Alzheimer's & Dementia最新文献

{"title":"Real-world clinical, biomarker, and imaging outcomes of lecanemab in Alzheimer's disease: a multicenter longitudinal cohort study in Jiangsu, China.","authors":"Limoran Tang, Xicheng Chen, Li Zhang, Lin Fan, Nihong Chen, Chaosheng Li, Zenglin Cai, Guofang Chen, Haifeng Chen, Min Ye, Huifen Zheng, Qi Li, Zhihong Ke, Zheqi Hu, Maohong Cao, Dan Yang, Shuai Xu, Chunming Xie, Xiaobo Li, Xiaotian Xu, Ming Yu, Xuegan Lian, Hua Hu, Hongfei Li, Xiuying Cai, Hong Chen, Wu Xu, Guiyun Cui, Yang Zhao, Jingde Dong, Lili Zhang, Xiaolei Zhu, Hui Zhao, Yun Xu","doi":"10.1002/alz.71936","DOIUrl":"https://doi.org/10.1002/alz.71936","url":null,"abstract":"<p><strong>Introduction: </strong>Real-world data on lecanemab's efficacy and the longitudinal dynamics of plasma biomarkers are scarce in Chinese patients with Alzheimer's disease (AD).</p><p><strong>Methods: </strong>In this multicenter cohort study, 181 AD patients received biweekly lecanemab. Disease-stage-specific Clinical Dementia Rating-Sum of Boxes meaningful within-patient change defined response at Months 3, 6, and 12. We used penalized models, receiver operating characteristic analysis, attrition comparisons, and exploratory Month 3 plasma biomarker analysis.</p><p><strong>Results: </strong>Cognitive response emerged at Month 6 and intensified by Month 12, largely restricted to mild cognitive impairment and mild dementia due to AD. Repeated five-fold cross-validated areas under the curve across the follow-up timepoints were 0.560, 0.747, and 0.773, with apolipoprotein E ε4 positivity and more severe cognitive impairment linked to lower response odds. Plasma phosphorylated tau 217 (p-tau217) and amyloid beta (Aβ) 42/40 altered as early as Month 3. Month 3 Aβ42/40 showed modest exploratory discrimination. The incidence of amyloid-related imaging abnormalities was 7.2%, all asymptomatic.</p><p><strong>Discussion: </strong>Lecanemab is effective and safe in AD over 6 to 12 months. Early biomarker changes (p-tau217, Aβ42/40) precede clinical improvement, serving as scalable response indicators.</p>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149260409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of improved access to diabetes medications on risk of Alzheimer's disease and related dementias.","authors":"Douglas Barthold, Julie Zissimopoulos, Anirban Basu, Bryan Tysinger","doi":"10.1002/alz.71794","DOIUrl":"10.1002/alz.71794","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes is associated with elevated risk of Alzheimer's disease and related dementias (ADRD). Disease management with pharmaceutical therapies may mitigate this increased risk, but access and use of diabetes therapies are limited, especially for persons at highest risk of ADRD.</p><p><strong>Methods: </strong>Using 10 years of data on Americans aged 51 and older with diabetes, we employed dynamic microsimulation to analyze the impact of increased utilization of glucagon-like peptide 1 receptor agonists (GLP1s) and sodium-glucose cotransporter-2 inhibitors (SGLT2s) on ADRD incidence.</p><p><strong>Results: </strong>Over 10 years, utilization of GLP1s and SGLT2s by people with diabetes and HbA1c > 7 could avert 76,000-201,000 ADRD cases. The risk reduction is largest for Black and Hispanic individuals and individuals with HbA1c > 8.</p><p><strong>Discussion: </strong>This study shows that improving diabetes management can lead to large reductions in ADRD risk. Improved adherence and access for those with higher HbA1c and higher risk of ADRD will have the largest benefit.</p>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":"e71794"},"PeriodicalIF":12.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Alzheimer's & dementia articles.","authors":"","doi":"10.1002/alz.71906","DOIUrl":"https://doi.org/10.1002/alz.71906","url":null,"abstract":"","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149260388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why sleep assessment belongs in the memory clinic.","authors":"Anastasia Suraev, Mariana Fernandes, Andrew Lim, Fang Han, Sharon L Naismith, Claudio Liguori","doi":"10.1002/alz.71880","DOIUrl":"https://doi.org/10.1002/alz.71880","url":null,"abstract":"<p><p>Sleep disturbances are highly prevalent in older adults and are particularly common among individuals attending memory