基于证据的指南,使用了分级推荐评估、发展和评估(GRADE)方法。GRADE的使用确保了一个透明、结构化和基于证据的过程,以评估证据的确定性并制定建议。这加强了指南的可信度和可重复性,并允许证据和建议之间的明确联系。本指南的主要读者是在专业护理环境中参与认知障碍诊断评估的专家。专家被定义为医疗保健提供者,通常是神经病学、精神病学或老年病学,负责照顾患有认知障碍或痴呆症的成年人。它也适用于初级保健提供者、执业护士和专业护理机构的医师助理。由阿尔茨海默氏症协会召集的11名临床医生(包括临床神经科医生、老年病医生、执业护士、医师助理和主题专家)组成的小组进行了一项系统审查,并制定了在客观认知障碍患者(包括轻度认知障碍(MCI)或痴呆症患者)中使用BBM测试的循证建议。最终的建议是由公众意见和协会的国家早期咨询小组提供的,其中包括患有早期阿尔茨海默氏症的人。对于该指南的初始迭代,BBMs包括血浆磷酸化tau (p-tau)和淀粉样蛋白β (Aβ)测试,测量以下分析物:p-tau217, p-tau217与非p-tau217的比率×100 (%p-tau217), p-tau181, p-tau231和a - β42与a - β40的比率。各种BBM测试测量淀粉样蛋白或tau蛋白的异常形式,这两种生物标志物与阿尔茨海默病有关。回顾了49项观察性研究,评估了31项BBM试验。该小组认为,批准特定的测试还为时过早,他们选择了一种与品牌无关的、基于表现的方法,使小组成员对他们正在评估的测试视而不见,以尽量减少偏见。这确保了指南的可信性、持久性和可操作性。根据专家组的说法:“目前对特定测试进行排名或认可还为时过早。 相反,本指南中报告的测试准确性数据和准确性判断旨在作为临床医生的资源……帮助他们选择订购哪种测试。”专家组制定了两项建议和一项良好做法声明,用于在专门护理中发现的客观认知障碍患者的诊断检查中使用BBM试验。建议1:对于客观认知障碍的患者,需要专门的记忆护理,专家组建议在阿尔茨海默病的诊断工作中使用高灵敏度的BBM测试作为分诊测试。建议2:对于需要专门记忆护理的客观认知障碍患者,专家组建议在阿尔茨海默病的诊断检查中使用高灵敏度和高特异性的BBM测试作为确认性测试。良好规范声明-在卫生保健专业人员进行全面的临床评估之前,不应进行BBM测试,并且测试结果应始终在临床背景下解释。该小组敦促临床医生在决定是否使用BBM测试时,考虑每位患者检测前阿尔茨海默病病理的可能性。该CPG是ALZPro的一部分,ALZPro是阿尔茨海默病协会的综合资源中心,旨在促进最佳实践,使跨学科的卫生专业人员能够降低风险,推进早期发现,改善护理,并扩大所有社区的公平获取。ALZPro将护理资源、相关科学发现、临床指南和见解、继续教育和实施工具整合在一个平台上。即将到来的CPGs将讨论认知评估工具,临床实施分期标准和治疗,以及阿尔茨海默氏症和其他痴呆症的预防。该CPG由阿尔茨海默病协会召集并资助,但该协会并未参与制定临床问题或建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Alzheimer's Association releases its first clinical practice guideline for blood-based biomarker tests

Alzheimer's Association releases its first clinical practice guideline for blood-based biomarker tests

Alzheimer's Association releases its first clinical practice guideline for blood-based biomarker tests

At the Alzheimer's Association International Conference 2025, the Association released release of its first clinical practice guideline (CPG) on the use of blood-based biomarker (BBM) tests.1 The CPG provides clear, evidence-based, brand-agnostic recommendations to support more accurate and accessible diagnosis of Alzheimer's using BBM tests. The recommendations are linked to a systematic review using a robust and transparent methodology and will be updated regularly as evidence evolves.

“This is a pivotal moment in Alzheimer's care,” said Maria C. Carrillo, PhD, Alzheimer's Association chief science officer and medical affairs lead, and a co-author of the guideline. “For the first time, we have a rigorously evidence-based guideline that empowers clinicians to use blood biomarker tests confidently and consistently. Adoption of these recommendations will lead to quicker, more accessible, more accurate diagnoses — and better outcomes for individuals and families affected by Alzheimer's.”

The guideline cautions that there is significant variability in diagnostic test accuracy and many commercially available BBM tests do not meet these thresholds.

“Not all BBM tests have been validated to the same standard or tested broadly across patient populations and clinical settings, yet patients and clinicians may assume these tests are interchangeable; they are not,” said Rebecca M. Edelmayer, PhD, Alzheimer's Association vice president of scientific engagement and a co-author of the guideline. “This guideline helps clinicians apply these tools responsibly, avoid overuse or inappropriate use, and ensure that patients have access to the latest scientific advancements.”

Compared to standard-of-care PET imaging and CSF tests, BBM tests are typically less costly, more accessible, and more acceptable to patients. The guideline emphasizes that BBM tests do not substitute for a comprehensive clinical evaluation by a health care professional, and should be ordered and interpreted by a health care professional in the context of clinical care.

This is the first evidence-based guideline in the Alzheimer's space that uses Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The use of GRADE ensures a transparent, structured, and evidence-based process for evaluating the certainty of evidence and formulating recommendations. This strengthens the credibility and reproducibility of the guideline and allows for explicit linkage between evidence and recommendations.

This guideline's primary audience is specialists involved in the diagnostic evaluation of cognitive impairment in specialized care settings. A specialist is defined as a health care provider, typically in neurology, psychiatry, or geriatrics, who cares for adults with cognitive impairment or dementia. It also applies to primary care providers, nurse practitioners, and physician assistants in specialized care settings.

