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IGEG-2 is a C. elegans EGFR ligand. IGEG-2是秀丽隐杆线虫的EGFR配体。
microPublication biology Pub Date : 2025-09-15 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001821
Melissa M Mailhot, Jesse G Jones, Dylan L Castro, Cheryl Van Buskirk
{"title":"IGEG-2 is a <i>C. elegans</i> EGFR ligand.","authors":"Melissa M Mailhot, Jesse G Jones, Dylan L Castro, Cheryl Van Buskirk","doi":"10.17912/micropub.biology.001821","DOIUrl":"10.17912/micropub.biology.001821","url":null,"abstract":"<p><p>Across species, Epidermal Growth Factor (EGF) family ligands and their receptors participate in developmental and physiological cell-cell signaling events. <i>C. elegans</i> possesses a single EGF receptor, LET-23 /EGFR, and two characterized EGF ligands. LIN-3 /EGF is well-known for its role in vulval induction, and SISS-1 /EGF mediates stress-induced sleep. The <i>C. elegans</i> genome harbors another predicted EGF family member, <i>igeg-2 ,</i> which has not been characterized. To determine if IGEG-2 is a functional EGFR ligand, we examined whether it can activate known LET-23-dependent processes. We found that ubiquitous overexpression of IGEG- <i>2</i> promotes both vulval induction and sleep, indicating that it is a functional EGF family ligand. The endogenous role of IGEG-2 remains unknown.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Immunoglobulin Domain of SISS-1/EGF is Required for its Function. SISS-1/EGF的免疫球蛋白结构域是其功能所必需的。
microPublication biology Pub Date : 2025-09-14 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001842
Jesse G Jones, Cheryl Van Buskirk
{"title":"The Immunoglobulin Domain of SISS-1/EGF is Required for its Function.","authors":"Jesse G Jones, Cheryl Van Buskirk","doi":"10.17912/micropub.biology.001842","DOIUrl":"10.17912/micropub.biology.001842","url":null,"abstract":"<p><p>Epidermal growth factor (EGF) signaling plays roles in development and physiology across the animal kingdom. In the nematode <i>C. elegans</i> , a single EGF receptor (EGFR) and two EGF family ligands have been characterized. LIN-3 /EGF is required for a variety of developmental processes as well as ovulation, and SISS-1 /EGF promotes a damage-responsive quiescent state known as stress-induced sleep. Like all EGF family ligands, SISS-1 and LIN-3 are produced as transmembrane proteins with an extracellular EGF-like domain, known for its function in receptor binding. The ectodomain of SISS-1 , but not of LIN-3 , also contains an Immunoglobulin-like (Ig) domain, putting it into a class of Ig-EGFs that includes <i>Drosophila</i> Vein and certain vertebrate Neuregulins. The function of the Ig domain within Ig-EGFs appears to vary. Here, we investigate the SISS-1 Ig domain and show that it is essential for stress-induced sleep.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene model for the ortholog of Mipp2 in Drosophila simulans. 拟果蝇Mipp2同源基因的基因模型。
microPublication biology Pub Date : 2025-09-14 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.000765
Graham M Jones, Natalie Ball, Alejandra Moreno, Cody Reece Puckett, Cindy Wolfe, Claudia Uhde-Stone, Nikolaos Tsotakos, Geoffrey D Findlay, Chinmay P Rele, Laura K Reed
{"title":"Gene model for the ortholog of <i>Mipp2</i> in <i>Drosophila simulans</i>.","authors":"Graham M Jones, Natalie Ball, Alejandra Moreno, Cody Reece Puckett, Cindy Wolfe, Claudia Uhde-Stone, Nikolaos Tsotakos, Geoffrey D Findlay, Chinmay P Rele, Laura K Reed","doi":"10.17912/micropub.biology.000765","DOIUrl":"10.17912/micropub.biology.000765","url":null,"abstract":"<p><p>Presenting a gene model for the ortholog of multiple inositol polyphosphate phosphatase 2 ( <i>Mipp2</i> ) in the May 2017 (Princeton ASM75419v2/DsimGB2) Genome Assembly (GenBank Accession: GCA_000754195.3 ) of <i>Drosophila simulans</i> . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus <i>Drosophila</i> using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene model for the ortholog of dock in Drosophila ananassae. 果蝇dock同源基因模型的研究。
