Alzheimer's & Dementia最新文献

{"title":"Precision residential greenspace, urban environmental exposures, and incident dementia among older adults in Sweden: A 16-year cohort study","authors":"Cecilia U. D. Stenfors,&nbsp;Jing Wu,&nbsp;Giulia Grande,&nbsp;Andrei Pyko,&nbsp;Mare Löhmus,&nbsp;Göran Pershagen,&nbsp;Debora Rizzuto","doi":"10.1002/alz.71835","DOIUrl":"https://doi.org/10.1002/alz.71835","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Residential greenspace is linked to mental and cardiometabolic health, but longitudinal studies on detailed greenspace and dementia incidence are limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We followed 2993 dementia-free participants in the Swedish National Study on Aging and Care Kungsholmen for 16 years; 477 developed clinically diagnosed dementia. Greenspace was assessed using normalized difference vegetation index within 100-, 250-, and 500-m residential buffers. Cox models estimated hazard ratios (HRs) per interquartile-range greenspace increment and tested effect modification by air pollution, road traffic noise, blue space, age, sex, and apolipoprotein E-ε4 (APOE-ε4).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Higher greenspace within 100 m was associated with lower dementia incidence (HR = 0.79, 95% confidence interval [CI] = 0.64–0.96), whereas associations for larger buffers were attenuated. Associations were stronger in women (HR = 0.69, 95% CI = 0.54–0.89) than men (HR = 0.93, 95% CI = 0.71–1.24).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Close residential greenspace may reduce dementia risk in older adults, particularly women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Trade Center neurotoxicant exposure severity is associated with cortical thinning and regional brain atrophy: a neuroimaging study of general responders at midlife","authors":"Sean A. P. Clouston,&nbsp;Chuan Huang,&nbsp;Temurbek Askarov,&nbsp;Yicun Wang,&nbsp;Zan Chaudhry,&nbsp;Melissa A. Carr,&nbsp;Yuan Yang,&nbsp;Steven West,&nbsp;Frank D. Mann,&nbsp;Ruth Marquez,&nbsp;Paul Vaska,&nbsp;Jaymie Meliker,&nbsp;Sam Gandy,&nbsp;Roberto G. Lucchini,&nbsp;Benjamin J. Luft,&nbsp;for the Alzheimer's Disease Neuroimaging Initiative","doi":"10.1002/alz.71878","DOIUrl":"https://doi.org/10.1002/alz.71878","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Exposure to aerosolized pollutants is a risk factor for cognitive impairment and dementia, but the specific features of exposure-related neurodegeneration remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We measured the World Trade Center Neurotoxicant Exposure Severity Index (WTC-NESI) in 218 responders and unexposed controls aged 44-65 years. The main outcome was cortical thickness. Correlation analyses reported unadjusted associations and multiple linear regression to adjust for correlates. Vertex-wise analyses were used with threshold-free cluster enhancement to examine associations after adjusting for cross-vertex clustering in atrophy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Cortical thickness was associated with WTC-NESI (<i>R =</i> −0.38, <i>p &lt;</i> 0.001) that survived multivariable adjustment. Vertex-wise analyses revealed reduced cortical thickness across much of the cortical surface that was associated with WTC exposure severity. Results were right-hemisphere asymmetric and focused in the precentral regions (partial <i>η²</i> ≥ 0.07).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>Our results provide an important reference for neurotoxicological investigators mapping the implications of airborne pollutant exposures. This study suggests that efforts to mitigate exposures in first responders might have long-term implications for cerebral health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71878","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives from Alzheimer's Disease Research Centers site directors on the early steps and the lasting impact","authors":"John H. Growdon,&nbsp;John C. Morris,&nbsp;Ronald C. Petersen,&nbsp;Mary Sano,&nbsp;Lon S. Schneider","doi":"10.1002/alz.71694","DOIUrl":"https://doi.org/10.1002/alz.71694","url":null,"abstract":"<p>Since the groundbreaking work of Alois Alzheimer in the early 1900s, Alzheimer's disease research has evolved immensely, most notably with the establishment of the Alzheimer's Disease Research Centers (ADRC). Fueled by the vision and funding of the National Institute on Aging (NIA), ADRCs have created a legacy through their work standardizing criteria for Alzheimer's disease diagnosis. Leveraging the experience of