Korean journal of clinical oncology最新文献

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Jejunogastric intussusception after totally laparoscopic distal gastrectomy for gastric cancer: a rare case report and review of the literature. 胃癌全腹腔镜远端胃切除术后空肠胃套叠一例罕见病例报告及文献复习。
Korean journal of clinical oncology Pub Date : 2022-06-01 DOI: 10.14216/kjco.22007
Geum Jong Song, Jong Hyuk Yun, Hae Il Jung, Myoung Won Son, Moon-Soo Lee
{"title":"Jejunogastric intussusception after totally laparoscopic distal gastrectomy for gastric cancer: a rare case report and review of the literature.","authors":"Geum Jong Song,&nbsp;Jong Hyuk Yun,&nbsp;Hae Il Jung,&nbsp;Myoung Won Son,&nbsp;Moon-Soo Lee","doi":"10.14216/kjco.22007","DOIUrl":"https://doi.org/10.14216/kjco.22007","url":null,"abstract":"<p><p>Jejunogastric intussusception (JGI) is a rare complication of gastric surgery, with most cases occurring in the form of long-term complications following gastric surgeries. We present a case of JGI in a 74-year-old man who presented with progressive abdominal pain and distention, and was admitted to our hospital. The patient had undergone a totally laparoscopic distal gastrectomy with a Billroth II gastrojejunostomy 9 days previously. Computed tomography and endoscopic findings revealed the presence of a small bowel loop within the gastric lumen, which we failed to reduce in size. We performed an emergency laparoscopic exploration and immediate reduction of the JGI. The efferent and afferent loops were then fixed to the mesentery and the stomach. The postoperative course was uneventful and the patient remained asymptomatic during the 1-year follow-up period.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 1","pages":"56-59"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/cb/kjco-18-1-56.PMC9942770.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9154427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical significance of additional gastrectomy after non-curative endoscopic submucosal dissection for early gastric cancer: a retrospective single-center study. 早期胃癌非治愈性内镜粘膜下剥离术后加行胃切除术的临床意义:一项回顾性单中心研究。
Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21011
Uicheon Jeong, Ho Yoon Bang, Pyeong Su Kim
{"title":"Clinical significance of additional gastrectomy after non-curative endoscopic submucosal dissection for early gastric cancer: a retrospective single-center study.","authors":"Uicheon Jeong,&nbsp;Ho Yoon Bang,&nbsp;Pyeong Su Kim","doi":"10.14216/kjco.21011","DOIUrl":"https://doi.org/10.14216/kjco.21011","url":null,"abstract":"<p><strong>Purpose: </strong>Additional surgery is recommended for patients after a non-curative endoscopic submucosal dissection (ESD) to prevent residual cancer (RC) or lymph node metastasis (LNM). We aimed to evaluate the clinicopathologic characteristics of patients who underwent an additional gastrectomy after a non-curative ESD procedure and identify the risk factors of RC and LNM.</p><p><strong>Methods: </strong>We retrospectively assessed the clinicopathological factors of 73 patients who underwent additional gastrectomy following a non-curative ESD between January 2009 and December 2019 at our center.</p><p><strong>Results: </strong>RC and LNM rates after additional gastrectomy were 9.6% and 8.2%, respectively. Invasion deeper than 500 μm (P=0.045), positive horizontal resection margin (P<0.001), and positive ESD margin (P=0.001) were identified as statistically significant factors in univariate analysis for RC, but not in multivariate analysis. Lymphatic invasion was the only risk factor found to be significant in both univariate and multivariate analyses (P=0.005 and P=0.012).</p><p><strong>Conclusion: </strong>Additional gastrectomy is necessary to prevent RC or LNM after non-curative ESD. Lymphatic invasion was also associated with LNM in patients who underwent an additional gastrectomy after a non-curative ESD, and in such cases, active treatment is required.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"68-72"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a7/6e/kjco-17-2-68.PMC9942757.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9529539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety of immediate use of totally implantable venous access ports in adult patients with cancer: a retrospective single-center study. 成年癌症患者立即使用完全植入式静脉通道的安全性:一项回顾性单中心研究。
Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21016
Jisu Lee, Sung Mo Hur, Zisun Kim, Cheol Wan Lim
