{"title":"ODR-10细胞外环2的多态框内缺失消除了双乙酰感知。","authors":"Aatira Mehraj, Rémy Mimbré, Katie Pelletier, Varsha Singh, Marie-Anne Félix","doi":"10.17912/micropub.biology.001722","DOIUrl":null,"url":null,"abstract":"<p><p>The <i>C. elegans</i> wild strain DL226 carries a 30 bp inframe deletion in the <i>odr-10</i> gene coding for the diacetyl olfactory receptor. DL226 animals are defective for attraction to diacetyl but not to pyrrole, an unrelated odorant also sensed by AWA neurons. Using genome editing in the N2 background, we show that this inframe deletion is causal for the defect in diacetyl sensing. The deletion specifically removes the predicted ligand-binding extracellular loop 2 (ECL2).</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368358/pdf/","citationCount":"0","resultStr":"{\"title\":\"A polymorphic inframe deletion in the ODR-10 extracellular loop 2 abolishes diacetyl sensing.\",\"authors\":\"Aatira Mehraj, Rémy Mimbré, Katie Pelletier, Varsha Singh, Marie-Anne Félix\",\"doi\":\"10.17912/micropub.biology.001722\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The <i>C. elegans</i> wild strain DL226 carries a 30 bp inframe deletion in the <i>odr-10</i> gene coding for the diacetyl olfactory receptor. DL226 animals are defective for attraction to diacetyl but not to pyrrole, an unrelated odorant also sensed by AWA neurons. Using genome editing in the N2 background, we show that this inframe deletion is causal for the defect in diacetyl sensing. The deletion specifically removes the predicted ligand-binding extracellular loop 2 (ECL2).</p>\",\"PeriodicalId\":74192,\"journal\":{\"name\":\"microPublication biology\",\"volume\":\"2025 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368358/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"microPublication biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17912/micropub.biology.001722\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"microPublication biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17912/micropub.biology.001722","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
A polymorphic inframe deletion in the ODR-10 extracellular loop 2 abolishes diacetyl sensing.
The C. elegans wild strain DL226 carries a 30 bp inframe deletion in the odr-10 gene coding for the diacetyl olfactory receptor. DL226 animals are defective for attraction to diacetyl but not to pyrrole, an unrelated odorant also sensed by AWA neurons. Using genome editing in the N2 background, we show that this inframe deletion is causal for the defect in diacetyl sensing. The deletion specifically removes the predicted ligand-binding extracellular loop 2 (ECL2).
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