Korean journal of clinical oncology最新文献_第2页

Radiomics and machine learning analysis of liver magnetic resonance imaging for prediction and early detection of tumor response in colorectal liver metastases. 肝脏磁共振成像的放射组学和机器学习分析用于预测和早期检测结直肠肝转移的肿瘤反应。

Korean journal of clinical oncology Pub Date : 2024-05-01 Epub Date: 2024-06-30 DOI: 10.14216/kjco.24005

Sungjin Yoon, Young Jae Kim, Ji Soo Jeon, Su Joa Ahn, Seung Joon Choi

{"title":"Radiomics and machine learning analysis of liver magnetic resonance imaging for prediction and early detection of tumor response in colorectal liver metastases.","authors":"Sungjin Yoon, Young Jae Kim, Ji Soo Jeon, Su Joa Ahn, Seung Joon Choi","doi":"10.14216/kjco.24005","DOIUrl":"10.14216/kjco.24005","url":null,"abstract":"Purpose: The aim of this study was to demonstrate the effectiveness of a machine learning-based radiomics model for distinguishing tumor response and overall survival in patients with unresectable colorectal liver metastases (CRLM) treated with targeted biological therapy.Methods: We prospectively recruited 17 patients with unresectable liver metastases of colorectal cancer, who had been given targeted biological therapy as the first line of treatment. All patients underwent liver magnetic resonance imaging (MRI) three times up until 8 weeks after chemotherapy. We evaluated the diagnostic performance of machine learning-based radiomics model in tumor response of liver MRI compared with the guidelines for the Response Evaluation Criteria in Solid Tumors. Overall survival was evaluated using the Kaplan-Meier analysis and compared to the Cox proportional hazard ratios following univariate and multivariate analyses.Results: Performance measurement of the trained model through metrics showed the accuracy of the machine learning model to be 76.5%, and the area under the receiver operating characteristic curve was 0.857 (95% confidence interval [CI], 0.605-0.976; P < 0.001). For the patients classified as non-progressing or progressing by the radiomics model, the median overall survival was 17.5 months (95% CI, 12.8-22.2), and 14.8 months (95% CI, 14.2-15.4), respectively (P = 0.431, log-rank test).Conclusion: Machine learning-based radiomics models could have the potential to predict tumor response in patients with unresectable CRLM treated with biologic therapy.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"20 1","pages":"27-35"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of the minimum amount of anti-adhesive agent required for entire intra-abdominal cavity using fluorescent dye. 利用荧光染料预测整个腹腔内所需的最低防粘剂用量。

Korean journal of clinical oncology Pub Date : 2024-05-01 Epub Date: 2024-06-30 DOI: 10.14216/kjco.24004

Ji-Hyeon Park, A Reum Park, Kiwon Kim, Seo Hyun Shin, Youngbae Jeon, Woon Kee Lee, Donghyuk Lee, Jeong-Heum Baek

{"title":"Prediction of the minimum amount of anti-adhesive agent required for entire intra-abdominal cavity using fluorescent dye.","authors":"Ji-Hyeon Park, A Reum Park, Kiwon Kim, Seo Hyun Shin, Youngbae Jeon, Woon Kee Lee, Donghyuk Lee, Jeong-Heum Baek","doi":"10.14216/kjco.24004","DOIUrl":"10.14216/kjco.24004","url":null,"abstract":"Purpose: Studies on the appropriate amount of anti-adhesive agents for preventing postoperative adhesion are lacking. This animal study aimed to investigate the distribution of an anti-adhesive agent in the abdominal cavity and estimate the necessary amount to cover the entire cavity.Methods: Fluorescent dye Flamma-552 was conjugated to Guardix-sol to create Guardix-Flamma, which was laparoscopically applied to the abdominal cavity of two 10-kg pigs in different amounts: 15 mL for G1 and 35 mL for G2. After 24 hours, the distribution of Guardix-Flamma was examined under the near-infrared mode of the laparoscope, and the thickness was measured in tissues from the omentum, small, and large intestine by immunohistochemistry.Results: The average area of the abdominal cavity in 10 kg pigs was 2,755 cm2. Guardix-Flamma fluorescence was detected in the greater omentum, ascites in the pelvis, and right quadrant area in G1, whereas in G2, it was detected everywhere. On average, the total thickness of G1 and G2 were 12.68 ± 9.80 μm and 18.16 ± 15.57 μm, respectively. Guardix-Flamma thickness applied to the omentum, small, and large intestines of G2 were 1.31-, 1.45-, and 1.49-times thicker than those of G1, respectively, and were all statistically significant (P < 0.05).Conclusion: The entire abdominal cavity of the 10 kg pig was not evenly covered with 15 mL of Guardix. Although 35 mL of Guardix is sufficient to cover the same area with an average thickness of 18 µm, further studies should evaluate the minimum thickness required for an effective anti-adhesive function.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"20 1","pages":"18-26"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rectal metastasis arising from breast cancer: a case report. 乳腺癌直肠转移：病例报告。

