Nature cardiovascular research最新文献

Left atrial wall shear stress correlates with fibrosis in patients with atrial fibrillation. 心房颤动患者左心房壁剪应力与纤维化相关。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-13 DOI: 10.1038/s44161-025-00651-z

Dionysios Adamopoulos, Georgios Rovas, Nicolas Johner, Hajo Müller, Jean-François Deux, Lindsey A Crowe, Jean-Paul Vallée, François Mach, Nikolaos Stergiopulos, Dipen Shah

{"title":"Left atrial wall shear stress correlates with fibrosis in patients with atrial fibrillation.","authors":"Dionysios Adamopoulos, Georgios Rovas, Nicolas Johner, Hajo Müller, Jean-François Deux, Lindsey A Crowe, Jean-Paul Vallée, François Mach, Nikolaos Stergiopulos, Dipen Shah","doi":"10.1038/s44161-025-00651-z","DOIUrl":"https://doi.org/10.1038/s44161-025-00651-z","url":null,"abstract":"Left atrial wall fibrosis has an important role in atrial fibrillation (AF) because of the abnormal electrophysiological properties of the fibrotic areas. However, the mechanisms behind the development of left atrial fibrosis are not well understood. Here, we examine the association between regional wall shear stress and areas with fibrosis in the left atrium of patients with AF. We recruited 15 patients with AF for an observational prospective study involving baseline three-dimensional (3D) electroanatomical mapping of the left atrium and preinterventional cardiovascular magnetic resonance imaging to detect left atrial fibrosis. We extracted a 3D anatomical model of the left atrium from the electroanatomical maps. Then, we calculated regional time-averaged wall shear stress (TAWSS) and blood stagnation by performing patient-specific computational fluid dynamic simulations. We found that fibrosis and electrical scarring were more prevalent in areas exposed to high TAWSS without blood stagnation, whereas areas with low TAWSS were associated with blood stagnation.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiscale and recursive unmixing of spatiotemporal rhythms for live-cell and intravital cardiac microscopy. 活细胞和活体心脏显微镜的时空节律的多尺度和递归解混。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI: 10.1038/s44161-025-00649-7

Zhi Ling, Wenhao Liu, Kyungduck Yoon, Jessica Hou, Parvin Forghani, Xuanwen Hua, Hansol Yoon, Maryam Bagheri, Lakshmi P Dasi, Biagio Mandracchia, Chunhui Xu, Shuyi Nie, Shu Jia

{"title":"Multiscale and recursive unmixing of spatiotemporal rhythms for live-cell and intravital cardiac microscopy.","authors":"Zhi Ling, Wenhao Liu, Kyungduck Yoon, Jessica Hou, Parvin Forghani, Xuanwen Hua, Hansol Yoon, Maryam Bagheri, Lakshmi P Dasi, Biagio Mandracchia, Chunhui Xu, Shuyi Nie, Shu Jia","doi":"10.1038/s44161-025-00649-7","DOIUrl":"10.1038/s44161-025-00649-7","url":null,"abstract":"Cardiovascular diseases remain a pressing public health issue, necessitating the development of advanced therapeutic strategies underpinned by precise cardiac observations. While fluorescence microscopy is an invaluable tool for probing biological processes, cardiovascular signals are often complicated by persistent autofluorescence, overlaying dynamic cardiovascular entities and nonspecific labeling from tissue microenvironments. Here we present multiscale recursive decomposition for the precise extraction of dynamic cardiovascular signals. Multiscale recursive decomposition constructs a comprehensive framework for cardiac microscopy that includes pixel-wise image enhancement, robust principal component analysis and recursive motion segmentation. This method has been validated in various cardiac systems, including in vitro studies with human induced pluripotent stem cell-derived cardiomyocytes and in vivo studies of cardiovascular morphology and function in Xenopus embryos. The approach advances light-field cardiac microscopy, facilitating simultaneous, multiparametric and volumetric analysis of cardiac activities with minimum photodamage. We anticipate that the methodology will advance cardiovascular studies across a broad spectrum of cardiac models.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":"637-648"},"PeriodicalIF":9.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphatic mysteries unzipped. 淋巴的奥秘解开了。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00643-z

Tatiana V Petrova, Gwendalyn J Randolph

引用次数: 0

Single-cell spatial transcriptomics of tertiary lymphoid organ-like structures in human atherosclerotic plaques. 人类动脉粥样硬化斑块中三级淋巴样器官样结构的单细胞空间转录组学。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-04-28 DOI: 10.1038/s44161-025-00639-9

