Nature cardiovascular research最新文献_第2页

A perspective on thrombogenesis through gut microbiota-derived bile acids and platelet activation. 通过肠道微生物来源的胆汁酸和血小板活化对血栓形成的看法。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00634-0

Cristina Menni, Ana M Valdes

引用次数: 0

Inherited traits from paternal cardiac lesions result in adapted response to cardiac injury in offspring. 来自父亲心脏病变的遗传特征导致后代对心脏损伤的适应性反应。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00663-9

Xiulin Koehler

引用次数: 0

Targeting atherosclerosis beyond cholesterol reduction. 除降低胆固醇外，还针对动脉粥样硬化。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00662-w

Gerburg Schwaerzer

引用次数: 0

The gut microbiota-bile acid-TGR5 axis orchestrates platelet activation and atherothrombosis. 肠道微生物-胆汁酸- tgr5轴协调血小板活化和动脉粥样硬化血栓形成。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-04-11 DOI: 10.1038/s44161-025-00637-x

Zhiyong Qi, Wei Zhang, Peng Zhang, Yanan Qu, Haoxuan Zhong, Luning Zhou, Wenxuan Zhou, Wenlong Yang, Huajie Xu, Xin Zhao, Hongyi Wu, Juying Qian, Junbo Ge

{"title":"The gut microbiota-bile acid-TGR5 axis orchestrates platelet activation and atherothrombosis.","authors":"Zhiyong Qi, Wei Zhang, Peng Zhang, Yanan Qu, Haoxuan Zhong, Luning Zhou, Wenxuan Zhou, Wenlong Yang, Huajie Xu, Xin Zhao, Hongyi Wu, Juying Qian, Junbo Ge","doi":"10.1038/s44161-025-00637-x","DOIUrl":"10.1038/s44161-025-00637-x","url":null,"abstract":"Gut microbiota-derived bile acids are crucial in the pathogenesis and treatment of metabolic diseases. However, their impact on platelet activation and thrombosis in coronary artery disease (CAD) remains poorly understood. In this study, we observed reduced serum deoxycholic acid (DCA) in patients with CAD and an underrepresentation of Bacteroides vulgatus in the gut microbiota of patients with CAD, affecting DCA metabolism. We used Takeda G-protein-coupled receptor 5 (TGR5) inhibitors and TGR5 knockout mice to show that DCA inhibited agonist-induced platelet activation and thrombosis by interacting with the platelet TGR5. Oral gavage treatments with DCA, B. vulgatus and stool from healthy individuals suppressed platelet hyperreactivity and thrombosis in atherosclerotic ApoE-/- mice, reduced microvascular thrombosis and protected the heart from myocardial ischemia/reperfusion injury. Here we describe the role of the bile acid DCA in platelet activation and suggest that targeting the gut microbiota and/or altering bile acid metabolism may be beneficial to treat CAD-associated thrombosis.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":"584-601"},"PeriodicalIF":9.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical mouse models of immune checkpoint inhibitor-associated myocarditis. 免疫检查点抑制剂相关性心肌炎的临床前小鼠模型。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI: 10.1038/s44161-025-00640-2

Reilly G Fankhauser, Douglas B Johnson, Javid J Moslehi, Justin M Balko

引用次数: 0

Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization. 开发由机器学习驱动的心脏数字双胞胎群体提供了传导和复极化的电生理学见解。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-05-16 DOI: 10.1038/s44161-025-00650-0

Shuang Qian, Devran Ugurlu, Elliot Fairweather, Laura Dal Toso, Yu Deng, Marina Strocchi, Ludovica Cicci, Richard E Jones, Hassan Zaidi, Sanjay Prasad, Brian P Halliday, Daniel Hammersley, Xingchi Liu, Gernot Plank, Edward Vigmond, Reza Razavi, Alistair Young, Pablo Lamata, Martin Bishop, Steven Niederer