{"title":"Safety of immediate use of totally implantable venous access ports in adult patients with cancer: a retrospective single-center study.","authors":"Jisu Lee,&nbsp;Sung Mo Hur,&nbsp;Zisun Kim,&nbsp;Cheol Wan Lim","doi":"10.14216/kjco.21016","DOIUrl":"https://doi.org/10.14216/kjco.21016","url":null,"abstract":"<p><strong>Purpose: </strong>Totally implantable venous access ports (TIVAPs) can be used long-term for safe administration of intravenous drugs. TIVAP complications include catheter-related infections, venous thrombosis, extravasation, TIVAP migration, and pain. The relationship between the timing of the first chemotherapy administration after port implantation and complications is controversial. This study aimed to investigate the safety of immediate use of TIVAPs and the associated risk factors for complications.</p><p><strong>Methods: </strong>Between January 2016 and December 2018, 305 patients (median age, 53 years; 256 women) who underwent TIVAP placement at our institution were included. Chemotherapy was administered within 2 days of implantation. A retrospective analysis of patients' clinical data was performed to investigate catheter days and complications of TIVAPs.</p><p><strong>Results: </strong>Overall, 305 patients were evaluated over 57,324 catheter days (median, 168 catheter days; interquartile range, 105). The median interval between placement and first use of TIVAPs was 0.98 days. The overall morbidity rate was 2.95%. Nine complications occurred in nine patients, including TIVAP-related infection (4), pain (2), port occlusion (1), thrombosis (1), and scar disunion (1), of which five required port removal (1.64%). The median number of catheter days before complications occurred was 61 (range, 10-457 days; interquartile range, 51). No complications occurred within 7 days of implantation. Body mass index was an independent risk factor for TIVAP-related complications in the Cox proportional hazards model (multivariable analysis: hazard ratio, 1.221; 95% confidence interval, 1.054-1.414; P=0.008).</p><p><strong>Conclusion: </strong>This study suggests the safe long-term use of TIVAPs following their immediate chemotherapy administration within 2 days of implantation.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"104-110"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/ec/kjco-17-2-104.PMC9942755.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9529545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer. 腹会阴切除与保留括约肌切除治疗低位直肠癌的肿瘤预后比较。
Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21012
Won Il Jo, Dae Ro Lim, Jung Cheol Kuk, Eung Jin Shin
{"title":"Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer.","authors":"Won Il Jo,&nbsp;Dae Ro Lim,&nbsp;Jung Cheol Kuk,&nbsp;Eung Jin Shin","doi":"10.14216/kjco.21012","DOIUrl":"https://doi.org/10.14216/kjco.21012","url":null,"abstract":"<p><strong>Purpose: </strong>The present study compares the peri/postoperative and oncological outcomes of abdominoperineal resections (APR) and sphincter saving resection (SSR) for low lying rectal cancer.</p><p><strong>Methods: </strong>Between January 2001 and December 2014, 176 patients who underwent SSR (n=67) and APR (n=109) for low rectal cancer, without stage IV, were retrieved from a retrospective database.</p><p><strong>Results: </strong>With a median follow-up of 66.5 months. The mean total number of harvested lymph nodes was 16.7 (SSR) versus 17.1 (APR) (P=0.801). The advanced T stage was higher in the APR group (82.6%) versus the SSR group (55.2%) (P=0.006). The positive rate of lymph nodes after surgery was significantly higher in the APR group (45.9%) versus SSR group (25.4%) (P<0.05). The 5-year overall survival rates for SSR and APR were 87.3% and 67.6%, respectively (P<0.005). The 5-year disease-free survival rate (DFS) was 83.6% (SSR) versus 65.5% (APR) (P=0.002). The recurrence rate was higher in the APR group (34.9%) versus the SSR group (14.9%) (P=0.004). Local recurrence rate was not different between the two groups. However, distant recurrence rate was significantly higher in the APR group (26.6% vs. 11.9%, P=0.023). In multivariate analysis, node positive (N0 vs. N1-2) was an independent prognostic factor for DFS (P<0.005).</p><p><strong>Conclusion: </strong>Based on the present data, SSR achieved better 5-year oncological outcome than APR. The positive lymph node ratio in the N stage after surgery was higher in the APR group and this seems to have an effect on the oncological outcomes of the APR group.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"73-81"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1d/29/kjco-17-2-73.PMC9942753.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9529544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experience of serious intestinal hemorrhage and perforation in small bowel lymphoma: a case report. 小肠淋巴瘤并发严重肠出血穿孔1例。
Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21020
Seo Ree Kim, Sang Hoon Chun, Jong Youl Jin, Tae-Geun Gweon, Hayemin Lee, Min-Sun Jin, Guk Jin Lee