the Consortium to Establish a Registry for Alzheimer's Disease, the ADRCs advanced standardized assessment tools, including the Clinical and Neuropsychological Batteries, as well as the CDR, which would make way for uniform data collection, in what we know today as the National Alzheimer's Coordinating Center (NACC). Collaborative data collection was expanded by NIA to support the development of treatments for Alzheimer's disease and related disorders (ADRD) through the Alzheimer's Disease Cooperative Study (ADCS) and the Alzheimer's Clinical Trial Consortium (ACTC) programs. These NIA sponsored programs have created a foundation for today's pharmacological and non-pharmacological interventions to improve cognition and function in persons living with ADRD.</p>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71694","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1R agonist semaglutide protects human forebrain organoids from cholesterol-induced neurotoxicity","authors":"Feifei Yu,&nbsp;Jiani Xu,&nbsp;Yibo Hou,&nbsp;Honghui Zheng,&nbsp;Lingyi Guo,&nbsp;Davit Khutsishvili,&nbsp;Cheng Hai,&nbsp;Wenxin Xu,&nbsp;Bailing Chen,&nbsp;Zitian Wang,&nbsp;Shaohua Ma","doi":"10.1002/alz.71888","DOIUrl":"https://doi.org/10.1002/alz.71888","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Dysregulated cholesterol metabolism represents a critical metabolic stressor in the central nervous system, contributing to neuronal injury across multiple neurological conditions, including Alzheimer's disease (AD). While glucagon-like peptide-1 receptor (GLP-1R) agonists show neuroprotective potential, their capacity to directly mitigate cholesterol-induced metabolic stress in human neural cells remains to be established.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>Here, we modeled metabolic stress using human induced pluripotent stem cell–derived forebrain organoids exposed to cholesterol overload. The protective effects of the GLP-1R agonist semaglutide were characterized by integrating bulk/single-cell transcriptomics, calcium imaging, and biochemical assays. Furthermore, clinical translatability was supported by mapping organoid expression signatures against human <i>post mortem</i> neurodegenerative brain datasets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Cholesterol overload induced cellular stress and transcriptomic alterations that partially overlapped with AD-associated signatures. Semaglutide protected neural cells from lipotoxic injury. Intracellularly, GLP-1R activation engaged the cyclic adenosine 3',5'-monophosphate–protein kinase A and phosphoinositide 3 kinase–protein kinase B–mechanistic target of rapamycin signaling pathways, consistent with reduced lipid droplet accumulation and oxidative stress. Intercellularly, single-cell analysis indicated partial preservation of disrupted cellular communication, including the neurotrophic midkine signaling network. Functionally, semaglutide stabilized cellular calcium activity patterns under metabolic stress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>These findings highlight the role of cholesterol homeostasis in maintaining neuronal integrity and position GLP-1R signaling as a candidate protective axis under metabolic stress, offering insights into therapeutic strategies for AD and broader neurodegenerative disorders.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71888","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term clinical performance and analytical robustness of the Lumipulse plasma p-tau217 assay in routine clinical practice","authors":"Susan Ashrafzadeh-Kian,&nbsp;Daniel J. Figdore,&nbsp;Joshua A. Bornhorst,&nbsp;Patrick M. Vanderboom,&nbsp;Sarah Callison,&nbsp;Gregory S. Day,&nbsp;Christian Lachner,&nbsp;Neill Graff-Radford,&nbsp;Dror Shir,&nbsp;Clifford R. Jack Jr.,&nbsp;David S. Knopman,&nbsp;Jonathan Graff-Radford,&nbsp;Ronald C. Petersen,&nbsp;Vijay K. Ramanan,&nbsp;Alicia Algeciras-Schimnich","doi":"10.1002/alz.71887","DOIUrl":"https://doi.org/10.1002/alz.71887","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Plasma phosphorylated tau 217 (p‑tau217) immunoassays are increasingly being used to assess Alzheimer's disease (AD) pathology despite limited data affirming test reliability over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>Clinical performance of the Fujirebio Lumipulse G p‑tau217 assay was assessed in 744 Mayo Clinic patients presenting for evaluation of cognitive impairment between July 2024 and December 2025. Cerebrospinal fluid p‑tau181/amyloid beta 42 or amyloid positron emission tomography, within 1 year of p-tau217 testing, were used as reference. Analytical robustness was evaluated by tracking result frequencies over time, conducting quality control checks, performing 10 lot‑to‑lot comparisons, and comparing two versions of reagents.