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Increased diameter of arteries and veins in the caudal fins of Danio rerio longfin t2 fish is accompanied by fin overgrowth. 长鳍鱼尾鳍动静脉直径增大，并伴有鳍的过度生长。
microPublication biology Pub Date : 2026-02-07 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.002008
Jennifer S Lanni, Benjamin W Lyon, Stacy V Nguyen
{"title":"Increased diameter of arteries and veins in the caudal fins of <i>Danio rerio</i> <i>longfin <sup>t2</sup></i> fish is accompanied by fin overgrowth.","authors":"Jennifer S Lanni, Benjamin W Lyon, Stacy V Nguyen","doi":"10.17912/micropub.biology.002008","DOIUrl":"https://doi.org/10.17912/micropub.biology.002008","url":null,"abstract":"<p><p>The classic dominant <i>longfin</i> zebrafish strain ( <i>lof <sup>t2</sup></i> ) has long fins due to ectopic expression of the potassium channel Kcnh2a in the fin mesenchyme. Potassium channel function is also known to affect the vasculature, but the fin vasculature has not been characterized in <i>lof <sup>t2</sup> </i> fish. Here we show that <i>lof <sup>t2</sup> </i> fish contain significantly increased artery and vein diameters in the caudal fin as compared to wildtype fish. Interestingly, these changes in blood vessel size are associated with areas of fin overgrowth, consistent with a possible role for the vasculature in fin size regulation.&nbsp.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term behavioral tracking of Paramecium bursaria. 法氏草履虫的长期行为追踪。
microPublication biology Pub Date : 2026-02-07 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001569
Azusa Kage, Hiroyuki J Kanaya
{"title":"Long-term behavioral tracking of <i>Paramecium bursaria</i>.","authors":"Azusa Kage, Hiroyuki J Kanaya","doi":"10.17912/micropub.biology.001569","DOIUrl":"https://doi.org/10.17912/micropub.biology.001569","url":null,"abstract":"<p><p>The ciliate protozoan <i>Paramecium</i> exhibits complex behaviors in response to environmental cues. Here we report a method that enables long-term observation (over 24 hours) of <i>Paramecium</i> with a simple experimental procedure. We observed the behavior of <i>Paramecium bursaria</i> , a species of <i>Paramecium</i> harboring symbiotic green algae, in gas-permeable chambers, where they exhibited light-dependent changes in behavior. We found that, in the 12-hour light-dark (LD) cycles, <i>P. bursaria</i> responds to both the dark-to-light and the light-to-dark transitions in different manners. This method provides a way to evaluate the long-term changes in the behaviors of <i>Paramecium</i> and other protists.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viability of Dugesia dorotocephala Planaria with the Senolytic Drug ARV-825. 抗衰老药物ARV-825对多头涡虫生存能力的影响。
microPublication biology Pub Date : 2026-02-06 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001636
Abbie Wells, William H Munroe
{"title":"Viability of <i>Dugesia dorotocephala</i> Planaria with the Senolytic Drug ARV-825.","authors":"Abbie Wells, William H Munroe","doi":"10.17912/micropub.biology.001636","DOIUrl":"https://doi.org/10.17912/micropub.biology.001636","url":null,"abstract":"<p><p>Planaria ( <i>Dugesia dorotocephala</i> ) are being utilized as a model system to test the effectiveness of ARV-825. ARV-825 belongs to the drug class proteolysis targeting chimeras (PROTACs), which targets and degrades the protein Bromodomain-containing protein 4 (BRD4) via the proteasome. To examine the impact of ARV-825 on the planaria, planaria viability was tested at different ARV-825 concentrations. This demonstrated a concentration-dependent reduction in viability, 91.7% survival with 1µM ARV-825 reduced to 25% survival in 10 µM ARV-825. This suggests ARV-825 has an effect on <i>Dugesia dorotocephala</i> , and indicates that this may be a suitable model organism for studying ARV-825.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The LDL pathway regulates actomyosin ring dynamics necessary for optimal cell wound repair. 低密度脂蛋白途径调节肌动球蛋白环动力学是最佳细胞伤口修复所必需的。
microPublication biology Pub Date : 2026-02-06 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.002019
Geethika Burugupally, Mitsutoshi Nakamura, Cassandra Aarrestad, Susan M Parkhurst
