Nature cardiovascular research最新文献_第3页

Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations. 全代谢组关联确定铁氧化还原蛋白-1 （FDX1）是亚洲人群胆固醇代谢和心血管风险的决定因素。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1038/s44161-025-00638-w

Nilanjana Sadhu, Rinkoo Dalan, Pritesh R Jain, Chang Jie Mick Lee, Leroy Sivappiragasam Pakkiri, Kai Yi Tay, Theresia H Mina, Dorrain Low, Yilin Min, Matthew Ackers-Johnson, Thi Tun Thi, Vishnu Goutham Kota, Yu Shi, Yan Liu, Hanry Yu, Vicky Lai, Yang Yang, Darwin Tay, Hong Kiat Ng, Xiaoyan Wang, Kari E Wong, Max Lam, Xue Li Guan, Nicolas Bertin, Eleanor Wong, James Best, Rangaprasad Sarangarajan, Paul Elliott, Elio Riboli, Jimmy Lee, Eng Sing Lee, Joanne Ngeow, Patrick Tan, Christine Cheung, Chester Lee Drum, Roger Sy Foo, Gregory A Michelotti, Haojie Yu, Patricia A Sheridan, Marie Loh, John C Chambers

{"title":"Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.","authors":"Nilanjana Sadhu, Rinkoo Dalan, Pritesh R Jain, Chang Jie Mick Lee, Leroy Sivappiragasam Pakkiri, Kai Yi Tay, Theresia H Mina, Dorrain Low, Yilin Min, Matthew Ackers-Johnson, Thi Tun Thi, Vishnu Goutham Kota, Yu Shi, Yan Liu, Hanry Yu, Vicky Lai, Yang Yang, Darwin Tay, Hong Kiat Ng, Xiaoyan Wang, Kari E Wong, Max Lam, Xue Li Guan, Nicolas Bertin, Eleanor Wong, James Best, Rangaprasad Sarangarajan, Paul Elliott, Elio Riboli, Jimmy Lee, Eng Sing Lee, Joanne Ngeow, Patrick Tan, Christine Cheung, Chester Lee Drum, Roger Sy Foo, Gregory A Michelotti, Haojie Yu, Patricia A Sheridan, Marie Loh, John C Chambers","doi":"10.1038/s44161-025-00638-w","DOIUrl":"10.1038/s44161-025-00638-w","url":null,"abstract":"The burden of cardiovascular disease is rising in the Asia-Pacific region, in contrast to falling cardiovascular disease mortality rates in Europe and North America. Here we perform quantification of 883 metabolites by untargeted mass spectroscopy in 8,124 Asian adults and investigate their relationships with carotid intima media thickness, a marker of atherosclerosis. Plasma concentrations of 3beta-hydroxy-5-cholestenoate (3BH5C), a cholesterol metabolite, were inversely associated with carotid intima media thickness, and Mendelian randomization studies supported a causal relationship between 3BH5C and coronary artery disease. The observed effect size was 5- to 6-fold higher in Asians than Europeans. Colocalization analyses indicated the presence of a shared causal variant between 3BH5C plasma levels and messenger RNA and protein expression of ferredoxin-1 (FDX1), a protein that is essential for sterol and bile acid synthesis. We validated FDX1 as a regulator of 3BH5C synthesis in hepatocytes and macrophages and demonstrated its role in cholesterol efflux in macrophages and aortic smooth muscle cells, using knockout and overexpression models.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":"567-583"},"PeriodicalIF":9.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular imaging techniques for electrophysiologists. 电生理学家的心血管成像技术。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1038/s44161-025-00648-8

Albert J Rogers, Olga Reynbakh, Adnan Ahmed, Mina K Chung, Rishi Charate, Hirad Yarmohammadi, Rakesh Gopinathannair, Hassan Khan, Dhanunjaya Lakkireddy, Miguel Leal, Uma Srivatsa, Natalia Trayanova, Elaine Y Wan

引用次数: 0

Stochastic virtual heart model predictions. 随机虚拟心脏模型预测。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-04-23 DOI: 10.1038/s44161-025-00641-1

Martin J Bishop, Gernot Plank

引用次数: 0

Signal tunnels of the developing heart. 发育中的心脏的信号通道。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00667-5

Vesna Todorovic

引用次数: 0

Functional genomics identifies a protective role for FDX1 in atherosclerosis. 功能基因组学鉴定了FDX1在动脉粥样硬化中的保护作用。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00636-y

Nicole Wayne, Marie A Guerraty

引用次数: 0

ARID5A orchestrates cardiac aging and inflammation through MAVS mRNA stabilization. ARID5A通过MAVS mRNA稳定调控心脏老化和炎症。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-04-29 DOI: 10.1038/s44161-025-00635-z

Yanling Fan, Yandong Zheng, Yiyuan Zhang, Gang Xu, Chun Liu, Jianli Hu, Qianzhao Ji, Shuo Zhang, Shuaiqi Fang, Jinghui Lei, Lan-Zhu Li, Xing Wang, Xi Xu, Cui Wang, Si Wang, Shuai Ma, Moshi Song, Wenjian Jiang, Junming Zhu, Yijia Feng, Jiangang Wang, Ying Yang, Guodong Zhu, Xiao-Li Tian, Hongjia Zhang, Weihong Song, Jiayin Yang, Yan Yao, Guang-Hui Liu, Jing Qu, Weiqi Zhang

