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The N-terminal α helix domain of the mitochondrial VDAC protein Por2 is dispensable for promoting the nuclear localization of yeast AMPK. 线粒体VDAC蛋白Por2的n端α螺旋结构域对于促进酵母AMPK的核定位是必不可少的。
microPublication biology Pub Date : 2026-02-23 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001040
Kerry Brown, Hemanth Singuluri, Frank Perkins, Sergei Kuchin
{"title":"The N-terminal α helix domain of the mitochondrial VDAC protein Por2 is dispensable for promoting the nuclear localization of yeast AMPK.","authors":"Kerry Brown, Hemanth Singuluri, Frank Perkins, Sergei Kuchin","doi":"10.17912/micropub.biology.001040","DOIUrl":"https://doi.org/10.17912/micropub.biology.001040","url":null,"abstract":"<p><p>In yeast, the mitochondrial voltage-dependent anion channel (VDAC) proteins Por1 and Por2 play regulatory roles in the regulation of Snf1, an ortholog of AMP-activated protein kinase (AMPK). An important question is whether Por1 and Por2 serve as Snf1-coupled energy sensors. VDACs are β-barrel proteins, but they have a flexibly-linked N-terminal α helix (NAH) domain, suggesting a possible role in Snf1 signaling. Here, we asked whether the NAH domain of Por2 is required for promoting Snf1 nuclear translocation. In our experimental setup, the Por2 NAH was dispensable. Further experiments are required to fully understand the regulatory roles of the Por1/2 NAH domains.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The conserved microtubule-associated protein Mini Spindles promotes dendrite branching and limits terminal branch elongation in Drosophila class III and IV dendritic arborization neurons. 保守的微管相关蛋白Mini Spindles在果蝇III类和IV类树突树突神经元中促进树突分支并限制末端分支的延伸。
microPublication biology Pub Date : 2026-02-19 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001056
Claire Kittock, Noor Anvery, Mala Misra
{"title":"The conserved microtubule-associated protein Mini Spindles promotes dendrite branching and limits terminal branch elongation in <i>Drosophila</i> class III and IV dendritic arborization neurons.","authors":"Claire Kittock, Noor Anvery, Mala Misra","doi":"10.17912/micropub.biology.001056","DOIUrl":"10.17912/micropub.biology.001056","url":null,"abstract":"<p><p>Microtubule dynamics influence neuron morphogenesis. We investigated the role of the conserved microtubule-associated protein Mini Spindles (Msps) in the morphogenesis of branched dendrite arbors using <i>Drosophila melanogaster</i> larval class III and class IV dendritic arborization neurons as two models of branch organization. In both classes, knocking down <i>msps</i> expression reduced dendrite branching but increased terminal dendrite length. In <i>msps <sup>RNAi</sup></i> class IV da neurons, dendrite growth failed to scale in proportion to increasing larval size between the second and third instar. These results suggest that Msps is required for the dynamic expansion of dendrite arbors during periods of rapid organismal growth.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12964058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extending Biopython to combine multiple sequence alignments with the same reference into a Multiple Sequence Alignment. 扩展bioppython，将具有相同引用的多个序列比对组合为多个序列比对。
microPublication biology Pub Date : 2026-02-18 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001966
Cassia Bastress, Michiel de Hoon, Manuel Lera-Ramirez, Jürg Bähler
{"title":"Extending Biopython to combine multiple sequence alignments with the same reference into a Multiple Sequence Alignment.","authors":"Cassia Bastress, Michiel de Hoon, Manuel Lera-Ramirez, Jürg Bähler","doi":"10.17912/micropub.biology.001966","DOIUrl":"10.17912/micropub.biology.001966","url":null,"abstract":"<p><p>Pairwise alignments (PWAs) are commonly used to compare sequences to a reference. Existing alignment tools provide algorithms to align multiple sequences to a single reference and to merge two sets of aligned sequences; but not to combine individually aligned PWAs with a common reference into a single MSA which preserves their original alignment structure. This is required for certain workflows. One example is aligning multiple sequencing traces with a circular plasmid sequence for validation. Some alignment tools that take into account the circularity of the plasmid sequence return a PWA per sequencing trace. For visualization, all PWAs have to be combined into a single MSA. For this purpose, we developed an algorithm that combines alignments sharing the same reference into an MSA, and implemented it as a classmethod in Biopython's Alignment class.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12961406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tau Regulates Endoreplication in Drosophila Malpighian Tubules. Tau蛋白调控果蝇马氏小管内复制。
