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Loss of epe1 + extends chronological lifespan in Schizosaccharomyces pombe. epe1 +的缺失延长了pombe裂糖菌的按时间顺序排列的寿命。
microPublication biology Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001507
Sohini Basu, Yongqi Xu, Tommy Vo
{"title":"Loss of <i>epe1 <sup>+</sup></i> extends chronological lifespan in <i>Schizosaccharomyces pombe</i>.","authors":"Sohini Basu, Yongqi Xu, Tommy Vo","doi":"10.17912/micropub.biology.001507","DOIUrl":"https://doi.org/10.17912/micropub.biology.001507","url":null,"abstract":"<p><p>Aging is a complex phenomenon that is characterized by the altered regulation of various biological processes over time. One of these, epigenetics, play a crucial role throughout the different stages of eukaryotic life and its alteration is considered a key molecular hallmark of aging. However, the epigenetic factors which are important for lifespan control remain elusive. Here, we used <i>S. pombe</i> as a model organism to study the epigenetic basis of aging. Our study reveals that loss of the <i>epe1</i> + gene, encoding for the JmjC domain protein Epe1 , extends chronological lifespan and increases H3K9me3 in aged <i>S. pombe</i> cells <i>.</i></p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The disruptive influence of the Ala218Val variant on the ENG protein. Ala218Val变异对ENG蛋白的破坏性影响。
microPublication biology Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001350
Jared Truitt, Cynthia L Stenger, Luke Terwilliger, Michele Morris
{"title":"The disruptive influence of the Ala218Val variant on the ENG protein.","authors":"Jared Truitt, Cynthia L Stenger, Luke Terwilliger, Michele Morris","doi":"10.17912/micropub.biology.001350","DOIUrl":"10.17912/micropub.biology.001350","url":null,"abstract":"<p><p>Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disease that interferes with the formation of arteries. The <i>ENG</i> gene encodes for the protein endoglin which is used to properly develop and remodel arteries. The removal of endoglin forms telangiectasias that cause bleeding from the nose and vital organs. This study investigates the impact of one of the many variants of uncertain significance of ENG associated with HHT. The missense swap of alanine for valine at position 218 (Ala218Val) was characterized through computational metrics from in silico pathogenicity prediction tools, conservation analysis, and molecular dynamics simulation (MDS). The structural residue is highly conserved over multiple species and buried. The missense swap resulted in a difference in movement from the wild type according to MDS in a simulated aqueous environment. Therefore, it is predicted to be likely pathogenic.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcription Regulatory Protein SIN3 (YOL004W) Influences Mutation Rates in Saccharomyces cerevisiae. 转录调节蛋白SIN3 （YOL004W）影响酿酒酵母的突变率。
microPublication biology Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001521
Alexandra Eftimie, Damon Meyer
{"title":"Transcription Regulatory Protein <i>SIN3</i> (YOL004W) Influences Mutation Rates in <i>Saccharomyces cerevisiae</i>.","authors":"Alexandra Eftimie, Damon Meyer","doi":"10.17912/micropub.biology.001521","DOIUrl":"10.17912/micropub.biology.001521","url":null,"abstract":"<p><p><i>SIN3</i> (YOL004W) codes for a protein in <i>Saccharomyces cerevisiae</i> which is suggested to function as a broad cellular transcription regulator through the binding of histone deacetylases and other enzymes to form a large protein complex that modifies chromatin. In addition, <i>SIN3</i> has also demonstrated potential roles in epigenetic silencing, DNA methylation, and centromere function. Here we report a new role of <i>SIN3</i> in affecting mutation rates within the <i>CAN1</i> reporter gene, suggesting an impact on genome stability.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-Type Specific Variation in X-Chromosome Dosage Compensation in Drosophila. 果蝇x染色体剂量补偿的细胞型特异性变异。
microPublication biology Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001501
Soumitra Pal, Brian Oliver, Teresa M Przytycka