microPublication biology Pub Date : 2025-09-14 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001025
Anne E Backlund, Tamica D'Souza, Jaskamaldip Kaur, Anya Goodman, James J Youngblom, Chinmay P Rele, Laura K Reed
{"title":"Gene model for the ortholog of <i>dock</i> in <i>Drosophila ananassae</i>.","authors":"Anne E Backlund, Tamica D'Souza, Jaskamaldip Kaur, Anya Goodman, James J Youngblom, Chinmay P Rele, Laura K Reed","doi":"10.17912/micropub.biology.001025","DOIUrl":"10.17912/micropub.biology.001025","url":null,"abstract":"<p><p>Gene model for the ortholog of <i>dreadlocks</i> ( <i>dock</i> ) in the May 2011 (Agencourt dana_caf1/DanaCAF1) Genome Assembly (GenBank Accession: GCA_000005115.1 ) of <i>Drosophila ananassae</i> . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus <i>Drosophila</i> using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C. elegans kinesin 1 regulates meiotic spindle size. 秀丽隐杆线虫的运动蛋白1调节减数分裂纺锤体大小。
microPublication biology Pub Date : 2025-09-13 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001820
Rebecca Do, Alma Aquino, Francis McNally
{"title":"<i>C. elegans</i> kinesin 1 regulates meiotic spindle size.","authors":"Rebecca Do, Alma Aquino, Francis McNally","doi":"10.17912/micropub.biology.001820","DOIUrl":"10.17912/micropub.biology.001820","url":null,"abstract":"<p><p>During <i>C. elegans</i> female meiosis, kinesin 1 transports yolk granules inward which appears to indirectly drive outward movement of the meiotic spindle to the cortex. Here we examined the size of the centrally located metaphase I meiotic spindle in a germline null allele of kinesin 1 heavy chain. Centrally located meiotic spindles were both longer and wider in kinesin germline null embryos compared with cortical meiotic spindles in controls. Spindle size might be minimized by cortically localized signaling machinery. Alternatively, kinesin 1 which localizes on the spindle during metaphase, may act directly on microtubules to minimize spindle size.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene model for the ortholog of S6k in Drosophila ananassae. 果蝇S6k同源基因的基因模型研究。
microPublication biology Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001030
Anne E Backlund, Joyce Lai, Jordan Hensley, Anya Goodman, James J Youngblom, Chinmay P Rele, Laura K Reed
{"title":"Gene model for the ortholog of <i>S6k</i> in <i>Drosophila ananassae</i>.","authors":"Anne E Backlund, Joyce Lai, Jordan Hensley, Anya Goodman, James J Youngblom, Chinmay P Rele, Laura K Reed","doi":"10.17912/micropub.biology.001030","DOIUrl":"10.17912/micropub.biology.001030","url":null,"abstract":"<p><p>Gene model for the ortholog of <i>Ribosomal protein S6 kinase</i> ( <i>S6k</i> ) in the May 2011 (Agencourt dana_caf1/DanaCAF1) Genome Assembly (GenBank Accession: GCA_000005115.1 ) of <i>Drosophila ananassae</i> . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus <i>Drosophila</i> using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
mTORC2 disruption reprograms nutrient-driven behavioral adaptations in C. elegans. mTORC2的破坏重新编程了秀丽隐杆线虫营养驱动的行为适应。
microPublication biology Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001794
Simran Motwani, Somya Bhandari, Arnab Mukhopadhyay
{"title":"mTORC2 disruption reprograms nutrient-driven behavioral adaptations in <i>C. elegans</i>.","authors":"Simran Motwani, Somya Bhandari, Arnab Mukhopadhyay","doi":"10.17912/micropub.biology.001794","DOIUrl":"10.17912/micropub.biology.001794","url":null,"abstract":"<p><p>Animals adapt their foraging behavior based on the quality and availability of food in the environment. Here, we examine how the disruption of mTORC2 affects such adaptations in <i>Caenorhabditis elegans</i> . Specifically, we characterize the food preference and dwelling behavior of the mutant of the <i>rict-1</i> gene, which codes for the core component of mTORC2, across two diets of differing nutritional value. Our findings show that <i>rict-1</i> mutants display altered behavioral responses shaped by prior dietary experience, indicating impaired dietary memory. This study reveals a critical role for mTORC2 signaling in integrating past nutritional states with current foraging decisions, providing insight into how metabolic pathways regulate context-dependent feeding behavior in <i>C. elegans</i> .</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene model for the ortholog of dock in Drosophila eugracilis. 果蝇dock同源基因模型的研究。
