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Lack of correlation between parasite burden and key weight metrics in poultry infected with intestinal ascarids. 感染肠道蛔虫的家禽体内寄生虫负担与主要体重指标之间缺乏相关性。
microPublication biology Pub Date : 2024-08-07 eCollection Date: 2024-01-01 DOI: 10.17912/micropub.biology.001197
J B Collins, Amanda O Shaver, Etta S Schaye, Tom Volpe, Leonardo R Nunn, Mostafa Zamanian, Erik C Andersen
{"title":"Lack of correlation between parasite burden and key weight metrics in poultry infected with intestinal ascarids.","authors":"J B Collins, Amanda O Shaver, Etta S Schaye, Tom Volpe, Leonardo R Nunn, Mostafa Zamanian, Erik C Andersen","doi":"10.17912/micropub.biology.001197","DOIUrl":"10.17912/micropub.biology.001197","url":null,"abstract":"<p><p><i>Ascaridia galli</i> and <i>Ascaridia dissimilis</i> are the most common and economically impactful nematode parasites of commercial poultry. These infections rarely cause clinical disease, but reduction in feed conversion efficiency is detected. To determine if feed conversion efficiency reductions correlate with any physiological measures independent of clinical disease, we determined if ascarid infections correlate with changes in the weights of the small intestine, liver, or total animal weight (quantitative measures of animal health). No correlation between parasite burden and these metrics were observed, supporting the concept that feed conversion is the only production metric impacted by ascarid infections.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11339651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular calcium promotes internalization and degradation of the fission yeast TRP-like calcium ion channel Pkd2. 细胞外钙促进裂殖酵母 TRP 样钙离子通道 Pkd2 的内化和降解。
microPublication biology Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI: 10.17912/micropub.biology.001265
Takayuki Koyano, Kaori Onishi, Makoto Matsuyama, Masaki Fukushima, Kazunori Kume
{"title":"Extracellular calcium promotes internalization and degradation of the fission yeast TRP-like calcium ion channel Pkd2.","authors":"Takayuki Koyano, Kaori Onishi, Makoto Matsuyama, Masaki Fukushima, Kazunori Kume","doi":"10.17912/micropub.biology.001265","DOIUrl":"10.17912/micropub.biology.001265","url":null,"abstract":"<p><p>The correct localization of proteins is linked to their cellular function. The <i>Schizosaccharomyces pombe</i> Pkd2 localizes to the endoplasmic reticulum and plasma membrane. Here we investigate the behavior of Pkd2 in response to calcium. Pkd2-GFP, normally enriched at the cell ends, is reduced from the plasma membrane by CaCl <sub>2</sub> addition, while cytoplasmic dots and free GFP are increased. This suggests that Pkd2 is internalized and degraded in response to extracellular CaCl <sub>2</sub> . This internalization is partially suppressed by treatment with an Arp2/3 inhibitor, CK-666. Our data provide new insights into the relationship between Pkd2 internalization and calcium response.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene model for the ortholog of Myc in Drosophila eugracilis. 八哥果蝇 Myc 同源物的基因模型
microPublication biology Pub Date : 2024-08-03 eCollection Date: 2024-01-01 DOI: 10.17912/micropub.biology.000912
Megan E Lawson, Alexa Hoffman, Isabel G Wellik, Jeffrey S Thompson, Joyce Stamm, Chinmay P Rele
{"title":"Gene model for the ortholog of <i>Myc</i> in <i>Drosophila eugracilis</i>.","authors":"Megan E Lawson, Alexa Hoffman, Isabel G Wellik, Jeffrey S Thompson, Joyce Stamm, Chinmay P Rele","doi":"10.17912/micropub.biology.000912","DOIUrl":"10.17912/micropub.biology.000912","url":null,"abstract":"<p><p>Gene model for the ortholog of Myc ( <i>Myc</i> ) in the <i>D. eugracilis</i> Apr. 2013 (BCM-HGSC/Deug_2.0) (DeugGB2) Genome Assembly (GenBank Accession: GCA_000236325.2) of <i>Drosophila eugracilis</i> . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus <i>Drosophila</i> using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11330573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-ovarian Wolbachia pipientis titer correlates with fertility rescue of a Drosophila melanogaster bag of marbles hypomorph. 非卵巢琵琶虫滴度与黑腹果蝇弹珠袋低倍型的生育力挽救相关。
microPublication biology Pub Date : 2024-08-02 eCollection Date: 2024-01-01 DOI: 10.17912/micropub.biology.001233
Catherine H Kagemann, Gabriela M Colocho, Charles F Aquadro
