Korean journal of clinical oncology最新文献

{"title":"Clinical influence of neoadjuvant chemoradiotherapy on immunonutritional status in locally advanced rectal cancer.","authors":"Soohyeon Lee,&nbsp;Dong Hyun Kang,&nbsp;Tae Sung Ahn,&nbsp;Dong Hee Jo,&nbsp;Eunhyeon Kim,&nbsp;Moo Jun Baek","doi":"10.14216/kjco.23002","DOIUrl":"https://doi.org/10.14216/kjco.23002","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer patients receiving various anti-cancer treatments commonly experience malnutrition, and many studies have reported that nutritional status is associated with survival and prognosis. Although standard neoadjuvant chemoradiotherapy (CRT) is commonly used in patients with locally advanced rectal cancer owing to its tumor-downsizing and downstaging effects, there is a lack of research on the impact of patients' nutritional status on the efficacy of neoadjuvant CRT.</p><p><strong>Methods: </strong>We investigated the immunonutritional markers before and after long-course neoadjuvant CRT in 131 patients diagnosed with locally advanced rectal cancer from March 2013 to March 2022.</p><p><strong>Results: </strong>We divided the patients into two groups: a low prognostic nutritional index (PNI) with a cutoff value of 50.92, and a high PNI. In both groups, significant decreases in lymphocyte count and PNI and an increase in neutrophil-to-lymphocyte ratio (NLR) were observed before and after CRT (P<0.001). Furthermore, a higher proportion of patients experienced adverse effects in the low PNI group than in the high PNI group (76.6% in low PNI vs. 54.8% in high PNI, P=0.013). The most commonly reported CRT-induced adverse effect was lower gastrointestinal tract toxicity.</p><p><strong>Conclusion: </strong>By measuring the PNI and NLR without additional tests prior to starting neoadjuvant CRT in patients with locally advanced rectal cancer, it is possible to predict the risk of acute adverse effects caused by CRT. Additionally, providing external nutritional support to reduce the immunonutritional changes that occur during CRT can decrease side effects and potentially increase treatment compliance.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 1","pages":"3-10"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/27/kjco-19-1-3.PMC10352710.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of C-reactive protein-to-prealbumin ratio in predicting early recurrence in resectable pancreatic cancer.","authors":"Chae Hwa Kwon,&nbsp;Hyung Il Seo,&nbsp;Dong Uk Kim,&nbsp;Sung Yong Han,&nbsp;Suk Kim,&nbsp;Nam Kyung Lee,&nbsp;Seung Baek Hong,&nbsp;Ji Hyun Ahn,&nbsp;Young Mok Park,&nbsp;Byung Gwan Noh","doi":"10.14216/kjco.23003","DOIUrl":"https://doi.org/10.14216/kjco.23003","url":null,"abstract":"<p><strong>Purpose: </strong>Resectable pancreatic ductal adenocarcinoma (PDAC) has a high risk of recurrence after curative resection; despite this, the preoperative risk factors for predicting early recurrence remain unclear. This study therefore aimed to identify preoperative inflammation and nutrition factors associated with early recurrence of resectable PDAC.</p><p><strong>Methods: </strong>From March 2021 to November 2021, a total of 20 patients who underwent curative resection for PDAC were enrolled in this study. We evaluated the risk factors for early recurrence within 1 year by univariate and multivariate analyses using Cox hazard proportional regression. The cutoff values for predicting recurrence were examined using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>In our univariate and multivariate analyses, C-reactive protein (CRP), CRP-albumin ratio, and CRP-prealbumin ratio, as well as sex and age, were significant independent prognostic factors for early recurrence in PDAC. However, known inflammatory factors (neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios), nutritional factors (albumin, prealbumin, ferritin, vitamin D), and inflammatory-nutritional factors (Glasgow Prognostic Score, modified Glasgow Prognostic Score, albumin-bilirubin) showed no association with early recurrence. In addition, using cutoff values by ROC curve analysis, a high preoperative CRP level of >5 mg/L, as well as high CRP-to-albumin (>5.3) and CRP-to-prealbumin (>1.3) ratios showed no prognostic value.