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Differences in stomatal conductance between leaf shape genotypes of Ipomoea hederacea suggest divergent ecophysiological strategies. 不同叶形基因型间气孔导度的差异提示不同的生态生理策略。
microPublication biology Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001528
Yash Kumar Singhal, Julia Anne Boyle, John R Stinchcombe
{"title":"Differences in stomatal conductance between leaf shape genotypes of <i>Ipomoea hederacea</i> suggest divergent ecophysiological strategies.","authors":"Yash Kumar Singhal, Julia Anne Boyle, John R Stinchcombe","doi":"10.17912/micropub.biology.001528","DOIUrl":"https://doi.org/10.17912/micropub.biology.001528","url":null,"abstract":"<p><p>Intraspecific variation in leaf shape affects many physiological processes but its impact on plant distribution is underexplored. Using a common garden, we studied daytime thermoregulation of lobed and entire leaf genotypes of <i>Ipomoea hederacea,</i> which displays a latitudinal leaf shape cline. Both leaf shapes maintained similar temperatures but entire leaf genotypes had significantly increased stomatal conductance in warmer/sunnier weather. With less potential water loss, lobed genotypes may have advantages in drier conditions. Lobed genotypes are more common in the north of the species' range, which receives less summer precipitation, suggesting water availability as a potential clinally varying selective agent.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of IgSF11-PKM2 pathway on gene expression in osteoclasts. IgSF11-PKM2通路对破骨细胞基因表达的影响。
microPublication biology Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001469
Hyunsoo Kim, Noriko Takegahara, Yongwon Choi
{"title":"The impact of IgSF11-PKM2 pathway on gene expression in osteoclasts.","authors":"Hyunsoo Kim, Noriko Takegahara, Yongwon Choi","doi":"10.17912/micropub.biology.001469","DOIUrl":"10.17912/micropub.biology.001469","url":null,"abstract":"<p><p>Osteoclasts are primary bone resorbing cells. Previously, we described metabolic regulation of osteoclasts through IgSF11-mediated phosphorylation of the glycolytic enzyme PKM2. Here, we report the impact of IgSF11-PKM2-mediated regulation on gene expression in osteoclasts, utilizing RNA sequencing on osteoclasts engineered to express a chimeric protein, lacking IgSF11, and pharmacologically modulating PKM2 activity. Our analysis identified osteoclast-related genes whose expression is altered by the absence of IgSF11 and by changes in PKM2 activity. This study reveals gene expression changes associated with the IgSF11-PKM2 pathway, providing new insight into its role in osteoclasts.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a new allele of catp-4. catp-4新等位基因的鉴定。
microPublication biology Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001523
Anushree Gurjar, Amber R Krauchunas
{"title":"Identification of a new allele of <i>catp-4</i>.","authors":"Anushree Gurjar, Amber R Krauchunas","doi":"10.17912/micropub.biology.001523","DOIUrl":"https://doi.org/10.17912/micropub.biology.001523","url":null,"abstract":"<p><p>CATP-4 is a subunit of a Na <sup>+</sup> /K <sup>+</sup> -ATPase important for sperm motility and fertility. Here, we report the characterization of a new allele of <i>catp-4</i> isolated from a forward genetic screen for sterile mutants. The <i>catp-4 ( as46 )</i> allele has a missense mutation that substitutes a highly conserved Glycine which lies close to an ATP binding site. This mutation results in a loss-of-function phenotype comparable to that of the <i>catp-4</i> null alleles, emphasizing the importance of this residue for CATP-4 function. This is for the first time that a phenotype has been reported for a single missense mutation in the <i>catp-4</i> gene.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptability in the aperiodic Drosophila populations and evolution of the life-history traits. 非周期性果蝇种群的适应性与生活史特征的进化。
microPublication biology Pub Date : 2025-03-23 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001436
Khushboo Sharma, Nalini Mishra, Mallikarjun N Shakarad