microPublication biology Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001848
Gabriella N Bicanovsky, Megan E Lawson, Alexandria Groeneveld, Jordan Elkinton, Eden Dowell, S F Shelley-Tremblay, Stephanie Toering Peters, Lindsey J Long, Anya Goodman, Melinda A Yang, Chinmay P Rele, Laura K Reed
{"title":"Gene model for the ortholog of <i>dock</i> in <i>Drosophila eugracilis</i>.","authors":"Gabriella N Bicanovsky, Megan E Lawson, Alexandria Groeneveld, Jordan Elkinton, Eden Dowell, S F Shelley-Tremblay, Stephanie Toering Peters, Lindsey J Long, Anya Goodman, Melinda A Yang, Chinmay P Rele, Laura K Reed","doi":"10.17912/micropub.biology.001848","DOIUrl":"10.17912/micropub.biology.001848","url":null,"abstract":"<p><p>Gene model for the ortholog of dreadlocks ( <i>dock</i> ) in the <i>D. eugracilis</i> Apr. 2013 (BCM-HGSC/Deug_2.0) (DeugGB2) Genome Assembly (GenBank Accession: GCA_000236325.2 ) of <i>Drosophila eugracilis</i> . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus <i>Drosophila</i> using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of elevated temperature on immunity-related hormone signaling in tomato plants. 高温对番茄植株免疫相关激素信号的影响。
microPublication biology Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001762
Karen Liu, Vanessa Shivnauth, Christian Danve Marco Castroverde
{"title":"Impact of elevated temperature on immunity-related hormone signaling in tomato plants.","authors":"Karen Liu, Vanessa Shivnauth, Christian Danve Marco Castroverde","doi":"10.17912/micropub.biology.001762","DOIUrl":"10.17912/micropub.biology.001762","url":null,"abstract":"<p><p>Molecular mechanisms governing the plant-pathogen-environment \"disease triangle\" are starting to emerge, although less so in agriculturally important species like tomato ( <i>Solanum lycopersicum</i> ). Here we analyzed defence hormone responses of tomato plants infected with the bacterial pathogen <i>Pseudomonas syringae</i> pv. <i>tomato</i> ( <i>Pst</i> ) DC3000 under two different temperatures. Our results showed that tomato plants exhibited temperature-sensitive expression of marker genes associated with salicylic acid (SA), jasmonic acid (JA) and abscisic acid (ABA) pathways, but not ethylene (ET). Our findings highlight the complexity of plant-microbe interactions and the importance of considering environmental conditions when studying plant defence responses.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Claremore Lake's Eutrophication: A Study of Happy Lake's Input. 克莱尔莫尔湖的富营养化：快乐湖输入的研究。
microPublication biology Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001742
Cheyanne Olson, Ashli Yaqub, Dustin Browning
{"title":"Claremore Lake's Eutrophication: A Study of Happy Lake's Input.","authors":"Cheyanne Olson, Ashli Yaqub, Dustin Browning","doi":"10.17912/micropub.biology.001742","DOIUrl":"10.17912/micropub.biology.001742","url":null,"abstract":"<p><p>Cultural eutrophication from human-driven nutrient loading threatens aquatic ecosystems globally. Claremore Lake, a drinking water source in Northeastern Oklahoma, is impaired by elevated chlorophyll-a. This study assessed nutrient inputs from Happy Lake, a retention pond connected to Claremore Lake. Monitoring from April through August of 2024 showed greater nutrient, oxygen, and algal fluctuations in Happy Lake than Claremore Lake. Results suggest targeted management strategies and further research on tributary sources like Happy Lake are needed to protect Claremore Lake's water quality.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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