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No degradation of temperature-mediated phenotypic plasticity in Drosophila melanogaster after more than 275 generations of artificial selection on body-size. 经过275代以上的体型人工选择后，黑腹果蝇温度介导的表型可塑性没有退化。
microPublication biology Pub Date : 2025-04-04 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001468
Yvonne L Ofodile, Judith Appenteng, Mubeen Jaffri, Ian Dworkin, Andrew D Stewart
{"title":"No degradation of temperature-mediated phenotypic plasticity in <i>Drosophila melanogaster</i> after more than 275 generations of artificial selection on body-size.","authors":"Yvonne L Ofodile, Judith Appenteng, Mubeen Jaffri, Ian Dworkin, Andrew D Stewart","doi":"10.17912/micropub.biology.001468","DOIUrl":"https://doi.org/10.17912/micropub.biology.001468","url":null,"abstract":"<p><p>Body size is a fundamental trait that shapes a species' development and evolution. Importantly, body size can also be affected by environmental variables, especially development temperature. Here we measure phenotypic plasticity in a series of lineages that had experienced artificial selection on body size for over 275 generations. We found, despite substantial changes in overall size and sexual size dimorphism, only modest effects on developmental plasticity. Still, there were some significant, changes in the sex specific slopes of the relationship between size and rearing temperature, largely due to a reduction in plasticity in the treatment selected for small body size.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prostaglandins limit nuclear actin rod formation during Drosophila oogenesis. 在果蝇卵发生过程中，前列腺素限制核肌动蛋白棒的形成。
microPublication biology Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001571
Tina L Tootle
{"title":"Prostaglandins limit nuclear actin rod formation during <i>Drosophila</i> oogenesis.","authors":"Tina L Tootle","doi":"10.17912/micropub.biology.001571","DOIUrl":"https://doi.org/10.17912/micropub.biology.001571","url":null,"abstract":"<p><p>Expression of GFP-Actin results in nuclear actin rod formation during specific stages of <i>Drosophila melanogaster</i> oogenesis. Loss of prostaglandin (PG) synthesis and signaling results in an increased frequency of cells with nuclear actin rods; there are less rods per cell, but the rods are longer. These findings suggest that loss of PGs results in increased nuclear actin and are consistent with prior findings assessing the roles of PGs in modulating endogenous nuclear actin. Thus, GFP-Actin rod formation can be used as a tool to screen for new regulators of nuclear actin.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene model for the ortholog of wrd in Drosophila ananassae. 果蝇wrd同源基因模型的研究。
microPublication biology Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.000928
Megan E Lawson, Samantha Hoffman, Mikhail Sanu, Daniel Morris, Evan Merkhofer, Stephanie Toering Peters, Nikolaos Tsotakos, Chinmay P Rele, Laura K Reed
{"title":"Gene model for the ortholog of <i>wrd</i> in <i>Drosophila ananassae</i>.","authors":"Megan E Lawson, Samantha Hoffman, Mikhail Sanu, Daniel Morris, Evan Merkhofer, Stephanie Toering Peters, Nikolaos Tsotakos, Chinmay P Rele, Laura K Reed","doi":"10.17912/micropub.biology.000928","DOIUrl":"https://doi.org/10.17912/micropub.biology.000928","url":null,"abstract":"<p><p>Gene model for the ortholog of <i>well-rounded</i> ( <i>wrd</i> ) in the May 2011 (Agencourt dana_caf1/DanaCAF1) Genome Assembly (GenBank Accession: GCA_000005115.1 ) of <i>Drosophila ananassae</i> . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus <i>Drosophila</i> using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene model for the ortholog of Sik3 in Drosophila mojavensis. 莫氏果蝇Sik3同源基因的基因模型。
microPublication biology Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001032
Gabriella N Bicanovsky, Karolina J Senkow, Cassidy McColl, Jennifer Mierisch, Kellie S Agrimson, Lindsey J Long, Judith Leatherman, Chinmay P Rele, Laura K Reed