{"title":"Non-ovarian <i>Wolbachia pipientis</i> titer correlates with fertility rescue of a <i>Drosophila melanogaster bag of marbles</i> hypomorph.","authors":"Catherine H Kagemann, Gabriela M Colocho, Charles F Aquadro","doi":"10.17912/micropub.biology.001233","DOIUrl":"10.17912/micropub.biology.001233","url":null,"abstract":"<p><p><i>Bag of marbles</i> ( <i>bam</i> ) is an essential gene that regulates germline stem cell maintenance and germline stem cell daughter cell differentiation in <i>Drosophila melanogaster</i> . When <i>bam</i> is partially functional (hypomorphic), the introduction of <i>Wolbachia pipientis</i> rescues the mutant fertility phenotype that would otherwise result in partial sterility. Infection by different <i>W. pipientis</i> variants results in differential rescue of the <i>bam</i> hypomorph fertility phenotype. We were intrigued by the varying degrees of rescue exhibited in the <i>bam</i> hypomorph when exposed to different <i>W. pipientis</i> variants, prompting us to investigate whether this phenomenon is attributable to variations in the titers of <i>W. pipientis</i> variants. We found no significant difference in ovarian titer between two <i>W. pipientis</i> variant groups, <i>w</i> Mel-like (low <i>bam</i> hypomorph fertility rescue) and <i>w</i> MelCS-like variants (higher <i>bam</i> hypomorph fertility rescue), at <i>bam</i> hypomorph peak fertility. However, carcass (whole flies without the ovaries) titer between <i>w</i> Mel-like and <i>w</i> MelCS-like infected <i>bam</i> hypomorph differed during peak fertility rescue. A positive correlation emerged between the combined titers of ovarian and carcass infections and fertility, implying a more extensive influence that extends beyond ovarian infection alone.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Left-right tympanal size asymmetry in the parasitoid fly Ormia ochracea. 寄生蝇 Ormia ochracea 的左右鼓膜大小不对称。
microPublication biology Pub Date : 2024-08-02 eCollection Date: 2024-01-01 DOI: 10.17912/micropub.biology.001243
Max R Mikel-Stites, Paul E Marek, Madeleine E Hellier, Anne E Staples
{"title":"Left-right tympanal size asymmetry in the parasitoid fly <i>Ormia ochracea</i>.","authors":"Max R Mikel-Stites, Paul E Marek, Madeleine E Hellier, Anne E Staples","doi":"10.17912/micropub.biology.001243","DOIUrl":"10.17912/micropub.biology.001243","url":null,"abstract":"<p><p><i>Ormia ochracea</i> is a parasitoid fly notable for its impressive hearing abilities relative to its small size. Here, we use it as a model organism to investigate if minor size differences in paired sensory organs may be beneficial or neutral to an organism's perception abilities. We took high-resolution images of tympanal organs from 21 <i>O. ochracea</i> specimens and found a statistically significant surface area asymmetry (up to 6.88%) between the left and right membranes. Numerical experiments indicated that peak values of key sound localization variables increased with increasing tympanal asymmetry, which may explain features of the limited available physiological data.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five tree species contained antibiotic-producing bacteria within their bark. 五个树种的树皮中含有产生抗生素的细菌。
microPublication biology Pub Date : 2024-08-01 eCollection Date: 2024-01-01 DOI: 10.17912/micropub.biology.001227
Caymen Hoffman, Kristina Blanke
{"title":"Five tree species contained antibiotic-producing bacteria within their bark.","authors":"Caymen Hoffman, Kristina Blanke","doi":"10.17912/micropub.biology.001227","DOIUrl":"10.17912/micropub.biology.001227","url":null,"abstract":"<p><p>Soil is a common source for identifying antibiotic-producing bacteria; however, other ecosystems in nature may contain novel bacteria capable of producing antibiotics. Bark from seven tree species was collected as a new source to culture bacterial isolates that were screened against nine tester bacteria related to antibiotic resistant pathogens. Five of the seven tree species contained isolates that showed antibiotic production against at least one of the tester bacteria. Bark should be further explored as a possible source for bacteria that produce unknown antibiotics.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Replication forks associated with long nuclear actin filaments in mild stress conditions display increased dynamics. 在轻度应激条件下，与长核肌动蛋白丝相关的复制叉显示出更强的动态性。
microPublication biology Pub Date : 2024-07-31 eCollection Date: 2024-01-01 DOI: 10.17912/micropub.biology.001259
Chiara Merigliano, Maria Dilia Palumbieri, Massimo Lopes, Irene Chiolo
{"title":"Replication forks associated with long nuclear actin filaments in mild stress conditions display increased dynamics.","authors":"Chiara Merigliano, Maria Dilia Palumbieri, Massimo Lopes, Irene Chiolo","doi":"10.17912/micropub.biology.001259","DOIUrl":"10.17912/micropub.biology.001259","url":null,"abstract":"<p><p>Nuclear actin filaments (F-actin) form during S-phase and in response to replication stress to promote fork remodeling and repair. In mild replication stress conditions, nuclear actin polymerization is required to limit PrimPol recruitment to the fork while promoting fork reversal. Both short and long filaments form during this response, but their function in the nuclear dynamics of replication sites was unclear. Here, we show that replication centers associated with long nuclear actin filaments become more mobile than the rest of the forks, suggesting relocalization of replication sites as a response to prolonged fork stalling and/or fork breakage, even in response to mild replication stress.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the effects of antipsychotic drugs as a treatment for improving the activity of the unc-33 /Dpysl2 gene in C. elegans. 研究抗精神病药物作为一种治疗方法对提高优雅小鼠 unc-33 /Dpysl2 基因活性的影响。