clinics for assessment of cognitive impairment. Emerging evidence links sleep disorders, including insomnia, obstructive sleep apnea, circadian rhythm disruption, and rapid eye movement sleep behavior disorder, to cognitive decline, neurodegenerative pathology, and reduced quality of life for patients and caregivers. Despite their high prevalence and clinical relevance, sleep disturbances are not routinely assessed within many memory clinic and neurologic, psychiatric, and geriatric settings, and approaches to screening, diagnosis, and management vary widely across health-care systems. This Perspective article examines current approaches to sleep assessment and management within memory clinic and specialized settings across four international contexts. We highlight the absence of systematic approaches to identifying and managing sleep disturbances in this population and propose the need for a pragmatic stepped-care framework to improve detection, guide referral pathways, and support more consistent and personalized care in memory clinic settings.</p>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149260452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excitation–inhibition imbalance links amyloid pathophysiology to cognition in non-demented individuals","authors":"Shaoshi Zhang,&nbsp;Sebastian N. Roemer-Cassiano,&nbsp;Joyce Ruifen Chong,&nbsp;Tian Fang,&nbsp;Yan Li,&nbsp;Ziwen Wang,&nbsp;Tianchu Zeng,&nbsp;Xin Li,&nbsp;Gustavo Deco,&nbsp;Narayanaswamy Venketasubramanian,&nbsp;Juan Helen Zhou,&nbsp;Christopher Li-Hsian Chen,&nbsp;Alzheimer's Disease Neuroimaging Initiative,&nbsp;Mitchell K. P. Lai,&nbsp;Nicolai Franzmeier,&nbsp;B. T. Thomas Yeo","doi":"10.1002/alz.71891","DOIUrl":"10.1002/alz.71891","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Excitation–inhibition (E/I) imbalance has been proposed as an early circuit-level mechanism in Alzheimer's disease (AD), but its relationship to molecular pathology and cognition in humans remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We integrated biophysical modeling of resting-state functional magnetic resonance imaging with cerebrospinal fluid (CSF) and plasma biomarkers to examine whether E/I ratio links amyloid pathophysiology to memory in non-demented individuals across two cohorts from North America (<i>N</i> = 302; CSF amyloid beta 42 [Aβ42]) and Singapore (<i>N</i> = 240; plasma phosphorylated tau 217 [p-tau217]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Elevated E/I ratio was associated with lower CSF Aβ42 and higher plasma p-tau217, with greater sensitivity in sensory–motor regions. In contrast, elevated E/I ratio in association cortices was more strongly related to worse memory function. Mediation analyses indicated E/I ratio partially accounted for the AD biomarker–memory relationship.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>E/I imbalance represents an intermediate, systems-level circuit mechanism that links AD pathophysiology to cognitive impairment, offering novel insight into early neurophysiological changes along the AD continuum.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of plasma HDL subclasses with incident dementia risk in older adults","authors":"Binchong An,&nbsp;Suad Ali,&nbsp;Karen Smith,&nbsp;Samantha Roemhild,&nbsp;Lindsey Neumann,&nbsp;Dwight R. Stoll,&nbsp;Ling Li,&nbsp;Pamela L Lutsey,&nbsp;Michelle M Mielke,&nbsp;Fang Yu,&nbsp;Ron C Hoogeveen,&nbsp;Lin Zhang,&nbsp;Alvaro Alonso,&nbsp;Danni Li","doi":"10.1002/alz.71893","DOIUrl":"10.1002/alz.71893","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Plasma high-density lipoprotein (HDL) varies in size. We examined the associations between HDL subclasses and their lipid composition and incident dementia risk in older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We included 23,790 United Kingdom (UK) Biobank (UKB) and 147 Atherosclerosis Risk in Communities (ARIC) older adults free of dementia at baseline. HDL subclasses and their lipid composition were characterized using two distinct approaches: Nightingale nuclear magnetic resonance (NMR) spectroscopy in UKB and anion-exchange chromatography followed by mass spectrometry-based lipidomics of physically isolated HDL subfractions (AEX-MS) in ARIC. Cox regression models were used to evaluate the associations, adjusting for