microPublication biology Pub Date : 2026-02-18 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001956
Neha Tiwari, Madhu Tapadia
{"title":"Tau Regulates Endoreplication in <i>Drosophila</i> Malpighian Tubules.","authors":"Neha Tiwari, Madhu Tapadia","doi":"10.17912/micropub.biology.001956","DOIUrl":"10.17912/micropub.biology.001956","url":null,"abstract":"<p><p>Endoreplication drives polyploidy in metabolically active epithelial tissues. Here we show that loss of <i>Drosophila</i> Tau increases nuclear size and DAPI fluorescence in principal and stellate cells of the Malpighian tubule, indicative of elevated DNA content. A similar increase is observed in the salivary gland, another polyploid tissue. These findings reveal a previously unrecognized role for Tau in restraining endoreplication in non-neuronal epithelia.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12961408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variable deep learning training horizons reveal the temporal complexity of biological systems. 可变的深度学习训练视野揭示了生物系统的时间复杂性。
microPublication biology Pub Date : 2026-02-18 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001926
Po-Hao Chiu, Jacob I Evarts, Patrick Feng, Neda Bagheri
{"title":"Variable deep learning training horizons reveal the temporal complexity of biological systems.","authors":"Po-Hao Chiu, Jacob I Evarts, Patrick Feng, Neda Bagheri","doi":"10.17912/micropub.biology.001926","DOIUrl":"10.17912/micropub.biology.001926","url":null,"abstract":"<p><p>The increasing quantity of time-series images presents new opportunities for extracting biological insights from data. Here, we introduce a deep learning framework with a variable input sequence length to predict cell and colony morphologies. We apply this framework to <i>in silico</i> and <i>in vitro</i> microscopy datasets, evaluating the impact of temporal data on performance. We find that while performance increases monotonically with increasing <i>in silico</i> training data, performance is varied in the <i>in vitro</i> case studies. The varying results reflect the intrinsic challenges stochastic, complex biological systems pose to data-driven modeling, and offer a new method through which we can identify biological transition points using temporal dynamics.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12961407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simulated drought with Polyethylene-Glycol (PEG) decreases above-ground performance and increases nodulation in the legume Medicago lupulina. 用聚乙二醇（PEG）模拟干旱降低了豆科植物紫花苜蓿（Medicago lupina）的地上性能并增加了结瘤。
microPublication biology Pub Date : 2026-02-17 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001997
Hana Cho, Emily Glasgow, Valmic Mukund, Julia A Boyle, John R Stinchcombe
{"title":"Simulated drought with Polyethylene-Glycol (PEG) decreases above-ground performance and increases nodulation in the legume <i>Medicago lupulina</i>.","authors":"Hana Cho, Emily Glasgow, Valmic Mukund, Julia A Boyle, John R Stinchcombe","doi":"10.17912/micropub.biology.001997","DOIUrl":"https://doi.org/10.17912/micropub.biology.001997","url":null,"abstract":"<p><p>We investigated drought growth responses in <i>Medicago lupulina</i> using PEG to simulate drought stress. We grew <i>Medicago lupulina</i> plants inoculated with <i>Sinorhizobium meliloti</i> in Magenta boxes under randomly assigned treatments: a control, PEG applied to the bottom (PEG added to the bottom-watering container), or PEG applied from the top (PEG poured over the growth media). PEG treatments significantly reduced above-ground growth but unexpectedly increased nodulation. Our results suggest that while PEG effectively simulates drought stress on above-ground growth parameters, it may not accurately simulate drought effects on rhizobial symbiosis.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12957989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147367542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. 利用实验进化修正酿酒酵母母系分离缺陷。
microPublication biology Pub Date : 2026-02-13 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001962
Lauren M Ackermann, Amanda Ro, Barbara Dunn, Ryan Moore, Greg Doss, Joseph O Armstrong, Maitreya J Dunham