microPublication biology Pub Date : 2024-07-31 eCollection Date: 2024-01-01 DOI: 10.17912/micropub.biology.001063
Maria C Miranda, Jessica Hyde, Kaylee Salazar, Balyssa Bell, Andrea Holgado
{"title":"Investigating the effects of antipsychotic drugs as a treatment for improving the activity of the <i>unc-33</i> /Dpysl2 gene in <i>C. elegans</i>.","authors":"Maria C Miranda, Jessica Hyde, Kaylee Salazar, Balyssa Bell, Andrea Holgado","doi":"10.17912/micropub.biology.001063","DOIUrl":"10.17912/micropub.biology.001063","url":null,"abstract":"<p><p>Prenatal stress is hypothesized to contribute to the development of schizophrenia. Lee and colleagues determined that prenatal stress in rats decreases levels of Dpysl2, which is found to be inactivated in schizophrenic patients. UNC-33 , the homolog to Dpysl2 in <i>C. elegans</i> , is important for axonal outgrowth and synapse formation. Herein, we study the effects of antipsychotic drugs on developing <i>C.elegans</i> exposed to stress through high temperatures. Results indicate that the <i>unc-33</i> promoter was not impacted by antipsychotic drug treatment, but the lifespan was decreased.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased expression of metabolism and lysosome-associated genes in a C. elegans dpy-7 cuticle furrow mutant. 优雅小鼠 dpy-7 角质层沟突变体中代谢和溶酶体相关基因的表达增加。
microPublication biology Pub Date : 2024-07-31 eCollection Date: 2024-01-01 DOI: 10.17912/micropub.biology.001241
Aiden Fong, Michael Rodriguez, Keith Patrick Choe
{"title":"Increased expression of metabolism and lysosome-associated genes in a <i>C. elegans</i> <i>dpy-7</i> cuticle furrow mutant.","authors":"Aiden Fong, Michael Rodriguez, Keith Patrick Choe","doi":"10.17912/micropub.biology.001241","DOIUrl":"10.17912/micropub.biology.001241","url":null,"abstract":"<p><p>The collagen-based epidermal 'cuticle' of <i>Caenorhabditis elegans</i> functions as an extracellular sensor for damage that regulates genes promoting osmotic balance, innate immunity, and detoxification. Prior studies demonstrate that SKN-1 , an ortholog of the mammalian Nrf transcription factors, activates core detoxification genes downstream from cuticle damage. Prior RNAseq data suggested that expression of five genes with functions in redox balance, ATP homeostasis, and lysosome function ( <i>gst-15</i> , <i>gst-24</i> , <i>cyts-1</i> , <i>argk-1</i> , and <i>mfsd-8.4</i> ) were increased in a cuticle collagen mutant; this study employed RT-qPCR to verify this observation and to test the role of SKN-1 . Activation of all five genes was verified in <i>dpy-7</i> mutants, but none were reduced by <i>skn-1 (RNAi)</i> suggesting parallel or distinct regulatory mechanisms.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11322832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Both Splice Variants of Zebrafish Tmem11 Localize to the Outer Membrane of Mitochondria. 斑马鱼 Tmem11 的两个剪接变体都定位在线粒体外膜上
microPublication biology Pub Date : 2024-07-31 eCollection Date: 2024-01-01 DOI: 10.17912/micropub.biology.001162
Saron S Tadesse, Melanie Schille, Paula Collado Cordon, Susan Walsh
{"title":"Both Splice Variants of Zebrafish Tmem11 Localize to the Outer Membrane of Mitochondria.","authors":"Saron S Tadesse, Melanie Schille, Paula Collado Cordon, Susan Walsh","doi":"10.17912/micropub.biology.001162","DOIUrl":"10.17912/micropub.biology.001162","url":null,"abstract":"<p><p>In mammalian and <i>Drosophila</i> systems, Transmembrane protein 11 (TMEM11) regulates mitochondrial morphology, mitophagy, and mitochondrial function. Here, we begin to expand these studies to the zebrafish model system. We identified two splice variants of <i>tmem11</i> , which are both expressed during early development. In addition, we determined that both zebrafish Tmem11 proteins localize to the mitochondria using fluorescent tags and expression in cell culture. Consistent with recent data, biochemical fractionation indicates that Tmem11 is embedded in the outer membrane of mitochondria. Overall, these studies will provide new insights into the complex protein network that mediates mitochondrial physiology in the zebrafish.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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