{"title":"ARID5A orchestrates cardiac aging and inflammation through MAVS mRNA stabilization.","authors":"Yanling Fan, Yandong Zheng, Yiyuan Zhang, Gang Xu, Chun Liu, Jianli Hu, Qianzhao Ji, Shuo Zhang, Shuaiqi Fang, Jinghui Lei, Lan-Zhu Li, Xing Wang, Xi Xu, Cui Wang, Si Wang, Shuai Ma, Moshi Song, Wenjian Jiang, Junming Zhu, Yijia Feng, Jiangang Wang, Ying Yang, Guodong Zhu, Xiao-Li Tian, Hongjia Zhang, Weihong Song, Jiayin Yang, Yan Yao, Guang-Hui Liu, Jing Qu, Weiqi Zhang","doi":"10.1038/s44161-025-00635-z","DOIUrl":"10.1038/s44161-025-00635-z","url":null,"abstract":"Elucidating the regulatory mechanisms of human cardiac aging remains a great challenge. Here, using human heart tissues from 74 individuals ranging from young (≤35 years) to old (≥65 years), we provide an overview of the histological, cellular and molecular alterations underpinning the aging of human hearts. We decoded aging-related gene expression changes at single-cell resolution and identified increased inflammation as the key event, driven by upregulation of ARID5A, an RNA-binding protein. ARID5A epi-transcriptionally regulated Mitochondrial Antiviral Signaling Protein (MAVS) mRNA stability, leading to NF-κB and TBK1 activation, amplifying aging and inflammation phenotypes. The application of gene therapy using lentiviral vectors encoding shRNA targeting ARID5A into the myocardium not only mitigated the inflammatory and aging phenotypes but also bolstered cardiac function in aged mice. Altogether, our study provides a valuable resource and advances our understanding of cardiac aging mechanisms by deciphering the ARID5A-MAVS axis in post-transcriptional regulation.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":"602-623"},"PeriodicalIF":9.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A perspective on thrombogenesis through gut microbiota-derived bile acids and platelet activation. 通过肠道微生物来源的胆汁酸和血小板活化对血栓形成的看法。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00634-0

Cristina Menni, Ana M Valdes

引用次数: 0

Inherited traits from paternal cardiac lesions result in adapted response to cardiac injury in offspring. 来自父亲心脏病变的遗传特征导致后代对心脏损伤的适应性反应。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00663-9

Xiulin Koehler

引用次数: 0

Targeting atherosclerosis beyond cholesterol reduction. 除降低胆固醇外，还针对动脉粥样硬化。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 DOI: 10.1038/s44161-025-00662-w

Gerburg Schwaerzer

引用次数: 0

The gut microbiota-bile acid-TGR5 axis orchestrates platelet activation and atherothrombosis. 肠道微生物-胆汁酸- tgr5轴协调血小板活化和动脉粥样硬化血栓形成。

IF 9.4

Nature cardiovascular research Pub Date : 2025-05-01 Epub Date: 2025-04-11 DOI: 10.1038/s44161-025-00637-x

Zhiyong Qi, Wei Zhang, Peng Zhang, Yanan Qu, Haoxuan Zhong, Luning Zhou, Wenxuan Zhou, Wenlong Yang, Huajie Xu, Xin Zhao, Hongyi Wu, Juying Qian, Junbo Ge

{"title":"The gut microbiota-bile acid-TGR5 axis orchestrates platelet activation and atherothrombosis.","authors":"Zhiyong Qi, Wei Zhang, Peng Zhang, Yanan Qu, Haoxuan Zhong, Luning Zhou, Wenxuan Zhou, Wenlong Yang, Huajie Xu, Xin Zhao, Hongyi Wu, Juying Qian, Junbo Ge","doi":"10.1038/s44161-025-00637-x","DOIUrl":"10.1038/s44161-025-00637-x","url":null,"abstract":"Gut microbiota-derived bile acids are crucial in the pathogenesis and treatment of metabolic diseases. However, their impact on platelet activation and thrombosis in coronary artery disease (CAD) remains poorly understood. In this study, we observed reduced serum deoxycholic acid (DCA) in patients with CAD and an underrepresentation of Bacteroides vulgatus in the gut microbiota of patients with CAD, affecting DCA metabolism. We used Takeda G-protein-coupled receptor 5 (TGR5) inhibitors and TGR5 knockout mice to show that DCA inhibited agonist-induced platelet activation and thrombosis by interacting with the platelet TGR5. Oral gavage treatments with DCA, B. vulgatus and stool from healthy individuals suppressed platelet hyperreactivity and thrombosis in atherosclerotic ApoE-/- mice, reduced microvascular thrombosis and protected the heart from myocardial ischemia/reperfusion injury. Here we describe the role of the bile acid DCA in platelet activation and suggest that targeting the gut microbiota and/or altering bile acid metabolism may be beneficial to treat CAD-associated thrombosis.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":"584-601"},"PeriodicalIF":9.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0