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Gene model for the ortholog of tgo in Drosophila mojavensis. 莫氏果蝇tgo同源基因模型的研究。
microPublication biology Pub Date : 2025-08-06 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001094
Megan E Lawson, Robert Mack Anderton, Jorge Perez, Jacqueline Wittke-Thompson, Paula Croonquist, Chinmay P Rele, Laura K Reed
{"title":"Gene model for the ortholog of <i>tgo</i> in <i>Drosophila mojavensis</i>.","authors":"Megan E Lawson, Robert Mack Anderton, Jorge Perez, Jacqueline Wittke-Thompson, Paula Croonquist, Chinmay P Rele, Laura K Reed","doi":"10.17912/micropub.biology.001094","DOIUrl":"10.17912/micropub.biology.001094","url":null,"abstract":"<p><p>Gene model for the ortholog of tango ( <i>tgo</i> ) in the <i>Drosophila mojavensis</i> May 2011 (Agencourt dmoj_caf1/DmojCAF1) Genome Assembly (GenBank Accession: GCA_000005175.1 ). This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus <i>Drosophila</i> using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Do Small Adjustments in Apical Surface Area Impact Tissue-Wide Homeostasis? 根尖表面积的微小调整如何影响组织范围内的内稳态？
microPublication biology Pub Date : 2025-08-06 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001727
Mohammadreza Hosseini Moghadam, Hadiya Omer, Anastasia Dilello, Lia Campbell-Enns, Paula Pineda, Derek Neufeld, Sofia Ertulova, Stephen Ingram, Ernest Ho, Tim Rogalsky, Juan Nicolas Malagon
{"title":"How Do Small Adjustments in Apical Surface Area Impact Tissue-Wide Homeostasis?","authors":"Mohammadreza Hosseini Moghadam, Hadiya Omer, Anastasia Dilello, Lia Campbell-Enns, Paula Pineda, Derek Neufeld, Sofia Ertulova, Stephen Ingram, Ernest Ho, Tim Rogalsky, Juan Nicolas Malagon","doi":"10.17912/micropub.biology.001727","DOIUrl":"10.17912/micropub.biology.001727","url":null,"abstract":"<p><p>Epithelial tissues, the primary origin of most cancers, undergo complex changes in organization and size. Understanding epithelial mechanisms is crucial for elucidating how their disruption leads to cancer, despite the stochastic nature of their dynamics. This study investigates complex spatial and temporal patterns of apical cell area (ACA) oscillations during sex comb rotation in the male <i>Drosophila melanogaster</i> forelegs, using <i>ImageJ</i> . We discovered that, although ACA oscillations appear irregular, the degree of size variation is consistent and predictable. These findings suggest such irregular oscillations may contribute to fine-tuning mechanisms and play a role in maintaining epithelial homeostasis.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examination of gene expression in Mu insertion alleles of oil yellow1 during vegetative development in Zea mays. 玉米营养发育过程中油黄基因Mu插入等位基因表达的研究。
microPublication biology Pub Date : 2025-08-05 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001643
Sophia Mihalatos, Kevin Tompkins, Victoria Busch, Olivia Fanuele, Nuranjalie Outar, Aaron N Saran, Pukhraj Kaur, Daniel Koulta, Gurninder Ahluwalia, Vanessa Froehlich, Stephanie Lee, Sicong Wang, Dafang F Wang
{"title":"Examination of gene expression in <i>Mu</i> insertion alleles of <i>oil yellow1</i> during vegetative development in <i>Zea mays</i>.","authors":"Sophia Mihalatos, Kevin Tompkins, Victoria Busch, Olivia Fanuele, Nuranjalie Outar, Aaron N Saran, Pukhraj Kaur, Daniel Koulta, Gurninder Ahluwalia, Vanessa Froehlich, Stephanie Lee, Sicong Wang, Dafang F Wang","doi":"10.17912/micropub.biology.001643","DOIUrl":"10.17912/micropub.biology.001643","url":null,"abstract":"<p><p>The <i>oil yellow1</i> ( <i>oy1</i> ) gene encodes the I subunit of magnesium chelatase, a key enzyme in chlorophyll biosynthesis in Z <i>ea mays</i> . Using Uniform <i>Mu</i> insertion lines, we examined how <i>Mu</i> insertions influence OY1 expression across vegetative development. Transcription remained unchanged during juvenile stages (V3-V5) but was consistently upregulated in adult stages (V7-V9). Related genes CHLD1 and CHLH1 showed similar patterns. Although transposon insertions often disrupt gene expression, our findings show they can also enhance transcription in a stage-specific manner.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: Analysis of mitochondrial Complex I activity and ATP hydrolysis capacity of ATP synthase in developing rat brains using frozen tissues. 勘误：分析线粒体复合体I的活性和ATP合成酶的ATP水解能力在发育中的大鼠脑冷冻组织。