{"title":"Gene model for the ortholog of <i>Sik3</i> in <i>Drosophila mojavensis</i>.","authors":"Gabriella N Bicanovsky, Karolina J Senkow, Cassidy McColl, Jennifer Mierisch, Kellie S Agrimson, Lindsey J Long, Judith Leatherman, Chinmay P Rele, Laura K Reed","doi":"10.17912/micropub.biology.001032","DOIUrl":"https://doi.org/10.17912/micropub.biology.001032","url":null,"abstract":"<p><p>Gene model for the ortholog of <i>Salt-inducible kinase 3</i> ( <i>Sik3</i> ) in the May 2011 (Agencourt dmoj_caf1/DmojCAF1) Genome Assembly (GenBank Accession: GCA_000005175.1 ) of <i>Drosophila mojavensis</i> . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus <i>Drosophila</i> using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvements of Paraquat Treatment in Liquid Media for Behavior and Neurodegenerative Tests. 百草枯在行为和神经退行性试验中液体介质处理的改进。
microPublication biology Pub Date : 2025-03-29 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001273
Axel J Ufarry Alvarado, Malik A Zaidi Pons, Jayvier Plaza Hernández, Ceidy Torres Ortiz
{"title":"Improvements of Paraquat Treatment in Liquid Media for Behavior and Neurodegenerative Tests.","authors":"Axel J Ufarry Alvarado, Malik A Zaidi Pons, Jayvier Plaza Hernández, Ceidy Torres Ortiz","doi":"10.17912/micropub.biology.001273","DOIUrl":"https://doi.org/10.17912/micropub.biology.001273","url":null,"abstract":"<p><p>Amyotrophic Lateral Sclerosis (ALS) is a disease characterized by misfolded and aggregated proteins that have toxic effects on motor neurons. The missense mutation, G85R, of the <i>sod-1</i> gene associated with ALS displays locomotor impairments in <i>Caenorhadbitis elegans</i> ( <i>C. elegans</i> ). We treated the <i>sod-1 (G85R)</i> strain with 0 and 2.5 mM Paraquat treatments in a liquid M9 buffer for 4 hours and in solid NGM media for 18 hours. In both methodologies, the locomotion defects and neurodegeneration were significantly increased with 2.5 mM Paraquat. Our work provides evidence of methodology that is more cost effective, rapid and reproducible to perform behavior and neurodegenerative assay in worms.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A knock-in translational reporter for NLP-29 reveals AMP secretion to the apical extracellular matrices following epidermal damage in Caenorhabditis elegans. NLP-29的敲入翻译报告基因揭示了秀丽隐杆线虫表皮损伤后顶端细胞外基质的AMP分泌。
microPublication biology Pub Date : 2025-03-29 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001435
Nathalie Pujol, Henrik Bringmann
{"title":"A knock-in translational reporter for NLP-29 reveals AMP secretion to the apical extracellular matrices following epidermal damage in <i>Caenorhabditis elegans</i>.","authors":"Nathalie Pujol, Henrik Bringmann","doi":"10.17912/micropub.biology.001435","DOIUrl":"https://doi.org/10.17912/micropub.biology.001435","url":null,"abstract":"<p><p>Antimicrobial peptides (AMPs) are small proteins produced and secreted as part of the innate immune response to infection and wounding. They target pathogens and can also function as signalling molecules, for example, promoting sleep in response to injury in <i>C. elegans</i> . A transcriptional reporter transgene for <i>nlp-29</i> has been pivotal in studying AMP gene expression and regulation, but to understand AMPs antimicrobial and signalling roles, protein expression and trafficking needs to be monitored. We have now created a knock-in translational reporter allele for <i>nlp-29</i> , with NLP-29 fused to mKate2, that enables visualisation of this secreted AMP. Using the NLP-29::mKate2 reporter, we demonstrate that NLP-29 is secreted into the cuticle upon genetic or physical cuticle damage. NLP-29::mKate2 will therefore be a valuable tool for visualising the secretion of this peptide in <i>C. elegans</i> and thus to dissect the different roles of this key AMP.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the microbial diversity in the fecal material of the critically endangered orangutan. 极度濒危猩猩粪便中微生物多样性分析。
microPublication biology Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001554
Carly M Smith, Dan Powell, Xiaoling Wan, JinSong Zheng, Durward L Bevis, Richard W McLaughlin