{"title":"Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast.","authors":"Lauren M Ackermann, Amanda Ro, Barbara Dunn, Ryan Moore, Greg Doss, Joseph O Armstrong, Maitreya J Dunham","doi":"10.17912/micropub.biology.001962","DOIUrl":"https://doi.org/10.17912/micropub.biology.001962","url":null,"abstract":"<p><p>Brewers have domesticated many strains of <i>Saccharomyces cerevisiae</i> with traits complementary to different beers, but these strains may also harbor undesirable characteristics. One example is the mother-daughter separation defect (MDSD) which is present in London Ale III, a popular brewing strain, and causes cells to form large clusters. MDSDs can be caused by mutations to several genes, making targeted genetic approaches to reduce MDSDs challenging. We passaged three populations for over 200 generations to generate strains with reduced MDSD, demonstrating how experimental evolution can be used to select against undesirable traits in industrial yeast strains.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salinity stress reduces tree reproductive allocation in coastal forests. 盐度胁迫降低了沿海森林树木的生殖分配。
microPublication biology Pub Date : 2026-02-13 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001778
Juan Ignacio Martínez, Aliya Khan, Keryn Gedan
{"title":"Salinity stress reduces tree reproductive allocation in coastal forests.","authors":"Juan Ignacio Martínez, Aliya Khan, Keryn Gedan","doi":"10.17912/micropub.biology.001778","DOIUrl":"https://doi.org/10.17912/micropub.biology.001778","url":null,"abstract":"<p><p>Plants adjust reproductive allocation in response to environmental changes to maximize fitness. As sea level rise increases salinity in coastal forests, we examined its effects on seed rain in two tree species. <i>Pinus taeda</i> showed a median 52% reduction relative investment in pine cone production in high-salinity areas relative to low salinity areas. <i>Juniperus virginiana</i> decreased relative investment in seed production by 64%, though with higher uncertainty. These results reveal that salinity stress reduces tree allocation to reproduction in coastal forests, and suggests species-specific reproductive responses to environmental change, with implications for coastal forest dynamics under rising salinity.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome Sequence of Bacteriophages Bouchard and Windest Isolated Using Arthrobacter globiformis B-2979. 利用球形节杆菌B-2979分离的噬菌体Bouchard和winddest的基因组序列
microPublication biology Pub Date : 2026-02-11 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001885
Taryn Marcum, Corena Racine, Kyle Johnson, Tyler Hildebrand, John Patton
{"title":"Genome Sequence of Bacteriophages Bouchard and Windest Isolated Using <i>Arthrobacter globiformis</i> B-2979.","authors":"Taryn Marcum, Corena Racine, Kyle Johnson, Tyler Hildebrand, John Patton","doi":"10.17912/micropub.biology.001885","DOIUrl":"10.17912/micropub.biology.001885","url":null,"abstract":"<p><p>Bacteriophages Bouchard and Windest are siphoviruses isolated using <i>Arthrobacter globiformis</i> B-2979-SEA. The genome of Bouchard is predicted to encode 91 proteins within its 57,304 bp genome, whereas the genome of Windest is predicted to encode 99 proteins and two tRNAs within its 51,773 bp genome. Based on gene content similarity of at least 35% to actinobacteriophages, Bouchard and Windest have been assigned to the AU2 subcluster and AY cluster of Actinobacteriophages, respectively.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12933202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Faster vegetative growth in Arabidopsis thaliana in heat and drought. 高温和干旱条件下拟南芥营养生长较快。
microPublication biology Pub Date : 2026-02-11 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001892
Basia Love, Jeffrey K Conner, Emily B Josephs, Sophia F Buysse
{"title":"Faster vegetative growth in <i>Arabidopsis thaliana</i> in heat and drought.","authors":"Basia Love, Jeffrey K Conner, Emily B Josephs, Sophia F Buysse","doi":"10.17912/micropub.biology.001892","DOIUrl":"https://doi.org/10.17912/micropub.biology.001892","url":null,"abstract":"<p><p>Climate change is increasing average temperature and decreasing water availability, both stressors that affect plant growth. High heat consistently decreases growth rate but plants may grow rapidly to escape drought or grow more slowly and avoid water loss. We use <i>Arabidopsis thaliana</i> to investigate how heat and drought together shape plant growth and if their impact differs between plants that escape or avoid drought. Our results show that leaf area growth differs but the response to heat and drought is consistent between locally adapted populations in widespread plants like <i>A. thaliana.</i></p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12936725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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