Korean journal of clinical oncology最新文献_第3页

Concordance of circulating tumor DNA and matched formalin-fixed paraffin-embedded tumor tissue in gastric cancer as a predictor of recurrence. 胃癌循环肿瘤 DNA 与匹配的福尔马林固定石蜡包埋肿瘤组织的一致性作为复发的预测指标

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23009

Soo Hyun Seo, Young Suk Park, Soo Kyung Nam, Hye Seung Lee, Do Joong Park, Kyoung Un Park

{"title":"Concordance of circulating tumor DNA and matched formalin-fixed paraffin-embedded tumor tissue in gastric cancer as a predictor of recurrence.","authors":"Soo Hyun Seo, Young Suk Park, Soo Kyung Nam, Hye Seung Lee, Do Joong Park, Kyoung Un Park","doi":"10.14216/kjco.23009","DOIUrl":"10.14216/kjco.23009","url":null,"abstract":"Purpose: Combined analysis of the variant composition of circulating tumor DNA (ctDNA) from cell-free plasma and DNA from tumor tissue could provide insight into the implications of the genetic alterations responsible for the intratumoral and intertumoral heterogeneity of gastric cancer. We aimed to evaluate the usefulness of this approach in these patients.Methods: Cell-free plasma and formalin-fixed paraffin-embedded tumor tissue samples from 46 patients with gastric cancer were examined. Targeted deep sequencing was performed using a commercially available kit.Results: The cell-free DNA (cfDNA) concentration was higher in stage II-IV versus stage I patients and in larger versus smaller tumors. Only 12 of the 36 (33.3%) alterations in the tumor tissue samples were in concordance with those in the ctDNA samples. Two variants were in concordance in stage I samples and 10 in stage II-IV samples. Actionable variants that were detected in concordance were in the stage II-IV samples. Preoperative ctDNA positivity of actionable variants was significantly associated with cfDNA concentration, lymphatic invasion, N stage, and TNM stage. Cancer recurrence was significantly associated with tumor size, lymphatic/vascular invasion, TNM stage, and ctDNA-tumor tissue variant concordance.Conclusion: Preoperative ctDNA genetic analysis using a multigene panel offers substantial clinical benefits when performed in conjunction with targeted deep sequencing of tumor tissue. Concordance between preoperative ctDNA and tumor tissue mutations may serve as a prognostic indicator in patients with gastric cancer.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 2","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-grade extrauterine endometrial stromal sarcoma arising from vaginal endometriosis: a case report and literature review. 阴道子宫内膜异位症引发的低级别宫外子宫内膜基质肉瘤：病例报告和文献综述。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23013

Seema Singhal, Aarthi S Jayraj, Ekta Dhamija, Sachin Khurana

{"title":"Low-grade extrauterine endometrial stromal sarcoma arising from vaginal endometriosis: a case report and literature review.","authors":"Seema Singhal, Aarthi S Jayraj, Ekta Dhamija, Sachin Khurana","doi":"10.14216/kjco.23013","DOIUrl":"10.14216/kjco.23013","url":null,"abstract":"Extrauterine endometrial stromal sarcoma arising from malignant transformation of the vagina is an extremely rare condition. The diagnosis is often difficult as the symptomatology and pathological features overlap with that of pelvic endometriosis. A 38 years old female presented with complaints of dyspareunia, dysmenorrhea, and painful defecation along with blood-stained vaginal discharge for a year. Examination revealed the presence of multiple brownish irregular nodules in posterior vaginal fornix and fixed tender nodules which on biopsy revealed florid vaginal endometriosis. She improved symptomatically on medical therapy. After 18 months of diagnosis, she presented again with a necrotic growth in posterior fornix, which on repeat biopsy revealed a low-grade endometrial stromal sarcoma. Laparotomy revealed a 7×5 cm mass in the pouch of Douglas, infiltrating the posterior vaginal wall and rectum. A complete cytoreductive surgery with retrograde hysterectomy, excision of posterior vaginal wall and rectosigmoid resection was done. The patient is disease-free at a follow-up of 65 months.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 2","pages":"73-79"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating ctDNA and tumor tissue analysis in gastric cancer: a synergistic approach unveils prognostic insights. 整合胃癌中的ctDNA和肿瘤组织分析：一种协同方法揭示了预后见解。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23008