microPublication biology Pub Date : 2025-08-05 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001787
{"title":"Erratum: Analysis of mitochondrial Complex I activity and ATP hydrolysis capacity of ATP synthase in developing rat brains using frozen tissues.","authors":"","doi":"10.17912/micropub.biology.001787","DOIUrl":"https://doi.org/10.17912/micropub.biology.001787","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.17912/micropub.biology.001641.].</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphoma-derived extracellular vesicles inhibit CAR T cell function. 淋巴瘤来源的细胞外囊泡抑制CAR - T细胞功能。
microPublication biology Pub Date : 2025-08-05 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001646
Khadiza Siddika, Katie R Flaherty, Reuben Benjamin, Anna Schurich, Molly S Cook
{"title":"Lymphoma-derived extracellular vesicles inhibit CAR T cell function.","authors":"Khadiza Siddika, Katie R Flaherty, Reuben Benjamin, Anna Schurich, Molly S Cook","doi":"10.17912/micropub.biology.001646","DOIUrl":"10.17912/micropub.biology.001646","url":null,"abstract":"<p><p>CD19-targeting CAR T cell therapy has shown remarkable efficacy in the treatment of relapsed/refractory B cell lymphoma. However, a proportion of patients exhibit resistance to treatment. We investigate the impact of lymphoma-derived Extracellular Vesicles (EV) on CD19-targeting CAR T cell function <i>in vitro</i> . We demonstrate that lymphoma-EV express B cell markers such as CD19 and CD20, which can be transferred to the CAR T cell membrane. In co-culture experiments, lymphoma-EV suppress the tumour-killing capacity of CAR T cells.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene model for the ortholog of gig in Drosophila mojavensis. 莫氏果蝇gig同源基因模型的研究。
microPublication biology Pub Date : 2025-08-04 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001027
Madeline L Gruys, Madison A Sharp, Corinne Croslyn, Meghan Yap-Chiongco, Laura K Reed, Joyce Stamm, Chinmay P Rele
{"title":"Gene model for the ortholog of <i>gig</i> in <i>Drosophila mojavensis</i>.","authors":"Madeline L Gruys, Madison A Sharp, Corinne Croslyn, Meghan Yap-Chiongco, Laura K Reed, Joyce Stamm, Chinmay P Rele","doi":"10.17912/micropub.biology.001027","DOIUrl":"10.17912/micropub.biology.001027","url":null,"abstract":"<p><p>Gene model for the ortholog of gigas ( <i>gig</i> ) in the May 2011 (Agencourt dmoj_caf1/DmojCAF1) Genome Assembly (GenBank Accession: GCA_000005175.1 ) of <i>Drosophila mojavensis</i> . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus <i>Drosophila</i> using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Programmed cell death throughout life influences the longevity of a defective mitochondrial mutant in C. elegans. 整个生命过程中的程序性细胞死亡影响秀丽隐杆线虫线粒体缺陷突变体的寿命。
microPublication biology Pub Date : 2025-08-04 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001686
Sumino Yanase, Rea Yamaguchi, Kayo Yasuda, Naoaki Ishii
{"title":"Programmed cell death throughout life influences the longevity of a defective mitochondrial mutant in <i>C. elegans</i>.","authors":"Sumino Yanase, Rea Yamaguchi, Kayo Yasuda, Naoaki Ishii","doi":"10.17912/micropub.biology.001686","DOIUrl":"10.17912/micropub.biology.001686","url":null,"abstract":"<p><p>In <i>C. elegans</i> , the <i>mev-1</i> gene mutation leads to increased mitochondrial dysfunction and embryonic abnormal apoptosis, thereby shortening the lifespan. A mutation in the <i>ced-3</i> gene encoding an ortholog of mammalian caspases reduces the excessive embryonic apoptosis and recovers the lifespan of the <i>mev-1</i> mutant. Here, we report the difference between temporary in early development and continuous knockdowns of the <i>ced-3</i> gene. We found that CED-3 /caspase is essential to the abnormal apoptosis in the <i>mev-1</i> mutant, not only during development but also during aging. These findings indicate an association of CED-3 /caspase with age-related cellular dysfunction even in somatic cells.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UltraCAST: A Flexible All-In-One Suicide Vector for Modifying Bacterial Genomes Using a CRISPR-Associated Transposon. 使用crispr相关转座子修饰细菌基因组的一种灵活的一体化自杀载体。
microPublication biology Pub Date : 2025-08-02 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001721