covariates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>In the UKB, Nightingale NMR-derived plasma small and very large HDL particle and six lipid concentrations (total lipids, triglycerides [TG], phospholipids, free cholesterol, cholesterol ester [CE], total cholesterol) were associated with lower and higher risks of incident dementia, respectively. These associations were likely driven mainly by particle concentration in NMR-derived small HDL and by both lipid and lipid concentrations in NMR-derived very large HDL. In the ARIC, total TG in AEX-defined HDL subfraction 1 (e.g., smaller HDL), total lysophosphatidylcholine (LPC) and phosphatidylethanolamine (PE), and TG in AEX-defined subfraction 2 (e.g., larger HDL) were associated with a lower incident dementia risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Although different HDL subclass characterization and lipid measurement methods made it difficult to compare results across cohorts, HDL subclasses and their lipid compositions were associated with the risk of incident dementia in both cohorts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149086016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZBP1-mediated Treg cell dysfunction exacerbates neuroimmune dysregulation in Alzheimer's disease under metabolic stress","authors":"Shanshan Huang,&nbsp;Zengyu Zhang,&nbsp;Jiajie Xia,&nbsp;Mengqiu Deng,&nbsp;Fangzheng Chen,&nbsp;Meng Wang,&nbsp;Yuchao Fei,&nbsp;Zhiwen Jiang,&nbsp;Chenyu Lu,&nbsp;Jiayu Fu,&nbsp;Jingchun Guo,&nbsp;Houguang Zhou","doi":"10.1002/alz.71896","DOIUrl":"10.1002/alz.71896","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Metabolic stress increases Alzheimer's disease (AD) risk, but mechanisms linking metabolic dysfunction to neuroimmune dysregulation remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We assessed cognition in community-dwelling participants and used high-fat diet (HFD)-fed 5xFAD mice, high glucose and high palmitate (HGHP)-treated regulatory T cell (Treg) co-cultures, and adoptive Treg transfer to evaluate metabolic stress-associated neuroimmune dysfunction. Flow cytometry, RNA sequencing, positron emission tomography computed tomography, and electrophysiology assessed Treg function, AD pathology, cerebral metabolism, and synaptic plasticity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Metabolic stress impaired Treg stability and function, accompanied by increased Z-DNA-binding protein 1 (ZBP1) expression and activation of apoptotic and necroptotic signaling. Treg dysfunction was associated with enhanced glial activation and neuronal injury. Under HGHP stress, ZBP1-deficient Tregs showed improved survival and stronger immunosuppressive activity, more effectively limiting glial activation and preserving neuronal integrity. In vivo, ZBP1-deficient Treg transfer conferred greater neuroprotection than wild-type Treg transfer in HFD-fed AD mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>ZBP1 may contribute to metabolic stress–induced Treg dysfunction and represent a candidate target to improve Treg-based therapy in HFD-fed AD mice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71896","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149086015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposome-wide association study and predictive risk score for incident Alzheimer's disease and related dementias","authors":"Chenshuang Li,&nbsp;Chenxu Zhao,&nbsp;Yiqun Lan,&nbsp;Randall J Ellis,&nbsp;Shakson Isaac,&nbsp;Sai Zhang,&nbsp;Gary W. Miller,&nbsp;Yi Sun,&nbsp;Shalini Jain,&nbsp;Hariom Yadav,&nbsp;Peng Gao,&nbsp;Chirag J Patel","doi":"10.1002/alz.71842","DOIUrl":"10.1002/alz.71842","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Environmental exposures contribute substantially to Alzheimer's disease and related dementias (ADRD), yet comprehensive exposome-wide investigations systematically evaluating multi-domain environmental factors remain limited and lacking utility for precision medicine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We conducted an exposome-wide association study (ExWAS) among 499,992 UK Biobank participants, examining 193 exposures across five domains (social, physical, chemical, lifestyle, and ecosystems). Cox proportional hazard models with Bonferroni correction identified ADRD-associated exposures. We used the XGBoost classifier to build a predictive model and further developed an exposomic risk score (ERS) for risk stratification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>During a 15.3-year median follow-up, 8881 participants (1.77%) developed ADRD, including 4000 with Alzheimer's disease. ExWAS identified 76 exposures after Bonferroni correction. The prediction model achieved area under the curve (AUC) = 0.718, outperforming demographics+apolipoprotein E (<i>APOE</i>) status alone (AUC = 0.678). The ERS stratified ADRD risk (highest vs lowest quartile hazard ratio [HR] = 2.97, 95% confidence interval [CI]: 2.59–3.41).