Advances in neurobiology最新文献_第3页

Oligodendrocyte and Myelin Pathophysiology in Multiple Sclerosis. 少突胶质细胞和髓磷脂在多发性硬化症中的病理生理。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-87919-7_12

Eneritz López-Muguruza, Carla Peiró-Moreno, Asier Ruiz, Carlos Matute

{"title":"Oligodendrocyte and Myelin Pathophysiology in Multiple Sclerosis.","authors":"Eneritz López-Muguruza, Carla Peiró-Moreno, Asier Ruiz, Carlos Matute","doi":"10.1007/978-3-031-87919-7_12","DOIUrl":"https://doi.org/10.1007/978-3-031-87919-7_12","url":null,"abstract":"Multiple sclerosis (MS) is a chronic autoimmune and progressive neurodegenerative disease of the central nervous system (CNS) that has a highly variable clinical manifestation and course. MS targets primarily myelin and oligodendroglia; however, all glial cells and neurons become involved early in the pathology. Thus, inflammation, which is widely thought to be initiated peripherally, expands through the CNS, with astrocytes and microglia entering an activated state not only around and within lesions but also widespread. This chapter will emphasize the pathophysiological changes in oligodendrocytes and myelin as a consequence of the inflammatory cascade driving the disease onset and progression. Learning about the mechanisms of oligodendrocyte and myelin damage beyond the immune attack will be instrumental in protecting these two CNS compartments from damage. In turn, knowledge about the axon-myelin unit will help in devising therapies to prevent axonal degeneration, a key clinical hallmark of MS, as it strongly correlates with the progression of CNS atrophy and symptoms. Finally, exploiting paradigms of oligodendrocyte repopulation and remyelination will definitively contribute to devising treatments for tissue repair and halting MS course. This chapter aims at summarizing the state of the art in all these experimental developments including the available clinical therapies and the current clinical trials.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"43 ","pages":"317-361"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIT Your Brain: Neuron and New Run. HIT Your Brain: Neuron and New Run。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-981-95-0066-6_18

Min-Chul Lee, Hideaki Soya

{"title":"HIT Your Brain: Neuron and New Run.","authors":"Min-Chul Lee, Hideaki Soya","doi":"10.1007/978-981-95-0066-6_18","DOIUrl":"10.1007/978-981-95-0066-6_18","url":null,"abstract":"The importance of physical activity in neuroscience is gaining increasing recognition. The question arises: What is the specific focus of exercise, and what factors contribute to the observed benefits of exercise in neuroscience? Various forms of exercise have been examined across physiological, psychological, and biochemical experiments within neuroscience. Still, there is a need for greater clarity to identify optimal exercise conditions, including the FITT-VP variables (frequency, intensity, type, and time).This chapter aims to shed light on the positive impacts of high-intensity training (HIT) exercises in facilitating physiological adaptation and exploring the newfound role in brain functions. Key areas explored include (1) exercise neuroscience at the structural level involving synaptic plasticity and neurogenesis; (2) functional level concerning behavioral development; and (3) molecular level addressing potential mechanisms underlying exercise-induced brain plasticity.Overall, high-intensity training emerges as a more cost-effective method for enhancing physiological adaptations, including improvements in aerobic capacity. Additionally, it has been shown to influence brain functions such as hippocampus-dependent learning and memory positively. These findings offer valuable insights into the practicality of high-intensity training for performance improvement and suggest directions for future research.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"44 ","pages":"335-341"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Role of Extracellular Vesicles in Mediating Effects of Exercise on Brain Function. 细胞外囊泡在运动对脑功能影响中的潜在作用。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-981-95-0066-6_8

Hyo Youl Moon, Henriette van Praag

{"title":"Potential Role of Extracellular Vesicles in Mediating Effects of Exercise on Brain Function.","authors":"Hyo Youl Moon, Henriette van Praag","doi":"10.1007/978-981-95-0066-6_8","DOIUrl":"10.1007/978-981-95-0066-6_8","url":null,"abstract":"Exercise has a remarkable capacity to improve brain function by fostering neuronal plasticity, which enables us to better cope with various psychological and cognitive challenges. Numerous studies have demonstrated the neuroprotective effects of exercise. However, the underlying molecular mechanisms of the neuroprotective effects of exercise are not yet fully understood. In particular, the role of exercise-induced secretion of peripheral factors into circulation that influence the brain is understudied. Recent research has shown that extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, are secreted during exercise. The discovery that EVs can mediate intracellular communication by delivering cargo signifies a promising area of research to understand the impact of exercise on the brain. In the present review, we provide an overview of recent advancements in understanding the regulatory mechanisms of EV biogenesis and discuss how EV molecular composition is influenced by exercise. Additionally, we highlight the potential role of EVs as exercise-specific mediators and as a promising therapeutic tool for neurodegenerative diseases, such as Alzheimer's disease.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"44 ","pages":"161-174"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Impact of High-Intensity Interval Training on Cognitive Functions-Muscle and Brain Interaction. 探索高强度间歇训练对认知功能-肌肉和大脑相互作用的影响。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-981-95-0066-6_13