Korean journal of clinical oncology Pub Date : 2024-05-01 Epub Date: 2024-06-30 DOI: 10.14216/kjco.24007

Kyeong Eui Kim, Hye Won Lee, Sung Uk Bae

{"title":"Rectal metastasis arising from breast cancer: a case report.","authors":"Kyeong Eui Kim, Hye Won Lee, Sung Uk Bae","doi":"10.14216/kjco.24007","DOIUrl":"10.14216/kjco.24007","url":null,"abstract":"Breast cancer is the most common cancer among women worldwide. Breast cancer often metastasizes to the regional lymph nodes, bone, brain, liver, and lungs, whereas gastrointestinal tract metastases are rare. Herein, we present a rare case of rectal metastasis from breast cancer that occurred during palliative chemotherapy. A 69-year-old female with a history of invasive ductal carcinoma, negative for hormonal receptors and positive for human epidermal growth factor receptor 2 (HER2) receptor, underwent various treatments, including neoadjuvant chemotherapy, breast-conserving surgery, and adjuvant therapy. Eight months postoperatively, the patient experienced axillary lymph node recurrence, requiring palliative chemotherapy. Despite ongoing treatment, metastatic lesions were confirmed in the lungs and pleura. During palliative chemotherapy, the patient developed anal pain, and subsequent examination revealed an infiltrating rectal lesion. Despite histological confirmation of metastatic breast carcinoma and tubular adenoma, a multidisciplinary decision was made regarding palliative chemotherapy over surgical intervention. Eribulin was administered, but due to the patient's inability to tolerate the treatment, she passed away 3 months after rectal lesion diagnosis. Although breast cancer metastasis to the rectum is rare, clinicians should consider the possibility of rectal involvement and perform a digital rectal examination if anal symptoms are present.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"20 1","pages":"41-45"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Margin-negative minimally invasive pancreatoduodenectomy following FOLFIRINOX neoadjuvant chemotherapy in invasive intraductal papillary mucinous neoplasm of pancreas: a case report. 浸润性胰腺内乳头状黏液瘤 FOLFIRINOX 新辅助化疗后边缘阴性微创胰十二指肠切除术：病例报告。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23014

Jinho Kim, Seokjin Park, Eunsang Yim, Su Hyeong Park, Chang Moo Kang

引用次数: 0

Concordance of circulating tumor DNA and matched formalin-fixed paraffin-embedded tumor tissue in gastric cancer as a predictor of recurrence. 胃癌循环肿瘤 DNA 与匹配的福尔马林固定石蜡包埋肿瘤组织的一致性作为复发的预测指标

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23009

Soo Hyun Seo, Young Suk Park, Soo Kyung Nam, Hye Seung Lee, Do Joong Park, Kyoung Un Park

{"title":"Concordance of circulating tumor DNA and matched formalin-fixed paraffin-embedded tumor tissue in gastric cancer as a predictor of recurrence.","authors":"Soo Hyun Seo, Young Suk Park, Soo Kyung Nam, Hye Seung Lee, Do Joong Park, Kyoung Un Park","doi":"10.14216/kjco.23009","DOIUrl":"10.14216/kjco.23009","url":null,"abstract":"Purpose: Combined analysis of the variant composition of circulating tumor DNA (ctDNA) from cell-free plasma and DNA from tumor tissue could provide insight into the implications of the genetic alterations responsible for the intratumoral and intertumoral heterogeneity of gastric cancer. We aimed to evaluate the usefulness of this approach in these patients.Methods: Cell-free plasma and formalin-fixed paraffin-embedded tumor tissue samples from 46 patients with gastric cancer were examined. Targeted deep sequencing was performed using a commercially available kit.Results: The cell-free DNA (cfDNA) concentration was higher in stage II-IV versus stage I patients and in larger versus smaller tumors. Only 12 of the 36 (33.3%) alterations in the tumor tissue samples were in concordance with those in the ctDNA samples. Two variants were in concordance in stage I samples and 10 in stage II-IV samples. Actionable variants that were detected in concordance were in the stage II-IV samples. Preoperative ctDNA positivity of actionable variants was significantly associated with cfDNA concentration, lymphatic invasion, N stage, and TNM stage. Cancer recurrence was significantly associated with tumor size, lymphatic/vascular invasion, TNM stage, and ctDNA-tumor tissue variant concordance.Conclusion: Preoperative ctDNA genetic analysis using a multigene panel offers substantial clinical benefits when performed in conjunction with targeted deep sequencing of tumor tissue. Concordance between preoperative ctDNA and tumor tissue mutations may serve as a prognostic indicator in patients with gastric cancer.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 2","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-grade extrauterine endometrial stromal sarcoma arising from vaginal endometriosis: a case report and literature review. 阴道子宫内膜异位症引发的低级别宫外子宫内膜基质肉瘤：病例报告和文献综述。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23013