{"title":"The LDL pathway regulates actomyosin ring dynamics necessary for optimal cell wound repair.","authors":"Geethika Burugupally, Mitsutoshi Nakamura, Cassandra Aarrestad, Susan M Parkhurst","doi":"10.17912/micropub.biology.002019","DOIUrl":"https://doi.org/10.17912/micropub.biology.002019","url":null,"abstract":"<p><p>Individual cells must rapidly repair any cortical damage from environmental or physiological stresses, to survive and to contribute to maintaining the proper function of tissues and organs. The formation of an actomyosin ring around the wound periphery is an important step in physically closing the cell wound. Here, we find that the Low-Density Lipoprotein (LDL) pathway, which is usually associated with plasma membrane homeostasis, is needed for optimal cell wound repair. In this context, the LDL pathway is required for robust actomyosin ring formation, revealing an unexpected role in regulating actin dynamics during cell wound repair.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variant identification and genotyping strategy for the smg-1(r861) allele in Caenorhabditis elegans. 秀丽隐杆线虫smg-1（r861）等位基因的变异鉴定及分型策略
microPublication biology Pub Date : 2026-02-05 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.002026
Michael Zoberman, John A Calarco
{"title":"Variant identification and genotyping strategy for the <i>smg-1(r861)</i> allele in <i>Caenorhabditis elegans</i>.","authors":"Michael Zoberman, John A Calarco","doi":"10.17912/micropub.biology.002026","DOIUrl":"https://doi.org/10.17912/micropub.biology.002026","url":null,"abstract":"<p><p>The <i>C. elegans</i> <i>smg-1</i> gene encodes a PI3K-related kinase responsible for initiating the process of nonsense-mediated decay (NMD). The <i>smg-1 ( r861 )</i> allele is a strong loss-of-function variant that disrupts NMD activity leading to the stabilization of transcripts containing premature stop codons (PTCs). This allele has been used extensively in studies of RNA surveillance, transcript stability, and transgene regulation. Despite its widespread use, the mutation in <i>smg-1 ( r861 )</i> has not been reported, and identification is often based solely on phenotype. Here, we identify the underlying mutation and present a restriction digestion-based genotyping strategy that enables quick confirmation of the <i>smg-1 ( r861 )</i> allele.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible regulation of Arabidopsis MYB93 by both SCARECROW and MPK3. 稻草人和MPK3可能调控拟南芥MYB93。
microPublication biology Pub Date : 2026-02-04 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001986
Xulyu Cao, Clare Clayton, Bethany Hutton, Nancy McMulkin, Juliet C Coates
{"title":"Possible regulation of <i>Arabidopsis</i> MYB93 by both SCARECROW and MPK3.","authors":"Xulyu Cao, Clare Clayton, Bethany Hutton, Nancy McMulkin, Juliet C Coates","doi":"10.17912/micropub.biology.001986","DOIUrl":"https://doi.org/10.17912/micropub.biology.001986","url":null,"abstract":"<p><p>The promoter of the <i>Arabidopsis</i> <i>MYB93</i> ( <i>MYB93</i> ) transcription factor was previously identified in a large-scale screen using the SCARECROW ( SCR ) transcription factor. Independent high-throughput studies also identified MYB93 as a protein-interaction partner of the MAP kinase 3 ( MPK3 ). Here, we validate and extend those observations using RT-PCR, yeast two-hybrid assays and phenotypic analysis. <i>MYB93</i> transcript levels were elevated in the <i>scr-3</i> mutant and reduced upon expression of SCR-GFP, indicating regulation by SCR. In yeast, the N-terminal domain of MYB93 , but not the C-terminal region, interacted with MPK3 . We also observed that <i>mpk3-1</i> mutants exhibited a lateral root phenotype similar to <i>myb93-1</i> . Together, these findings support a model in which both <i>MYB93</i> gene expression and MYB93 protein function are modulated by SCR and MPK3 , respectively.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokinin signaling mediated by KMD2 promotes Arabidopsis hypocotyl grafting success. KMD2介导的细胞分裂素信号传导促进拟南芥下胚轴嫁接成功。
microPublication biology Pub Date : 2026-02-03 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001768
JoonJae Kim, Lucia Strader, Suresh Damodaran
{"title":"Cytokinin signaling mediated by KMD2 promotes Arabidopsis hypocotyl grafting success.","authors":"JoonJae Kim, Lucia Strader, Suresh Damodaran","doi":"10.17912/micropub.biology.001768","DOIUrl":"https://doi.org/10.17912/micropub.biology.001768","url":null,"abstract":"<p><p>Grafting and adventitious root formation are plant regeneration mechanisms used in horticulture. In grafting, a scion (shoot) of one plant is joined to a stock (root) of another plant through vascular reconnection. Adventitious roots arise from above-ground plant tissue, and graft failure occurs when the scion develops adventitious roots. The molecular mechanisms underlying grafting success and adventitious root formation are unclear. We developed a hypocotyl grafting approach to determine regulators involved in grafting success <i>vs</i> adventitious root formation. We suggest that reduced cytokinin signaling by the F-box protein, KISS ME DEADLY2 (KMD2, AT1G15670), promotes adventitious root formation over successful grafting.&nbsp.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12910299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exogenous abscisic acid inhibits leaf elevation during shade avoidance response in Arabidopsis thaliana. 外源脱落酸在拟南芥遮荫躲避反应中抑制叶片升高。
