Nature cardiovascular research最新文献_第4页

Preclinical mouse models of immune checkpoint inhibitor-associated myocarditis. 免疫检查点抑制剂相关性心肌炎的临床前小鼠模型。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI: 10.1038/s44161-025-00640-2

Reilly G Fankhauser, Douglas B Johnson, Javid J Moslehi, Justin M Balko

引用次数: 0

Reply to: Stochastic virtual heart model predictions. 回复：随机虚拟心脏模型预测。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-04-23 DOI: 10.1038/s44161-025-00642-0

Eric Sung, Adityo Prakosa, Natalia Trayanova

引用次数: 0

ARID5A promotes inflammation and fibrosis during cardiac aging. ARID5A在心脏老化过程中促进炎症和纤维化。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00621-5

Shoval Miyara, Eldad Tzahor

引用次数: 0

Tertiary lymphoid organs in human atherosclerotic plaques. 人类动脉粥样硬化斑块的三级淋巴器官。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00645-x

Devadatta Gosavi, Klaus Ley

引用次数: 0

Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization. 开发由机器学习驱动的心脏数字双胞胎群体提供了传导和复极化的电生理学见解。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-05-16 DOI: 10.1038/s44161-025-00650-0

Shuang Qian, Devran Ugurlu, Elliot Fairweather, Laura Dal Toso, Yu Deng, Marina Strocchi, Ludovica Cicci, Richard E Jones, Hassan Zaidi, Sanjay Prasad, Brian P Halliday, Daniel Hammersley, Xingchi Liu, Gernot Plank, Edward Vigmond, Reza Razavi, Alistair Young, Pablo Lamata, Martin Bishop, Steven Niederer

{"title":"Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization.","authors":"Shuang Qian, Devran Ugurlu, Elliot Fairweather, Laura Dal Toso, Yu Deng, Marina Strocchi, Ludovica Cicci, Richard E Jones, Hassan Zaidi, Sanjay Prasad, Brian P Halliday, Daniel Hammersley, Xingchi Liu, Gernot Plank, Edward Vigmond, Reza Razavi, Alistair Young, Pablo Lamata, Martin Bishop, Steven Niederer","doi":"10.1038/s44161-025-00650-0","DOIUrl":"10.1038/s44161-025-00650-0","url":null,"abstract":"Large-cohort imaging and diagnostic studies often assess cardiac function but overlook underlying biological mechanisms. Cardiac digital twins (CDTs) are personalized physics-constrained and physiology-constrained in silico representations, uncovering multi-scale insights tied to these mechanisms. In this study, we constructed 3,461 CDTs from the UK Biobank and another 359 from an ischemic heart disease (IHD) cohort, using cardiac magnetic resonance images and electrocardiograms. We show here that sex-specific differences in QRS duration were fully explained by myocardial anatomy while their myocardial conduction velocity (CV) remains similar across sexes but changes with age and obesity, indicating myocardial tissue remodeling. Longer QTc intervals in obese females were attributed to larger delayed rectifier potassium conductance <math> <msub><mrow><mi>G</mi></mrow> <mrow><mi>KrKs</mi></mrow> </msub> </math> . These findings were validated in the IHD cohort. Moreover, CV and <math> <msub><mrow><mi>G</mi></mrow> <mrow><mi>KrKs</mi></mrow> </msub> </math> were associated with cardiac function, lifestyle and mental health phenotypes, and CV was also linked with adverse clinical outcomes. Our study demonstrates how CDT development at scale reveals biological insights across populations.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 5","pages":"624-636"},"PeriodicalIF":9.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal high-fat diet exacerbates atherosclerosis development in offspring through epigenetic memory. 母体高脂肪饮食会通过表观遗传记忆加剧后代动脉粥样硬化的发展。

IF 9.4

Nature cardiovascular research Pub Date : 2025-04-01 Epub Date: 2025-03-14 DOI: 10.1038/s44161-025-00622-4

Kan Li, Weiqi Qian, Fangni Zhang, Wenhui Zhang, Huizhen Lv, Meixi Quan, Weiyan Sun, Ruixin Liu, Xinyi Cao, Zhong Xian, Suya Bao, Hongfeng Jiang, Jie Du, Meng Zhang, Yupeng Chen, Jian Zhang, Cha Han, Ding Ai

