Korean journal of clinical oncology最新文献_第3页

Unusual mesentery metastasis of differentiated thyroid cancer: a case report. 分化型甲状腺癌的异常肠系膜转移：病例报告。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23015

Sunyoung Chwa, Seung Hun Lee, Seung Hyun Lee

引用次数: 0

Impact of Nrf2 overexpression on cholangiocarcinoma treatment and clinical prognosis. Nrf2过表达对胆管癌治疗及临床预后的影响。

Korean journal of clinical oncology Pub Date : 2023-06-01 DOI: 10.14216/kjco.23004

Huisong Lee, Seog Ki Min, Min-Sun Cho, Hyeon Kook Lee

{"title":"Impact of Nrf2 overexpression on cholangiocarcinoma treatment and clinical prognosis.","authors":"Huisong Lee, Seog Ki Min, Min-Sun Cho, Hyeon Kook Lee","doi":"10.14216/kjco.23004","DOIUrl":"https://doi.org/10.14216/kjco.23004","url":null,"abstract":"Purpose: Nrf2 regulates antioxidant protein expression and protects against drug toxicity and oxidative stress, whereas Keap1 controls Nrf2 activity. The Keap1-Nrf2 pathway affects the prognosis of various cancers, however, its effect on cholangiocarcinoma chemoresistance and prognosis remains unclear. This study aimed to determine whether the Keap1-Nrf2 pathway affects chemoresistance and prognosis of distal cholangiocarcinoma.Methods: We investigated the correlation between Nrf2 and Keap1 expression and clinical characteristics and prognosis in 91 patients with distal cholangiocarcinoma who underwent curative surgery. Immunohistochemical staining was performed on paraffin blocks using primary antibodies against Nrf2 and Keap1. The relationship between Keap1 and Nrf2 protein expression levels, and clinical characteristics and prognosis was examined.Results: Nrf2 expression was not associated with overall survival in patients who did not receive adjuvant chemotherapy (P=0.994). Among patients receiving adjuvant chemotherapy, the Nrf2 low expression group had a significantly longer median overall survival than the Nrf2 high expression group in Kaplan-Meier survival analysis (P=0.019). In multivariate analysis, high expression of Nrf2 was confirmed as an independent poor prognostic factor in the group receiving adjuvant chemotherapy (P=0.041).Conclusion: This study suggests that Nrf2 overexpression reduces the efficacy of adjuvant chemotherapy in distal cholangiocarcinoma.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 1","pages":"18-26"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dc/f6/kjco-19-1-18.PMC10352705.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9826704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic metastasis from papillary thyroid cancer: a case report and literature review. 甲状腺乳头状癌胰腺转移1例并文献复习。

Korean journal of clinical oncology Pub Date : 2023-06-01 DOI: 10.14216/kjco.23006

Sang Hwa Song, Young Hoe Hur, Chol Kyoon Cho, Yang Seok Koh, Eun Kyu Park, Hee Joon Kim, Sang Hoon Shin, Sung Yeol Yu, Chae Yung Oh

{"title":"Pancreatic metastasis from papillary thyroid cancer: a case report and literature review.","authors":"Sang Hwa Song, Young Hoe Hur, Chol Kyoon Cho, Yang Seok Koh, Eun Kyu Park, Hee Joon Kim, Sang Hoon Shin, Sung Yeol Yu, Chae Yung Oh","doi":"10.14216/kjco.23006","DOIUrl":"https://doi.org/10.14216/kjco.23006","url":null,"abstract":"Pancreatic metastasis from papillary thyroid cancer (PTC) is extremely rare; only 18 cases have been reported in the literature. However, several reviews have highlighted similar characteristics between metastatic and primary pancreatic tumors. The patient was a 51-year-old male with a history of total thyroidectomy, modified radical neck dissection, and radioactive iodine ablation for PTC in 2014. Nodules suspected of metastasis were found in both lungs on chest computed tomography (CT). However, after 6 months, a follow-up chest CT showed no increase in size; thus, a follow-up observation was planned. Six years after his initial diagnosis, abdominal CT and pancreas magnetic resonance imaging revealed a 4.7 cm cystic mass with a 2.5 cm enhancing mural nodule in the pancreas tail. We diagnosed the pancreatic lesion as either metastatic cancer or primary pancreas cancer. The patient underwent distal pancreato-splenectomy. After surgery, the pathological report revealed that the mass was metastatic PTC. Pancreatic metastasis from PTC indicates an advanced tumor stage and poor prognosis. However, pancreatectomy can increase the survival rate when the lesion is completely resectable. Therefore, surgical resection should be considered as a treatment for pancreatic metastasis from PTC.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 1","pages":"32-37"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/58/kjco-19-1-32.PMC10352708.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9826703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical influence of neoadjuvant chemoradiotherapy on immunonutritional status in locally advanced rectal cancer. 新辅助放化疗对局部晚期直肠癌患者免疫营养状况的影响。