{"title":"Experience of serious intestinal hemorrhage and perforation in small bowel lymphoma: a case report.","authors":"Seo Ree Kim,&nbsp;Sang Hoon Chun,&nbsp;Jong Youl Jin,&nbsp;Tae-Geun Gweon,&nbsp;Hayemin Lee,&nbsp;Min-Sun Jin,&nbsp;Guk Jin Lee","doi":"10.14216/kjco.21020","DOIUrl":"https://doi.org/10.14216/kjco.21020","url":null,"abstract":"<p><p>There have been several reports of complications of small bowel lymphoma, such as bleeding, obstruction, and perforation, often require emergency surgery. It is hardly showed complications of bleeding and wound dehiscence for diffuse large B cell lymphoma with distal ileum involvement, which needed urgent surgery and medical management. A 65-year-old man with diffuse large B-cell lymphoma with distal ileum involvement experienced both intestinal bleeding and perforation during the course of treatment. As the patient was diagnosed with stage III disease, resection before chemotherapy was not considered due to the resulting delay in chemotherapy, which necessitated sufficient tissue healing. Chemotherapy is important when treating small bowel lymphoma, complications such as bleeding and perforation should always be considered for the treatment of small bowel lymphoma, and surgery is necessary in this situation. After surgery of the small bowel, subsequent chemotherapy could cause wound dehiscence and perforation; therefore, adequate recovery time should be given before chemotherapy.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"126-130"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/ad/kjco-17-2-126.PMC9942752.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the quality of total mesorectal excision after robotic and laparoscopic surgery for rectal cancer: a multicenter, propensity score-matched study. 直肠癌机器人手术和腹腔镜手术后全肠系膜切除质量的比较:一项多中心、倾向评分匹配的研究。
Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21013
Keehyun Park, Sohyun Kim, Hye Won Lee, Sung Uk Bae, Seong Kyu Baek, Woon Kyung Jeong
{"title":"Comparison of the quality of total mesorectal excision after robotic and laparoscopic surgery for rectal cancer: a multicenter, propensity score-matched study.","authors":"Keehyun Park,&nbsp;Sohyun Kim,&nbsp;Hye Won Lee,&nbsp;Sung Uk Bae,&nbsp;Seong Kyu Baek,&nbsp;Woon Kyung Jeong","doi":"10.14216/kjco.21013","DOIUrl":"https://doi.org/10.14216/kjco.21013","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate and compare the quality of total mesorectal excision (TME) and disease-free and overall survival rates between robotic and laparoscopic surgeries for rectal cancer.</p><p><strong>Methods: </strong>From January 2015 to December 2018, 234 patients underwent curative robotic or laparoscopic surgery for rectal cancer at two centers. Ultimately, 201 patients were enrolled. To control for different demographic factors in the two groups, propensity score matching was used at a 1:1 ratio. Propensity scores were generated with the baseline characteristics, including age, sex, body mass index, American Society of Anesthesiologists score, previous abdominal surgery, tumor location, preoperative chemotherapy, and preoperative radiation. Finally, 134 patients were matched with 67 patients in the robotic surgery group and 67 patients in the laparoscopic surgery group.</p><p><strong>Results: </strong>There was no significant difference in the pathologic stages between the robotic and laparoscopic surgery groups. Distal margin involvement was only observed in the robotic surgery group (1/67, 1.5%). Circumferential resection margin involvement was not different between the robotic surgery and laparoscopic surgery groups (3/67 [4.5%] and 4/67 [6.0%], respectively, P=1.000). The quality of TME (complete, nearly complete, and incomplete) was similar between the robotic surgery and laparoscopic surgery groups (88.0%, 6.0%, 6.0% and 79.1%, 9.0%, 11.9%, respectively, P=0.358). The disease-free and overall survival rates were not significantly different between the groups.</p><p><strong>Conclusion: </strong>The quality of TME and disease-free and overall survival rates between the two surgeries were similar. There was no oncologic advantage of robotic surgery for rectal cancer compared to laparoscopic surgery.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"82-89"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/61/30/kjco-17-2-82.PMC9942754.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9529543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of sentinel lymph node biopsy in papillary thyroid microcarcinoma. 前哨淋巴结活检在甲状腺乳头状微癌中的应用。
Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21018
Hyun Yul Kim, Dong-Il Kim, Chang Shin Jung, Seung Joo Lee, Dong Won Im, Youn Joo Jung, Jeong-A Yeom, Jeong Bum Choi
