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Microbiota-Influenced Toxicological Responses in Caenorhabditis elegans Exposed to Strawberry and Menthol E-Liquids. 草莓和薄荷醇电子烟液对秀丽隐杆线虫毒理学反应的影响。
microPublication biology Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001699
Zahira Quinones Tavarez, Deborah J Ossip, Dongmei Li, Daniel P Croft, Irfan Rahman, Andrew P Wojtovich
{"title":"Microbiota-Influenced Toxicological Responses in <i>Caenorhabditis elegans</i> Exposed to Strawberry and Menthol E-Liquids.","authors":"Zahira Quinones Tavarez, Deborah J Ossip, Dongmei Li, Daniel P Croft, Irfan Rahman, Andrew P Wojtovich","doi":"10.17912/micropub.biology.001699","DOIUrl":"10.17912/micropub.biology.001699","url":null,"abstract":"<p><p>Electronic nicotine delivery systems are marketed as safer than cigarettes, but their flavoring agents may be toxic. We evaluated reproductive effects of menthol- and strawberry-flavored e-liquids in <i>Caenorhabditis elegans</i> using wild-type and chemosensory-defective mutants ( <i>ocr-2 ; osm-9 ; ocr-1 ; trpa-1</i> ). L4-stage worms were exposed to flavored e-liquids on peptone-free media with <i>Escherichia coli</i> or natural microbiota ( <i>Lelliottia amnigena</i> , <i>Stenotrophomonas indicatrix</i> , <i>Comamonas piscis</i> ). Flavored exposure reduced brood size; menthol delayed egg-laying. Microbiota mitigated effects in most strains except <i>ocr-2 ; osm-9 ; ocr-1</i> with strawberry. Findings show flavored e-liquids harm reproduction, and microbiota may protect against flavor-induced toxicity.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial Effects of the Folk Remedy "Amish Amoxicillin" Against Staphylococcus aureus. 民间偏方“阿米什阿莫西林”对金黄色葡萄球菌的抗菌作用。
microPublication biology Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001753
Mary M Decker, Emily G Ramcharan, Avery T Stephens, Kevin M Drace
{"title":"Antimicrobial Effects of the Folk Remedy \"Amish Amoxicillin\" Against <i>Staphylococcus aureus</i>.","authors":"Mary M Decker, Emily G Ramcharan, Avery T Stephens, Kevin M Drace","doi":"10.17912/micropub.biology.001753","DOIUrl":"10.17912/micropub.biology.001753","url":null,"abstract":"<p><p>The popularity of natural remedies, often amplified by social media, has led many to turn to home treatments like \"Amish Amoxicillin\" (AA) in place of traditional medicine. Promoted as a \"natural\" cure for infectious disease symptoms, AA has gained viral attention despite little scientific validation. This study tested the antimicrobial effects of AA against <i>Staphylococcus aureus</i> and evaluated the contribution of its individual ingredients. We found that AA has measurable inhibitory activity <i>in vitro</i> , primarily due to garlic and vinegar. However, it lacks evidence to support its use over conventional treatments.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondria-ER contact site components regulate the formation and localization of specialized high-capacity mitochondria in the C. elegans anchor cell. 线粒体-内质网接触位点组分调节秀丽隐杆线虫锚细胞中特化高容量线粒体的形成和定位。
microPublication biology Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001679
Isabel W Kenny-Ganzert, David R Sherwood
{"title":"Mitochondria-ER contact site components regulate the formation and localization of specialized high-capacity mitochondria in the <i>C. elegans</i> anchor cell.","authors":"Isabel W Kenny-Ganzert, David R Sherwood","doi":"10.17912/micropub.biology.001679","DOIUrl":"10.17912/micropub.biology.001679","url":null,"abstract":"<p><p>Mitochondria-endoplasmic reticulum contact sites (MERCS) play crucial roles in mediating calcium signaling and lipid metabolism, and regulate mitochondrial morphology, function, and quality control. Recent studies have found that the <i>C. elegans</i> anchor cell (AC) harbors a specialized pool of high-capacity mitochondria that localize to the invasive front and are enriched with electron transport chain proteins to generate high ATP levels to fuel invasion. We conducted an RNAi screen of 59 MERCS-encoding components and identified over 30 required for high-capacity mitochondria formation. Our results suggest that MERCS may play a key role in the formation of specialized high-capacity mitochondria.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation, Identification, and Characterization of Antibiotic-Producing Bacteria from the Phyllosphere of Zea mays. 玉米叶层中产抗生素细菌的分离、鉴定和特性研究。
microPublication biology Pub Date : 2025-08-08 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001777
Katie Christensen, Hanna Lefevers, Bashir Akhlaq Akhoon, Kendall R Corbin