{"title":"Cell-Type Specific Variation in X-Chromosome Dosage Compensation in Drosophila.","authors":"Soumitra Pal, Brian Oliver, Teresa M Przytycka","doi":"10.17912/micropub.biology.001501","DOIUrl":"10.17912/micropub.biology.001501","url":null,"abstract":"<p><p>Male <i>Drosophila melanogaster</i> require dosage compensation to equalize X-linked gene expression with autosomal expression. Leveraging the single-nucleus Fly Cell Atlas (FCA) dataset, which includes 388,918 nuclei across diverse tissues, we investigated cell-type-specific patterns of X-chromosome dosage compensation. Our analysis identified a continuum of cell groups based on their X-to-autosome (X/A) expression ratios ranging from anti-compensated to effectively compensated and overcompensated. Anti-compensation was predominantly observed in male reproductive tissues, while overcompensation was prevalent in neural cells. The expression levels of the dosage compensation machinery's non-coding RNAs, <i>RoX1</i> and <i>RoX2</i> , correlated with compensation levels, but were insufficient to fully explain the observed patterns of compensation. These findings reveal the complexity of dosage compensation and suggest that its regulation by the <i>RoX</i> RNAs is nonlinear, implicating potential alternative mechanisms in certain cell types.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of P suc , a sucrose-inducible promoter in Caulobacter crescentus. 蔗糖诱导启动子pso在新月形茎杆菌中的调控。
microPublication biology Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001458
Erin NewRingeisen, Jacy Jordahl, Lisa Bowers
{"title":"Regulation of <i>P <sub>suc</sub></i> , a sucrose-inducible promoter in <i>Caulobacter crescentus</i>.","authors":"Erin NewRingeisen, Jacy Jordahl, Lisa Bowers","doi":"10.17912/micropub.biology.001458","DOIUrl":"10.17912/micropub.biology.001458","url":null,"abstract":"<p><p>In gram-negative bacteria, when nutrients are too large or too scarce to diffuse through outer membrane porins, TonB-dependent receptors (TBDRs) are utilized to actively translocate substrates across the outer membrane. <i>Caulobacter crescentus</i> is a gram-negative bacterium with a large set of TBDRs, many which have not been fully characterized. Previous studies identified SucA, a <i>Caulobacter</i> TBDR that transports sucrose. Our experiments further characterize the expression of <i>sucA</i> from the <i>P <sub>suc</sub></i> promoter and we identify <i>P <sub>suc</sub></i> as a tightly controlled, tunable promoter, responsive to changes in sucrose concentration with and without other carbon sources in the media.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum: Not All Bacterial Outer-Membrane Proteins Are β-Barrels. 勘误：并非所有细菌外膜蛋白都是β-桶。
microPublication biology Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001556
{"title":"Corrigendum: Not All Bacterial Outer-Membrane Proteins Are β-Barrels.","authors":"","doi":"10.17912/micropub.biology.001556","DOIUrl":"https://doi.org/10.17912/micropub.biology.001556","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.17912/micropub.biology.001394.].</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11851173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Argentine ant chemical profiles vary by location on the Stanford University campus. 在斯坦福大学校园里，阿根廷蚂蚁的化学特征因地点而异。
microPublication biology Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001475
Aayesha Nangia, Mabel Gonzalez, Lauren A O'Connell, Katherine Fiocca
{"title":"Argentine ant chemical profiles vary by location on the Stanford University campus.","authors":"Aayesha Nangia, Mabel Gonzalez, Lauren A O'Connell, Katherine Fiocca","doi":"10.17912/micropub.biology.001475","DOIUrl":"10.17912/micropub.biology.001475","url":null,"abstract":"<p><p>The Argentine ant ( <i>Linepithema humile</i> ) is an invasive ant species found across California. Many invasive ant species, including the Argentine ant, can use chemical defense compounds to ward off predators or compete with native ant species, which aids in invasive spread. Previously, Stanford undergraduate researchers found variation in the potency of Argentine ant chemical profiles (collected in varying locations on campus) in repelling <i>Caenorhabditis elegans</i> during chemotaxis assays. Here, we asked if variation in Argentine ant chemical extracts was related to collection location on the Stanford campus. We collected Argentine ants from five different locations and analyzed differences in their chemical profiles. Using gas chromatography coupled to mass spectrometry, we found variation in ant chemical profiles based on location collected, where many metabolites contributed to these differences. Five of these compounds were successfully annotated, including pyrazines that are known to have a repulsive function in insects. This work highlights the importance of sampling location impacting naturally-derived ant compounds and the importance of this variable in future chemotaxis assays in the classroom.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schwann cell deletion of Tumor Susceptibility Gene 101 ( Tsg101 ) in mice results in severe peripheral neuropathy. 小鼠肿瘤易感基因101 （Tsg101）的雪旺细胞缺失可导致严重的周围神经病变。
