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The alpha tubulin acetyltransferase atat-2 genetically interacts with klp-4 in C. elegans. 在秀丽隐杆线虫中，α微管蛋白乙酰转移酶atat-2与klp-4基因相互作用。
microPublication biology Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001536
Claire E Reist, Michael D Webb, Cortlen M Mathews, Jay N Pieczynski
{"title":"The alpha tubulin acetyltransferase <i>atat-2</i> genetically interacts with <i>klp-4</i> in <i>C. elegans</i>.","authors":"Claire E Reist, Michael D Webb, Cortlen M Mathews, Jay N Pieczynski","doi":"10.17912/micropub.biology.001536","DOIUrl":"https://doi.org/10.17912/micropub.biology.001536","url":null,"abstract":"<p><p>Microtubules dynamics are in part regulated by post-translational modification, including acetylation. Little is known about the relationship between microtubule acetylation status and how this affects kinesin function, especially <i>in vivo</i> . Using a series of aldicarb sensitivity assays in <i>C. elegans</i> where we combined pharmacological manipulation of microtubule dynamics with genetic approaches, we demonstrate a specific genetic interaction between the alpha tubulin acetyltransferase <i>atat-2</i> and the kinesin motor <i>klp-4</i> . Our work highlights interactions between kinesin activity and the tubulin code <i>in vivo and</i> lays the foundation of future work on these two parallel, yet related processes in cells.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome Sequence of Microbacterium foliorum Phage KingKamren. 叶状微细菌噬菌体KingKamren基因组序列。
microPublication biology Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001483
Alyssa Gleichsner, Kamren Harden, Kathryn Salphine, Jill Sandel, Mikaela Bova, Bella Denapole, Anastasia Godlewski, Samara Acevedo, Alexander Galarneau, Mazon Zales, Gustavia Twumasi, Sophia Voss, Faith Haynes, Rebekah Abdul-Wahhab, Banfy Bu, Abigail Favro, Amen Zergaw, Meherun Maisha, Bian Oliva, Sukhpreet Kaur, Amma Kwatia, Ashley Rufino, Cesia Arzu, Luke Tyrrell, Pamela Pena, Megan Valentine
{"title":"Genome Sequence of <i>Microbacterium foliorum</i> Phage KingKamren.","authors":"Alyssa Gleichsner, Kamren Harden, Kathryn Salphine, Jill Sandel, Mikaela Bova, Bella Denapole, Anastasia Godlewski, Samara Acevedo, Alexander Galarneau, Mazon Zales, Gustavia Twumasi, Sophia Voss, Faith Haynes, Rebekah Abdul-Wahhab, Banfy Bu, Abigail Favro, Amen Zergaw, Meherun Maisha, Bian Oliva, Sukhpreet Kaur, Amma Kwatia, Ashley Rufino, Cesia Arzu, Luke Tyrrell, Pamela Pena, Megan Valentine","doi":"10.17912/micropub.biology.001483","DOIUrl":"https://doi.org/10.17912/micropub.biology.001483","url":null,"abstract":"<p><p>We report the discovery and genome sequence of a cluster EK bacteriophage, KingKamren, isolated from a soil sample collected in Plattsburgh, New York using the bacteria <i>Microbacterium foliorum</i> , B-24224. Its 54,721 bp genome contains 51 putative genes, 17 of which have predicted functions.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating potential impact of monoamine oxidase A missense L32S on the function of the enzyme monoamine oxidase A using in silico prediction tools and molecular modeling. 利用计算机预测工具和分子模型评估单胺氧化酶A错义L32S对单胺氧化酶A功能的潜在影响。
microPublication biology Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001414
Jared Laughlin, Cynthia L Stenger, Hanna J Jefcoat
{"title":"Evaluating potential impact of monoamine oxidase A missense L32S on the function of the enzyme monoamine oxidase A using <i>in silico</i> prediction tools and molecular modeling.","authors":"Jared Laughlin, Cynthia L Stenger, Hanna J Jefcoat","doi":"10.17912/micropub.biology.001414","DOIUrl":"https://doi.org/10.17912/micropub.biology.001414","url":null,"abstract":"<p><p>Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects 6-7% of people worldwide (Wilcutt, 2012). MAOA is a gene that encodes monoamine oxidase A, an enzyme responsible for the regulation and metabolism of monoamines thought to be associated with ADHD. This study investigates a leucine to serine swap at amino acid position 32 in FAD-binding domain of the enzyme monoamine oxidase A. Results from <i>in silico</i> prediction tools and molecular dynamics modeling provide evidence to support pathogenicity of the L32S missense variant of monoamine oxidase A.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On X-ray Sensitivity in Xenopus Embryogenesis. 非洲爪蟾胚胎发生的x射线敏感性研究。
