Neurocognitive disorders, depression, and associated factors in younger and older adults from an urban-marginalized area of Peru

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-10-11 DOI:10.1002/alz.70798

Monica M. Diaz, Eder Herrera-Perez, Rosa Montesinos, Chhitij Tiwari, Nilton Custodio, Serggio C. Lanata

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引用次数: 0

Abstract

INTRODUCTION

In urban-marginalized areas of low-to-middle-income countries (LMICs), neurocognitive disorders (NCDs) and depression present significant public health issues, exacerbated by socioeconomic disparities.

METHODS

This study explores the prevalence and risk factors of NCDs and depression among 1064 community-dwelling adults in an urban-marginalized district of Lima, Peru. Structured questionnaires collected demographic, health, and socioeconomic data; neurocognitive assessments and depression screening were conducted.

RESULTS

Mean age was 50.5 years, with 71% female, and a mean of 9.1 years of education. Among older adults, 32% had mild NCD and 4.2% had major NCD; 21.1% of younger adults had any NCD. Nearly 40% of the cohort was depressed. Risk factors for MCI and NCD included lower education, hypertension, and non-Spanish native language, while depression was associated with female sex, lower education, overcrowding, and chronic diseases.

DISCUSSION

The study emphasizes the need for targeted interventions to address NCDs and mental health in urban-marginalized areas of LMICs.

Highlights

Among older adults, 32% had mild neurocognitive disorder (NCD) and 4.2% had major NCD; 21.1% of younger adults had any NCD.
Nearly 40% of the cohort was depressed.
Risk factors for mild cognitive impairment (MCI) and NCD included lower education, hypertension, and non-Spanish native language, while depression was associated with female sex, lower education, overcrowding, and chronic diseases.

Abstract Image

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秘鲁城市边缘地区年轻人和老年人的神经认知障碍、抑郁症及其相关因素

在中低收入国家（LMICs）的城市边缘地区，神经认知障碍（NCDs）和抑郁症构成了严重的公共卫生问题，并因社会经济差异而加剧。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.