Korean journal of clinical oncology最新文献_第5页

Efficacy of a rehabilitation program using minor muscles in colorectal cancer patients with chemotherapy-induced neuropathy: preliminary study. 使用小肌肉的康复方案对结直肠癌化疗引起的神经病变的疗效:初步研究。

Korean journal of clinical oncology Pub Date : 2022-06-01 DOI: 10.14216/kjco.22002

Kyung Sook Hong, Soon Sup Chung, Kwang Ho Kim, Ryung-Ah Lee

{"title":"Efficacy of a rehabilitation program using minor muscles in colorectal cancer patients with chemotherapy-induced neuropathy: preliminary study.","authors":"Kyung Sook Hong, Soon Sup Chung, Kwang Ho Kim, Ryung-Ah Lee","doi":"10.14216/kjco.22002","DOIUrl":"https://doi.org/10.14216/kjco.22002","url":null,"abstract":"Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the common reasons that colorectal cancer patients cannot maintain their routine chemotherapy schedules. Some medications are used for pain relief; however, the effect of medication is disappointing. We carried out this study to confirm that a rehabilitation program using minor muscles might provide a valuable aid in symptom relief of CIPN.Methods: Eleven colorectal cancer patients participated in the basic craftwork program which encouraged the use of the minor muscles of the hands to make and decorate the handicrafts and it was held for 2 hours once a week, for a total of four times. There were no limitations in the stage of cancer or types of chemotherapy to participate the program. Questionnaires were obtained from participants before and after the basic handicrafts program.Results: Of the 11 patients (3 men, 8 women; mean age, 53.0±11.2 years), six received 5-fluorouracil (5-FU) chemotherapy, four received FOLFOX4 (combination of 5-FU, leucovorin, and oxaliplatin) chemotherapy, and one received 5-FU, FOLFOX4, and FOLFIRI (combination of 5-FU, leucovorin, and irinotecan) chemotherapy sequentially. Patients attended the program a mean of 3.8±0.4 times. Common symptoms of CIPN were \"throbbing pain,\" \"aching pain,\" and \"numbness.\" The mean score of the questionnaires between pre- and post-program was 34.1±31.7 points and 24.4±21.5 points each, and it was significantly decreased (P=0.040).Conclusion: Patients often suffered from CIPN symptoms like throbbing or aching pain and numbness during their adjuvant chemotherapy. A rehabilitation program using minor muscles for CIPN is expected to be effective.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 1","pages":"11-16"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/b4/kjco-18-1-11.PMC9942769.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is a cutoff value of 12 still useful in stage II right-sided colon cancer without risk factors? 对于没有危险因素的II期右侧结肠癌，12的临界值仍然有用吗?

Korean journal of clinical oncology Pub Date : 2022-06-01 DOI: 10.14216/kjco.22004

Jinseok Hwang, Donghyoun Lee, Jung Kyong Shin, Jae Hyuck Jang, Jung Wook Huh, Yoon Ah Park, Yong Beom Cho, Hee Cheol Kim, Seong Hyeon Yun, Woo Yong Lee, Ho-Kyung Chun

{"title":"Is a cutoff value of 12 still useful in stage II right-sided colon cancer without risk factors?","authors":"Jinseok Hwang, Donghyoun Lee, Jung Kyong Shin, Jae Hyuck Jang, Jung Wook Huh, Yoon Ah Park, Yong Beom Cho, Hee Cheol Kim, Seong Hyeon Yun, Woo Yong Lee, Ho-Kyung Chun","doi":"10.14216/kjco.22004","DOIUrl":"https://doi.org/10.14216/kjco.22004","url":null,"abstract":"Purpose: Various clinical practice guidelines recommend at least 12 regional lymph nodes should be removed for resected colon cancer. According to a recent study, the lymph node yield (LNY) in colon cancer surgery in the last 20 years has tended to increase from 14.91 to 21.30. However, it is unclear whether these guidelines adequately reflect recent findings on the number of harvested lymph nodes in colon cancer surgery. The aim of this study is to assess the impact of an LNY of more than 25 on survival in right-sided colon cancer.Methods: We included 285 patients who underwent a right hemicolectomy during the period from January 2010 through December 2015. Patients were divided into two groups (<25 nodes and ≥25 nodes). Primary endpoints included 5-year and 10-year survival including disease-free and overall.Results: We found that survival outcomes of patients with a harvest of ≥25 nodes were not significantly different compared with a <25 group. Large tumor size (5 cm) is significantly associated with poor 5-year and 10-year overall survival.Conclusion: Survival outcomes of patients with a harvest of ≥25 nodes were not significantly different compared with the <25 group in stage II colon cancer with no risk.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 1","pages":"27-35"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/11/kjco-18-1-27.PMC9942765.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Apurinic/apyrimidinic endonuclease 1 is associated with poor prognosis after curative resection followed by adjuvant chemotherapy in patients with stage III colon cancer. 无尿嘧啶/无嘧啶内切酶1与III期结肠癌患者根治性切除后辅助化疗预后不良相关。

