发布求助
文献互助 智能选刊 最新文献

Alzheimer's & Dementia最新文献

筛选
英文 中文
Comparative brain metabolomics reveals shared and distinct metabolic alterations in Alzheimer's disease and progressive supranuclear palsy 脑代谢组学比较揭示了阿尔茨海默病和进行性核上性麻痹共同和独特的代谢改变
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-10-22 DOI: 10.1002/alz.14249
Richa Batra, Jan Krumsiek, Xue Wang, Mariet Allen, Colette Blach, Gabi Kastenmüller, Matthias Arnold, Nilüfer Ertekin-Taner, Rima Kaddurah-Daouk
{"title":"Comparative brain metabolomics reveals shared and distinct metabolic alterations in Alzheimer's disease and progressive supranuclear palsy","authors":"Richa Batra, Jan Krumsiek, Xue Wang, Mariet Allen, Colette Blach, Gabi Kastenmüller, Matthias Arnold, Nilüfer Ertekin-Taner, Rima Kaddurah-Daouk","doi":"10.1002/alz.14249","DOIUrl":"https://doi.org/10.1002/alz.14249","url":null,"abstract":"Metabolic dysregulation is a hallmark of neurodegenerative diseases, including Alzheimer's disease (AD) and progressive supranuclear palsy (PSP). Although metabolic dysregulation is a common link between these two tauopathies, a comprehensive brain metabolic comparison of the diseases has not yet been performed.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"125 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing clinical progression measures in Alzheimer's disease trials: A systematic review and meta-analysis 评估阿尔茨海默病试验中的临床进展措施：系统回顾与荟萃分析
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-10-22 DOI: 10.1002/alz.14314
Jonathan McLaughlin, William J. Scotton, Natalie S. Ryan, John A. Hardy, Maryam Shoai
{"title":"Assessing clinical progression measures in Alzheimer's disease trials: A systematic review and meta-analysis","authors":"Jonathan McLaughlin, William J. Scotton, Natalie S. Ryan, John A. Hardy, Maryam Shoai","doi":"10.1002/alz.14314","DOIUrl":"https://doi.org/10.1002/alz.14314","url":null,"abstract":"Assessing treatments for Alzheimer's disease (AD) relies on reliable tools for measuring AD progression. In this analysis, we evaluate the sensitivity of clinical progression measures in AD within randomized controlled trials (RCTs) with confirmed positive amyloid (Aβ+) status prior to trial enrollment.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"17 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microscopy assessment of a fluorescence [18F] flortaucipir analog (T726) shows neuropathological overlap with 3R and 4R tau lesions 荧光[18F]氟陶西哌类似物（T726）的显微镜评估显示神经病理学与3R和4R tau病变重叠
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-10-22 DOI: 10.1002/alz.14330
Rodolfo G. Gatto, Youssef Hossam, R. Ross Reichard, Val J. Lowe, Jennifer L. Whitwell, Keith A. Josephs
{"title":"Microscopy assessment of a fluorescence [18F] flortaucipir analog (T726) shows neuropathological overlap with 3R and 4R tau lesions","authors":"Rodolfo G. Gatto, Youssef Hossam, R. Ross Reichard, Val J. Lowe, Jennifer L. Whitwell, Keith A. Josephs","doi":"10.1002/alz.14330","DOIUrl":"https://doi.org/10.1002/alz.14330","url":null,"abstract":"[<sup>18</sup>F] flortaucipir (FTP) binding to paired helical filament (PHF) tau in Alzheimer's disease (AD) is well accepted. Binding to 3R and 4R tau in frontotemporal lobar degeneration (FTLD) is controversial. We aimed to investigate whether an FTP fluorescent analog (T726) can help shed light on this controversy.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"67 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timing of Alzheimer's disease biomarker progressions: A two-decade observational study from the Alzheimer's Disease Neuroimaging Initiative (ADNI) 阿尔茨海默病生物标志物进展的时间：阿尔茨海默病神经影像学倡议（ADNI）的一项长达二十年的观察研究
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-10-21 DOI: 10.1002/alz.14306
Tamar Schaap, Pamela Thropp, Duygu Tosun