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>The ERS has the potential to contribute to clinically relevant prevention strategies for ADRD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical considerations for characterization of the external exposome in Alzheimer's disease and related dementias cohorts","authors":"Zachary Popp,&nbsp;Allison James,&nbsp;Marco Chivardi,&nbsp;Cameron J Reimer,&nbsp;Charlotte Robbins,&nbsp;Tara Jenson,&nbsp;Jeroen M van Baar,&nbsp;Peter James,&nbsp;Kevin J Lane,&nbsp;Marcia Pescador Jiménez","doi":"10.1002/alz.71841","DOIUrl":"https://doi.org/10.1002/alz.71841","url":null,"abstract":"<p>External exposome research offers opportunities to evaluate complex relationships between multiple environmental determinants of Alzheimer's disease and related dementias (ADRD). However, selecting specific exposure domains, identifying metrics, and downloading, processing, and managing big data are key challenges in translating the potential of exposome research into empirical data analyses. To overcome these issues, we have established a reproducible system that protects data privacy, setting the stage for an unparalleled examination of associations between environmental exposures and ADRD risk within an exposome framework. In this perspective, we provide a comprehensive guide, including examples, to linking natural, built, and social environment metrics to nationwide time-varying participants’ residential address data. Further, as a proof of concept, we report descriptive statistics and spatial distribution of external exposome metrics across the contiguous United States in 2015. The external exposome can be securely and comprehensively characterized across multiple cohorts using this highly scalable approach.</p>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71841","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision residential greenspace, urban environmental exposures, and incident dementia among older adults in Sweden: A 16-year cohort study","authors":"Cecilia U. D. Stenfors,&nbsp;Jing Wu,&nbsp;Giulia Grande,&nbsp;Andrei Pyko,&nbsp;Mare Löhmus,&nbsp;Göran Pershagen,&nbsp;Debora Rizzuto","doi":"10.1002/alz.71835","DOIUrl":"https://doi.org/10.1002/alz.71835","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> INTRODUCTION</h3>\u0000 \u0000 <p>Residential greenspace is linked to mental and cardiometabolic health, but longitudinal studies on detailed greenspace and dementia incidence are limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> METHODS</h3>\u0000 \u0000 <p>We followed 2993 dementia-free participants in the Swedish National Study on Aging and Care Kungsholmen for 16 years; 477 developed clinically diagnosed dementia. Greenspace was assessed using normalized difference vegetation index within 100-, 250-, and 500-m residential buffers. Cox models estimated hazard ratios (HRs) per interquartile-range greenspace increment and tested effect modification by air pollution, road traffic noise, blue space, age, sex, and apolipoprotein E-ε4 (APOE-ε4).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Higher greenspace within 100 m was associated with lower dementia incidence (HR = 0.79, 95% confidence interval [CI] = 0.64–0.96), whereas associations for larger buffers were attenuated. Associations were stronger in women (HR = 0.69, 95% CI = 0.54–0.89) than men (HR = 0.93, 95% CI = 0.71–1.24).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> DISCUSSION</h3>\u0000 \u0000 <p>Close residential greenspace may reduce dementia risk in older adults, particularly women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 10","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.71835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}