{"title":"Utility of sentinel lymph node biopsy in papillary thyroid microcarcinoma.","authors":"Hyun Yul Kim,&nbsp;Dong-Il Kim,&nbsp;Chang Shin Jung,&nbsp;Seung Joo Lee,&nbsp;Dong Won Im,&nbsp;Youn Joo Jung,&nbsp;Jeong-A Yeom,&nbsp;Jeong Bum Choi","doi":"10.14216/kjco.21018","DOIUrl":"https://doi.org/10.14216/kjco.21018","url":null,"abstract":"<p><strong>Purpose: </strong>There are many studies on sentinel lymph node (SLN) biopsy in thyroid carcinoma but SLN biopsy (SLNB) in papillary thyroid carcinoma (PTC) remains open to debate. Therefore in this retrospective study, the usefulness of SLNB in thyroid carcinoma patients who had micro-PTC without cervical lymphadenopathy was assessed.</p><p><strong>Methods: </strong>SLNB was performed in 114 patients who were diagnosed with micro-PTC in a single lobe without palpable or ultrasound-detected lymph node at the tertiary center between January 2012 and December 2013. After SLNB, all patients underwent total thyroidectomy and central neck dissection or thyroid lobectomy and central neck dissection of the single side.</p><p><strong>Results: </strong>SLNs were identified in 112 of 114 patients with 41 positive SLNs and 71 negative SLNs on intraoperative frozen sections. However, eight negative patients were found to be positive in the final pathology. Sentinel node identification rate and false negative value of SLNB were 98.2% and 11.3%, respectively. In the univariate analysis, higher lymph node metastasis was detected in men than in women. Higher detection number of SLN showed higher probability of lymph node metastasis.</p><p><strong>Conclusion: </strong>SLNB may be helpful in papillary thyroid cancer, especially in male patients. Also, it is useful for the staging of nodal status and clearance of persistent disease.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"117-121"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/15/kjco-17-2-117.PMC9942750.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Initial experience with laparoscopic posterior retroperitoneal adrenalectomy in single tertiary center. 单三级中心腹腔镜后腹膜肾上腺切除术的初步经验。
Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21014
Jeong Hee Han, Byoung Chul Lee, Young Mok Park, Hyuk Jae Jung, Dong-Il Kim, Jung Bum Choi
{"title":"Initial experience with laparoscopic posterior retroperitoneal adrenalectomy in single tertiary center.","authors":"Jeong Hee Han,&nbsp;Byoung Chul Lee,&nbsp;Young Mok Park,&nbsp;Hyuk Jae Jung,&nbsp;Dong-Il Kim,&nbsp;Jung Bum Choi","doi":"10.14216/kjco.21014","DOIUrl":"https://doi.org/10.14216/kjco.21014","url":null,"abstract":"<p><strong>Purpose: </strong>Laparoscopic posterior retroperitoneal adrenalectomy (LPRA) is a surgical method that accesses the adrenal gland through the back. The aim of this study was to report initial experience of LPRA and evaluate possibilities for surgical application.</p><p><strong>Methods: </strong>From March 2018 to December 2019, a total of 30 consecutive patients diagnosed with adrenal tumor underwent surgical treatment at Pusan National University Hospital were enrolled. Clinicopathologic features and various peri- and postoperative parameters were analyzed by retrospective medical record review. The mean age of the patients was 48.20±13.66 years.</p><p><strong>Results: </strong>The mean body mass index (BMI) was 25.50±4.30 kg/m<sup>2</sup>. Primary hyperaldosteronism was the most frequently preoperative diagnosed disease (n=13, 43.4%), followed by adrenal incidentaloma (n=8, 26.6%), Cushing syndrome (n=5, 16.6%) and pheochromocytoma (n=4, 13.3%). The mean size of postoperative adrenal tumor was 2.72±1.76 cm. The mean operating time was 162±58.14 minutes. Among the 30 patients, 28 patients underwent total adrenalectomy (93.3%) and two patients underwent cortical sparing adrenalectomy (6.7%). When LPRA was performed for patients with BMI >23.16 kg/m<sup>2</sup>, the operating time was longer than the average (P=0.016).</p><p><strong>Conclusion: </strong>LPRA was suitable and safe for patients with benign adrenal tumors. BMI, retroperitoneal fat density and postoperative adrenal weight may be related to the operating time, so they should be considered when deciding on a surgical method for adrenalectomy.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"90-95"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/72/kjco-17-2-90.PMC9942749.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9158594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical relevance and prognostic role of preoperative cell-free single-stranded DNA concentrations in colorectal cancer patients. 结直肠癌患者术前细胞游离单链DNA浓度的临床相关性和预后作用
Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21010