{"title":"Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization.","authors":"Shuang Qian, Devran Ugurlu, Elliot Fairweather, Laura Dal Toso, Yu Deng, Marina Strocchi, Ludovica Cicci, Richard E Jones, Hassan Zaidi, Sanjay Prasad, Brian P Halliday, Daniel Hammersley, Xingchi Liu, Gernot Plank, Edward Vigmond, Reza Razavi, Alistair Young, Pablo Lamata, Martin Bishop, Steven Niederer","doi":"10.1038/s44161-025-00650-0","DOIUrl":"https://doi.org/10.1038/s44161-025-00650-0","url":null,"abstract":"Large-cohort imaging and diagnostic studies often assess cardiac function but overlook underlying biological mechanisms. Cardiac digital twins (CDTs) are personalized physics-constrained and physiology-constrained in silico representations, uncovering multi-scale insights tied to these mechanisms. In this study, we constructed 3,461 CDTs from the UK Biobank and another 359 from an ischemic heart disease (IHD) cohort, using cardiac magnetic resonance images and electrocardiograms. We show here that sex-specific differences in QRS duration were fully explained by myocardial anatomy while their myocardial conduction velocity (CV) remains similar across sexes but changes with age and obesity, indicating myocardial tissue remodeling. Longer QTc intervals in obese females were attributed to larger delayed rectifier potassium conductance <math> <msub><mrow><mi>G</mi></mrow> <mrow><mi>KrKs</mi></mrow> </msub> </math> . These findings were validated in the IHD cohort. Moreover, CV and <math> <msub><mrow><mi>G</mi></mrow> <mrow><mi>KrKs</mi></mrow> </msub> </math> were associated with cardiac function, lifestyle and mental health phenotypes, and CV was also linked with adverse clinical outcomes. Our study demonstrates how CDT development at scale reveals biological insights across populations.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 5","pages":"624-636"},"PeriodicalIF":9.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to: Stochastic virtual heart model predictions. 回复：随机虚拟心脏模型预测。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-04-23 DOI: 10.1038/s44161-025-00642-0

Eric Sung, Adityo Prakosa, Natalia Trayanova

引用次数: 0

ARID5A promotes inflammation and fibrosis during cardiac aging. ARID5A在心脏老化过程中促进炎症和纤维化。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00621-5

Shoval Miyara, Eldad Tzahor

引用次数: 0

Tertiary lymphoid organs in human atherosclerotic plaques. 人类动脉粥样硬化斑块的三级淋巴器官。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00645-x

Devadatta Gosavi, Klaus Ley

引用次数: 0

Maternal high-fat diet exacerbates atherosclerosis development in offspring through epigenetic memory. 母体高脂肪饮食会通过表观遗传记忆加剧后代动脉粥样硬化的发展。

IF 9.4

Nature cardiovascular research Pub Date : 2025-04-01 Epub Date: 2025-03-14 DOI: 10.1038/s44161-025-00622-4

Kan Li, Weiqi Qian, Fangni Zhang, Wenhui Zhang, Huizhen Lv, Meixi Quan, Weiyan Sun, Ruixin Liu, Xinyi Cao, Zhong Xian, Suya Bao, Hongfeng Jiang, Jie Du, Meng Zhang, Yupeng Chen, Jian Zhang, Cha Han, Ding Ai

{"title":"Maternal high-fat diet exacerbates atherosclerosis development in offspring through epigenetic memory.","authors":"Kan Li, Weiqi Qian, Fangni Zhang, Wenhui Zhang, Huizhen Lv, Meixi Quan, Weiyan Sun, Ruixin Liu, Xinyi Cao, Zhong Xian, Suya Bao, Hongfeng Jiang, Jie Du, Meng Zhang, Yupeng Chen, Jian Zhang, Cha Han, Ding Ai","doi":"10.1038/s44161-025-00622-4","DOIUrl":"10.1038/s44161-025-00622-4","url":null,"abstract":"Maternal exposure to a Western-type diet (WD) increases the susceptibility of adult offspring to atherosclerosis, partly because fetal endothelial cells (ECs) become dysfunctional and inflamed due to risk factors transmitted via maternal-fetal blood exchange. However, the underlying mechanisms remain unclear. Here we show that maternal WD accelerates atherogenesis in adult offspring mice by regulating chromatin dynamics through activator protein-1 (AP-1) in aortic ECs, inducing inflammatory memory at the chromatin level. We found that 27-hydroxycholesterol is involved in memory establishment and also acts as a secondary stimulator, amplifying the expression of inflammatory factors and enhancing the enrichment of AP-1/p300 and H3K27ac in ECs. Inhibiting AP-1 binding to chromatin reduced the inflammatory response in human umbilical vein ECs from mothers with hypercholesterolemia and decreased atherogenesis in offspring mice exposed to maternal WD. Our findings demonstrate that maternal WD exacerbates EC dysfunction and atherosclerosis in adult offspring by inducing AP-1-associated epigenetic memory, which increases chromatin accessibility to inflammatory genes.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":"362-379"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0