microPublication biology Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001406
Derek Silvius, Edward Hurley, Yannick Poitelon, Kay-Uwe Wagner, M Laura Feltri, Teresa M Gunn
{"title":"Schwann cell deletion of <i>Tumor Susceptibility Gene 101</i> ( <i>Tsg101</i> ) in mice results in severe peripheral neuropathy.","authors":"Derek Silvius, Edward Hurley, Yannick Poitelon, Kay-Uwe Wagner, M Laura Feltri, Teresa M Gunn","doi":"10.17912/micropub.biology.001406","DOIUrl":"10.17912/micropub.biology.001406","url":null,"abstract":"<p><p>Myelinating Schwann cells are particularly susceptible to defects in endosomal trafficking. TSG101 is a component of the endosomal trafficking machinery that mediates the sorting of ubiquitinated receptors into multivesicular bodies. We previously demonstrated that deleting <i>Tsg101</i> from mouse oligodendrocytes in the central nervous system causes rapid onset de/dys-myelination and vacuolation of white matter, suggesting an important role for TSG101-dependent trafficking in myelination. Here, we show that TSG101 is also required for normal myelination in the peripheral nervous system.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Autophagy and the Anticipatory Unfolded Protein Response Leads to Increased Breast Cancer Cell Death. 靶向自噬和预期未折叠蛋白反应导致乳腺癌细胞死亡增加。
microPublication biology Pub Date : 2025-02-20 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001376
Jeffrey Brooks, Antonina Pizzo, Caela Fedraw, Florina Gojcaj, Myles Harris, Destiny Proffett, Ahed Anbari, Liselle Tungol, Mara R Livezey
{"title":"Targeting Autophagy and the Anticipatory Unfolded Protein Response Leads to Increased Breast Cancer Cell Death.","authors":"Jeffrey Brooks, Antonina Pizzo, Caela Fedraw, Florina Gojcaj, Myles Harris, Destiny Proffett, Ahed Anbari, Liselle Tungol, Mara R Livezey","doi":"10.17912/micropub.biology.001376","DOIUrl":"10.17912/micropub.biology.001376","url":null,"abstract":"<p><p>Activation of the anticipatory unfolded protein response (aUPR) by the small molecule 3,3-bis(4-hydroxyphenyl)-7-methyl-1,3,dihydro-2H-indol-2-one (BHPI) leads to necrotic cell death in a variety of cancer cells containing Estrogen Receptor alpha (ERα). A key feature of BHPI's mechanism of action is depletion of cellular ATP. Other pathways such as autophagy can regulate cellular energy levels and ATP production. We present data that suggests targeting both the aUPR and autophagy leads to a significant increase in cell death in T47D and TYS breast cancer cells treated with BHPI. This combination presents itself as a possible therapeutic strategy against breast cancer.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global γH2AX phosphorylation in Drosophila is reversed by the phosphatase Mts. 果蝇体内γ - h2ax的磷酸化被磷酸酶Mts逆转。
microPublication biology Pub Date : 2025-02-19 eCollection Date: 2025-01-01 DOI: 10.17912/micropub.biology.001474
Zivkos Apostolou, Silke Krause, Peter B Becker
{"title":"Global γH2AX phosphorylation in <i>Drosophila</i> is reversed by the phosphatase Mts.","authors":"Zivkos Apostolou, Silke Krause, Peter B Becker","doi":"10.17912/micropub.biology.001474","DOIUrl":"10.17912/micropub.biology.001474","url":null,"abstract":"<p><p>The phosphorylation of the histone variant H2AX to form γH2AX is an early and critical histone modification during the DNA damage response. This phosphorylation has proven to be a highly specific molecular marker for tracking the initiation and resolution of DNA damage. In this study, we investigate the roles of three phosphatases in removing the 'γ' phospho-epitope from H2AX in <i>Drosophila</i> Kc167 cells. We found that the bulk of the X-ray-induced γH2AX signal is erased by the PP2A-type phosphatase MTS (microtubule star).</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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