{"title":"寻找RyR2磷酸化的正确平衡以预防心律失常。","authors":"Daniel J. Blackwell, Björn C. Knollmann","doi":"10.1038/s44161-025-00701-6","DOIUrl":null,"url":null,"abstract":"Ryanodine receptor (RyR2) phosphorylation was thought to regulate cardiac calcium handling and contractility. Research now shows that preventing RyR2 phosphorylation has no effect on heart rate or contractile function in response to catecholamines and instead drives an electrogenic process that can trigger lethal arrhythmia.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 8","pages":"962-963"},"PeriodicalIF":10.8000,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Finding the right balance of RyR2 phosphorylation for arrhythmia prevention\",\"authors\":\"Daniel J. Blackwell, Björn C. Knollmann\",\"doi\":\"10.1038/s44161-025-00701-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ryanodine receptor (RyR2) phosphorylation was thought to regulate cardiac calcium handling and contractility. Research now shows that preventing RyR2 phosphorylation has no effect on heart rate or contractile function in response to catecholamines and instead drives an electrogenic process that can trigger lethal arrhythmia.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 8\",\"pages\":\"962-963\"},\"PeriodicalIF\":10.8000,\"publicationDate\":\"2025-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-025-00701-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00701-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Finding the right balance of RyR2 phosphorylation for arrhythmia prevention
Ryanodine receptor (RyR2) phosphorylation was thought to regulate cardiac calcium handling and contractility. Research now shows that preventing RyR2 phosphorylation has no effect on heart rate or contractile function in response to catecholamines and instead drives an electrogenic process that can trigger lethal arrhythmia.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
