Nature cardiovascular research最新文献

Hemolyzed red blood cells prevent microvascular bleeding in ischemic organs. 溶血红细胞可防止缺血器官的微血管出血。

IF 9.4

Nature cardiovascular research Pub Date : 2025-07-02 DOI: 10.1038/s44161-025-00689-z

Gerburg Schwaerzer

引用次数: 0

Multimodal AI to forecast arrhythmic death in hypertrophic cardiomyopathy. 多模式人工智能预测肥厚性心肌病患者心律失常死亡。

IF 9.4

Nature cardiovascular research Pub Date : 2025-07-02 DOI: 10.1038/s44161-025-00679-1

Changxin Lai, Minglang Yin, Eugene G Kholmovski, Dan M Popescu, Dai-Yin Lu, Erica Scherer, Edem Binka, Stefan L Zimmerman, Jonathan Chrispin, Allison G Hays, Dermot M Phelan, M Roselle Abraham, Natalia A Trayanova

{"title":"Multimodal AI to forecast arrhythmic death in hypertrophic cardiomyopathy.","authors":"Changxin Lai, Minglang Yin, Eugene G Kholmovski, Dan M Popescu, Dai-Yin Lu, Erica Scherer, Edem Binka, Stefan L Zimmerman, Jonathan Chrispin, Allison G Hays, Dermot M Phelan, M Roselle Abraham, Natalia A Trayanova","doi":"10.1038/s44161-025-00679-1","DOIUrl":"https://doi.org/10.1038/s44161-025-00679-1","url":null,"abstract":"Sudden cardiac death from ventricular arrhythmias is a leading cause of mortality worldwide. Arrhythmic death prognostication is challenging in patients with hypertrophic cardiomyopathy (HCM), a setting where current clinical guidelines show low performance and inconsistent accuracy. Here, we present a deep learning approach, MAARS (Multimodal Artificial intelligence for ventricular Arrhythmia Risk Stratification), to forecast lethal arrhythmia events in patients with HCM by analyzing multimodal medical data. MAARS' transformer-based neural networks learn from electronic health records, echocardiogram and radiology reports, and contrast-enhanced cardiac magnetic resonance images, the latter being a unique feature of this model. MAARS achieves an area under the curve of 0.89 (95% confidence interval (CI) 0.79-0.94) and 0.81 (95% CI 0.69-0.93) in internal and external cohorts and outperforms current clinical guidelines by 0.27-0.35 (internal) and 0.22-0.30 (external). In contrast to clinical guidelines, it demonstrates fairness across demographic subgroups. We interpret MAARS' predictions on multiple levels to promote artificial intelligence transparency and derive risk factors warranting further investigation.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Milli-spinner promises faster and safer blood clot removal. millispinner承诺更快、更安全地清除血块。

IF 9.4

Nature cardiovascular research Pub Date : 2025-07-01 DOI: 10.1038/s44161-025-00690-6

Elisa Martini

引用次数: 0

Ablating low-voltage areas does not suppress atrial fibrillation. 消融低压区不能抑制心房颤动。

IF 9.4

Nature cardiovascular research Pub Date : 2025-07-01 DOI: 10.1038/s44161-025-00688-0

Andrea Tavosanis

引用次数: 0

Mechanosensitive PIEZO2 channels shape coronary artery development. 机械敏感的PIEZO2通道影响冠状动脉的发育。

IF 9.4

Nature cardiovascular research Pub Date : 2025-06-27 DOI: 10.1038/s44161-025-00677-3

Mireia Pampols-Perez, Carina Fürst, Oscar Sánchez-Carranza, Elena Cano, Jonathan Alexis Garcia-Contreras, Lisa Mais, Wenhan Luo, Sandra Raimundo, Eric L Lindberg, Martin Taube, Arnd Heuser, Anje Sporbert, Dagmar Kainmueller, Miguel O Bernabeu, Norbert Hübner, Holger Gerhardt, Gary R Lewin, Annette Hammes