Korean journal of clinical oncology Pub Date : 2022-06-01 DOI: 10.14216/kjco.22001

Ji Hyeong Song, Myung Sun Lee, Eun Young Cha, Kyung Ha Lee, Ji Yeon Kim, Jin Soo Kim

{"title":"Apurinic/apyrimidinic endonuclease 1 is associated with poor prognosis after curative resection followed by adjuvant chemotherapy in patients with stage III colon cancer.","authors":"Ji Hyeong Song, Myung Sun Lee, Eun Young Cha, Kyung Ha Lee, Ji Yeon Kim, Jin Soo Kim","doi":"10.14216/kjco.22001","DOIUrl":"https://doi.org/10.14216/kjco.22001","url":null,"abstract":"Purpose: Apurinic/apyrimidinic endonuclease 1 (APE1) is a key enzyme involved in the base excision repair pathway. It also has redox activity and maintains various transcription factors in an active reduced state. APE1 may be associated with chemoresistance. In the present study, we first investigated the expression level of APE1 protein and its correlation with oncologic outcomes of oxaliplatin-based chemotherapy in patients with stage III colon cancer. Further, we investigated the effects of human APE1 siRNA on the sensitivity of oxaliplatin in SNU-C2A colon cancer cells.Methods: Tissue specimens from tumor and normal colon of 33 patients with stage III colon cancer were obtained from 2006 to 2009. The patients received at least eight cycles of oxaliplatin-based chemotherapy. APE1 expression was analyzed by immunohistochemistry and Western blotting using a cultured SNU-C2A cell line. Cell viability and apoptosis were determined by Cell Counting Kit-8 and caspase-3 cleavage using Western blotting.Results: All the colon cancer tissues showed APE1 staining in the nucleus, whereas all the normal colon tissues were negative for APE1 staining in the cytoplasm. The group with a higher expression of APE1 demonstrated poorer prognosis than the group with low expression (P=0.026 for overall survival and P=0.021 for disease-free survival). Treatment with oxaliplatin resulted in a dose-dependent increase in APE1 expression in SNU-C2A cells. APE1 siRNA significantly enhanced oxaliplatin-induced growth inhibition, and also increased oxaliplatin-induced apoptosis in SNU-C2A cells.Conclusion: APE1 could be considered a prognostic factor in colon cancer patients treated with oxaliplatin-based chemotherapy.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/ea/kjco-18-1-1.PMC9942767.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9154426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Expression of miR-221 and miR-18a in patients with hepatocellular carcinoma and its clinical significance. miR-221和miR-18a在肝癌患者中的表达及其临床意义

Korean journal of clinical oncology Pub Date : 2022-06-01 DOI: 10.14216/kjco.22003