{"title":"Adaptability in the aperiodic <i>Drosophila</i> populations and evolution of the life-history traits.","authors":"Khushboo Sharma, Nalini Mishra, Mallikarjun N Shakarad","doi":"10.17912/micropub.biology.001436","DOIUrl":"10.17912/micropub.biology.001436","url":null,"abstract":"<p><p>Exposure of diurnal animals to constant light for extended periods dampens the clock gene circadian rhythms, which in turn affect the life history traits. However, animals are expected to maintain some form of rhythm for the body to function effectively. In this study, we used three populations of <i>Drosophila melanogaster</i> that were maintained under constant light for 312 generations. We entrained three other populations (derived from those in constant light for 312 generations) to 12L:12D cycles. The adaptive evolution under aperiodic conditions has compromised on longevity and fecundity- two most important fitness traits for an iteroparous species.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of MAP Kinase signaling by the insulin-like growth factor pathway during C. elegans vulval development. 胰岛素样生长因子途径对秀丽隐杆线虫外阴发育过程中MAP激酶信号的调控。
microPublication biology Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001557
Matthew Eroglu, W Brent Derry
{"title":"Regulation of MAP Kinase signaling by the insulin-like growth factor pathway during <i>C. elegans</i> vulval development.","authors":"Matthew Eroglu, W Brent Derry","doi":"10.17912/micropub.biology.001557","DOIUrl":"10.17912/micropub.biology.001557","url":null,"abstract":"<p><p>Organ development depends on multiple signaling pathways working in concert to specify cell fates. Improper activity or inactivity of specific signaling pathways such as EGF-Ras-MAPK can lead to dedifferentiation and cancer. In <i>C. elegans</i> , gain of function mutations in Ras/ <i>let-60</i> lead to ectopic development of multiple ventral vulva-like lesions resembling tumors. However, this phenotype depends on normal insulin-like growth factor (IGF) signaling. Here, we probe how factors downstream of the IGF receptor <i>daf-2</i> modify Ras signaling. These investigations led us to identify regulators of cell fate such as the Zinc finger protein encoding gene <i>mstr-1</i> ( <i>F22D6.2</i> ), homologous to mammalian <i>Zfand3</i> / <i>5</i> / <i>6</i> .</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disruption of the EmrAB-TolC efflux pump of Escherichia coli induces global metabolic changes in multiple growth conditions. 破坏大肠杆菌的EmrAB-TolC外排泵可诱导多种生长条件下的全局代谢变化。
microPublication biology Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001437
Dana E Harmon, Klay Adamson, Joseph Wiersma
{"title":"Disruption of the EmrAB-TolC efflux pump of <i>Escherichia coli</i> induces global metabolic changes in multiple growth conditions.","authors":"Dana E Harmon, Klay Adamson, Joseph Wiersma","doi":"10.17912/micropub.biology.001437","DOIUrl":"10.17912/micropub.biology.001437","url":null,"abstract":"<p><p>Multidrug efflux pumps are transporters that are important for the removal of exogenous toxic molecules in bacteria. Recently, efflux pumps have been implicated in the regulation of metabolic homeostasis in <i>Escherichia coli</i> . Here, we investigated the contribution of EmrAB-TolC to metabolism in various conditions. Deletion of EmrB led to changes in several metabolic pathways, both in standard growth conditions and during nutrient stress. The pathways impacted include the tricarboxylic acid (TCA) cycle, and carbohydrate and amino acid metabolism. Our findings suggest that EmrAB-TolC contributes to maintaining metabolic homeostasis and adapts metabolism based on cellular needs.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neopterin extends C. elegans lifespan in an ATFS-1-dependent manner. 新蝶呤以依赖atfs -1的方式延长线虫的寿命。
microPublication biology Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001543
Miina Pitkänen, Geoffray Monteuuis, Christopher B Jackson, Olli Matilainen
{"title":"Neopterin extends <i>C. elegans</i> lifespan in an ATFS-1-dependent manner.","authors":"Miina Pitkänen, Geoffray Monteuuis, Christopher B Jackson, Olli Matilainen","doi":"10.17912/micropub.biology.001543","DOIUrl":"10.17912/micropub.biology.001543","url":null,"abstract":"<p><p>Neopterin, a byproduct of tetrahydrobiopterin synthesis, is commonly used as a biomarker for immune system activation. In addition to its role in immune responses, neopterin levels are known to increase with age. Its impact on longevity, however, remains unclear. Here, we demonstrate that neopterin supplementation extends lifespan in <i>Caenorhabditis elegans .</i> Additionally, neopterin shows moderate activation of the mitochondrial unfolded protein response (UPR <sup>mt</sup> ), and that the neopterin-mediated lifespan extension is dependent on ATFS-1 , the primary transcription factor regulating UPR <sup>mt</sup> . These findings highlight the need for further investigation into the biological functions and health-promoting effects of neopterin.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation on possible resistance of Candida auris to irradiation with UVC (254 nm). 耳念珠菌对UVC （254 nm）照射的耐药性研究。