Korean journal of clinical oncology Pub Date : 2023-06-01 DOI: 10.14216/kjco.23002

Soohyeon Lee, Dong Hyun Kang, Tae Sung Ahn, Dong Hee Jo, Eunhyeon Kim, Moo Jun Baek

{"title":"Clinical influence of neoadjuvant chemoradiotherapy on immunonutritional status in locally advanced rectal cancer.","authors":"Soohyeon Lee, Dong Hyun Kang, Tae Sung Ahn, Dong Hee Jo, Eunhyeon Kim, Moo Jun Baek","doi":"10.14216/kjco.23002","DOIUrl":"https://doi.org/10.14216/kjco.23002","url":null,"abstract":"Purpose: Cancer patients receiving various anti-cancer treatments commonly experience malnutrition, and many studies have reported that nutritional status is associated with survival and prognosis. Although standard neoadjuvant chemoradiotherapy (CRT) is commonly used in patients with locally advanced rectal cancer owing to its tumor-downsizing and downstaging effects, there is a lack of research on the impact of patients' nutritional status on the efficacy of neoadjuvant CRT.Methods: We investigated the immunonutritional markers before and after long-course neoadjuvant CRT in 131 patients diagnosed with locally advanced rectal cancer from March 2013 to March 2022.Results: We divided the patients into two groups: a low prognostic nutritional index (PNI) with a cutoff value of 50.92, and a high PNI. In both groups, significant decreases in lymphocyte count and PNI and an increase in neutrophil-to-lymphocyte ratio (NLR) were observed before and after CRT (P<0.001). Furthermore, a higher proportion of patients experienced adverse effects in the low PNI group than in the high PNI group (76.6% in low PNI vs. 54.8% in high PNI, P=0.013). The most commonly reported CRT-induced adverse effect was lower gastrointestinal tract toxicity.Conclusion: By measuring the PNI and NLR without additional tests prior to starting neoadjuvant CRT in patients with locally advanced rectal cancer, it is possible to predict the risk of acute adverse effects caused by CRT. Additionally, providing external nutritional support to reduce the immunonutritional changes that occur during CRT can decrease side effects and potentially increase treatment compliance.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 1","pages":"3-10"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/27/kjco-19-1-3.PMC10352710.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory and nutritional markers in patients with resectable pancreatic cancer. 可切除胰腺癌患者的炎症和营养指标。

Korean journal of clinical oncology Pub Date : 2023-06-01 DOI: 10.14216/kjco.23001

Hae Il Jung

引用次数: 0

Supra-ampullary duodenectomy in a patient with positive distal resection margin after subtotal gastrectomy for gastric cancer: a case report. 胃癌次全胃切除术后远端切缘阳性患者行壶腹上十二指肠切除术1例。

Korean journal of clinical oncology Pub Date : 2023-06-01 DOI: 10.14216/kjco.23007

Kyung-Goo Lee, Jin Ho Jeong, Jong Eun Joo, Hyun Beom Kim

{"title":"Supra-ampullary duodenectomy in a patient with positive distal resection margin after subtotal gastrectomy for gastric cancer: a case report.","authors":"Kyung-Goo Lee, Jin Ho Jeong, Jong Eun Joo, Hyun Beom Kim","doi":"10.14216/kjco.23007","DOIUrl":"https://doi.org/10.14216/kjco.23007","url":null,"abstract":"Resection margin involvement after curative intent resection for gastric cancer results in a poor prognosis and deprives the patient of the chance for a cure. Reoperation to achieve an R0 status should guarantee tolerable morbidity and achievement of negative margins. We performed laparoscopic distal gastrectomy with extracorporeal Billroth II reconstruction in a 56-year-old woman with gastric cancer following neoadjuvant chemotherapy. Scattered cancer cells were observed in the proximal and distal resection margins on immunohistochemical staining for cytokeratin. Two weeks postoperatively, remnant total gastrectomy and supra-ampullary duodenectomy were performed. Before reoperation, percutaneous transhepatic gallbladder drainage and angiocatheter placement outside the ampulla of Vater (AoV) via the cystic duct were performed to avoid pancreaticoduodenectomy and to obtain the maximal distal margin. Duodenal transection was performed 1 cm above the AoV. The resected duodenum was 4 cm in length. The patient had no postoperative complications and received adjuvant chemotherapy 1 month after the reoperation.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 1","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/0b/kjco-19-1-38.PMC10352706.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical impact of serum prealbumin in pancreaticobiliary disease. 血清前白蛋白对胰胆疾病的临床影响。

