Nature cardiovascular research最新文献

Left ventricular entry during catheter ablation reduces risk of brain lesions.

IF 9.4

Nature cardiovascular research Pub Date : 2025-04-03 DOI: 10.1038/s44161-025-00646-w

Xiulin Koehler

引用次数: 0

CD248⁺ fibroblasts drive cardiac fibrosis by interacting with immune cells.

IF 9.4

Nature cardiovascular research Pub Date : 2025-03-27 DOI: 10.1038/s44161-025-00625-1

引用次数: 0

Dynamic molecular atlas of cardiac fibrosis at single-cell resolution shows CD248 in cardiac fibroblasts orchestrates interactions with immune cells.

IF 9.4

Nature cardiovascular research Pub Date : 2025-03-27 DOI: 10.1038/s44161-025-00617-1

Guohua Li, Cheng Ni, Jiacheng Wang, Feimu Zhang, Zaiyang Fu, Lingjun Wang, Biqing Wang, Ye Liu, Jing Zhao, Mo Li, Hao Lin, Fei Liao, Shuchang Ye, Yu Zhang, Jiayue Cai, Shaohui Shi, Zhiwei Zhong, Yanna Shi, Junhua He, Xushen Xiong, Yang Xu, Jinghai Chen, Wei Zhu, Yibin Wang, Jian'an Wang, Xinyang Hu

{"title":"Dynamic molecular atlas of cardiac fibrosis at single-cell resolution shows CD248 in cardiac fibroblasts orchestrates interactions with immune cells.","authors":"Guohua Li, Cheng Ni, Jiacheng Wang, Feimu Zhang, Zaiyang Fu, Lingjun Wang, Biqing Wang, Ye Liu, Jing Zhao, Mo Li, Hao Lin, Fei Liao, Shuchang Ye, Yu Zhang, Jiayue Cai, Shaohui Shi, Zhiwei Zhong, Yanna Shi, Junhua He, Xushen Xiong, Yang Xu, Jinghai Chen, Wei Zhu, Yibin Wang, Jian'an Wang, Xinyang Hu","doi":"10.1038/s44161-025-00617-1","DOIUrl":"https://doi.org/10.1038/s44161-025-00617-1","url":null,"abstract":"Post-injury remodeling is a complex process involving temporal specific cellular interactions in the injured tissue where the resident fibroblasts play multiple roles. Here, we performed single-cell and spatial transcriptome analysis in human and mouse infarcted hearts to dissect the molecular basis of these interactions. We identified a unique fibroblast subset with high CD248 expression, strongly associated with extracellular matrix remodeling. Genetic Cd248 deletion in fibroblasts mitigated cardiac fibrosis and dysfunction following ischemia/reperfusion. Mechanistically, CD248 stabilizes type I transforming growth factor beta receptor and thus upregulates fibroblast ACKR3 expression, leading to enhanced T cell retention. This CD248-mediated fibroblast-T cell interaction is required to sustain fibroblast activation and scar expansion. Disrupting this interaction using monoclonal antibody or chimeric antigen receptor T cell reduces T cell infiltration and consequently ameliorates cardiac fibrosis and dysfunction. Our findings reveal a CD248+ fibroblast subpopulation as a key regulator of immune-fibroblast cross-talk and a potential therapy to treat tissue fibrosis.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory CD248⁺ activated fibroblasts are a potential therapeutic target in ischemic heart disease.

IF 9.4

Nature cardiovascular research Pub Date : 2025-03-27 DOI: 10.1038/s44161-025-00632-2

Joel G Rurik

引用次数: 0

27-hydroxycholesterol and endothelial cell immune memory link maternal hypercholesterolemia with atherosclerosis in the offspring.

IF 9.4

Nature cardiovascular research Pub Date : 2025-03-27 DOI: 10.1038/s44161-025-00631-3

Chieko Mineo, Philip W Shaul

引用次数: 0

Single-nucleus multi-omics implicates androgen receptor signaling in cardiomyocytes and NR4A1 regulation in fibroblasts during atrial fibrillation.

IF 9.4

Nature cardiovascular research Pub Date : 2025-03-25 DOI: 10.1038/s44161-025-00626-0

Francis J A Leblanc, Chi Him Kendrick Yiu, Lucia M Moreira, Aaron M Johnston, Neelam Mehta, Antonios Kourliouros, Rana Sayeed, Stanley Nattel, Svetlana Reilly, Guillaume Lettre