{"title":"Timing of Alzheimer's disease biomarker progressions: A two-decade observational study from the Alzheimer's Disease Neuroimaging Initiative (ADNI)","authors":"Tamar Schaap, Pamela Thropp, Duygu Tosun","doi":"10.1002/alz.14306","DOIUrl":"https://doi.org/10.1002/alz.14306","url":null,"abstract":"Alzheimer's Disease Neuroimaging Initiative (ADNI) has been pivotal in identifying and refining Alzheimer's disease (AD) biomarkers for clinical trials. This study leverages longitudinal data from participants who have progressed to amyloid-positivity during their study participation to track evolution of biomarkers and cognitive function.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"33 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dementia risk scores, apolipoprotein E, and risk of Alzheimer's disease: One size does not fit all 痴呆症风险评分、载脂蛋白 E 和阿尔茨海默病风险：一刀切
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-10-21 DOI: 10.1002/alz.14300
Shea J. Andrews, Ana I. Boeriu, Michael E. Belloy, Alan E. Renton, Brian Fulton-Howard, Willa D. Brenowitz, Kristine Yaffe
{"title":"Dementia risk scores, apolipoprotein E, and risk of Alzheimer's disease: One size does not fit all","authors":"Shea J. Andrews, Ana I. Boeriu, Michael E. Belloy, Alan E. Renton, Brian Fulton-Howard, Willa D. Brenowitz, Kristine Yaffe","doi":"10.1002/alz.14300","DOIUrl":"https://doi.org/10.1002/alz.14300","url":null,"abstract":"Evaluating the generalizability of dementia risk scores, primarily developed in non-Latinx White (NLW) participants, and interactions with genetic risk factors in diverse populations is crucial for addressing health disparities.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"18 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arterial spin labeling perfusion MRI in the Alzheimer's Disease Neuroimaging Initiative: Past, present, and future 阿尔茨海默病神经成像计划中的动脉自旋标记灌注磁共振成像：过去、现在和未来
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-10-21 DOI: 10.1002/alz.14310
Pamela Thropp, Eliana Phillips, Youngkyoo Jung, David L. Thomas, Duygu Tosun
{"title":"Arterial spin labeling perfusion MRI in the Alzheimer's Disease Neuroimaging Initiative: Past, present, and future","authors":"Pamela Thropp, Eliana Phillips, Youngkyoo Jung, David L. Thomas, Duygu Tosun","doi":"10.1002/alz.14310","DOIUrl":"https://doi.org/10.1002/alz.14310","url":null,"abstract":"On the 20th anniversary of the Alzheimer's Disease Neuroimaging Initiative (ADNI), this paper provides a comprehensive overview of the role of arterial spin labeling (ASL) magnetic resonance imaging (MRI) in understanding perfusion changes in the aging brain and the relationship with Alzheimer's disease (AD) pathophysiology and its comorbid conditions. We summarize previously used acquisition protocols, available data, and the motivation for adopting a multi-post-labeling delay (PLD) acquisition scheme in the latest ADNI MRI protocol (ADNI 4). We also detail the process of setting up this scheme on different scanners, emphasizing the potential of ASL imaging in future AD research.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"194 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis 内皮功能障碍和认知的生物标志物：两步IPD荟萃分析
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-10-20 DOI: 10.1002/alz.14272
Magdalena Beran, Willemijn J. Jansen, Julie E. Oomens, Justine E. F. Moonen, P. Eline Slagboom, Martijn Huisman, Almar A. L. Kok, Astrid C. J. Nooyens, Wilhelmina Maria Monique Verschuren, Coen D. A. Stehouwer, Casper Schalkwijk, Sebastian Köhler, Marian Beekman, Pieternella Eline Slagboom, Frank J. Wolters, M. Arfan Ikram, Costanza L. Vallerga, Joyce B. J. van Meurs, Mohsen Ghanbari, Jet M. J. Vonk, Mirjam I. Geerlings, Thomas T. van Sloten, Miranda T. Schram