Jong Hyuk Yun

引用次数: 0

The prognostic impact of body mass index in breast cancer according to tumor subtype. 肿瘤亚型对乳腺癌体重指数预后的影响。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23010

Jae-Myung Kim, Ju-Yeon Kim, Eun Jung Jung, Seung-Jin Kwag, Ji-Ho Park, Jin-Kyu Cho, Han-Gil Kim, Chi-Young Jeong, Young-Tae Ju, Young-Joon Lee

{"title":"The prognostic impact of body mass index in breast cancer according to tumor subtype.","authors":"Jae-Myung Kim, Ju-Yeon Kim, Eun Jung Jung, Seung-Jin Kwag, Ji-Ho Park, Jin-Kyu Cho, Han-Gil Kim, Chi-Young Jeong, Young-Tae Ju, Young-Joon Lee","doi":"10.14216/kjco.23010","DOIUrl":"10.14216/kjco.23010","url":null,"abstract":"Purpose: Several studies demonstrated that obesity and underweight were negatively associated with outcomes of breast cancer. However, the results are still controversial, and the impact of body mass index (BMI) on distant metastasis-free survival (MFS), which might directly affect mortality, was less well evaluated. Our study aimed to verify the prognostic effect of BMI in breast cancer.Methods: A retrospective analysis of 504 patients with stage I-III breast cancer who underwent surgery from January 2005 to December 2013 was performed. The patients were divided into three groups according to preoperative BMI: underweight <18.5 kg/m2, normal weight 18.5-24.9 kg/m2, and overweight ≥25 kg/m2. The association between body weight status and breast cancer recurrence was analyzed. Subgroup analysis by tumor subtype according to receptor status was also performed.Results: The median follow-up period was 88 months. For disease recurrence, histologic grade and human epidermal growth factor receptor 2 (HER2)-positivity were independent prognostic factors in multivariate analysis. Stage, histologic grade, HER2-positivity, and BMI status were independent prognostic factors for distant metastasis. In survival analysis, overweight and underweight were significant predisposing factors for MFS, but not for disease-free survival (DFS). In the estrogen receptor (ER)-positive group, overweight and underweight patients had significantly worse DFS and MFS than normal weight patients. In the ER-negative or HER2-positive group, BMI status had no significant association with DFS and MFS.Conclusion: The prognostic role of BMI on the survival outcomes of patients with breast cancer was different by tumor subtype. In ER-positive patients, overweight and underweight statuses had a negative prognostic effect on DFS and MFS, respectively.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 2","pages":"52-59"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual mesentery metastasis of differentiated thyroid cancer: a case report. 分化型甲状腺癌的异常肠系膜转移：病例报告。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23015

Sunyoung Chwa, Seung Hun Lee, Seung Hyun Lee

引用次数: 0

Extraosseous Ewing sarcoma of the pancreas: a case report. 胰腺骨外尤文肉瘤：病例报告。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23012

Neslihan Nisa Gecici, Vedat Burkay Camurdan, Mai Al Khatalin, Onur Yildirim

引用次数: 0

The relative isoform expression levels of isocitrate dehydrogenase in breast cancer: IDH2 is a potential target in MDA-MB-231 cells. 乳腺癌中异柠檬酸脱氢酶的相对同工酶表达水平：IDH2 是 MDA-MB-231 细胞的潜在靶点。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23011

Shuyu Piao, Seonhee Kim, Youngduk Seo, Jinsun Lee, Sunhee Jeon, Giang-Huong Vu, Min-Kyung Yeo, Cuk-Seong Kim