{"title":"Single-nucleus multi-omics implicates androgen receptor signaling in cardiomyocytes and NR4A1 regulation in fibroblasts during atrial fibrillation.","authors":"Francis J A Leblanc, Chi Him Kendrick Yiu, Lucia M Moreira, Aaron M Johnston, Neelam Mehta, Antonios Kourliouros, Rana Sayeed, Stanley Nattel, Svetlana Reilly, Guillaume Lettre","doi":"10.1038/s44161-025-00626-0","DOIUrl":"https://doi.org/10.1038/s44161-025-00626-0","url":null,"abstract":"The dysregulation of gene expression programs in the human atria during persistent atrial fibrillation (AF) is not completely understood. Here, we reanalyze bulk RNA-sequencing datasets from two studies (N = 242) and identified 755 differentially expressed genes in left atrial appendages of individuals with persistent AF and non-AF controls. We combined the bulk RNA-sequencing differentially expressed genes with a left atrial appendage single-nucleus multi-omics dataset to assign genes to specific atrial cell types. We found noncoding genes at the IFNG locus (LINC01479, IFNG-AS1) strongly dysregulated in cardiomyocytes. We defined a gene expression signature potentially driven by androgen receptor signaling in cardiomyocytes from individuals with AF. Cell-type-specific gene expression modules suggested an increase in T cell and a decrease in adipocyte and neuronal cell gene expression in AF. Lastly, we showed that reducing NR4A1 expression, a marker of a poorly characterized human atrial fibroblast subtype, fibroblast activation markers, extracellular matrix remodeling and cell proliferation decreased.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining the transcriptional basis of organ-specific endothelial cell specialization.

IF 9.4

Nature cardiovascular research Pub Date : 2025-03-21 DOI: 10.1038/s44161-025-00620-6

引用次数: 0

Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse.

IF 9.4

Nature cardiovascular research Pub Date : 2025-03-17 DOI: 10.1038/s44161-025-00618-0

Manuel E Cantu Gutierrez, Matthew C Hill, Gabrielle E Largoza, William B Gillespie, James F Martin, Joshua D Wythe

{"title":"Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse.","authors":"Manuel E Cantu Gutierrez, Matthew C Hill, Gabrielle E Largoza, William B Gillespie, James F Martin, Joshua D Wythe","doi":"10.1038/s44161-025-00618-0","DOIUrl":"10.1038/s44161-025-00618-0","url":null,"abstract":"The vascular endothelium features unique molecular and functional properties across different vessel types, such as between arteries, veins and capillaries, as well as between different organs, such as the leaky sinusoidal endothelium of the liver versus the impermeable vessels of the brain. However, the transcriptional networks governing endothelial organ specialization remain unclear. Here we profile the accessible chromatin and transcriptional landscapes of the endothelium from the mouse liver, lung, heart, kidney, brain and retina, across developmental time, to identify potential transcriptional regulators of endothelial heterogeneity. We then determine which of these putative regulators are conserved in human brain endothelial cells, and using single-cell transcriptomic profiling, we define which regulatory networks are active during brain maturation. Finally, we show that the putative transcriptional regulators identified by these three approaches molecularly and functionally reprogram naive endothelial cells. Thus, this resource can be used to identify potential transcriptional regulators controlling the establishment and maintenance of organ-specific endothelial specialization.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal high-fat diet exacerbates atherosclerosis development in offspring through epigenetic memory. 母体高脂肪饮食会通过表观遗传记忆加剧后代动脉粥样硬化的发展。

IF 9.4

Nature cardiovascular research Pub Date : 2025-03-14 DOI: 10.1038/s44161-025-00622-4

Kan Li, Weiqi Qian, Fangni Zhang, Wenhui Zhang, Huizhen Lv, Meixi Quan, Weiyan Sun, Ruixin Liu, Xinyi Cao, Zhong Xian, Suya Bao, Hongfeng Jiang, Jie Du, Meng Zhang, Yupeng Chen, Jian Zhang, Cha Han, Ding Ai

{"title":"Maternal high-fat diet exacerbates atherosclerosis development in offspring through epigenetic memory.","authors":"Kan Li, Weiqi Qian, Fangni Zhang, Wenhui Zhang, Huizhen Lv, Meixi Quan, Weiyan Sun, Ruixin Liu, Xinyi Cao, Zhong Xian, Suya Bao, Hongfeng Jiang, Jie Du, Meng Zhang, Yupeng Chen, Jian Zhang, Cha Han, Ding Ai","doi":"10.1038/s44161-025-00622-4","DOIUrl":"10.1038/s44161-025-00622-4","url":null,"abstract":"Maternal exposure to a Western-type diet (WD) increases the susceptibility of adult offspring to atherosclerosis, partly because fetal endothelial cells (ECs) become dysfunctional and inflamed due to risk factors transmitted via maternal-fetal blood exchange. However, the underlying mechanisms remain unclear. Here we show that maternal WD accelerates atherogenesis in adult offspring mice by regulating chromatin dynamics through activator protein-1 (AP-1) in aortic ECs, inducing inflammatory memory at the chromatin level. We found that 27-hydroxycholesterol is involved in memory establishment and also acts as a secondary stimulator, amplifying the expression of inflammatory factors and enhancing the enrichment of AP-1/p300 and H3K27ac in ECs. Inhibiting AP-1 binding to chromatin reduced the inflammatory response in human umbilical vein ECs from mothers with hypercholesterolemia and decreased atherogenesis in offspring mice exposed to maternal WD. Our findings demonstrate that maternal WD exacerbates EC dysfunction and atherosclerosis in adult offspring by inducing AP-1-associated epigenetic memory, which increases chromatin accessibility to inflammatory genes.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered heart muscles in non-human primates sustain heart remuscularization

IF 9.4

Nature cardiovascular research Pub Date : 2025-03-13 DOI: 10.1038/s44161-025-00630-4

Elisa Martini

引用次数: 0