Sylwester Kujach, Robert Antoni Olek, Radosław Laskowski

{"title":"Exploring the Impact of High-Intensity Interval Training on Cognitive Functions-Muscle and Brain Interaction.","authors":"Sylwester Kujach, Robert Antoni Olek, Radosław Laskowski","doi":"10.1007/978-981-95-0066-6_13","DOIUrl":"10.1007/978-981-95-0066-6_13","url":null,"abstract":"Recent research highlights the relationship between physical activity and cognitive functions. It has been shown that aerobic and resistance exercises, including a wide range of intensity and duration, can evoke a positive impact on cognitive functions and mental health in various age groups. Also, high-intensity interval training (HIT) has been recognized as an exercise modality inducing desired adaptive changes at the level of physical performance (muscle) as well as cognitive functions (brain). Previous research has also shown HIT to be an effective strategy due to its minimal time commitment and significant multiple health benefits. The mechanism behind the cognitive function facilitation as a result of acute and chronic HIT may involve the induction of neurotransmitters, as well as the synthesis of neuroprotective factors and increased activation of brain areas critical for cognitive functioning. Moreover, HIT also causes robustly increased lactate production, recently identified as the \"first myokine\" modulating cerebral metabolism. Additionally, HIT may initially disrupt the redox balance where the moderate formation of reactive oxygen species (ROS) may act as a signaling mechanism, also improving cognitive functions. Although research supports the potential of HIT to improve cognitive function, challenges remain due to differences in exercise structure, duration, and intensity of HIT protocols as well as cognitive domains and cognitive testing timing that make it difficult to draw firm conclusions.To summarize, despite many variables that may influence differences in adaptive changes, existing research highlights the potential health benefits of HIT, also suggesting its effectiveness in enhancing human cognitive functions.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"44 ","pages":"231-250"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Substrate Binding and Conformational Dynamics of the Monoamine Transporters. 单胺转运体的底物结合和构象动力学。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-96364-3_2

Jeppe C Nielsen, Claus J Loland

{"title":"Substrate Binding and Conformational Dynamics of the Monoamine Transporters.","authors":"Jeppe C Nielsen, Claus J Loland","doi":"10.1007/978-3-031-96364-3_2","DOIUrl":"10.1007/978-3-031-96364-3_2","url":null,"abstract":"The monoamine transporters move substrates across the plasma membrane by an alternating-access mechanism, in which a central substrate-binding site is alternately exposed to either the extracellular milieu or the cytoplasm at any given time. This process is driven by co-transport of sodium ions along the inwardly directed sodium gradient. Alternating access to the central substrate-binding site is facilitated by a stepwise series of changes to the transporter conformation, referred to as the transport cycle. The focus of this chapter is to discuss the conformational dynamics of the monoamine transporters that are orchestrated by the binding of substrate and ions, as part of the transport cycle. Firstly, we describe the substrate-binding event, and how it is fine-tuned to induce the conformational flexibility needed to initiate transport. Secondly, we discuss how sodium fuels the substrate transport as well as how it is aided by potassium and chloride. We also provide a mechanistic description of the cooperativity of the two sodium-binding sites and how they couple allosterically to the intracellular gating mechanism. Thirdly, we go over the amino acid residues of the intra- and extracellular gates and how they affect the transporter conformation.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"46 ","pages":"35-62"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pupil Dynamics Predict Exercise Brain Stimulation: An Overview of Exercise Pupillometry. 瞳孔动态预测运动脑刺激：运动瞳孔测量概述。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-981-95-0066-6_6

Ryuta Kuwamizu, Yudai Yamazaki, Kazuya Suwabe, Kenji Suzuki, Yoshiyuki Sankai, Hideaki Soya