{"title":"Analysis of the microbial diversity in the fecal material of the critically endangered orangutan.","authors":"Carly M Smith, Dan Powell, Xiaoling Wan, JinSong Zheng, Durward L Bevis, Richard W McLaughlin","doi":"10.17912/micropub.biology.001554","DOIUrl":"https://doi.org/10.17912/micropub.biology.001554","url":null,"abstract":"<p><p>The orangutan ( <i>Pongo</i> spp.) is a critically endangered species. Today, populations of these animals are rapidly declining by up to 75%. They are found in the tropical rainforests of Borneo and Sumatra. In this study, using a next generation sequencing approach, the bacterial and fungal diversity in the fecal material of orangutans living in the Racine Zoo were investigated. The most predominant bacterial phyla were the Bacillota along with Bacteroidota. The most predominant fungal phylum was Ascomycota. Finally, the various functions of the bacterial communities present in the fecal material were predicted with PICRUSt2 using the KEGG database.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome Sequence of Arthrobacter globiformis B-2979 Phage Raphaella. 球形节杆菌B-2979噬菌体Raphaella基因组序列。
microPublication biology Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001464
Hannah Alapati, Adam Parks, Tyler Hildebrand, Joshua Leazer, Kateryn Rodriguez, John Patton
{"title":"Genome Sequence of <i>Arthrobacter globiformis</i> B-2979 Phage Raphaella.","authors":"Hannah Alapati, Adam Parks, Tyler Hildebrand, Joshua Leazer, Kateryn Rodriguez, John Patton","doi":"10.17912/micropub.biology.001464","DOIUrl":"https://doi.org/10.17912/micropub.biology.001464","url":null,"abstract":"<p><p>Bacteriophage Raphaella was isolated from a soil sample collected in Springfield, MO using <i>Arthrobacter globiformis</i> B2979-SEA <i>.</i> Raphaella has a genome of 51692 base pairs with a GC content of 62.6%, 96 putative protein encoding genes and one tRNA. It has been placed in the AY cluster of Actinobacteriophages based on gene content similarity.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy-deficient budding yeast cells are sensitive to freeze-thaw stress. 自噬缺陷的出芽酵母细胞对冻融胁迫敏感。
microPublication biology Pub Date : 2025-03-27 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.000929
Maria James, Grace K Klain, Stacey O Brito, Lupita Trejo, Teresa M A Okello, Verónica A Segarra
{"title":"Autophagy-deficient budding yeast cells are sensitive to freeze-thaw stress.","authors":"Maria James, Grace K Klain, Stacey O Brito, Lupita Trejo, Teresa M A Okello, Verónica A Segarra","doi":"10.17912/micropub.biology.000929","DOIUrl":"https://doi.org/10.17912/micropub.biology.000929","url":null,"abstract":"<p><p>Autophagy enables eukaryotes to recycle damaged and unneeded materials to ensure survival in times of stress such as starvation. However, the full range of cellular stress responses that activate and require autophagy remains unknown. This study has compared the survival of wild type, <i>atg1Δ,</i> and <i>atg5Δ</i> budding yeast cells following freeze-thaw stress. The results indicate that cells deficient in autophagy exhibit enhanced sensitivity to freeze-thaw stress.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Filamin A interacting protein 1-like (FILIP1L) has mitochondrial localization. Filamin A相互作用蛋白1-like （FILIP1L）具有线粒体定位。
microPublication biology Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001572
Sarah Henretta, Karisa Bockley, Jacob Odell, Jan Lammerding
{"title":"Filamin A interacting protein 1-like (FILIP1L) has mitochondrial localization.","authors":"Sarah Henretta, Karisa Bockley, Jacob Odell, Jan Lammerding","doi":"10.17912/micropub.biology.001572","DOIUrl":"https://doi.org/10.17912/micropub.biology.001572","url":null,"abstract":"<p><p>Filamin A interacting protein 1-like (FILIP1L) is a multifunctional protein that plays a role in cancer progression, apoptosis, and angiogenesis. However, FILIP1L remains a relatively underexplored protein, and many of FILIP1L's key mechanisms and interacting partners are still unknown. Using immunofluorescence staining for endogenous FILIP1L and high-resolution confocal microscopy, we show that FILIP1L colocalizes with the mitochondrial marker, TOM20, suggesting a novel connection between FILIP1L and mitochondria. Further exploring the relationship between FILIP1L and mitochondria might provide a deeper understanding of the emerging function of FILIP1L in health and disease.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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