{"title":"Biomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis","authors":"Magdalena Beran, Willemijn J. Jansen, Julie E. Oomens, Justine E. F. Moonen, P. Eline Slagboom, Martijn Huisman, Almar A. L. Kok, Astrid C. J. Nooyens, Wilhelmina Maria Monique Verschuren, Coen D. A. Stehouwer, Casper Schalkwijk, Sebastian Köhler, Marian Beekman, Pieternella Eline Slagboom, Frank J. Wolters, M. Arfan Ikram, Costanza L. Vallerga, Joyce B. J. van Meurs, Mohsen Ghanbari, Jet M. J. Vonk, Mirjam I. Geerlings, Thomas T. van Sloten, Miranda T. Schram","doi":"10.1002/alz.14272","DOIUrl":"https://doi.org/10.1002/alz.14272","url":null,"abstract":"This study assessed the association of plasma biomarkers of endothelial dysfunction with cognitive performance and decline.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"32 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of CSF α-synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer's Disease Neuroimaging Initiative study 脑脊液α-突触核蛋白种子扩增检测阳性与疾病进展和认知能力下降的关系：阿尔茨海默病神经影像学纵向研究
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-10-20 DOI: 10.1002/alz.14276
Duygu Tosun, Zachary Hausle, Pamela Thropp, Luis Concha-Marambio, Jennifer Lamoureux, Russ Lebovitz, Leslie M. Shaw, Andrew B. Singleton, Michael W. Weiner, , Cornelis Blauwendraat
{"title":"Association of CSF α-synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer's Disease Neuroimaging Initiative study","authors":"Duygu Tosun, Zachary Hausle, Pamela Thropp, Luis Concha-Marambio, Jennifer Lamoureux, Russ Lebovitz, Leslie M. Shaw, Andrew B. Singleton, Michael W. Weiner, , Cornelis Blauwendraat","doi":"10.1002/alz.14276","DOIUrl":"https://doi.org/10.1002/alz.14276","url":null,"abstract":"Cerebrospinal fluid (CSF) α-synuclein (α-syn) seed amplification assay (SAA) is a sensitive and specific tool for detecting Lewy body co-pathology in Alzheimer's disease.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"1 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Whole-genome sequencing study in Koreans identifies novel loci for Alzheimer's disease 韩国人的全基因组测序研究确定了阿尔茨海默病的新基因位点
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-10-20 DOI: 10.1002/alz.14128
Moonil Kang, John J. Farrell, Congcong Zhu, Hyeonseul Park, Sarang Kang, Eun Hyun Seo, Kyu Yeong Choi, Gyungah R. Jun, Sungho Won, Jungsoo Gim, Kun Ho Lee, Lindsay A. Farrer
{"title":"Whole-genome sequencing study in Koreans identifies novel loci for Alzheimer's disease","authors":"Moonil Kang, John J. Farrell, Congcong Zhu, Hyeonseul Park, Sarang Kang, Eun Hyun Seo, Kyu Yeong Choi, Gyungah R. Jun, Sungho Won, Jungsoo Gim, Kun Ho Lee, Lindsay A. Farrer","doi":"10.1002/alz.14128","DOIUrl":"https://doi.org/10.1002/alz.14128","url":null,"abstract":"The genetic basis of Alzheimer's disease (AD) in Koreans is poorly understood.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"8 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project 通过阿尔茨海默病测序项目的全基因组测序，13,000 多名不同个体中的常见和罕见变异与阿尔茨海默病的关系
IF 14 1区 医学
Alzheimer's & Dementia Pub Date : 2024-10-20 DOI: 10.1002/alz.14283
Wan-Ping Lee, Seung Hoan Choi, Margaret G. Shea, Po-Liang Cheng, Beth A. Dombroski, Achilleas N. Pitsillides, Nancy L. Heard-Costa, Hui Wang, Katia Bulekova, Amanda B. Kuzma, Yuk Yee Leung, John J. Farrell, Honghuang Lin, Brian W. Kunkle, Adam Naj, Elizabeth E. Blue, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle, William S. Bush, Xiaoling Zhang, Philip L. De Jager, Josée Dupuis, Lindsay A. Farrer, Myriam Fornage, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M. Wijsman, Li-San Wang, , Gerard D. Schellenberg, Anita L. Destefano, Jonathan L. Haines, Gina M. Peloso
{"title":"Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project","authors":"Wan-Ping Lee, Seung Hoan Choi, Margaret G. Shea, Po-Liang Cheng, Beth A. Dombroski, Achilleas N. Pitsillides, Nancy L. Heard-Costa, Hui Wang, Katia Bulekova, Amanda B. Kuzma, Yuk Yee Leung, John J. Farrell, Honghuang Lin, Brian W. Kunkle, Adam Naj, Elizabeth E. Blue, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle, William S. Bush, Xiaoling Zhang, Philip L. De Jager, Josée Dupuis, Lindsay A. Farrer, Myriam Fornage, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M. Wijsman, Li-San Wang, , Gerard D. Schellenberg, Anita L. Destefano, Jonathan L. Haines, Gina M. Peloso","doi":"10.1002/alz.14283","DOIUrl":"https://doi.org/10.1002/alz.14283","url":null,"abstract":"Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"75 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信