microPublication biology Pub Date : 2026-02-03 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001972
Brett E Harris, Helena E Heiberger, ByungHoon B Kim
{"title":"Exogenous abscisic acid inhibits leaf elevation during shade avoidance response in <i>Arabidopsis thaliana</i>.","authors":"Brett E Harris, Helena E Heiberger, ByungHoon B Kim","doi":"10.17912/micropub.biology.001972","DOIUrl":"https://doi.org/10.17912/micropub.biology.001972","url":null,"abstract":"<p><p>Plant shade avoidance response includes elongated hypocotyls and petioles as well as increased leaf elevation angles. Our time-course image analyses indicate that the phytohormone abscisic acid (ABA) affects leaf elevation angles in Arabidopsis. While mutants with impaired ABA production ( <i>aba1-6</i> ) or with insensitivity to ABA ( <i>abi5-10</i> ) did not fully increase the angles under shade avoidance conditions, a higher concentration of exogenous ABA inhibited leaf elevation under the same conditions. These suggest that certain levels of ABA production and sensing are required for leaf elevation during shade avoidance response, whereas higher concentrations of ABA can inhibit the process.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12910301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome Sequence of Corynebacterium glutamicum Phage MicyPS. 谷氨酸棒状杆菌噬菌体MicyPS基因组序列。
microPublication biology Pub Date : 2026-02-03 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001936
Ombeline Rossier, Florence Constantinesco-Becker, Anne Lopes, Daniel Delaruelle, Ana A Arteni, Lydia Hassissene, Malika Ouldali, Laura Pieri, Avril Zappini, Katia Zaidi, Armand Tomasella, Perla Tannous, Michel Nouhra, Mickael Marques, Cindy Goodur, Louis Gachot, Erine Dumond, Alizée Dias, Heather Desolle, Meissan Chikhi, Chahine Belhachem, Adel Amriche, Christophe Regeard
{"title":"Genome Sequence of <i>Corynebacterium glutamicum</i> Phage MicyPS.","authors":"Ombeline Rossier, Florence Constantinesco-Becker, Anne Lopes, Daniel Delaruelle, Ana A Arteni, Lydia Hassissene, Malika Ouldali, Laura Pieri, Avril Zappini, Katia Zaidi, Armand Tomasella, Perla Tannous, Michel Nouhra, Mickael Marques, Cindy Goodur, Louis Gachot, Erine Dumond, Alizée Dias, Heather Desolle, Meissan Chikhi, Chahine Belhachem, Adel Amriche, Christophe Regeard","doi":"10.17912/micropub.biology.001936","DOIUrl":"https://doi.org/10.17912/micropub.biology.001936","url":null,"abstract":"<p><p>MicyPS is a bacteriophage with siphovirus morphology infecting <i>Corynebacterium glutamicum</i> strain MB001. It was isolated from soil near a henhouse in Villiers-sur-Marne, France. Its 78,208-bp genome encodes 115 predicted protein-encoding genes and 5 tRNAs. Based on gene-content similarity with actinobacteriophage PSonyx, MicyPS was assigned to the new cluster EQ.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of the siss-1 gene in C. elegans. siss1基因在秀丽隐杆线虫中的表达。
microPublication biology Pub Date : 2026-02-02 eCollection Date: 2026-01-01 DOI: 10.17912/micropub.biology.001976
Marine Barsegyan, Cheryl Van Buskirk
{"title":"Expression of the <i>siss-1</i> gene in <i>C. elegans</i>.","authors":"Marine Barsegyan, Cheryl Van Buskirk","doi":"10.17912/micropub.biology.001976","DOIUrl":"10.17912/micropub.biology.001976","url":null,"abstract":"<p><p><i>C. elegans</i> SISS-1 is an Epidermal Growth Factor (EGF) family ligand that signals from&nbsp;damaged cells to sleep-promoting neurons during s tress- i nduced s leep (SIS). Damage to a range of tissues can trigger SIS, and we reasoned that <i>siss-1</i> should be widely expressed. Here we investigate <i>siss-1</i> expression using both endogenous and transgenic fluorescent reporters. Our endogenous reporter reveals <i>siss-1</i> expression in the pharynx, gut, rectal gland, vulval muscles, and a subset of neurons. Our transgenic reporters reveal expression in additional cell types including the distal tip cell of the migrating gonad and vulF cells of the developing vulva. This expression is specific relative to our expectation and suggests that not all tissues are capable of signaling to sleep neurons.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2026 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12910300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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