Zhichao Lai, Deqiang Kong, Qingsong Li, Yue Wang, Kang Li, Xiaohan Duan, Jiang Shao, Yiyun Xie, Junye Chen, Tianjing Zhang, Yuyao Feng, Haohao Deng, Jiaxian Wang, Chaonan Wang, Keqiang Shu, Hongmei Zhao, Hanze Du, Congwei Jia, Huanyu Dai, Lizhi Xie, Jianlin Liu, Xujiao Luo, Lin Wang, Leyin Xu, Zhan Zhu, Xiangling Lei, Yuru Wang, Yixuan Yang, Yanan Liu, Yuyu Liang, Yang Yang, Jun Xie, Bao Liu, Ziqing Deng, Xin Liu

{"title":"Single-cell spatial transcriptomics of tertiary lymphoid organ-like structures in human atherosclerotic plaques.","authors":"Zhichao Lai, Deqiang Kong, Qingsong Li, Yue Wang, Kang Li, Xiaohan Duan, Jiang Shao, Yiyun Xie, Junye Chen, Tianjing Zhang, Yuyao Feng, Haohao Deng, Jiaxian Wang, Chaonan Wang, Keqiang Shu, Hongmei Zhao, Hanze Du, Congwei Jia, Huanyu Dai, Lizhi Xie, Jianlin Liu, Xujiao Luo, Lin Wang, Leyin Xu, Zhan Zhu, Xiangling Lei, Yuru Wang, Yixuan Yang, Yanan Liu, Yuyu Liang, Yang Yang, Jun Xie, Bao Liu, Ziqing Deng, Xin Liu","doi":"10.1038/s44161-025-00639-9","DOIUrl":"10.1038/s44161-025-00639-9","url":null,"abstract":"Tertiary lymphoid organs have been identified in the arterial adventitia in both mouse models of atherosclerosis and patients with atherosclerosis, yet their role in the disease remains insufficiently explored. Here we present a spatially resolved single-cell transcriptome atlas of human atherosclerotic plaques, identifying 14 distinct cell types and providing evidence of plaque tertiary lymphoid organs (PTLOs). The development of PTLOs was associated with the expression of lymphangiogenic chemokine genes and the adhesion molecule gene in fibroblast-like smooth muscle cells. PTLOs harbor abundant B cells with expanded and diversified B cell receptors, suggesting substantial immune involvement. We also observed that B cells may be exchanged between PTLOs and perivascular adipose tissues. The presence of PTLO-like structures correlates with cerebrovascular events, which may be mediated by PTLO-derived IgG antibodies enhancing macrophage functional activity. Our findings suggest the existence and characteristics of PTLOs in human atherosclerosis, elucidating their cellular functions and clinical implications and offering avenues for understanding, diagnosing and treating this condition.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":"547-566"},"PeriodicalIF":9.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular imaging techniques for electrophysiologists. 电生理学家的心血管成像技术。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1038/s44161-025-00648-8

Albert J Rogers, Olga Reynbakh, Adnan Ahmed, Mina K Chung, Rishi Charate, Hirad Yarmohammadi, Rakesh Gopinathannair, Hassan Khan, Dhanunjaya Lakkireddy, Miguel Leal, Uma Srivatsa, Natalia Trayanova, Elaine Y Wan

引用次数: 0

Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations. 全代谢组关联确定铁氧化还原蛋白-1 （FDX1）是亚洲人群胆固醇代谢和心血管风险的决定因素。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1038/s44161-025-00638-w

Nilanjana Sadhu, Rinkoo Dalan, Pritesh R Jain, Chang Jie Mick Lee, Leroy Sivappiragasam Pakkiri, Kai Yi Tay, Theresia H Mina, Dorrain Low, Yilin Min, Matthew Ackers-Johnson, Thi Tun Thi, Vishnu Goutham Kota, Yu Shi, Yan Liu, Hanry Yu, Vicky Lai, Yang Yang, Darwin Tay, Hong Kiat Ng, Xiaoyan Wang, Kari E Wong, Max Lam, Xue Li Guan, Nicolas Bertin, Eleanor Wong, James Best, Rangaprasad Sarangarajan, Paul Elliott, Elio Riboli, Jimmy Lee, Eng Sing Lee, Joanne Ngeow, Patrick Tan, Christine Cheung, Chester Lee Drum, Roger Sy Foo, Gregory A Michelotti, Haojie Yu, Patricia A Sheridan, Marie Loh, John C Chambers