{"title":"Isolation, Identification, and Characterization of Antibiotic-Producing Bacteria from the Phyllosphere of <i>Zea mays</i>.","authors":"Katie Christensen, Hanna Lefevers, Bashir Akhlaq Akhoon, Kendall R Corbin","doi":"10.17912/micropub.biology.001777","DOIUrl":"10.17912/micropub.biology.001777","url":null,"abstract":"<p><p>Plants are a largely untapped source of antibiotic-producing microorganisms. In this study, 237 bacteria were isolated from the leaf surface of field-grown <i>Zea mays</i> . Screening 49 Gammaproteobacteria isolates for antibiotic activity identified eighteen isolates of interest. These findings underscore the plant phyllosphere as a valuable reservoir for discovering novel antibiotics.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Below-ground tissues of Capsicum annuum respond to conserved bacterial peptides with pattern-triggered immunity. 辣椒地下组织对保守细菌肽的模式触发免疫反应。
microPublication biology Pub Date : 2025-08-08 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001726
Morgan Murff, Brooke Pilkey, Rebecca Leuschen-Kohl, Anjali Iyer-Pascuzzi
{"title":"Below-ground tissues of <i>Capsicum annuum</i> respond to conserved bacterial peptides with pattern-triggered immunity.","authors":"Morgan Murff, Brooke Pilkey, Rebecca Leuschen-Kohl, Anjali Iyer-Pascuzzi","doi":"10.17912/micropub.biology.001726","DOIUrl":"10.17912/micropub.biology.001726","url":null,"abstract":"<p><p>Plants have an innate immune system that deters and reduces infection by pathogenic microbes. <i>Solanaceous</i> plants such as <i>Solanum lycopersicum</i> (tomato) use cell-surface immune receptors to perceive microbe-associated molecular patterns (MAMPs) and activate pattern-triggered immunity (PTI), but these responses have been seldom explored in roots of other members of the <i>Solanaceae</i> . To investigate the PTI responses in roots of <i>Capsicum annuum</i> (pepper), oxidative luminescence and temporary root growth inhibition assays were used to measure PTI upon treatment with three bacterial MAMPs: two flagellin (flg)-derived peptides (flg22 and flgII-28), and one cold shock protein-derived peptide (csp22), in multiple pepper accessions. Our results show that pepper roots exhibit a significant increase in ROS production in response to csp22, flg22, and flgII-28 treatment, while only flg22 causes temporary root growth inhibition. PTI responses differ in amplitude among MAMPs and genotypes. Together, these results suggest that downstream immune signaling or immune receptor expression may differ among pepper genotypes and MAMP treatments and highlight the importance of investigating immune response variation in various crop plants.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genes underlying hereditary hearing impairment in humans and in mice. 人类和小鼠遗传性听力损伤的潜在基因。
microPublication biology Pub Date : 2025-08-08 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001728
Morag A Lewis, Karen P Steel
{"title":"Genes underlying hereditary hearing impairment in humans and in mice.","authors":"Morag A Lewis, Karen P Steel","doi":"10.17912/micropub.biology.001728","DOIUrl":"10.17912/micropub.biology.001728","url":null,"abstract":"<p><p>Hearing impairment is a very common disease in the human population, with a high genetic contribution. Here we present a list of genes known to underlie hearing impairment when mutated in humans or in mice. Analysis of the pathways in which the encoded proteins are involved indicates the importance of different signalling pathways to the development and function of the inner ear. The gene list is also useful for identifying candidate genes from human studies such as GWAS or exome sequencing studies.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Cys-His-Gly triplet within the WNT motif is essential for Wnt16 function in vivo. WNT基序中的Cys-His-Gly三联体对于Wnt16在体内的功能至关重要。
microPublication biology Pub Date : 2025-08-08 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001736
Emily G Ramirez, Maria F Rojas, Jyoti Rai, W Joyce Tang, Claire J Watson, Ronald Young Kwon
{"title":"The Cys-His-Gly triplet within the WNT motif is essential for Wnt16 function <i>in vivo</i>.","authors":"Emily G Ramirez, Maria F Rojas, Jyoti Rai, W Joyce Tang, Claire J Watson, Ronald Young Kwon","doi":"10.17912/micropub.biology.001736","DOIUrl":"10.17912/micropub.biology.001736","url":null,"abstract":"<p><p>WNTs are critical to many developmental and disease processes. They are post-translationally acylated at a serine within a highly conserved sequence termed the \"WNT motif\". Changes in individual amino acids in the WNT motif reduce but do not eliminate WNT function. However, the role of a highly conserved triplet of residues (Cys-His-Gly) upstream of the serine has yet to be examined. We show that an in-frame deletion of the Cys-His-Gly triplet in zebrafish Wnt16 likely functions as a null mutation. These findings highlight the utility of using small in-frame indels that target conserved amino acid regions to modulate protein function.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The reticulon protein, TtRET1, is required for the initiation of mating in Tetrahymena thermophila. 网状蛋白TtRET1是嗜热四膜虫开始交配所必需的。