{"title":"Pupil Dynamics Predict Exercise Brain Stimulation: An Overview of Exercise Pupillometry.","authors":"Ryuta Kuwamizu, Yudai Yamazaki, Kazuya Suwabe, Kenji Suzuki, Yoshiyuki Sankai, Hideaki Soya","doi":"10.1007/978-981-95-0066-6_6","DOIUrl":"10.1007/978-981-95-0066-6_6","url":null,"abstract":"Proper physical activity, even at a very light intensity such as walking or slow running, improves brain health related to prefrontal executive function and hippocampal memory. However, the neural mechanism behind the cognitive enhancement that occurs during dynamic aerobic exercise is elusive and remains unclear in humans. Recently, pupillometry has been attracting attention as a kind of readout of the brain's ascending arousal mechanism, especially for brain noradrenergic and cholinergic system activation. Thus, to identify the neural mechanism behind the effects of very-light-intensity exercise, our recent work has focused on pupillometry during aerobic exercise, and we have successfully shown the efficacy of pupil dilation as a biological marker, even during very-light-/light-intensity exercise (below the ventilatory threshold). Interestingly, neuromelanin-MRI contrast in the LC, a marker of LC integrity, predicted the magnitude of exercise-induced pupil dilation and psychological arousal changes at the individual level. In addition, we have found that pupil dilation during exercise predicted the positive impact of acute very-light-/light-intensity exercise on prefrontal executive performance and hippocampal memory performance. The series of exercise pupillometry studies we will discuss here provides essential insights into the neural substrates of the advantages of exercise-induced brain stimulation in humans.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"44 ","pages":"113-131"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Minimum Exercise Model to the Hypoxic Environment. 最小运动模型在低氧环境中的应用。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-981-95-0066-6_20

Genta Ochi, Yuhki Yamada, Hideaki Soya

{"title":"Application of Minimum Exercise Model to the Hypoxic Environment.","authors":"Genta Ochi, Yuhki Yamada, Hideaki Soya","doi":"10.1007/978-981-95-0066-6_20","DOIUrl":"10.1007/978-981-95-0066-6_20","url":null,"abstract":"While moderate exercise has been demonstrated to enhance executive function, this beneficial effect may vary depending on the exercise environment. For instance, the decline in blood oxygen levels (hypoxemia) associated with ascent to high altitude has been shown not only to induce acute mountain sickness but also to potentially cause decreased cognitive performance. Therefore, exercise under hypoxic conditions may reduce oxygen delivery to various tissues, thereby attenuating the executive function-enhancing effects of exercise. Previous studies have examined the impact of exercise in hypoxic environments on cognitive function using cognitive task paradigms; however, a consensus has not been reached. One contributing factor to this lack of consensus is the insufficient investigation of how exercise in hypoxic environments affects neural activity in brain regions specific to cognitive function tasks. This limitation stems from the practical difficulties of utilizing positron emission tomography (PET) and magnetic resonance imaging (MRI) systems in hypoxic environments. We addressed these challenges by employing functional near-infrared spectroscopy (fNIRS), which requires only a compact experimental system, is portable, and can be readily installed in gym settings. Our findings revealed that exercise in hypoxic environments induces decreasing cognitive performance, specifically cognitive fatigue, by reducing task-specific neural activity. This chapter provides an overview of our research methodology and results.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"44 ","pages":"371-388"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interoceptive Signaling by Circulating Insulin Like Growth Factor I and Neuroprotection by Exercise. 胰岛素样生长因子I循环的内感受性信号传导与运动的神经保护作用。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-981-95-0066-6_12

Jonathan Zegarra-Valdivia, Estrella Fernandez de Sevilla, Jaime Pignatelli, Ignacio Torres Aleman