</p><p><strong>Conclusion: </strong>Our results showed that inflammatory and perioperative nutritional factors, especially CRP-to-prealbumin ratio, have significant associations with early recurrence after curative resection in resectable PDAC. Therefore, for such patients, a cautious approach is needed when inflammation and poor nutritional status are present.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 1","pages":"11-17"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/7c/kjco-19-1-11.PMC10352711.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory and nutritional markers in patients with resectable pancreatic cancer.","authors":"Hae Il Jung","doi":"10.14216/kjco.23001","DOIUrl":"https://doi.org/10.14216/kjco.23001","url":null,"abstract":"Article : Clinical significance of C-reactive protein-to-prealbumin ratio in predicting early recurrence in resectable pancreatic","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9c/27/kjco-19-1-1.PMC10352707.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supra-ampullary duodenectomy in a patient with positive distal resection margin after subtotal gastrectomy for gastric cancer: a case report.","authors":"Kyung-Goo Lee,&nbsp;Jin Ho Jeong,&nbsp;Jong Eun Joo,&nbsp;Hyun Beom Kim","doi":"10.14216/kjco.23007","DOIUrl":"https://doi.org/10.14216/kjco.23007","url":null,"abstract":"<p><p>Resection margin involvement after curative intent resection for gastric cancer results in a poor prognosis and deprives the patient of the chance for a cure. Reoperation to achieve an R0 status should guarantee tolerable morbidity and achievement of negative margins. We performed laparoscopic distal gastrectomy with extracorporeal Billroth II reconstruction in a 56-year-old woman with gastric cancer following neoadjuvant chemotherapy. Scattered cancer cells were observed in the proximal and distal resection margins on immunohistochemical staining for cytokeratin. Two weeks postoperatively, remnant total gastrectomy and supra-ampullary duodenectomy were performed. Before reoperation, percutaneous transhepatic gallbladder drainage and angiocatheter placement outside the ampulla of Vater (AoV) via the cystic duct were performed to avoid pancreaticoduodenectomy and to obtain the maximal distal margin. Duodenal transection was performed 1 cm above the AoV. The resected duodenum was 4 cm in length. The patient had no postoperative complications and received adjuvant chemotherapy 1 month after the reoperation.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 1","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/0b/kjco-19-1-38.PMC10352706.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of serum prealbumin in pancreaticobiliary disease.","authors":"Young Mok Park,&nbsp;Hyung Il Seo,&nbsp;Byeong Gwan Noh,&nbsp;Suk Kim,&nbsp;Seung Baek Hong,&nbsp;Nam Kyung Lee,&nbsp;Dong Uk Kim,&nbsp;Sung Yong Han","doi":"10.14216/kjco.22008","DOIUrl":"https://doi.org/10.14216/kjco.22008","url":null,"abstract":"<p><strong>Purpose: </strong>Although there are many studies on prealbumin in individual diseases such as malignant or inflammatory diseases, there are few comparative studies. This study aimed to compare the clinical differences between prealbumin levels in cholecystitis and pancreaticobiliary malignancies and investigate the clinical impact of low prealbumin levels in pancreaticobiliary malignancies.</p><p><strong>Methods: </strong>From June 2021 to September 2021, 61 patients who had undergone surgery for various pancreaticobiliary diseases were enrolled in this study, and their clinicopathological data were retrospectively analyzed.</p><p><strong>Results: </strong>Many elderly patients with malignant diseases had poor American Society of Anesthesiologists (ASA) scores, significantly lower albumin and prealbumin levels, and higher systemic immune inflammation indices. The low prealbumin group was older; had poorer ASA scores; and had significantly lower body mass index and hemoglobin and albumin levels and higher systemic immune inflammation indices than the normal prealbumin group. In malignant diseases, the low prealbumin group had significantly lower body mass index and hemoglobin levels and a tendency toward more advanced disease (lymph node and distant metastasis).</p><p><strong>Conclusion: </strong>Preoperative low prealbumin levels had an area under the receiver operator characteristic curve of 0.69, suggesting that it may be useful for predicting pancreaticobiliary malignancies. Prealbumin levels were lower in malignant diseases, possibly related to poor nutritional status and systemic immune inflammation. Low prealbumin levels may predict the risk of more advanced disease.