{"title":"Mechanosensitive PIEZO2 channels shape coronary artery development.","authors":"Mireia Pampols-Perez, Carina Fürst, Oscar Sánchez-Carranza, Elena Cano, Jonathan Alexis Garcia-Contreras, Lisa Mais, Wenhan Luo, Sandra Raimundo, Eric L Lindberg, Martin Taube, Arnd Heuser, Anje Sporbert, Dagmar Kainmueller, Miguel O Bernabeu, Norbert Hübner, Holger Gerhardt, Gary R Lewin, Annette Hammes","doi":"10.1038/s44161-025-00677-3","DOIUrl":"https://doi.org/10.1038/s44161-025-00677-3","url":null,"abstract":"Coronary arteries develop under constant mechanical stress. However, the role of mechanosensitive ion channels in this process remains poorly understood. Here we show that the ion channel PIEZO2, which responds to mechanical stimuli, is expressed in specific coronary endothelial cell populations during a critical phase of coronary vasculature remodeling. These Piezo2+ coronary endothelial cells show distinct transcriptional profiles and have mechanically activated ionic currents. Strikingly, PIEZO2 loss-of-function mouse embryos and mice with human pathogenic variants of PIEZO2 show abnormal coronary vessel development and cardiac left ventricular hyperplasia. We conclude that an optimal balance of PIEZO2 channel function contributes to proper coronary vessel formation, structural integrity and remodeling, and is likely to support normal cardiac function. Our study highlights the importance of mechanical cues in cardiovascular development and suggests that defects in this mechanosensing pathway may contribute to congenital heart conditions.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AIMP3 maintains cardiac homeostasis by regulating the editing activity of methionyl-tRNA synthetase. AIMP3通过调节甲硫基trna合成酶的编辑活性来维持心脏稳态。

IF 9.4

Nature cardiovascular research Pub Date : 2025-06-25 DOI: 10.1038/s44161-025-00670-w

Anindhya S Das, Charles P Rabolli, Colton R Martens, Han-Kai Jiang, Yingshen Zhang, Aubree A Zimmer, Kevin Lin, Kedryn K Baskin, Juan D Alfonzo, Federica Accornero

{"title":"AIMP3 maintains cardiac homeostasis by regulating the editing activity of methionyl-tRNA synthetase.","authors":"Anindhya S Das, Charles P Rabolli, Colton R Martens, Han-Kai Jiang, Yingshen Zhang, Aubree A Zimmer, Kevin Lin, Kedryn K Baskin, Juan D Alfonzo, Federica Accornero","doi":"10.1038/s44161-025-00670-w","DOIUrl":"https://doi.org/10.1038/s44161-025-00670-w","url":null,"abstract":"In mammals, nine aminoacyl tRNA synthetases (ARSs) and three auxiliary proteins (ARS-interacting multifunctional proteins 1-3 (AIMP1-3)) form the multisynthetase complex (MSC), a molecular hub that provides a subset of aminoacylated tRNAs to the ribosome and partakes in translation-independent signaling. Knowledge of the role of AIMPs in organ physiology is currently limited. AIMP3 (also known as EEF1E1) was proposed to anchor methionyl tRNA synthetase (MetRS) in the complex and regulate protein synthesis through translation initiation and elongation. Here we show that a cardiomyocyte-specific conditional knockout of AIMP3 in mice leads to lethal cardiomyopathy. MetRS localization, aminoacylation efficiency and global protein synthesis were unaffected in our model, suggesting an alternative mechanism for the pathology. We found that AIMP3 is essential for homocysteine editing by MetRS, a reaction that is necessary for the maintenance of translation fidelity. Homocysteine accumulation induced reactive oxygen species production, protein aggregation, mitochondrial dysfunction, autophagy and ultimately cell death.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maturation of human cardiac organoids enables complex disease modeling and drug discovery. 人类心脏类器官的成熟使复杂的疾病建模和药物发现成为可能。

IF 9.4

Nature cardiovascular research Pub Date : 2025-06-25 DOI: 10.1038/s44161-025-00669-3