{"title":"The relative isoform expression levels of isocitrate dehydrogenase in breast cancer: IDH2 is a potential target in MDA-MB-231 cells.","authors":"Shuyu Piao, Seonhee Kim, Youngduk Seo, Jinsun Lee, Sunhee Jeon, Giang-Huong Vu, Min-Kyung Yeo, Cuk-Seong Kim","doi":"10.14216/kjco.23011","DOIUrl":"10.14216/kjco.23011","url":null,"abstract":"Purpose: The isocitrate dehydrogenase (IDH) family plays an essential role in metabolism and energy production. The relative expression levels of IDH isoforms (IDH1, IDH2, and IDH3) have prognostic significance in several malignancies, including breast carcinoma. However, the IDH isozyme expression levels in different cancer stages and types have not been determined in breast carcinoma tissues.Methods: We analyzed the messenger RNA (mRNA) and protein levels of IDH (IDH1, IDH2, and IDH3A) and α-ketoglutarate (α-KG) in 59 breast carcinoma tissues.Results: The mRNA level of IDH2 was significantly increased at stages 2 and 3 in triple-negative and (ER-/PR-/HER+) breast cancers. However, the elevated α-KG level was only observed in stages 2 and 3, with no differences in the various breast carcinoma types. Western blotting analysis showed that IDH2 protein expression increased in the patient tissues and cell lines. An in vitro study showed IDH2 downregulation in the triple-negative breast cancer cell line MDA-MB-231 that inhibited cell proliferation and migration and induced cell cycle arrest in the G0/G1 phase.Conclusion: These findings suggest that different from IDH1 and IDH3, IDH2 is more highly expressed in stages 2 and 3 breast cancer tissues, especially in triple-negative breast cancer. IDH2 potentially serves as a target to detect unknown mechanisms in breast cancer.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 2","pages":"60-68"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Nrf2 overexpression on cholangiocarcinoma treatment and clinical prognosis. Nrf2过表达对胆管癌治疗及临床预后的影响。

Korean journal of clinical oncology Pub Date : 2023-06-01 DOI: 10.14216/kjco.23004

Huisong Lee, Seog Ki Min, Min-Sun Cho, Hyeon Kook Lee

{"title":"Impact of Nrf2 overexpression on cholangiocarcinoma treatment and clinical prognosis.","authors":"Huisong Lee, Seog Ki Min, Min-Sun Cho, Hyeon Kook Lee","doi":"10.14216/kjco.23004","DOIUrl":"https://doi.org/10.14216/kjco.23004","url":null,"abstract":"Purpose: Nrf2 regulates antioxidant protein expression and protects against drug toxicity and oxidative stress, whereas Keap1 controls Nrf2 activity. The Keap1-Nrf2 pathway affects the prognosis of various cancers, however, its effect on cholangiocarcinoma chemoresistance and prognosis remains unclear. This study aimed to determine whether the Keap1-Nrf2 pathway affects chemoresistance and prognosis of distal cholangiocarcinoma.Methods: We investigated the correlation between Nrf2 and Keap1 expression and clinical characteristics and prognosis in 91 patients with distal cholangiocarcinoma who underwent curative surgery. Immunohistochemical staining was performed on paraffin blocks using primary antibodies against Nrf2 and Keap1. The relationship between Keap1 and Nrf2 protein expression levels, and clinical characteristics and prognosis was examined.Results: Nrf2 expression was not associated with overall survival in patients who did not receive adjuvant chemotherapy (P=0.994). Among patients receiving adjuvant chemotherapy, the Nrf2 low expression group had a significantly longer median overall survival than the Nrf2 high expression group in Kaplan-Meier survival analysis (P=0.019). In multivariate analysis, high expression of Nrf2 was confirmed as an independent poor prognostic factor in the group receiving adjuvant chemotherapy (P=0.041).Conclusion: This study suggests that Nrf2 overexpression reduces the efficacy of adjuvant chemotherapy in distal cholangiocarcinoma.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 1","pages":"18-26"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dc/f6/kjco-19-1-18.PMC10352705.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9826704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is bone mineral density a prognostic factor in postmenopausal women with luminal A breast cancer? 骨矿物质密度是绝经后a腔乳腺癌患者的预后因素吗?