Hyun Soo Song, Dong Hyun Kang, Hyunjung Kim, Tae Sung Ahn, Tae Wan Kim, Moo-Jun Baek
{"title":"Clinical relevance and prognostic role of preoperative cell-free single-stranded DNA concentrations in colorectal cancer patients.","authors":"Hyun Soo Song,&nbsp;Dong Hyun Kang,&nbsp;Hyunjung Kim,&nbsp;Tae Sung Ahn,&nbsp;Tae Wan Kim,&nbsp;Moo-Jun Baek","doi":"10.14216/kjco.21010","DOIUrl":"https://doi.org/10.14216/kjco.21010","url":null,"abstract":"<p><strong>Purpose: </strong>Circulating cell-free single-stranded DNA (ccf-ssDNA) is extracellular DNA and it is a useful biomarker for the diagnosis of tumors and predicting the prognosis of tumors. However, the clinical usefulness of ccf-ssDNA in colorectal cancer (CRC) is not well known. Thus, the purpose of this study was to investigate the clinical usefulness of ccf-ssDNA in CRC.</p><p><strong>Methods: </strong>The study was conducted on 44 patients who had undergone surgery for CRC, and ccf-ssDNA level was measured before surgery and statistical analysis was performed on clinical factors.</p><p><strong>Results: </strong>The association between ccf-ssDNA level and clinicopathological factors was analyzed and compared, and these factors included age, sex, body mass index, diabetes mellitus, hypertension, tumor markers (carcinoembryonic antigen and carbohydrate antigen 19-9), tumor location, size, stage (TNM), recurrence, and death. The group with a ccf-ssDNA level of ≥7.5 ng/μL had a lower age (P=0.010), and was associated with diabetes mellitus (P=0.037) and lymph node metastasis (P=0.049). Multivariate analysis of disease-free survival showed that lymph node metastasis and ccf-ssDNA level (hazard ratio, 10.011; 95% confidence interval, 2.269-44.175; P=0.002) were independent prognostic factors for recurrence. In terms of overall survival, there were no statistically significant results except for vascular invasion.</p><p><strong>Conclusion: </strong>This study showed that ccf-ssDNA level in plasma in CRC patients was an independent prognostic factor that could predict recurrence non-invasively. In this regard, further evaluation with a prospective, large sample size study will be needed to obtain additional results.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"59-67"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/e5/kjco-17-2-59.PMC9942756.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9529542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Video-assisted transthoracic liver resection in patients with marginal liver function: a retrospective cohort study. 视频辅助经胸肝切除术治疗边缘性肝功能患者:一项回顾性队列研究。
Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21019
Ryong Ho Jung, Hyug Won Kim, Sam-Youl Yoon
{"title":"Video-assisted transthoracic liver resection in patients with marginal liver function: a retrospective cohort study.","authors":"Ryong Ho Jung,&nbsp;Hyug Won Kim,&nbsp;Sam-Youl Yoon","doi":"10.14216/kjco.21019","DOIUrl":"https://doi.org/10.14216/kjco.21019","url":null,"abstract":"<p><strong>Purpose: </strong>Laparoscopic hepatectomy has been widely performed by hepatobiliary surgeons for malignancy of liver and gained wide acceptance for various liver tumors, thanks to advances in surgical techniques and devices. But, there are some challenges for right side tumor in patients of cirrhotic liver. Especially, tumor located in right upper area is difficult for wedge resection in patients with marginal liver function, because trans-abdominal approach requires normal parenchymal dissection. Radiofrequency wave ablation is also difficult for such a lesion. So, we demonstrate unique technique of video-assisted transthoracic liver resection (VTLR) for overcome right upper side tumor abutting diaphragm.</p><p><strong>Methods: </strong>Four patients underwent VTLR. Four ports in right chest wall were created by a chest surgeon and diaphragm was open. Then traction of the diaphragm was done by suture. After exposure of liver surface, tumor localization was done by ultrasound. The mass excision was done by ultrasonic shear.</p><p><strong>Results: </strong>Four patients were discharged without complications within 11.3 days (range, 6-15 days). On average, patients started to consume a normal diet on an average of 2.4 days (range, 1-4 days).</p><p><strong>Conclusion: </strong>VTLR is could be performed by an experienced surgeon and chest surgeon for right upper liver malignancy abutting diaphragm in patient of marginal liver function.</p>","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"122-125"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/f1/kjco-17-2-122.PMC9942747.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9529538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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