microPublication biology Pub Date : 2025-04-08 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001567
Hugo Mauricio, Jose G Abreu, Leonid Peshkin
{"title":"On X-ray Sensitivity in <i>Xenopus</i> Embryogenesis.","authors":"Hugo Mauricio, Jose G Abreu, Leonid Peshkin","doi":"10.17912/micropub.biology.001567","DOIUrl":"https://doi.org/10.17912/micropub.biology.001567","url":null,"abstract":"<p><p>We examined the effects of X-ray irradiation on <i>Xenopus</i> <i>laevis</i> , focusing on pre- and post-fertilization exposure. We applied X-ray doses of 10, 50, 100, 250, and 500 Gy. Fifty percent of the 360 eggs irradiated at 250 Gy failed to fertilize, while fertilized eggs developed normally until the gastrula stage. Doses ranging from 10 to 250 Gy caused developmental anomalies. High mortality rates were observed at doses of 100 to 500 Gy. Post-fertilization irradiation at 50 to 100 Gy resulted in 100% lethality, while exposure to 10 Gy led to only 13% lethality, although both exposure levels produced similar types of developmental anomalies compared to pre-fertilization irradiation. This study highlights how the timing and intensity of exposure critically affect embryo viability, especially during the sensitive stages of fertilization and gastrulation. We establish the necessary and sufficient dosage to further investigate the molecular mechanisms of X-ray damage to DNA and protein.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
purpleoid 1 , a classic Drosophila eye color mutation, is an allele of the t-SNARE-encoding gene SNAP29. purpleoid 1是一种典型的果蝇眼睛颜色突变，是t- snare编码基因SNAP29的等位基因。
microPublication biology Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001563
Derek M Dean, Lillian E Codd, Ruben Constanza, Xavier M Segel
{"title":"<i>purpleoid <sup>1</sup></i> , a classic <i>Drosophila</i> eye color mutation, is an allele of the t-SNARE-encoding gene <i>SNAP29</i>.","authors":"Derek M Dean, Lillian E Codd, Ruben Constanza, Xavier M Segel","doi":"10.17912/micropub.biology.001563","DOIUrl":"https://doi.org/10.17912/micropub.biology.001563","url":null,"abstract":"<p><p>The <i>Drosophila</i> mutant eye color trait <i>purpleoid</i> ( <i>pd</i> ) was first observed by Calvin Bridges over a century ago. Although <i>pd</i> mutant strains have been maintained ever since, the <i>pd</i> locus has not been identified. Using complementation tests, genetic rescue, and DNA sequencing, we show that <i>pd <sup>1</sup></i> is a missense mutation in <i>SNAP29</i> ; this gene encodes a key component of the SNARE complex, which facilitates vesicle docking and fusion at cellular membranes. After describing how <i>pd <sup>1</sup></i> was mapped, we discuss ways that the mutation could be used in future studies of eye pigmentation, SNARE complex assembly, and vesicle trafficking.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence for direct use of terminal organ for spermatophore transfer in giant squid, Architeuthis dux. 巨乌贼直接利用末端器官转移精囊的证据。
microPublication biology Pub Date : 2025-04-04 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001476
Seiji Sasai, Yoshiaki Tanaka, Noritaka Hirohashi
{"title":"Evidence for direct use of terminal organ for spermatophore transfer in giant squid, <i>Architeuthis dux</i>.","authors":"Seiji Sasai, Yoshiaki Tanaka, Noritaka Hirohashi","doi":"10.17912/micropub.biology.001476","DOIUrl":"https://doi.org/10.17912/micropub.biology.001476","url":null,"abstract":"<p><p>During mating, males of most cephalopods use a modified arm, known as a hectocotylus, to transfer spermatophores into the female. However, a long-standing enigma has been whether some deep-sea squids use a terminal organ (TO), similar to a penis, for direct spermatophore transfer, as suggested by anatomical observations. Here, we present evidence supporting this hypothesis in the giant squid, <i>Architeuthis dux</i> . Two male squids in the moribund condition were discovered in shallow water, with their TOs passing through their own funnels and being able of active movement, a behavior previously observed in <i>Pholidoteuthis adami</i> in deep water.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No degradation of temperature-mediated phenotypic plasticity in Drosophila melanogaster after more than 275 generations of artificial selection on body-size. 经过275代以上的体型人工选择后，黑腹果蝇温度介导的表型可塑性没有退化。
microPublication biology Pub Date : 2025-04-04 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001468