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Diagnostic accuracy for detection of AD pathology was 93% (95% confidence interval 91–95) with 23% intermediate results. Reduced estimated glomerular filtration rate was associated with increased intermediate results among amyloid-negative individuals. Result frequencies remained stable, average imprecision was 8%, and analytical bias between lots and version changes were ≤ 11%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>The findings support plasma p-tau217 reliability in clinical practice for evaluation of cognitively impaired individuals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel genetic profile linked to cognitive decline in Hispanics/Latinos","authors":"Yana Hrytsenko,&nbsp;Yogesh Purushotham,&nbsp;Zhirou Li,&nbsp;Carmen R Isasi,&nbsp;Wassim Tarraf,&nbsp;Alberto R Ramos,&nbsp;Martha L Daviglus,&nbsp;Humberto Parada Jr.,&nbsp;Brian W Spitzer,&nbsp;Mariko Isshiki,&nbsp;Srilakshmi M Raj,&nbsp;Charles DeCarli,&nbsp;Hector M González,&nbsp;Myriam Fornage,&nbsp;Tamar Sofer","doi":"10.1002/alz.71855","DOIUrl":"https://doi.org/10.1002/alz.71855","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>The <i>APOE</i> ε4 allele has weaker association with ADRD outcomes in Hispanic/Latino populations compared to non-Hispanic White and East Asian populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We used whole-genome sequencing data from 13,025 Hispanic/Latino adults to infer population groups (clusters) from short DNA sequences at the <i>APOE</i> gene region. We estimated the associations between these clusters and mild cognitive impairment (MCI) and age-adjusted significant cognitive decline assessed via the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) study (<i>n</i> = 5334). We compared these associations to those of the conventional <i>APOE</i> alleles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>We identified three clusters of individuals. Relative to the largest Cluster 1, being in Cluster 3 had higher likelihood of having significant cognitive decline, with odds ratio (OR) = 1.47, 95% confidence interval (CI) [1.18, 1.84], <i>p</i> &lt; 0.001. The association with having prevalent MCI at the SOL-INCA exam was not statistically significant, with OR = 1.33, 95% CI [0.97, 1.83], <i>p</i> = 0.08. Associations of the ε4 allele with these traits were not statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>The new <i>APOE</i> profile has stronger risk association with age-adjusted significant cognitive decline in SOL-INCA Hispanics/Latinos compared to the ε4 allele.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71855","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative prediction of Alzheimer's disease and related dementias using multi-omics aging clocks and genetic data","authors":"Shayan Mostafaei,&nbsp;Karolina Gustavsson,&nbsp;Hampus Hagelin,&nbsp;Jonathan K. L. Mak,&nbsp;Trung Nghia Vu,&nbsp;Ida K. Karlsson,&nbsp;Sara Hägg","doi":"10.1002/alz.71869","DOIUrl":"https://doi.org/10.1002/alz.71869","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>We tested whether combining Alzheimer's disease and related dementias (ADRD) polygenic risk scores (PRS) with biological aging markers improves ADRD risk prediction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>In 16,215 UK Biobank (UKB) participants free of ADRD at baseline (median follow-up: 10.08 years), 397 incident diagnoses were identified. Biological aging measures included clinical, telomere, proteomic, and metabolomic aging markers. External validation/replication was performed in TwinGene (<i>N</i> = 3772; 331 cases).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The fully integrated model achieved area under the curve (AUC) = 0.90 and area under the precision-recall curve (AUPRC) = 0.24 in the UKB held-out test set. PRS was the strongest predictor (subdistribution hazard ratio [sHR] = 2.24, 95% CI: 2.02–2.48), followed by ProtAge (sHR = 2.01, 95% CI: 1.13–3.58). The top predicted-risk quartile showed higher ADRD incidence (sHR = 16.73, 95% CI: 6.49–43.11). TwinGene showed moderate transportability (AUC = 0.757; AUPRC = 0.223) and preserved risk stratification (sHR = 4.02, 95% CI: 3.25–5.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Integrating PRS and biological aging measures improved ADRD risk stratification.