{"title":"通过HIF-1α过度激活将磷脂代谢与脓毒性心肌病联系起来。","authors":"Gizem Kayki Mutlu, Walter J. Koch","doi":"10.1038/s44161-025-00680-8","DOIUrl":null,"url":null,"abstract":"Septic cardiomyopathy arises from complex molecular dysfunctions including cytopathic hypoxia that impair cardiac performance. Research shows that LPS-induced phospholipid metabolism stabilizes HIF-1α in cardiomyocytes, suppressing mitochondrial function and contractility, and identifies promising targets for sepsis-related cardiac dysfunction.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 9","pages":"1036-1037"},"PeriodicalIF":10.8000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Linking phospholipid metabolism to septic cardiomyopathy via HIF-1α overactivation\",\"authors\":\"Gizem Kayki Mutlu, Walter J. Koch\",\"doi\":\"10.1038/s44161-025-00680-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Septic cardiomyopathy arises from complex molecular dysfunctions including cytopathic hypoxia that impair cardiac performance. Research shows that LPS-induced phospholipid metabolism stabilizes HIF-1α in cardiomyocytes, suppressing mitochondrial function and contractility, and identifies promising targets for sepsis-related cardiac dysfunction.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 9\",\"pages\":\"1036-1037\"},\"PeriodicalIF\":10.8000,\"publicationDate\":\"2025-08-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-025-00680-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00680-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Linking phospholipid metabolism to septic cardiomyopathy via HIF-1α overactivation
Septic cardiomyopathy arises from complex molecular dysfunctions including cytopathic hypoxia that impair cardiac performance. Research shows that LPS-induced phospholipid metabolism stabilizes HIF-1α in cardiomyocytes, suppressing mitochondrial function and contractility, and identifies promising targets for sepsis-related cardiac dysfunction.
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