{"title":"氧化磷酸化是鱼心脏再生所必需的。","authors":"","doi":"10.1038/s44161-025-00723-0","DOIUrl":null,"url":null,"abstract":"Oxidative phosphorylation was considered detrimental for heart regeneration, as it produces reactive oxygen species that block cardiomyocyte proliferation by causing DNA damage. However, harnessing natural variation in the regenerative capacity of seven wild-type zebrafish strains has revealed that the activation of oxidative metabolism after proliferation is essential for cardiomyocyte maturation and successful regeneration.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 10","pages":"1219-1220"},"PeriodicalIF":10.8000,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oxidative phosphorylation is required for fish heart regeneration\",\"authors\":\"\",\"doi\":\"10.1038/s44161-025-00723-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Oxidative phosphorylation was considered detrimental for heart regeneration, as it produces reactive oxygen species that block cardiomyocyte proliferation by causing DNA damage. However, harnessing natural variation in the regenerative capacity of seven wild-type zebrafish strains has revealed that the activation of oxidative metabolism after proliferation is essential for cardiomyocyte maturation and successful regeneration.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 10\",\"pages\":\"1219-1220\"},\"PeriodicalIF\":10.8000,\"publicationDate\":\"2025-10-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-025-00723-0\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00723-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Oxidative phosphorylation is required for fish heart regeneration
Oxidative phosphorylation was considered detrimental for heart regeneration, as it produces reactive oxygen species that block cardiomyocyte proliferation by causing DNA damage. However, harnessing natural variation in the regenerative capacity of seven wild-type zebrafish strains has revealed that the activation of oxidative metabolism after proliferation is essential for cardiomyocyte maturation and successful regeneration.
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