Korean journal of clinical oncology Pub Date : 2022-12-01 DOI: 10.14216/kjco.22008

Young Mok Park, Hyung Il Seo, Byeong Gwan Noh, Suk Kim, Seung Baek Hong, Nam Kyung Lee, Dong Uk Kim, Sung Yong Han

{"title":"Clinical impact of serum prealbumin in pancreaticobiliary disease.","authors":"Young Mok Park, Hyung Il Seo, Byeong Gwan Noh, Suk Kim, Seung Baek Hong, Nam Kyung Lee, Dong Uk Kim, Sung Yong Han","doi":"10.14216/kjco.22008","DOIUrl":"https://doi.org/10.14216/kjco.22008","url":null,"abstract":"Purpose: Although there are many studies on prealbumin in individual diseases such as malignant or inflammatory diseases, there are few comparative studies. This study aimed to compare the clinical differences between prealbumin levels in cholecystitis and pancreaticobiliary malignancies and investigate the clinical impact of low prealbumin levels in pancreaticobiliary malignancies.Methods: From June 2021 to September 2021, 61 patients who had undergone surgery for various pancreaticobiliary diseases were enrolled in this study, and their clinicopathological data were retrospectively analyzed.Results: Many elderly patients with malignant diseases had poor American Society of Anesthesiologists (ASA) scores, significantly lower albumin and prealbumin levels, and higher systemic immune inflammation indices. The low prealbumin group was older; had poorer ASA scores; and had significantly lower body mass index and hemoglobin and albumin levels and higher systemic immune inflammation indices than the normal prealbumin group. In malignant diseases, the low prealbumin group had significantly lower body mass index and hemoglobin levels and a tendency toward more advanced disease (lymph node and distant metastasis).Conclusion: Preoperative low prealbumin levels had an area under the receiver operator characteristic curve of 0.69, suggesting that it may be useful for predicting pancreaticobiliary malignancies. Prealbumin levels were lower in malignant diseases, possibly related to poor nutritional status and systemic immune inflammation. Low prealbumin levels may predict the risk of more advanced disease.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 2","pages":"61-65"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/ff/kjco-18-2-61.PMC9942763.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Metastatic breast cancer from a hepatocellular carcinoma: a case report. 肝细胞癌转移性乳腺癌：病例报告。

Korean journal of clinical oncology Pub Date : 2022-12-01 Epub Date: 2022-12-30 DOI: 10.14216/kjco.22013

Hyewon Bang, Nam-Hee Kim, Seung Hye Choi, Si Hyun Bae, Eun Sun Jung, Ki Ouk Min, Yong Hwa Eom

{"title":"Metastatic breast cancer from a hepatocellular carcinoma: a case report.","authors":"Hyewon Bang, Nam-Hee Kim, Seung Hye Choi, Si Hyun Bae, Eun Sun Jung, Ki Ouk Min, Yong Hwa Eom","doi":"10.14216/kjco.22013","DOIUrl":"10.14216/kjco.22013","url":null,"abstract":"Breast metastases from extramammary malignancies are rare. Here, we report a case of breast metastasis from hepatocellular carcinoma (HCC) after breast mass excision in a 63-year-old woman. A new breast nodule was noticed after transarterial chemoembolization, transarterial radioembolization, and stereotactic body radiation therapy for HCC. Breast ultrasound and core needle biopsy were performed to differentiate between the breast tumors. The biopsy result was invasive breast carcinoma, and wide excision of the breast was performed. The final pathological diagnosis was HCC breast metastasis based on histological findings and immunohistochemical staining results. After 9 months of follow-up, HCC and breast metastasis recurred. Despite palliative treatment, the patient died due to complications and general health deterioration. Although breast metastasis due to HCC is very rare, HCC breast metastasis should be considered when a new breast mass is discovered in a patient with a history of HCC for effective treatment and management.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 2","pages":"93-96"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/d1/kjco-18-2-93.PMC9942762.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FSP-1 expression in cancer cells is relevant to long-term oncological outcomes in nonmetastatic colorectal cancer. 肿瘤细胞中FSP-1的表达与非转移性结直肠癌的长期肿瘤预后有关。

Korean journal of clinical oncology Pub Date : 2022-12-01 DOI: 10.14216/kjco.22009