Anthony J VanDieren, Jeffrey E Barrick
{"title":"UltraCAST: A Flexible All-In-One Suicide Vector for Modifying Bacterial Genomes Using a CRISPR-Associated Transposon.","authors":"Anthony J VanDieren, Jeffrey E Barrick","doi":"10.17912/micropub.biology.001721","DOIUrl":"10.17912/micropub.biology.001721","url":null,"abstract":"<p><p>CRISPR-associated transposons (CASTs) are RNA-guided mobile genetic elements that are widespread in bacterial genomes. Here, we describe the UltraCAST, a suicide vector with the <i>Vibrio cholerae</i> Type I-F CAST system and Golden Gate assembly sites with fluorescent protein gene dropouts for guide RNA and a mini-transposon cargo cloning. We show an example of UltraCAST genome editing by disrupting a gene in the chromosome of <i>Serratia symbiotica</i> CWBI-2.3 <sup>T</sup> , a culturable relative of aphid endosymbionts. The UltraCAST can be used to flexibly insert DNA into specific genomic sites and facilitates testing this genome editing platform in non-model bacterial species that lack genetic tools.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Climate Change Does Not Directly Influence Red Squirrel ( Sciurus vulgaris ) Distribution in Western Europe. 气候变化不会直接影响红松鼠在西欧的分布。
microPublication biology Pub Date : 2025-08-02 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001589
Alyson E V Buchanan, Phillipa K Gillingham, Demetra Andreou, Kathy H Hodder, Melissa A Toups, Helen Butler, Emilie A Hardouin
{"title":"Climate Change Does Not Directly Influence Red Squirrel ( <i>Sciurus vulgaris</i> ) Distribution in Western Europe.","authors":"Alyson E V Buchanan, Phillipa K Gillingham, Demetra Andreou, Kathy H Hodder, Melissa A Toups, Helen Butler, Emilie A Hardouin","doi":"10.17912/micropub.biology.001589","DOIUrl":"10.17912/micropub.biology.001589","url":null,"abstract":"<p><p>Climate change presents ongoing risks to species like the red squirrel, which, despite its wide range, faces pressures from multiple threats (fragmentation, invasive species, among others). This study assesses the relationship of red squirrel distribution across Western Europe with bioclimatic variables to predict future climate impacts. However, our results suggest that bioclimatic factors have limited predictive power, with no direct impacts identified. Indirect effects, such as the expansion of grey squirrels, may still worsen challenges for red squirrel populations. Addressing these by maintaining habitat quality and connectivity through targeted conservation measures will be crucial for ensuring red squirrel persistence.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isoform differences drive functional diversity of NHR-49. 同种异构体差异驱动NHR-49的功能多样性。
microPublication biology Pub Date : 2025-08-01 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001655
Lexus Tatge, Peter M Douglas
{"title":"Isoform differences drive functional diversity of NHR-49.","authors":"Lexus Tatge, Peter M Douglas","doi":"10.17912/micropub.biology.001655","DOIUrl":"10.17912/micropub.biology.001655","url":null,"abstract":"<p><p>The <i>C. elegans</i> nuclear hormone receptor, NHR-49 , is a critical regulator of lipid metabolism, which possesses five isoforms differing predominantly within their N-termini. Yet functional distinctions between these different isoforms remain largely unexplored. Using CRISPR-based N- and C-terminal epitope tagging with the biotin ligase, TurboID, we observed that the longest isoform displays a more dynamic subcellular localization, partitioning between nucleus and cytoplasm. Proximity labeling revealed differences in interactomes with N-terminally tagged long isoform of NHR-49 enriched for cytoplasmic proteins, including endocytic machinery like RAB-10 and RAB-11.1 , while C-terminal tags associated primarily with inner nuclear pore components and transcriptional regulators. These findings highlight isoform-specific differences for NHR-49 which dramatically impact its subcellular localization and interaction networks. Our study reveals a previously uncharacterized layer of regulatory complexity in nuclear receptor biology, which emphasize the importance of isoform preferences when interpreting functional genomics data in <i>C. elegans</i> and beyond.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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