Mark W Pocock, Janice D Reid, Harley R Robinson, Natalie Charitakis, James R Krycer, Simon R Foster, Rebecca L Fitzsimmons, Mary Lor, Lynn A C Devilée, Christopher A P Batho, Natasha Tuano, Sara E Howden, Katerina Vlahos, Kevin I Watt, Adam T Piers, Kaitlyn Bibby, James W McNamara, Rebecca Sutton, Valerii Iaprintsev, Jacob Mathew, Holly K Voges, Patrick R J Fortuna, Sebastian Bass-Stringer, Celine Vivien, James Rae, Robert G Parton, Anthony B Firulli, Leszek Lisowski, Hannah Huckstep, Sean J Humphrey, Sean Lal, Igor E Konstantinov, Robert G Weintraub, David A Elliott, Mirana Ramialison, Enzo R Porrello, Richard J Mills, James E Hudson

{"title":"Maturation of human cardiac organoids enables complex disease modeling and drug discovery.","authors":"Mark W Pocock, Janice D Reid, Harley R Robinson, Natalie Charitakis, James R Krycer, Simon R Foster, Rebecca L Fitzsimmons, Mary Lor, Lynn A C Devilée, Christopher A P Batho, Natasha Tuano, Sara E Howden, Katerina Vlahos, Kevin I Watt, Adam T Piers, Kaitlyn Bibby, James W McNamara, Rebecca Sutton, Valerii Iaprintsev, Jacob Mathew, Holly K Voges, Patrick R J Fortuna, Sebastian Bass-Stringer, Celine Vivien, James Rae, Robert G Parton, Anthony B Firulli, Leszek Lisowski, Hannah Huckstep, Sean J Humphrey, Sean Lal, Igor E Konstantinov, Robert G Weintraub, David A Elliott, Mirana Ramialison, Enzo R Porrello, Richard J Mills, James E Hudson","doi":"10.1038/s44161-025-00669-3","DOIUrl":"https://doi.org/10.1038/s44161-025-00669-3","url":null,"abstract":"Maturation of human pluripotent stem (hPS) cell-derived cardiomyocytes is critical for their use as a model system. Here we mimic human heart maturation pathways in the setting of hPS cell-derived cardiac organoids (hCOs). Specifically, transient activation of 5' AMP-activated protein kinase and estrogen-related receptor enhanced cardiomyocyte maturation, inducing expression of mature sarcomeric and oxidative phosphorylation proteins, and increasing metabolic capacity. hCOs generated using the directed maturation protocol (DM-hCOs) recapitulate cardiac drug responses and, when derived from calsequestrin 2 (CASQ2) and ryanodine receptor 2 (RYR2) mutant hPS cells exhibit a pro-arrhythmia phenotype. These DM-hCOs also comprise multiple cell types, which we characterize and benchmark to the human heart. Modeling of cardiomyopathy caused by a desmoplakin (DSP) mutation resulted in fibrosis and cardiac dysfunction and led to identifying the bromodomain and extra-terminal inhibitor INCB054329 as a drug mitigating the desmoplakin-related functional defect. These findings establish DM-hCOs as a versatile platform for applications in cardiac biology, disease and drug screening.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of effector T_reg signature in APOB-reactive CD4⁺ T cells in patients with coronary artery disease. 冠状动脉疾病患者apob反应性CD4+ T细胞中效应Treg信号的缺失

IF 9.4

Nature cardiovascular research Pub Date : 2025-06-18 DOI: 10.1038/s44161-025-00671-9

Payel Roy, Anusha Bellapu, Sujit Silas Armstrong Suthahar, Mohammad Oliaeimotlagh, Qingkang Lyu, Smriti Parashar, Jeffrey Makings, Runpei Wu, Sunil Kumar, Megh Mehta, Austin W T Chiang, Alessandro Sette, Coleen A McNamara, Klaus Ley