Sun Bin Im, Jae Min Cho, Han Byul Kim, Dong-Hoon Shin, Myeong Sook Kwon, In Young Lee, Gyung Mo Son

{"title":"FSP-1 expression in cancer cells is relevant to long-term oncological outcomes in nonmetastatic colorectal cancer.","authors":"Sun Bin Im, Jae Min Cho, Han Byul Kim, Dong-Hoon Shin, Myeong Sook Kwon, In Young Lee, Gyung Mo Son","doi":"10.14216/kjco.22009","DOIUrl":"https://doi.org/10.14216/kjco.22009","url":null,"abstract":"Purpose: Recent studies have revealed that the expression of cancer-associated fibroblast (CAF) activation biomarkers in cancer cells is associated with clinical outcomes in patients with certain types of malignant tumors. However, whether the expression of CAF activation biomarkers affects the prognosis of colorectal cancer (CRC) has not been fully elucidated. This study aimed to evaluate the association between the expression of CAF activation biomarkers in cancer cells with cancer invasion and long-term oncological outcomes in patients with CRC.Methods: Cancer specimens obtained from 135 patients with stage I-III CRC were examined using immunohistochemical staining to evaluate the expression of fibroblast specific protein-1 (FSP-1), fibroblast activation protein α (FAPα), α-smooth muscle actin (α-SMA), and vimentin in cancer cells.Results: FSP-1 expression in cancer cells was significantly associated with lymphatic invasion, perineural invasion, tumor (T) status, and lymph node (N) status. FAPα expression in cancer cells was significantly associated with lymphatic invasion. On univariate and multivariate analyses, FSP-1 and α-SMA expression in cancer cells were associated with a short 10-year overall survival (OS) and high 10-year systemic recurrence (SR), respectively. Tumor budding was associated with a short 10-year OS. However, FAPα and vimentin did not contribute to the prognosis in this study.Conclusion: In this study, we found that FSP-1 expression in cancer cells was related to cancer invasion. Additionally, FSP-1 and α-SMA expression in cancer cells was associated with 10-year OS and SR, respectively. Therefore, these markers may be used as predictors of long-term oncological outcomes in patients with CRC.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 2","pages":"66-77"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/66/kjco-18-2-66.PMC9942758.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appendiceal mucocele masquerading as an epithelial borderline ovarian tumor: a case report and literature review. 阑尾黏液囊肿伪装成上皮性交界性卵巢肿瘤:1例报告及文献复习。

Korean journal of clinical oncology Pub Date : 2022-12-01 DOI: 10.14216/kjco.22011

Young Joo Kim, Jong Hyuk Yun, Sung Hoon Hong, GeumJong Song, Jong Eun Lee, Myong Won Son, Sun Wook Han, Sung Yong Kim, Moon-Soo Lee

{"title":"Appendiceal mucocele masquerading as an epithelial borderline ovarian tumor: a case report and literature review.","authors":"Young Joo Kim, Jong Hyuk Yun, Sung Hoon Hong, GeumJong Song, Jong Eun Lee, Myong Won Son, Sun Wook Han, Sung Yong Kim, Moon-Soo Lee","doi":"10.14216/kjco.22011","DOIUrl":"https://doi.org/10.14216/kjco.22011","url":null,"abstract":"Appendiceal mucocele is a rare mucin-producing neoplasm of appendiceal origin. Due to its location and imaging findings, appendiceal mucocele is easily confused with tumors of the right adnexa. We present a rare case of a patient initially misdiagnosed with an ovarian tumor intraoperatively diagnosed as an appendiceal mucocele and successfully treated. A 66-year-old postmenopausal woman was admitted to the gynecology department for an asymptomatic pelvic mass. Preoperative pelvic imaging showed an 8-cm cystic mass. Exploratory laparoscopy for the suspected epithelial borderline tumor from the right ovary revealed a cystic mass in the right pelvic area and normal uterus, fallopian tubes, and ovaries. Intraoperative consultation with the general surgery department confirmed the appendiceal origin. Laparoscopic appendectomy was performed. Histopathological examination confirmed a low-grade mucinous neoplasm of appendiceal origin. The patient was discharged on a postoperative day 5 without complications. The outpatient follow-up performed 1 month later showed no evidence of disease progression. Despite the use of advanced diagnostic tools, appendiceal mucocele may be confused for ovarian malignancies. Because the clinical features of appendiceal mucocele are nonspecific, clinicians and radiologists know the specific imaging findings. A multidisciplinary approach including general surgery, gynecology, and radiology is required for preoperative diagnosis and treatment.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 2","pages":"83-88"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/0a/kjco-18-2-83.PMC9942759.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0