microPublication biology Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001421
Anna-Maria Gierke, Blende Demelezi, Martin Hessling
{"title":"Investigation on possible resistance of <i>Candida auris</i> to irradiation with UVC (254 nm).","authors":"Anna-Maria Gierke, Blende Demelezi, Martin Hessling","doi":"10.17912/micropub.biology.001421","DOIUrl":"10.17912/micropub.biology.001421","url":null,"abstract":"<p><p><i>Candida auris</i> is a yeast that is increasingly pathogenic due to increased multiresistance to antimycotics. UV (ultraviolet) radiation is still capable of reducing <i>C. auris</i> and offers possible applications in radiation disinfection of surfaces and air. However, it is unknown whether <i>C. auris</i> could also develop a resistance against UV radiation. For this reason, the extent to which <i>C. auris</i> can develop resistance to UVC radiation (254 nm) over several irradiation cycles is being examined. The yeast is irradiated with a UVC dose of 18.2 mJ/cm <sup>2</sup> per cycle, followed by a recovery phase under dark conditions. This irradiation-recovery process was repeated for 16 consecutive cycles, ensuring that the UVC dose of 18.2 mJ/cm <sup>2</sup> remained constant throughout all cycles. It was observed that the log reduction (a log 1 reduction corresponds to a 90% reduction) decreased with increasing number of cycles. Resistance development against UVC could be presented.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome characteristics of cluster EA Microbacterium bacteriophages HungryHenry, CaptainRex, and ChikPic isolated from soil in Tennessee. 从田纳西州土壤中分离的EA微细菌噬菌体HungryHenry、CaptainRex和ChikPic的基因组特征
microPublication biology Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001499
Sergei Markov, Clayton Barnes, Ariel Hensley, Nicholas More
{"title":"Genome characteristics of cluster EA <i>Microbacterium</i> bacteriophages HungryHenry, CaptainRex, and ChikPic isolated from soil in Tennessee.","authors":"Sergei Markov, Clayton Barnes, Ariel Hensley, Nicholas More","doi":"10.17912/micropub.biology.001499","DOIUrl":"10.17912/micropub.biology.001499","url":null,"abstract":"<p><p>Bacteriophages HungryHenry, CaptainRex, and ChikPic were isolated from soil collected in Tennessee using the bacterium <i>Microbacterium foliorum</i> . These bacteriophages have genomes that are 41,516 bp, 39,941 bp, and 40,333 bp in length and encode 62, 61, and 63 putative genes, respectively. Based on gene content similarity, all three bacteriophages are assigned to actinobacteriophage cluster EA (subclusters EA1, EA2 and EA5, respectively).</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A commonly used anti-SOX15 antibody fails to demonstrate specificity in mouse embryos. 一种常用的抗sox15抗体在小鼠胚胎中无法显示特异性。
microPublication biology Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001558
Farina Aziz, Bin Gu, Amy Ralston
{"title":"A commonly used anti-SOX15 antibody fails to demonstrate specificity in mouse embryos.","authors":"Farina Aziz, Bin Gu, Amy Ralston","doi":"10.17912/micropub.biology.001558","DOIUrl":"10.17912/micropub.biology.001558","url":null,"abstract":"<p><p>SOX15 is a broadly conserved transcription factor involved in many critical processes, including mammalian cell fate specification and pluripotency. We investigated the specificity of a commercially available, polyclonal anti-SOX15 antibody advertised as knockout-validated. We generated a new mouse line carrying a null allele of <i>Sox15</i> , and then evaluated anti-SOX15 activity in <i>Sox15</i> null mouse embryos. Nuclear signal was detected in both wild type and null embryos, even when potential maternally or paternally-contributed <i>Sox15</i> was eliminated. We conclude that this SOX15-detecting reagent may not be suitable for all applications, and caution the growing community of users accordingly.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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