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 2","pages":"61-65"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/ff/kjco-18-2-61.PMC9942763.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic breast cancer from a hepatocellular carcinoma: a case report.","authors":"Hyewon Bang, Nam-Hee Kim, Seung Hye Choi, Si Hyun Bae, Eun Sun Jung, Ki Ouk Min, Yong Hwa Eom","doi":"10.14216/kjco.22013","DOIUrl":"10.14216/kjco.22013","url":null,"abstract":"<p><p>Breast metastases from extramammary malignancies are rare. Here, we report a case of breast metastasis from hepatocellular carcinoma (HCC) after breast mass excision in a 63-year-old woman. A new breast nodule was noticed after transarterial chemoembolization, transarterial radioembolization, and stereotactic body radiation therapy for HCC. Breast ultrasound and core needle biopsy were performed to differentiate between the breast tumors. The biopsy result was invasive breast carcinoma, and wide excision of the breast was performed. The final pathological diagnosis was HCC breast metastasis based on histological findings and immunohistochemical staining results. After 9 months of follow-up, HCC and breast metastasis recurred. Despite palliative treatment, the patient died due to complications and general health deterioration. Although breast metastasis due to HCC is very rare, HCC breast metastasis should be considered when a new breast mass is discovered in a patient with a history of HCC for effective treatment and management.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 2","pages":"93-96"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/d1/kjco-18-2-93.PMC9942762.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FSP-1 expression in cancer cells is relevant to long-term oncological outcomes in nonmetastatic colorectal cancer.","authors":"Sun Bin Im,&nbsp;Jae Min Cho,&nbsp;Han Byul Kim,&nbsp;Dong-Hoon Shin,&nbsp;Myeong Sook Kwon,&nbsp;In Young Lee,&nbsp;Gyung Mo Son","doi":"10.14216/kjco.22009","DOIUrl":"https://doi.org/10.14216/kjco.22009","url":null,"abstract":"<p><strong>Purpose: </strong>Recent studies have revealed that the expression of cancer-associated fibroblast (CAF) activation biomarkers in cancer cells is associated with clinical outcomes in patients with certain types of malignant tumors. However, whether the expression of CAF activation biomarkers affects the prognosis of colorectal cancer (CRC) has not been fully elucidated. This study aimed to evaluate the association between the expression of CAF activation biomarkers in cancer cells with cancer invasion and long-term oncological outcomes in patients with CRC.</p><p><strong>Methods: </strong>Cancer specimens obtained from 135 patients with stage I-III CRC were examined using immunohistochemical staining to evaluate the expression of fibroblast specific protein-1 (FSP-1), fibroblast activation protein α (FAPα), α-smooth muscle actin (α-SMA), and vimentin in cancer cells.</p><p><strong>Results: </strong>FSP-1 expression in cancer cells was significantly associated with lymphatic invasion, perineural invasion, tumor (T) status, and lymph node (N) status. FAPα expression in cancer cells was significantly associated with lymphatic invasion. On univariate and multivariate analyses, FSP-1 and α-SMA expression in cancer cells were associated with a short 10-year overall survival (OS) and high 10-year systemic recurrence (SR), respectively. Tumor budding was associated with a short 10-year OS. However, FAPα and vimentin did not contribute to the prognosis in this study.</p><p><strong>Conclusion: </strong>In this study, we found that FSP-1 expression in cancer cells was related to cancer invasion. Additionally, FSP-1 and α-SMA expression in cancer cells was associated with 10-year OS and SR, respectively. Therefore, these markers may be used as predictors of long-term oncological outcomes in patients with CRC.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 2","pages":"66-77"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/66/kjco-18-2-66.PMC9942758.