{"title":"Interoceptive Signaling by Circulating Insulin Like Growth Factor I and Neuroprotection by Exercise.","authors":"Jonathan Zegarra-Valdivia, Estrella Fernandez de Sevilla, Jaime Pignatelli, Ignacio Torres Aleman","doi":"10.1007/978-981-95-0066-6_12","DOIUrl":"10.1007/978-981-95-0066-6_12","url":null,"abstract":"Physical activity has been proven to be beneficial for brain function. Due to a lack of appropriate therapies for the majority of brain diseases, exercise has become a favored alternative to prevent and even treat several of these pathologies. Thus, the mechanisms underlying the neuroprotective actions of exercise are under intense scrutiny. Furthermore, since many patients afflicted with different neurological conditions are not able to perform exercise, development of pharmacological mimics based on knowledge of underlying cellular and molecular mechanisms is of therapeutic interest (Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Cell 134:405-415, 2008). As part of these mechanisms, we will examine the role of insulin-like growth factor I (IGF-I), a pleiotropic neuroprotective signal, and one of the established mediators of the beneficial actions of exercise in the brain. Exercise stimulates the entrance of circulating IGF-I into the brain where it mediates pro-neurogenic, pro-cognitive, and mood modulatory effects known to be associated to exercise. Through its potent cytoprotective actions (anti-apoptotic, anti-oxidant, anti-inflammatory), IGF-I participates in reparative and homeostatic processes associated to exercise. We postulate that circulating IGF-I, a regulator of muscle and bone mass, forms part of an interoceptive system within a humoral branch informing the brain of muscle/bone mass. In this way, IGF-I conveys interoceptive signaling to brain areas involved in orchestrating physical activity to adapt them to available vigor, i.e., muscle strength. Because exercise engages the activity of many brain areas, neuroprotection by exercise-elicited entrance of circulating IGF-I is brain-wide.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"44 ","pages":"217-229"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimum Exercise Model in Humans Based on Oxygen Uptake and Physiological Parameters. 基于摄氧量和生理参数的人体最小运动模型。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-981-95-0066-6_4

Morimasa Kato, Hyukki Chang, Hideaki Soya

{"title":"Minimum Exercise Model in Humans Based on Oxygen Uptake and Physiological Parameters.","authors":"Morimasa Kato, Hyukki Chang, Hideaki Soya","doi":"10.1007/978-981-95-0066-6_4","DOIUrl":"10.1007/978-981-95-0066-6_4","url":null,"abstract":"Understanding exercise intensity is essential for optimizing training outcomes and minimizing health risks. This chapter introduces key physiological and subjective parameters used to assess exercise intensity, including heart rate reserve (HRR), oxygen uptake reserve (VO2R), maximal oxygen consumption (VO2max), and ratings of perceived exertion (RPE). Standardized classifications from organizations such as the American College of Sports Medicine (ACSM) are presented, alongside practical methods like the Talk Test for field applications. Incremental exercise testing is highlighted for identifying physiological thresholds, including lactate and ventilatory thresholds, which serve as critical markers for personalized training. Additionally, recent advances in neuroimaging-including electroencephalography (EEG), near-infrared spectroscopy (NIRS), and functional magnetic resonance imaging (fMRI)-are reviewed to explore how different exercise intensities affect brain activity. Evidence suggests that even low to moderate-intensity exercise can positively influence cognitive function and cerebral blood flow. The integration of wearable technologies has further enabled real-time monitoring of both physiological and neurocognitive responses. Overall, this chapter underscores the importance of individualized, evidence-based approaches in exercise prescription and highlights emerging methods for linking exercise intensity with brain function.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"44 ","pages":"83-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrophysiological Methods to Explore the Function of Monoamine Transporters. 探索单胺转运蛋白功能的电生理方法。

Advances in neurobiology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-96364-3_6

Danila Boytsov, Michael Freissmuth, Walter Sandtner

{"title":"Electrophysiological Methods to Explore the Function of Monoamine Transporters.","authors":"Danila Boytsov, Michael Freissmuth, Walter Sandtner","doi":"10.1007/978-3-031-96364-3_6","DOIUrl":"10.1007/978-3-031-96364-3_6","url":null,"abstract":"In this chapter we will show how electrophysiological recordings were used to gain insights into the transport kinetics and pharmacology of monoamine transporters (MATs). We will discuss data obtained from whole cell patch clamp recordings that allow for real time monitoring of MAT function. A notable property of MATs is that they carry so-called uncoupled currents. We will begin this chapter by reviewing the experimental evidence that has led to the conclusion that the currents carried by MATs are largely uncoupled and, therefore, not directly related to substrate transport. We will discuss how this has made it difficult to understand the operation of MATs. We will also explain why the existence of these currents has led to the proposition that MATs do not operate by alternate access but rather by a single file diffusion mechanism. However, we will show that ultimately the uncoupled currents carried by MATs can be most parsimoniously explained within the framework of the alternate access mechanism. We will review the existing evidence that MATs, like most other transporters, undergo a cycle during which they visit outward and inward-facing conformations (i.e., the transport cycle). We will outline what we have learned about the transport cycle of MATs from electrophysiological recordings. Thereafter, we will describe how electrophysiological recordings can be utilized to understand how drugs that target MATs affect their operation. To this end, we will discuss the binding modes of three different MAT ligands: (i) amphetamines, (ii) ibogaine, and (iii) zinc.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"46 ","pages":"143-162"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0