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tau-PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head-to-head comparison of Flortaucipir and MK6240","authors":"Isabella Bizzi,&nbsp;Arthur C. Macedo,&nbsp;Lydia Trudel,&nbsp;Joseph Therriault,&nbsp;Nesrine Rahmouni,&nbsp;Firoza Z. Lussier,&nbsp;Cécile Tissot,&nbsp;Gleb Bezgin,&nbsp;Étienne Aumont,&nbsp;Tevy Chan,&nbsp;Seyyed Ali Hosseini,&nbsp;Delphine Oliva-Lopez,&nbsp;Marina Pereira Gonçalves,&nbsp;Guilherme Povala,&nbsp;Pamela C. L. Ferreira,&nbsp;Bruna Bellaver,&nbsp;Livia Amaral,&nbsp;Emma Ruppert,&nbsp;Marina Scop Medeiros,&nbsp;Rayan Mroué,&nbsp;Andréia Rocha,&nbsp;Kok Pin Ng,&nbsp;Eduardo R. Zimmer,&nbsp;Joseph Masdeu,&nbsp;Belen Pascual,&nbsp;Val J. Lowe,&nbsp;Hwamee Oh,&nbsp;David N. Soleimani-Meigooni,&nbsp;Juan Fortea,&nbsp;Zahinoor Ismail,&nbsp;Suzanne Baker,&nbsp;Tharick A Pascoal,&nbsp;Pedro Rosa-Neto,&nbsp;for the HEAD Study","doi":"10.1002/alz.71861","DOIUrl":"https://doi.org/10.1002/alz.71861","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>We compared the association between mild behavioral impairment (MBI) and first- versus second-generation tau-positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We assessed 110 individuals with head-to-head [¹⁸F]MK6240 and [¹⁸F]Flortaucipir tau-PET. Voxel-wise and region-of-interest analyses investigated relationships between tau-PET and MBI Checklist (MBI-C) scores, which were also compared across tau-PET positivity and PET-Braak stages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>For both tracers, MBI severity was associated with tau-PET signal in all Braak regions and increased across PET-Braak stages. [¹⁸F]MK6240 showed more extensive voxel-wise associations with MBI-C scores and additional correlations with affective symptoms in stratified analyses by diagnostic groups. Tau positivity was associated with a higher frequency of MBI. Individuals positive for [¹⁸F]MK6240 but negative for [¹⁸F]Flortaucipir exhibited greater MBI burden than individuals negative for both tracers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>MBI in early AD is associated with tau-PET, with [¹⁸F]MK6240 providing greater sensitivity to detect MBI-related symptoms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71861","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Dementia Council Update","authors":"","doi":"10.1002/alz.71876","DOIUrl":"https://doi.org/10.1002/alz.71876","url":null,"abstract":"","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"46 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic association of insomnia and anxiety with cognitive impairment and dementia in older adults","authors":"Yan Chen, Qianxi Wang, Ling Li, Shixing Qian, Li Bai, Tih Shih Lee, Shaowei Zhang, Yaping Li, Qianqian Guo, Yang Yang, Feng Yan, Lei Feng, Xia Li","doi":"10.1002/alz.71853","DOIUrl":"https://doi.org/10.1002/alz.71853","url":null,"abstract":"INTRODUCTION We investigated the synergistic effects of comorbid insomnia and anxiety on cognitive impairment and dementia and explored the underlying plasma biomarker mechanisms. METHODS We included adults ≥ 60 years from the cross‐sectional cohort named The Shanghai Action to Prevent Dementia in the Elderly (SHAPE) and used data from the longitudinal United Kingdom (UK) Biobank for validation. Regression models and additive interactions were used to evaluate the associations between comorbid insomnia and anxiety and cognitive outcomes. Biomarker mediation effects (tau phosphorylated at threonine 217 [p‐tau217], glial fibrillary acidic protein [GFAP], and neurofilament light chain [NfL]) were assessed in a SHAPE subcohort. RESULTS Comorbid insomnia and anxiety were synergistically associated with incident cognitive impairment in the SHAPE cohort. This vulnerability was validated longitudinally in individuals with incident dementia in the UK Biobank cohort. Additionally, p‐tau217 and GFAP mediated this association, predominantly driven by p‐tau217, with GFAP showing a modest but significant independent contribution. DISCUSSION Comorbid insomnia and anxiety are synergistically associated with a higher prevalence of cognitive impairment and incidence of dementia. This vulnerability is partially mediated by amyloid pathology, with astrogliosis providing a modest but significant contribution. These findings underscore the need for combined screening and targeted interventions to mitigate dementia risk.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"192 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}