A panel of 11 clinicians convened by the Alzheimer's Association — including clinical neurologists, geriatricians, nurse practitioners, physician assistants, and subject-matter experts — conducted a systematic review and formulated evidence-based recommendations for using BBM tests in individuals with objective cognitive impairment, including those with mild cognitive impairment (MCI) or dementia. Final recommendations were informed by public comments and input from the Association's National Early-Stage Advisory Group, which includes people living with early-stage Alzheimer's.

For this initial iteration of the guideline, the BBMs included plasma phosphorylated-tau (p-tau) and amyloid-beta (Aβ) tests measuring the following analytes: p-tau217, ratio of p-tau217 to non-p-tau217 ×100 (%p-tau217), p-tau181, p-tau231, and ratio of Aβ42 to Aβ40. The various BBM tests measure abnormal forms of either amyloid beta or tau protein, the two biomarkers associated with Alzheimer's disease. Forty-nine (49) observational studies were reviewed and 31 BBM tests were evaluated.

The panel determined that endorsing specific tests was premature, opting for a brand-agnostic, performance-based approach that blinded panel members to the tests they were evaluating to minimize bias. This ensures the guideline's credibility, durability, and actionability. According to the panel: “Ranking or endorsing specific tests is premature at this time. Instead, test accuracy data and accuracy judgments reported in this guideline are meant to serve as a resource for clinicians … to aid them in choosing which test(s) to order.”

This CPG is part of ALZPro, the Alzheimer's Association's comprehensive hub of resources to promote best practices, empowering health professionals across disciplines to reduce risk, advance early detection, improve care, and expand equitable access for all communities. ALZPro unites care resources, relevant scientific findings, clinical guidelines and insights, continuing education and implementation tools on one platform.

Upcoming CPGs will address cognitive assessment tools, clinical implementation of staging criteria and treatment, and prevention of Alzheimer's and other dementias.

This CPG was convened and funded by the Alzheimer's Association, but the Association was not involved in formulating the clinical questions or recommendations.

The Alzheimer's Association Center for Dementia Respite Innovation (CDRI) is awarding more than $4 million in grants to 41 community-based service providers to drive innovative models of quality dementia-specific respite care. The CDRI is administered through a partnership of the Alzheimer's Association, the University of Minnesota School of Public Health and USAging.

The 41 grant recipients are the second-year recipients of a 5-year, $25 million grant program to enhance respite services for the nearly 12 million dementia caregivers nationwide. Respite care provides caregivers with a temporary rest from caregiving, while the person living with Alzheimer's continues to receive person-centered care in a supportive environment. Respite care can be provided at home — by a friend, other family member, volunteer or paid service — or in a professional or community-based care setting, such as adult day care or a faith-based organization.

“Caring for someone living with dementia is often a 24/7 responsibility,” said Sam Fazio, PhD, vice president, Care and Support Programs and Research at the Alzheimer's Association. “These grants are aimed at creating dementia-specific respite programs that give caregivers a break, while ensuring the person living with dementia gets high-quality care in a safe, caring environment. There is a tremendous need for these programs across the country, and we hope these grants can start bridging current gaps.”

The 41 grant recipients span 26 states from Alaska to Florida and include new pilot and start-up programs to bring or expand dementia-specific respite programs in these communities. Several of the service providers selected serve communities at higher risk for Alzheimer's or other dementia — an important objective of the 5-year program. See a complete list of this year's grant recipients.

In conjunction with the grant, the CDRI will also provide online training and ongoing technical assistance to the grant recipients focusing on improving person-centered care efforts to support program sustainability after the grant period and to ensure that respite services are dementia-capable, especially in communities at higher risk for Alzheimer's or other dementia. The CDRI will also collect data and evaluate the impact of these innovative projects over the 5 years to inform public policy.

“In our second year, we have incorporated insights and experiences from our first year of programming. We've strategically enhanced our education resources to provide more comprehensive support, doubled the number of grants awarded to extend our national reach, and introduced a 2-year start-up award option,” said Isabella Marini, associate director, Center for Dementia Respite Innovation. “This allows grant recipients more flexibility and stability as they develop critical respite programs that provide much-needed relief to families navigating the challenging journey of dementia care. Our goal is not just to fund programs, but to create meaningful, sustainable support systems that recognize the incredible dedication of caregivers across the country.”

According to the 2022 National Strategy to Support Family Caregivers, gaps in the availability of and access to respite can be significant, adding to the stress and burden of unpaid caregivers. Respite care is often costly, and with limited availability in many communities, caregivers are frequently left with responsibility for the bulk of the expenses. The CDRI grant and the sub-grants it will generate will result in developing and piloting cost-efficient, effective, strengths-based, person-centered, innovative models of dementia-specific respite care.

The Alzheimer's Association created the CDRI in 2024 after receiving a $25 million grant from the Administration for Community Living (ACL), a division of the U.S. Department of Health and Human Services. The ACL grant is the largest ever made to the Association.

ACKNOWLEDGMENTS

This project is supported by the Administration for Community Living (ACL), U.S. Department of Health and Human Services (HHS), as part of a financial assistance award totaling $13,261,685 with 75% funded by ACL/HHS and 25% funded by non-government sources. The contents are those of the authors and do not necessarily represent the official views of, nor an endorsement by, ACL/HHS, or the U.S. Government.

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来源期刊
Alzheimer's & Dementia
Alzheimer's & Dementia 医学-临床神经学
CiteScore
14.50
自引率
5.00%
发文量
299
审稿时长
3 months
期刊介绍: Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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