Korean journal of clinical oncology Pub Date : 2023-06-01 DOI: 10.14216/kjco.23005

Seungju Lee, Hyun Yul Kim, Youn Joo Jung, Seok-Kyung Kang, Jee Yeon Kim, Mi Sook Yun

{"title":"Is bone mineral density a prognostic factor in postmenopausal women with luminal A breast cancer?","authors":"Seungju Lee, Hyun Yul Kim, Youn Joo Jung, Seok-Kyung Kang, Jee Yeon Kim, Mi Sook Yun","doi":"10.14216/kjco.23005","DOIUrl":"https://doi.org/10.14216/kjco.23005","url":null,"abstract":"Purpose: Several studies are concerned about the association between bone mineral density (BMD) and the risk of breast cancer in postmenopausal women, but it is controversial. Therefore, we evaluated whether BMD might be a risk factor for recurrences, or metastases in menopausal luminal A breast cancer patients.Methods: In this retrospective study, data of 348 patients with luminal A breast cancer who received treatment at Pusan National University Yangsan Hospital between 2012 and 2016 were analyzed. Patients were divided into two groups: normal BMD and low BMD including osteopenia or osteoporosis in preoperative examination. Patients were also divided into three groups according to BMD changes: no change in BMD; improvement in BMD, and deterioration in BMD. Events were defined as recurrence, occurrence of contralateral breast cancer, and metastasis to any other organ.Results: Preoperative examination revealed normal BMD in 129 of 348 patients and low BMD in 219 patients. During a median follow-up period of 78 months, only 14 patients (4.0%) experienced recurrences, distant metastases, or occurrences of contralateral breast cancer. Five-year disease-free survival rate was 98.2% for 219 patients with low BMD and 95.0% for 129 patients with normal BMD (P=0.33). Disease-free survival at 5 years was 97.0% for the no change in the BMD group, 94.6% for the BMD improvement group, and 98.4% for the BMD deterioration group (P=0.79).Conclusion: In this study, BMD had no statistically significant associations on recurrences, metastases, or incidences of contralateral breast cancer in postmenopausal patients with luminal A breast cancer.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 1","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/a4/kjco-19-1-27.PMC10352709.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic metastasis from papillary thyroid cancer: a case report and literature review. 甲状腺乳头状癌胰腺转移1例并文献复习。

Korean journal of clinical oncology Pub Date : 2023-06-01 DOI: 10.14216/kjco.23006

Sang Hwa Song, Young Hoe Hur, Chol Kyoon Cho, Yang Seok Koh, Eun Kyu Park, Hee Joon Kim, Sang Hoon Shin, Sung Yeol Yu, Chae Yung Oh

{"title":"Pancreatic metastasis from papillary thyroid cancer: a case report and literature review.","authors":"Sang Hwa Song, Young Hoe Hur, Chol Kyoon Cho, Yang Seok Koh, Eun Kyu Park, Hee Joon Kim, Sang Hoon Shin, Sung Yeol Yu, Chae Yung Oh","doi":"10.14216/kjco.23006","DOIUrl":"https://doi.org/10.14216/kjco.23006","url":null,"abstract":"Pancreatic metastasis from papillary thyroid cancer (PTC) is extremely rare; only 18 cases have been reported in the literature. However, several reviews have highlighted similar characteristics between metastatic and primary pancreatic tumors. The patient was a 51-year-old male with a history of total thyroidectomy, modified radical neck dissection, and radioactive iodine ablation for PTC in 2014. Nodules suspected of metastasis were found in both lungs on chest computed tomography (CT). However, after 6 months, a follow-up chest CT showed no increase in size; thus, a follow-up observation was planned. Six years after his initial diagnosis, abdominal CT and pancreas magnetic resonance imaging revealed a 4.7 cm cystic mass with a 2.5 cm enhancing mural nodule in the pancreas tail. We diagnosed the pancreatic lesion as either metastatic cancer or primary pancreas cancer. The patient underwent distal pancreato-splenectomy. After surgery, the pathological report revealed that the mass was metastatic PTC. Pancreatic metastasis from PTC indicates an advanced tumor stage and poor prognosis. However, pancreatectomy can increase the survival rate when the lesion is completely resectable. Therefore, surgical resection should be considered as a treatment for pancreatic metastasis from PTC.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 1","pages":"32-37"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/58/kjco-19-1-32.PMC10352708.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9826703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0