伴侣犬作为阿尔茨海默病的转化模型:纵向研究平台和尸检协议的发展

IF 11.1 1区 医学 Q1 CLINICAL NEUROLOGY
Stephanie McGrath, Emily Hull, Matthew D. Dunbar, Jena Prescott, Amber J. Keyser, Evan MacLean, Martin Darvas, Caitlin Latimer, Julie Moreno, Michael J. MacCoss, Mandy Kauffman, Paul Litwin, Marta Castelhano, Matt Kaeberlein, C. Dirk Keene, Dog Aging Project Consortium
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引用次数: 0

摘要

犬类认知功能障碍是阿尔茨海默病(AD)和阿尔茨海默病相关痴呆(ADRD)的一个有价值的模型,因为它们的寿命较短,临床症状自然发生,遗传多样性,与人类共享环境,以及相似的分子和神经病理特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols

The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols

INTRODUCTION

Canine cognitive dysfunction is a valuable model for Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRD) due to condensed lifespan, naturally occurring clinical signs, genetic diversity, shared environment with humans, and similar molecular and neuropathological hallmarks.

METHODS

The objective of the Brain Health Study was to build infrastructure to support a diverse national cohort of companion dogs for in-depth, longitudinal analysis of brain and cognitive health over their lifespan. A complex and well-maintained research platform was critical to facilitate enrollment, retention, and biobanking of biofluids and postmortem tissue.

RESULTS

The research infrastructure is in place for longitudinal data collection, annual biospecimen collection and postmortem sample collection. The team has conducted 21 postmortem exams.

DISCUSSION

Although most of the 500 enrolled subjects remain alive, biomarker identification, neuropathology, and proteomics analysis is underway. Future outcomes will benefit the worldwide research community through an Open Data sharing platform.

Highlights

  • The dog serves as a novel translational large animal model for Alzheimer's disease (AD) and ad and related dementias.
  • A large research platform supports collection of biofluids and post mortem tissue.
  • The companion dog has key molecular and neuropathological hallmarks of AD.
  • The Brain Health Study research platform has successfully enrolled 500 dogs across the United States.
  • Post mortem biofluid and tissue has been donated from 21 enrolled dogs.
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来源期刊
Alzheimer's & Dementia
Alzheimer's & Dementia 医学-临床神经学
CiteScore
14.50
自引率
5.00%
发文量
299
审稿时长
3 months
期刊介绍: Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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