microPublication biology Pub Date : 2025-08-08 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001763
Sabrice Guerrier, Jordon Williams, Brandon Garcia
{"title":"The reticulon protein, TtRET1, is required for the initiation of mating in <i>Tetrahymena thermophila</i>.","authors":"Sabrice Guerrier, Jordon Williams, Brandon Garcia","doi":"10.17912/micropub.biology.001763","DOIUrl":"10.17912/micropub.biology.001763","url":null,"abstract":"<p><p>We recently identified <i>Tetrahymena thermophila</i> reticulon (TtRET1) as a novel marker of the endoplasmic reticulum (ER) that reveals ER morphology during the conjugation phase of mating, but its functional role was previously unknown. Here, we show that TtRET1 is required for the early initiation of mating, prior to conjugation. Furthermore, TtRET1 relocalizes during the mating reaction, suggesting it may regulate ER remodeling events necessary to initiate the mating program.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indole induces acute paralysis followed by compensatory stress-induced sleep. 吲哚诱导急性麻痹，随后是代偿性应激性睡眠。
microPublication biology Pub Date : 2025-08-07 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001738
Nikki Diya, Mercedes I Pierce, Shantanu Bhatt, Matthew D Nelson
{"title":"Indole induces acute paralysis followed by compensatory stress-induced sleep.","authors":"Nikki Diya, Mercedes I Pierce, Shantanu Bhatt, Matthew D Nelson","doi":"10.17912/micropub.biology.001738","DOIUrl":"10.17912/micropub.biology.001738","url":null,"abstract":"<p><p>Stress-induced sleep of <i>Caenorhabditis elegans</i> occurs following exposure to noxious stressors, such as pore forming toxins, extreme temperature, ultraviolet irradiation, tissue wounding, and viral infections. Enteropathogenic <i>Escherichia coli</i> (EPEC) is a pathogenic bacterium which can infect <i>C. elegans</i> , however stress-induced sleep in response to EPEC has not been investigated. EPEC affects worms via two distinct mechanisms: 1) Contact-independent paralysis which occurs following the release of the toxin indole; 2) Contact-dependent bacterial colonization of the intestine. Here we examine mechanism one; we find that indole induced paralysis is regulated independently of the ALA and RIS sleep neurons. In fact, impairing ALA and RIS function caused animals to paralyze significantly faster than controls. Increasing cholinergic or GABAergic input, accelerated or delayed paralysis, respectively. Worms exposed to indole who were subsequently rescued to normal growth plates displayed a compensatory stress-induced sleep that was RIS but not ALA dependent. This work will allow for detailed future investigations into indole's mechanism of action, EPEC pathogenicity, and how bacterial infection leads to recovery sleep.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening for toxicity of azole fungicides in Caenorhabditis elegans identifies triflumizole as a potent reproductive and developmental toxicant. 唑类杀菌剂对秀丽隐杆线虫的毒性筛选表明，三氟唑是一种有效的生殖和发育毒物。
microPublication biology Pub Date : 2025-08-07 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001755
Samantha Hughes, Charlotte Koopmans, Majorie van Duursen
{"title":"Screening for toxicity of azole fungicides in <i>Caenorhabditis elegans</i> identifies triflumizole as a potent reproductive and developmental toxicant.","authors":"Samantha Hughes, Charlotte Koopmans, Majorie van Duursen","doi":"10.17912/micropub.biology.001755","DOIUrl":"10.17912/micropub.biology.001755","url":null,"abstract":"<p><p>Azoles are broad spectrum anti-fungal compounds that can disrupt steroid hormone synthesis, raising significant concerns regarding their impact on human development and reproduction. Chemical exposure in <i>Caenorhabditis elegans</i> may provide insights into the broader impact of azole fungicides relevant to human health. Exposure to triflumizole, resulted in a significant reduction in brood size as well as a dose-dependent decrease in worm development. Similarly, clotrimazole negatively impacted development, but not reproduction, while ketoconazole had no detrimental effect. Together this suggests further research is urgently needed to explore the impact of azole chemicals on human reproductive health.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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