Seema Singhal, Aarthi S Jayraj, Ekta Dhamija, Sachin Khurana

{"title":"Low-grade extrauterine endometrial stromal sarcoma arising from vaginal endometriosis: a case report and literature review.","authors":"Seema Singhal, Aarthi S Jayraj, Ekta Dhamija, Sachin Khurana","doi":"10.14216/kjco.23013","DOIUrl":"10.14216/kjco.23013","url":null,"abstract":"Extrauterine endometrial stromal sarcoma arising from malignant transformation of the vagina is an extremely rare condition. The diagnosis is often difficult as the symptomatology and pathological features overlap with that of pelvic endometriosis. A 38 years old female presented with complaints of dyspareunia, dysmenorrhea, and painful defecation along with blood-stained vaginal discharge for a year. Examination revealed the presence of multiple brownish irregular nodules in posterior vaginal fornix and fixed tender nodules which on biopsy revealed florid vaginal endometriosis. She improved symptomatically on medical therapy. After 18 months of diagnosis, she presented again with a necrotic growth in posterior fornix, which on repeat biopsy revealed a low-grade endometrial stromal sarcoma. Laparotomy revealed a 7×5 cm mass in the pouch of Douglas, infiltrating the posterior vaginal wall and rectum. A complete cytoreductive surgery with retrograde hysterectomy, excision of posterior vaginal wall and rectosigmoid resection was done. The patient is disease-free at a follow-up of 65 months.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 2","pages":"73-79"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating ctDNA and tumor tissue analysis in gastric cancer: a synergistic approach unveils prognostic insights. 整合胃癌中的ctDNA和肿瘤组织分析：一种协同方法揭示了预后见解。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23008

Jong Hyuk Yun

引用次数: 0

The prognostic impact of body mass index in breast cancer according to tumor subtype. 肿瘤亚型对乳腺癌体重指数预后的影响。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23010

Jae-Myung Kim, Ju-Yeon Kim, Eun Jung Jung, Seung-Jin Kwag, Ji-Ho Park, Jin-Kyu Cho, Han-Gil Kim, Chi-Young Jeong, Young-Tae Ju, Young-Joon Lee

{"title":"The prognostic impact of body mass index in breast cancer according to tumor subtype.","authors":"Jae-Myung Kim, Ju-Yeon Kim, Eun Jung Jung, Seung-Jin Kwag, Ji-Ho Park, Jin-Kyu Cho, Han-Gil Kim, Chi-Young Jeong, Young-Tae Ju, Young-Joon Lee","doi":"10.14216/kjco.23010","DOIUrl":"10.14216/kjco.23010","url":null,"abstract":"Purpose: Several studies demonstrated that obesity and underweight were negatively associated with outcomes of breast cancer. However, the results are still controversial, and the impact of body mass index (BMI) on distant metastasis-free survival (MFS), which might directly affect mortality, was less well evaluated. Our study aimed to verify the prognostic effect of BMI in breast cancer.Methods: A retrospective analysis of 504 patients with stage I-III breast cancer who underwent surgery from January 2005 to December 2013 was performed. The patients were divided into three groups according to preoperative BMI: underweight <18.5 kg/m2, normal weight 18.5-24.9 kg/m2, and overweight ≥25 kg/m2. The association between body weight status and breast cancer recurrence was analyzed. Subgroup analysis by tumor subtype according to receptor status was also performed.Results: The median follow-up period was 88 months. For disease recurrence, histologic grade and human epidermal growth factor receptor 2 (HER2)-positivity were independent prognostic factors in multivariate analysis. Stage, histologic grade, HER2-positivity, and BMI status were independent prognostic factors for distant metastasis. In survival analysis, overweight and underweight were significant predisposing factors for MFS, but not for disease-free survival (DFS). In the estrogen receptor (ER)-positive group, overweight and underweight patients had significantly worse DFS and MFS than normal weight patients. In the ER-negative or HER2-positive group, BMI status had no significant association with DFS and MFS.Conclusion: The prognostic role of BMI on the survival outcomes of patients with breast cancer was different by tumor subtype. In ER-positive patients, overweight and underweight statuses had a negative prognostic effect on DFS and MFS, respectively.","PeriodicalId":74045,"journal":{"name":"Korean journal of clinical oncology","volume":"19 2","pages":"52-59"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual mesentery metastasis of differentiated thyroid cancer: a case report. 分化型甲状腺癌的异常肠系膜转移：病例报告。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23015

Sunyoung Chwa, Seung Hun Lee, Seung Hyun Lee

引用次数: 0

Extraosseous Ewing sarcoma of the pancreas: a case report. 胰腺骨外尤文肉瘤：病例报告。

Korean journal of clinical oncology Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.14216/kjco.23012

Neslihan Nisa Gecici, Vedat Burkay Camurdan, Mai Al Khatalin, Onur Yildirim

引用次数: 0