Jong Hyuk Yun, Moo-Jun Baek, Hae Il Jung

{"title":"Expression of miR-221 and miR-18a in patients with hepatocellular carcinoma and its clinical significance.","authors":"Jong Hyuk Yun, Moo-Jun Baek, Hae Il Jung","doi":"10.14216/kjco.22003","DOIUrl":"https://doi.org/10.14216/kjco.22003","url":null,"abstract":"Purpose: Recently, microRNA (miRNA) has been evaluated to provide a new diagnostic and therapeutic modality hepatocellular carcinoma (HCC) and other tumors. They are small non-coding RNA molecules that function as transcriptional and post-transcriptional regulators of gene expression by silencing target genes. The aim of this study was to evaluate the clinical significance of microRNA-18a, 221 (miR-18a, miR-221) expression in HCC formalin-fixed paraffin-embedded (FFPE) tissue.Methods: miR-18a and miR-221 expressions were assessed by reverse transcription and real-time quantitative reverse transcription polymerase chain reaction in 50 pairs of FFPE HCC and the adjacent noncancerous liver tissues. And we evaluated the expression level in HCC tissues as compared with their adjacent noncancerous counterparts. And the relationship between miR-18a, miR-221 level and clinicopathological data and survival rates were analyzed.Results: miR-221 and miR-18a were overexpressed in HCC tissue as compared with their adjacent noncancerous liver tissue (P<0.001). miR-221 expression was found to be correlated with larger tumor size (P=0.048). miR-18a expression was correlated with modified Union for International Cancer Control stage (P=0.05). The overall survival (P=0.02) of HCC patients with high miR-221 expression was significantly poorer compared to those patients with low expression. Multivariate analyses demonstrated that miR-221 may be a poor prognostic factor of HCC patients.Conclusion: High expression of miR-221 in FFPE tissues could provide significance for prognosis of HCC patients. Although, miR-18a expression was significantly upregulated in HCC tissues, they are not correlated with prognosis. Further large prospective studies are needed to determine their clinical significance.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 1","pages":"17-26"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/80/de/kjco-18-1-17.PMC9942768.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally invasive treatments for early colorectal cancer: comparison of endoscopic resection and laparoscopic surgery. 早期结直肠癌的微创治疗:内镜切除与腹腔镜手术的比较。

Korean journal of clinical oncology Pub Date : 2022-06-01 DOI: 10.14216/kjco.22006

Kyeong Eui Kim, Yoo Jin Lee, Ju Yup Lee, Woon Kyung Jeong, Seong Kyu Baek, Sung Uk Bae

{"title":"Minimally invasive treatments for early colorectal cancer: comparison of endoscopic resection and laparoscopic surgery.","authors":"Kyeong Eui Kim, Yoo Jin Lee, Ju Yup Lee, Woon Kyung Jeong, Seong Kyu Baek, Sung Uk Bae","doi":"10.14216/kjco.22006","DOIUrl":"https://doi.org/10.14216/kjco.22006","url":null,"abstract":"Purpose: Endoscopic treatment and laparoscopic surgery are minimally invasive options for early treatment of colorectal cancer, however, more evidence of the long-term outcomes between the two procedures is needed to guide clinical decisions. Therefore, this study aimed to compare the oncologic outcomes between endoscopic and laparoscopic treatment for early colorectal cancer.Methods: The study group included 60 patients who underwent endoscopic treatment and 38 patients who underwent laparoscopic surgery for early colorectal adenocarcinoma between January 2010 and December 2013 at a single study site.Results: Histopathological diagnoses showed that 43 (78.3%) carcinomas in the endoscopic submucosal dissection group were mucosal to sm1, 13 (21.7%) were sm2 or deeper, and 17 high-risk cases (28.3%) in the endoscopic group underwent additional surgery. The median operation time, time to sips of water, and length of hospital stay were significantly shorter in the endoscopic group than in the laparoscopic group. The overall survival rates of patients in the endoscopic group and laparoscopic groups were 91.5% and 87.4%, respectively (P=0.391), and the disease-free survival rates were 90.4% and 87.4% (P=0.614), respectively. Systemic recurrences occurred in two patients (1.6%) in the endoscopic group and one patient (2.0%) in the laparoscopic group. Local recurrence combined with systemic recurrence in one patient (0.8%) in the endoscopic group.Conclusion: Endoscopic resection for early colorectal cancer can be performed safely with better short-term outcomes and comparable long-term oncological outcomes compared to laparoscopic surgery.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 1","pages":"47-55"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/69/55/kjco-18-1-47.PMC9942766.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9160834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local complications are related to poor long-term outcome in patients undergoing curative gastrectomy for advanced gastric cancer. 局部并发症与晚期胃癌患者行根治性胃切除术的远期预后不良有关。

Korean journal of clinical oncology Pub Date : 2022-06-01 DOI: 10.14216/kjco.22005

Tae Sun Ha, Gyu Seok Cho, Eung Jin Shin, Seung Wan Ryu, Keun Won Ryu, Min Chan Kim, Woo Jin Hyung, Chan Young Kim, Hyuk-Joon Lee, Dong Woo Shin, Jun Ho Lee

