Melissa M Mailhot, Jesse G Jones, Dylan L Castro, Cheryl Van Buskirk
{"title":"IGEG-2是秀丽隐杆线虫的EGFR配体。","authors":"Melissa M Mailhot, Jesse G Jones, Dylan L Castro, Cheryl Van Buskirk","doi":"10.17912/micropub.biology.001821","DOIUrl":null,"url":null,"abstract":"<p><p>Across species, Epidermal Growth Factor (EGF) family ligands and their receptors participate in developmental and physiological cell-cell signaling events. <i>C. elegans</i> possesses a single EGF receptor, LET-23 /EGFR, and two characterized EGF ligands. LIN-3 /EGF is well-known for its role in vulval induction, and SISS-1 /EGF mediates stress-induced sleep. The <i>C. elegans</i> genome harbors another predicted EGF family member, <i>igeg-2 ,</i> which has not been characterized. To determine if IGEG-2 is a functional EGFR ligand, we examined whether it can activate known LET-23-dependent processes. We found that ubiquitous overexpression of IGEG- <i>2</i> promotes both vulval induction and sleep, indicating that it is a functional EGF family ligand. The endogenous role of IGEG-2 remains unknown.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485627/pdf/","citationCount":"0","resultStr":"{\"title\":\"IGEG-2 is a <i>C. elegans</i> EGFR ligand.\",\"authors\":\"Melissa M Mailhot, Jesse G Jones, Dylan L Castro, Cheryl Van Buskirk\",\"doi\":\"10.17912/micropub.biology.001821\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Across species, Epidermal Growth Factor (EGF) family ligands and their receptors participate in developmental and physiological cell-cell signaling events. <i>C. elegans</i> possesses a single EGF receptor, LET-23 /EGFR, and two characterized EGF ligands. LIN-3 /EGF is well-known for its role in vulval induction, and SISS-1 /EGF mediates stress-induced sleep. The <i>C. elegans</i> genome harbors another predicted EGF family member, <i>igeg-2 ,</i> which has not been characterized. To determine if IGEG-2 is a functional EGFR ligand, we examined whether it can activate known LET-23-dependent processes. We found that ubiquitous overexpression of IGEG- <i>2</i> promotes both vulval induction and sleep, indicating that it is a functional EGF family ligand. The endogenous role of IGEG-2 remains unknown.</p>\",\"PeriodicalId\":74192,\"journal\":{\"name\":\"microPublication biology\",\"volume\":\"2025 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485627/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"microPublication biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17912/micropub.biology.001821\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"microPublication biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17912/micropub.biology.001821","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Across species, Epidermal Growth Factor (EGF) family ligands and their receptors participate in developmental and physiological cell-cell signaling events. C. elegans possesses a single EGF receptor, LET-23 /EGFR, and two characterized EGF ligands. LIN-3 /EGF is well-known for its role in vulval induction, and SISS-1 /EGF mediates stress-induced sleep. The C. elegans genome harbors another predicted EGF family member, igeg-2 , which has not been characterized. To determine if IGEG-2 is a functional EGFR ligand, we examined whether it can activate known LET-23-dependent processes. We found that ubiquitous overexpression of IGEG- 2 promotes both vulval induction and sleep, indicating that it is a functional EGF family ligand. The endogenous role of IGEG-2 remains unknown.
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