{"title":"Loss of effector Treg signature in APOB-reactive CD4+ T cells in patients with coronary artery disease.","authors":"Payel Roy, Anusha Bellapu, Sujit Silas Armstrong Suthahar, Mohammad Oliaeimotlagh, Qingkang Lyu, Smriti Parashar, Jeffrey Makings, Runpei Wu, Sunil Kumar, Megh Mehta, Austin W T Chiang, Alessandro Sette, Coleen A McNamara, Klaus Ley","doi":"10.1038/s44161-025-00671-9","DOIUrl":"https://doi.org/10.1038/s44161-025-00671-9","url":null,"abstract":"Atherosclerosis underlies most coronary artery disease (CAD). It involves a significant autoimmune component against apolipoprotein B (APOB). In this study, we used short activation-induced marker (AIM) assays to characterize APOB-reactive CD4+ T cells in patients with angiographically verified CAD. APOB-reactive CD4+ T cells expressing CD25 and 4-1BB markers were the most abundant. Their frequency correlated positively with CAD severity. Transcriptomic analysis revealed that these cells were clonally expanded and significantly enriched in genes expressed in tissue-homing effector regulatory T (eTreg) cells. They shared signatures with CD4+ T cells in mouse and human plaques, including expression of the plaque-homing chemokine receptor CXCR6. With increasing disease severity, the Treg signature was progressively and significantly lost. Conversely, APOB-specific Treg cells from patients with severe CAD gained glycolytic and interferon response signatures. We conclude that mild CAD is associated with a regulatory program in APOB-reactive CD4+ T cells, which is replaced by a pro-inflammatory program in patients with severe CAD.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A tunable gene therapy for heart regeneration. 心脏再生的可调基因疗法。

IF 9.4

Nature cardiovascular research Pub Date : 2025-06-13 DOI: 10.1038/s44161-025-00666-6

Gabriele D'Uva

引用次数: 0

The drug-elicitable alternative splicing module for tunable vector expression in the heart. 用于心脏可调载体表达的药物诱导替代剪接模块。

IF 9.4

Nature cardiovascular research Pub Date : 2025-06-13 DOI: 10.1038/s44161-025-00665-7

Zhan Chen, Luzi Yang, Yueyang Zhang, Jiting Li, Yuhan Yang, Yue Li, Linwei Fan, Wei Chen, Lei Miao, Jin Liu, Gonglie Chen, Ze Wang, Yifei Li, Fei Gao, Jing Zhou, Lemin Zheng, Yan Zhang, Dongyu Zhao, William T Pu, Ke Yang, Erdan Dong, Yuxuan Guo

{"title":"The drug-elicitable alternative splicing module for tunable vector expression in the heart.","authors":"Zhan Chen, Luzi Yang, Yueyang Zhang, Jiting Li, Yuhan Yang, Yue Li, Linwei Fan, Wei Chen, Lei Miao, Jin Liu, Gonglie Chen, Ze Wang, Yifei Li, Fei Gao, Jing Zhou, Lemin Zheng, Yan Zhang, Dongyu Zhao, William T Pu, Ke Yang, Erdan Dong, Yuxuan Guo","doi":"10.1038/s44161-025-00665-7","DOIUrl":"https://doi.org/10.1038/s44161-025-00665-7","url":null,"abstract":"Adeno-associated viruses (AAVs) are commonly used for gene therapy, but a clinically relevant method to fine-tune AAV expression is lacking, restricting their therapeutic efficacy and safety. Here we develop the drug-elicitable alternative splicing module (DreAM), which is responsive to risdiplam, a Food and Drug Administration-approved alternative splicing modulator. Risdiplam activated DreAM-regulated AAV expression in a dose-dependent manner with a 2,000-fold inducible change, depending on the dose of risdiplam and the organ of interest. With a temporal resolution of 2 days, DreAM could transiently, reversibly and repeatedly activate AAV expression according to the frequency and duration of risdiplam administration. In this proof-of-concept study, we incorporated DreAM into the cardiomyocyte-specific, liver-detargeted AAV9-Tnnt2-miR122TS vector to transiently activate the cardiomyocyte regeneration factor YAP5SA. A dedifferentiation-proliferation-redifferentiation cycle was established in adult cardiomyocytes, improving cardiac regeneration after myocardial infarction while limiting animal death, AAV9-Tnnt2 expression in the liver and hepatic tumorigenesis. Therefore, DreAM may enhance the efficacy, safety and scope of gene therapy.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0