{"title":"Maternal high-fat diet exacerbates atherosclerosis development in offspring through epigenetic memory.","authors":"Kan Li, Weiqi Qian, Fangni Zhang, Wenhui Zhang, Huizhen Lv, Meixi Quan, Weiyan Sun, Ruixin Liu, Xinyi Cao, Zhong Xian, Suya Bao, Hongfeng Jiang, Jie Du, Meng Zhang, Yupeng Chen, Jian Zhang, Cha Han, Ding Ai","doi":"10.1038/s44161-025-00622-4","DOIUrl":"10.1038/s44161-025-00622-4","url":null,"abstract":"Maternal exposure to a Western-type diet (WD) increases the susceptibility of adult offspring to atherosclerosis, partly because fetal endothelial cells (ECs) become dysfunctional and inflamed due to risk factors transmitted via maternal-fetal blood exchange. However, the underlying mechanisms remain unclear. Here we show that maternal WD accelerates atherogenesis in adult offspring mice by regulating chromatin dynamics through activator protein-1 (AP-1) in aortic ECs, inducing inflammatory memory at the chromatin level. We found that 27-hydroxycholesterol is involved in memory establishment and also acts as a secondary stimulator, amplifying the expression of inflammatory factors and enhancing the enrichment of AP-1/p300 and H3K27ac in ECs. Inhibiting AP-1 binding to chromatin reduced the inflammatory response in human umbilical vein ECs from mothers with hypercholesterolemia and decreased atherogenesis in offspring mice exposed to maternal WD. Our findings demonstrate that maternal WD exacerbates EC dysfunction and atherosclerosis in adult offspring by inducing AP-1-associated epigenetic memory, which increases chromatin accessibility to inflammatory genes.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":"362-379"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex and the Garden of Eden. 性与伊甸园。

IF 9.4

Nature cardiovascular research Pub Date : 2025-04-01 DOI: 10.1038/s44161-025-00624-2

Peter Libby, Michael C Honigberg, Amélie Vromman

引用次数: 0

Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse. 在发育和成年小鼠中绘制器官型内皮多样性的转录和表观遗传景观。

IF 9.4

Nature cardiovascular research Pub Date : 2025-04-01 Epub Date: 2025-03-17 DOI: 10.1038/s44161-025-00618-0

Manuel E Cantu Gutierrez, Matthew C Hill, Gabrielle E Largoza, William B Gillespie, James F Martin, Joshua D Wythe

{"title":"Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse.","authors":"Manuel E Cantu Gutierrez, Matthew C Hill, Gabrielle E Largoza, William B Gillespie, James F Martin, Joshua D Wythe","doi":"10.1038/s44161-025-00618-0","DOIUrl":"10.1038/s44161-025-00618-0","url":null,"abstract":"The vascular endothelium features unique molecular and functional properties across different vessel types, such as between arteries, veins and capillaries, as well as between different organs, such as the leaky sinusoidal endothelium of the liver versus the impermeable vessels of the brain. However, the transcriptional networks governing endothelial organ specialization remain unclear. Here we profile the accessible chromatin and transcriptional landscapes of the endothelium from the mouse liver, lung, heart, kidney, brain and retina, across developmental time, to identify potential transcriptional regulators of endothelial heterogeneity. We then determine which of these putative regulators are conserved in human brain endothelial cells, and using single-cell transcriptomic profiling, we define which regulatory networks are active during brain maturation. Finally, we show that the putative transcriptional regulators identified by these three approaches molecularly and functionally reprogram naive endothelial cells. Thus, this resource can be used to identify potential transcriptional regulators controlling the establishment and maintenance of organ-specific endothelial specialization.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":"473-495"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left ventricular entry during catheter ablation reduces risk of brain lesions. 导管消融时左心室进入可降低脑损伤风险。

IF 9.4

Nature cardiovascular research Pub Date : 2025-04-01 DOI: 10.1038/s44161-025-00646-w

Xiulin Koehler

引用次数: 0

Defining the transcriptional basis of organ-specific endothelial cell specialization. 定义器官特异性内皮细胞特化的转录基础。

IF 9.4

Nature cardiovascular research Pub Date : 2025-04-01 DOI: 10.1038/s44161-025-00620-6

引用次数: 0