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appendiceal mucocele masquerading as an epithelial borderline ovarian tumor: a case report and literature review.","authors":"Young Joo Kim,&nbsp;Jong Hyuk Yun,&nbsp;Sung Hoon Hong,&nbsp;GeumJong Song,&nbsp;Jong Eun Lee,&nbsp;Myong Won Son,&nbsp;Sun Wook Han,&nbsp;Sung Yong Kim,&nbsp;Moon-Soo Lee","doi":"10.14216/kjco.22011","DOIUrl":"https://doi.org/10.14216/kjco.22011","url":null,"abstract":"<p><p>Appendiceal mucocele is a rare mucin-producing neoplasm of appendiceal origin. Due to its location and imaging findings, appendiceal mucocele is easily confused with tumors of the right adnexa. We present a rare case of a patient initially misdiagnosed with an ovarian tumor intraoperatively diagnosed as an appendiceal mucocele and successfully treated. A 66-year-old postmenopausal woman was admitted to the gynecology department for an asymptomatic pelvic mass. Preoperative pelvic imaging showed an 8-cm cystic mass. Exploratory laparoscopy for the suspected epithelial borderline tumor from the right ovary revealed a cystic mass in the right pelvic area and normal uterus, fallopian tubes, and ovaries. Intraoperative consultation with the general surgery department confirmed the appendiceal origin. Laparoscopic appendectomy was performed. Histopathological examination confirmed a low-grade mucinous neoplasm of appendiceal origin. The patient was discharged on a postoperative day 5 without complications. The outpatient follow-up performed 1 month later showed no evidence of disease progression. Despite the use of advanced diagnostic tools, appendiceal mucocele may be confused for ovarian malignancies. Because the clinical features of appendiceal mucocele are nonspecific, clinicians and radiologists know the specific imaging findings. A multidisciplinary approach including general surgery, gynecology, and radiology is required for preoperative diagnosis and treatment.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 2","pages":"83-88"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/0a/kjco-18-2-83.PMC9942759.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic cervical thymic squamous cell carcinoma misdiagnosed as thyroid cancer: a case report.","authors":"Ju-Yeon Kim,&nbsp;Eun Jung Jung,&nbsp;Jae-Myung Kim,&nbsp;Han Shin Lee,&nbsp;Taejin Park,&nbsp;Sang-Ho Jeong,&nbsp;Chi-Young Jeong,&nbsp;Young-Tae Ju","doi":"10.14216/kjco.22012","DOIUrl":"https://doi.org/10.14216/kjco.22012","url":null,"abstract":"<p><p>Ectopic thymic neoplasm, particularly ectopic thymic carcinoma, is a rare disease that presents as a neck mass. Here, we present a case of ectopic thymic squamous carcinoma in a 65-year-old man who presented with persistent hoarseness. After fine needle aspiration cytology, the patient underwent total thyroidectomy with lymph node dissection. The final histopathological examination revealed the ectopic thymic squamous carcinoma. The patient was discharged without any postoperative complications. The patient received adjuvant radiation therapy and did not progress during the 1-year follow-up period.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 2","pages":"89-92"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/ab/kjco-18-2-89.PMC9942761.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative management of intractable chylous ascites following robot-assisted pancreaticoduodenectomy of Viscum album sclerotherapy: a case report.","authors":"Beom Soo Kim,&nbsp;Youngbin Seo,&nbsp;Chang Moo Kang","doi":"10.14216/kjco.22010","DOIUrl":"https://doi.org/10.14216/kjco.22010","url":null,"abstract":"<p><p>A patient showed signs of fever and Hemovac insertion site discharge 8 days after surgery and was admitted. Abdominal paracentesis found milky ascites with triglyceride levels of the peritoneal fluid as high as 1,603 g/mL. Diagnosed as chylous ascites, symptomatic therapy such as empirical antibodies and diuretics was administered with paracentesis before being discharged. The ascites volume increased again, and the patient was re-admitted. The patient was treated with orlistat, octreotide, total parenteral nutrition administration, ascites drainage, and diuretics. Ascites levels increased further and intraperitoneal Viscum was administered. Clear ascites was observed, and the patient was discharged. We reported a case where conventional treatment for chylous ascites that occurred after pancreaticoduodenectomy was shown to be ineffective while Viscum extracted from mistletoe was able to manage chylous ascites.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 2","pages":"78-82"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/42/9c/kjco-18-2-78.PMC9942760.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}