{"title":"Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.","authors":"Nilanjana Sadhu, Rinkoo Dalan, Pritesh R Jain, Chang Jie Mick Lee, Leroy Sivappiragasam Pakkiri, Kai Yi Tay, Theresia H Mina, Dorrain Low, Yilin Min, Matthew Ackers-Johnson, Thi Tun Thi, Vishnu Goutham Kota, Yu Shi, Yan Liu, Hanry Yu, Vicky Lai, Yang Yang, Darwin Tay, Hong Kiat Ng, Xiaoyan Wang, Kari E Wong, Max Lam, Xue Li Guan, Nicolas Bertin, Eleanor Wong, James Best, Rangaprasad Sarangarajan, Paul Elliott, Elio Riboli, Jimmy Lee, Eng Sing Lee, Joanne Ngeow, Patrick Tan, Christine Cheung, Chester Lee Drum, Roger Sy Foo, Gregory A Michelotti, Haojie Yu, Patricia A Sheridan, Marie Loh, John C Chambers","doi":"10.1038/s44161-025-00638-w","DOIUrl":"10.1038/s44161-025-00638-w","url":null,"abstract":"The burden of cardiovascular disease is rising in the Asia-Pacific region, in contrast to falling cardiovascular disease mortality rates in Europe and North America. Here we perform quantification of 883 metabolites by untargeted mass spectroscopy in 8,124 Asian adults and investigate their relationships with carotid intima media thickness, a marker of atherosclerosis. Plasma concentrations of 3beta-hydroxy-5-cholestenoate (3BH5C), a cholesterol metabolite, were inversely associated with carotid intima media thickness, and Mendelian randomization studies supported a causal relationship between 3BH5C and coronary artery disease. The observed effect size was 5- to 6-fold higher in Asians than Europeans. Colocalization analyses indicated the presence of a shared causal variant between 3BH5C plasma levels and messenger RNA and protein expression of ferredoxin-1 (FDX1), a protein that is essential for sterol and bile acid synthesis. We validated FDX1 as a regulator of 3BH5C synthesis in hepatocytes and macrophages and demonstrated its role in cholesterol efflux in macrophages and aortic smooth muscle cells, using knockout and overexpression models.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":"567-583"},"PeriodicalIF":9.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stochastic virtual heart model predictions. 随机虚拟心脏模型预测。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-04-23 DOI: 10.1038/s44161-025-00641-1

Martin J Bishop, Gernot Plank

引用次数: 0

Signal tunnels of the developing heart. 发育中的心脏的信号通道。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00667-5

Vesna Todorovic

引用次数: 0

Functional genomics identifies a protective role for FDX1 in atherosclerosis. 功能基因组学鉴定了FDX1在动脉粥样硬化中的保护作用。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00636-y

Nicole Wayne, Marie A Guerraty

引用次数: 0

ARID5A orchestrates cardiac aging and inflammation through MAVS mRNA stabilization. ARID5A通过MAVS mRNA稳定调控心脏老化和炎症。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-04-29 DOI: 10.1038/s44161-025-00635-z

Yanling Fan, Yandong Zheng, Yiyuan Zhang, Gang Xu, Chun Liu, Jianli Hu, Qianzhao Ji, Shuo Zhang, Shuaiqi Fang, Jinghui Lei, Lan-Zhu Li, Xing Wang, Xi Xu, Cui Wang, Si Wang, Shuai Ma, Moshi Song, Wenjian Jiang, Junming Zhu, Yijia Feng, Jiangang Wang, Ying Yang, Guodong Zhu, Xiao-Li Tian, Hongjia Zhang, Weihong Song, Jiayin Yang, Yan Yao, Guang-Hui Liu, Jing Qu, Weiqi Zhang

{"title":"ARID5A orchestrates cardiac aging and inflammation through MAVS mRNA stabilization.","authors":"Yanling Fan, Yandong Zheng, Yiyuan Zhang, Gang Xu, Chun Liu, Jianli Hu, Qianzhao Ji, Shuo Zhang, Shuaiqi Fang, Jinghui Lei, Lan-Zhu Li, Xing Wang, Xi Xu, Cui Wang, Si Wang, Shuai Ma, Moshi Song, Wenjian Jiang, Junming Zhu, Yijia Feng, Jiangang Wang, Ying Yang, Guodong Zhu, Xiao-Li Tian, Hongjia Zhang, Weihong Song, Jiayin Yang, Yan Yao, Guang-Hui Liu, Jing Qu, Weiqi Zhang","doi":"10.1038/s44161-025-00635-z","DOIUrl":"10.1038/s44161-025-00635-z","url":null,"abstract":"Elucidating the regulatory mechanisms of human cardiac aging remains a great challenge. Here, using human heart tissues from 74 individuals ranging from young (≤35 years) to old (≥65 years), we provide an overview of the histological, cellular and molecular alterations underpinning the aging of human hearts. We decoded aging-related gene expression changes at single-cell resolution and identified increased inflammation as the key event, driven by upregulation of ARID5A, an RNA-binding protein. ARID5A epi-transcriptionally regulated Mitochondrial Antiviral Signaling Protein (MAVS) mRNA stability, leading to NF-κB and TBK1 activation, amplifying aging and inflammation phenotypes. The application of gene therapy using lentiviral vectors encoding shRNA targeting ARID5A into the myocardium not only mitigated the inflammatory and aging phenotypes but also bolstered cardiac function in aged mice. Altogether, our study provides a valuable resource and advances our understanding of cardiac aging mechanisms by deciphering the ARID5A-MAVS axis in post-transcriptional regulation.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":"602-623"},"PeriodicalIF":9.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0