{"title":"Local complications are related to poor long-term outcome in patients undergoing curative gastrectomy for advanced gastric cancer.","authors":"Tae Sun Ha, Gyu Seok Cho, Eung Jin Shin, Seung Wan Ryu, Keun Won Ryu, Min Chan Kim, Woo Jin Hyung, Chan Young Kim, Hyuk-Joon Lee, Dong Woo Shin, Jun Ho Lee","doi":"10.14216/kjco.22005","DOIUrl":"https://doi.org/10.14216/kjco.22005","url":null,"abstract":"Purpose: The present study was performed to investigate the effects of local complications (LC) on long-term survival and cancer recurrence in patients undergoing curative gastrectomy for gastric cancer.Methods: We analyzed 2,627 patients after curative gastrectomy for gastric cancer between January 2001 and December 2006. Patients were classified into groups no complications (NC), LC, or systemic complications (SC).Results: Among the 2,627 patients, 475 patients developed complications (LC group [n=374, 14.2%] and SC group [n=101, 3.9%]). The 5-year cancer-specific survival rate was significantly poorer in the LC group compared to the NC and SC groups (LC, 78.0%; NC, 85.4%; SC, 80.2%; P=0.007). The occurrence of LC was identified as a significant independent prognostic factor for overall and cancer-specific survival (hazard ratio [HR], 2.08; 95% confidence interval [CI], 1.46-2.97; P=0.001 and HR, 1.77; 95% CI, 1.12-2.81; P=0.015). The tumor recurrence rates were higher in the LC group than the in other two groups (LC, 23.5%; NC, 15.4%; SC, 15.8%; P<0.001). The occurrence of LC was an independent predictor of tumor recurrence in patients undergoing curative gastrectomy for gastric cancer (HR, 1.55; 95% CI, 1.11-2.17; P=0.011).Conclusion: LC are associated with adverse long-term outcomes in patients after curative gastrectomy for advanced gastric cancer.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"18 1","pages":"36-46"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f5/23/kjco-18-1-36.PMC9942764.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9154425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jejunogastric intussusception after totally laparoscopic distal gastrectomy for gastric cancer: a rare case report and review of the literature. 胃癌全腹腔镜远端胃切除术后空肠胃套叠一例罕见病例报告及文献复习。

Korean journal of clinical oncology Pub Date : 2022-06-01 DOI: 10.14216/kjco.22007

Geum Jong Song, Jong Hyuk Yun, Hae Il Jung, Myoung Won Son, Moon-Soo Lee

引用次数: 0

Clinical significance of additional gastrectomy after non-curative endoscopic submucosal dissection for early gastric cancer: a retrospective single-center study. 早期胃癌非治愈性内镜粘膜下剥离术后加行胃切除术的临床意义:一项回顾性单中心研究。

Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21011

Uicheon Jeong, Ho Yoon Bang, Pyeong Su Kim

{"title":"Clinical significance of additional gastrectomy after non-curative endoscopic submucosal dissection for early gastric cancer: a retrospective single-center study.","authors":"Uicheon Jeong, Ho Yoon Bang, Pyeong Su Kim","doi":"10.14216/kjco.21011","DOIUrl":"https://doi.org/10.14216/kjco.21011","url":null,"abstract":"Purpose: Additional surgery is recommended for patients after a non-curative endoscopic submucosal dissection (ESD) to prevent residual cancer (RC) or lymph node metastasis (LNM). We aimed to evaluate the clinicopathologic characteristics of patients who underwent an additional gastrectomy after a non-curative ESD procedure and identify the risk factors of RC and LNM.Methods: We retrospectively assessed the clinicopathological factors of 73 patients who underwent additional gastrectomy following a non-curative ESD between January 2009 and December 2019 at our center.Results: RC and LNM rates after additional gastrectomy were 9.6% and 8.2%, respectively. Invasion deeper than 500 μm (P=0.045), positive horizontal resection margin (P<0.001), and positive ESD margin (P=0.001) were identified as statistically significant factors in univariate analysis for RC, but not in multivariate analysis. Lymphatic invasion was the only risk factor found to be significant in both univariate and multivariate analyses (P=0.005 and P=0.012).Conclusion: Additional gastrectomy is necessary to prevent RC or LNM after non-curative ESD. Lymphatic invasion was also associated with LNM in patients who underwent an additional gastrectomy after a non-curative ESD, and in such cases, active treatment is required.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"68-72"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a7/6e/kjco-17-2-68.PMC9942757.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9529539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of immediate use of totally implantable venous access ports in adult patients with cancer: a retrospective single-center study. 成年癌症患者立即使用完全植入式静脉通道的安全性:一项回顾性单中心研究。

Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21016

Jisu Lee, Sung Mo Hur, Zisun Kim, Cheol Wan Lim

{"title":"Safety of immediate use of totally implantable venous access ports in adult patients with cancer: a retrospective single-center study.","authors":"Jisu Lee, Sung Mo Hur, Zisun Kim, Cheol Wan Lim","doi":"10.14216/kjco.21016","DOIUrl":"https://doi.org/10.14216/kjco.21016","url":null,"abstract":"Purpose: Totally implantable venous access ports (TIVAPs) can be used long-term for safe administration of intravenous drugs. TIVAP complications include catheter-related infections, venous thrombosis, extravasation, TIVAP migration, and pain. The relationship between the timing of the first chemotherapy administration after port implantation and complications is controversial. This study aimed to investigate the safety of immediate use of TIVAPs and the associated risk factors for complications.Methods: Between January 2016 and December 2018, 305 patients (median age, 53 years; 256 women) who underwent TIVAP placement at our institution were included. Chemotherapy was administered within 2 days of implantation. A retrospective analysis of patients' clinical data was performed to investigate catheter days and complications of TIVAPs.Results: Overall, 305 patients were evaluated over 57,324 catheter days (median, 168 catheter days; interquartile range, 105). The median interval between placement and first use of TIVAPs was 0.98 days. The overall morbidity rate was 2.95%. Nine complications occurred in nine patients, including TIVAP-related infection (4), pain (2), port occlusion (1), thrombosis (1), and scar disunion (1), of which five required port removal (1.64%). The median number of catheter days before complications occurred was 61 (range, 10-457 days; interquartile range, 51). No complications occurred within 7 days of implantation. Body mass index was an independent risk factor for TIVAP-related complications in the Cox proportional hazards model (multivariable analysis: hazard ratio, 1.221; 95% confidence interval, 1.054-1.414; P=0.008).Conclusion: This study suggests the safe long-term use of TIVAPs following their immediate chemotherapy administration within 2 days of implantation.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"104-110"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/ec/kjco-17-2-104.PMC9942755.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9529545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer. 腹会阴切除与保留括约肌切除治疗低位直肠癌的肿瘤预后比较。

Korean journal of clinical oncology Pub Date : 2021-12-01 DOI: 10.14216/kjco.21012

Won Il Jo, Dae Ro Lim, Jung Cheol Kuk, Eung Jin Shin

{"title":"Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer.","authors":"Won Il Jo, Dae Ro Lim, Jung Cheol Kuk, Eung Jin Shin","doi":"10.14216/kjco.21012","DOIUrl":"https://doi.org/10.14216/kjco.21012","url":null,"abstract":"Purpose: The present study compares the peri/postoperative and oncological outcomes of abdominoperineal resections (APR) and sphincter saving resection (SSR) for low lying rectal cancer.Methods: Between January 2001 and December 2014, 176 patients who underwent SSR (n=67) and APR (n=109) for low rectal cancer, without stage IV, were retrieved from a retrospective database.Results: With a median follow-up of 66.5 months. The mean total number of harvested lymph nodes was 16.7 (SSR) versus 17.1 (APR) (P=0.801). The advanced T stage was higher in the APR group (82.6%) versus the SSR group (55.2%) (P=0.006). The positive rate of lymph nodes after surgery was significantly higher in the APR group (45.9%) versus SSR group (25.4%) (P<0.05). The 5-year overall survival rates for SSR and APR were 87.3% and 67.6%, respectively (P<0.005). The 5-year disease-free survival rate (DFS) was 83.6% (SSR) versus 65.5% (APR) (P=0.002). The recurrence rate was higher in the APR group (34.9%) versus the SSR group (14.9%) (P=0.004). Local recurrence rate was not different between the two groups. However, distant recurrence rate was significantly higher in the APR group (26.6% vs. 11.9%, P=0.023). In multivariate analysis, node positive (N0 vs. N1-2) was an independent prognostic factor for DFS (P<0.005).Conclusion: Based on the present data, SSR achieved better 5-year oncological outcome than APR. The positive lymph node ratio in the N stage after surgery was higher in the APR group and this seems to have an effect on the oncological outcomes of the APR group.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"17 2","pages":"73-81"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1d/29/kjco-17-2-73.PMC9942753.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9529544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0