Yvonne L Ofodile, Judith Appenteng, Mubeen Jaffri, Ian Dworkin, Andrew D Stewart
{"title":"No degradation of temperature-mediated phenotypic plasticity in <i>Drosophila melanogaster</i> after more than 275 generations of artificial selection on body-size.","authors":"Yvonne L Ofodile, Judith Appenteng, Mubeen Jaffri, Ian Dworkin, Andrew D Stewart","doi":"10.17912/micropub.biology.001468","DOIUrl":"https://doi.org/10.17912/micropub.biology.001468","url":null,"abstract":"<p><p>Body size is a fundamental trait that shapes a species' development and evolution. Importantly, body size can also be affected by environmental variables, especially development temperature. Here we measure phenotypic plasticity in a series of lineages that had experienced artificial selection on body size for over 275 generations. We found, despite substantial changes in overall size and sexual size dimorphism, only modest effects on developmental plasticity. Still, there were some significant, changes in the sex specific slopes of the relationship between size and rearing temperature, largely due to a reduction in plasticity in the treatment selected for small body size.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prostaglandins limit nuclear actin rod formation during Drosophila oogenesis. 在果蝇卵发生过程中，前列腺素限制核肌动蛋白棒的形成。
microPublication biology Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001571
Tina L Tootle
{"title":"Prostaglandins limit nuclear actin rod formation during <i>Drosophila</i> oogenesis.","authors":"Tina L Tootle","doi":"10.17912/micropub.biology.001571","DOIUrl":"https://doi.org/10.17912/micropub.biology.001571","url":null,"abstract":"<p><p>Expression of GFP-Actin results in nuclear actin rod formation during specific stages of <i>Drosophila melanogaster</i> oogenesis. Loss of prostaglandin (PG) synthesis and signaling results in an increased frequency of cells with nuclear actin rods; there are less rods per cell, but the rods are longer. These findings suggest that loss of PGs results in increased nuclear actin and are consistent with prior findings assessing the roles of PGs in modulating endogenous nuclear actin. Thus, GFP-Actin rod formation can be used as a tool to screen for new regulators of nuclear actin.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene model for the ortholog of wrd in Drosophila ananassae. 果蝇wrd同源基因模型的研究。
microPublication biology Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.000928
Megan E Lawson, Samantha Hoffman, Mikhail Sanu, Daniel Morris, Evan Merkhofer, Stephanie Toering Peters, Nikolaos Tsotakos, Chinmay P Rele, Laura K Reed
{"title":"Gene model for the ortholog of <i>wrd</i> in <i>Drosophila ananassae</i>.","authors":"Megan E Lawson, Samantha Hoffman, Mikhail Sanu, Daniel Morris, Evan Merkhofer, Stephanie Toering Peters, Nikolaos Tsotakos, Chinmay P Rele, Laura K Reed","doi":"10.17912/micropub.biology.000928","DOIUrl":"https://doi.org/10.17912/micropub.biology.000928","url":null,"abstract":"<p><p>Gene model for the ortholog of <i>well-rounded</i> ( <i>wrd</i> ) in the May 2011 (Agencourt dana_caf1/DanaCAF1) Genome Assembly (GenBank Accession: GCA_000005115.1 ) of <i>Drosophila ananassae</i> . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus <i>Drosophila</i> using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene model for the ortholog of Sik3 in Drosophila mojavensis. 莫氏果蝇Sik3同源基因的基因模型。
microPublication biology Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001032
Gabriella N Bicanovsky, Karolina J Senkow, Cassidy McColl, Jennifer Mierisch, Kellie S Agrimson, Lindsey J Long, Judith Leatherman, Chinmay P Rele, Laura K Reed
{"title":"Gene model for the ortholog of <i>Sik3</i> in <i>Drosophila mojavensis</i>.","authors":"Gabriella N Bicanovsky, Karolina J Senkow, Cassidy McColl, Jennifer Mierisch, Kellie S Agrimson, Lindsey J Long, Judith Leatherman, Chinmay P Rele, Laura K Reed","doi":"10.17912/micropub.biology.001032","DOIUrl":"https://doi.org/10.17912/micropub.biology.001032","url":null,"abstract":"<p><p>Gene model for the ortholog of <i>Salt-inducible kinase 3</i> ( <i>Sik3</i> ) in the May 2011 (Agencourt dmoj_caf1/DmojCAF1) Genome Assembly (GenBank Accession: GCA_000005175.1 ) of <i>Drosophila mojavensis</i> . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus <i>Drosophila</i> using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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