Advances in neurobiology最新文献_第10页

Delineating a Pathway for the Discovery of Functional Connectome Biomarkers of Autism. 为发现自闭症的功能连接组生物标志物划定途径。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-69491-2_18

Shinwon Park, Phoebe Thomson, Gregory Kiar, F Xavier Castellanos, Michael P Milham, Boris Bernhardt, Adriana Di Martino

{"title":"Delineating a Pathway for the Discovery of Functional Connectome Biomarkers of Autism.","authors":"Shinwon Park, Phoebe Thomson, Gregory Kiar, F Xavier Castellanos, Michael P Milham, Boris Bernhardt, Adriana Di Martino","doi":"10.1007/978-3-031-69491-2_18","DOIUrl":"https://doi.org/10.1007/978-3-031-69491-2_18","url":null,"abstract":"The promise of individually tailored care for autism has driven efforts to establish biomarkers. This chapter appraises the state of precision-medicine research focused on biomarkers based on the functional brain connectome. This work is grounded on abundant evidence supporting the brain dysconnection model of autism and the advantages of resting-state functional MRI (R-fMRI) for studying the brain in vivo. After considering biomarker requirements of consistency and clinical relevance, we provide a scoping review of R-fMRI studies of individual prediction in autism. In the past 10 years, responding to the availability of open data through the Autism Brain Imaging Data Exchange, machine learning studies have surged. Nearly all have focused on diagnostic label classification. These efforts have shown that autism prediction is feasible using functional connectome markers, with accuracy reported well above chance. In parallel, emerging approaches more directly addressing autism heterogeneity are paving the way for much-needed biomarkers of longitudinal outcome and treatment response. We conclude with key challenges to be addressed by the next generation of studies.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"40 ","pages":"511-544"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mismatch Negativity (MMN) as a Pharmacodynamic/Response Biomarker for NMDA Receptor and Excitatory/Inhibitory Imbalance-Targeted Treatments in Schizophrenia. 错配负性（MMN）作为精神分裂症 NMDA 受体和兴奋/抑制失衡靶向治疗的药效学/反应生物标记物。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-69491-2_15

Daniel C Javitt

{"title":"Mismatch Negativity (MMN) as a Pharmacodynamic/Response Biomarker for NMDA Receptor and Excitatory/Inhibitory Imbalance-Targeted Treatments in Schizophrenia.","authors":"Daniel C Javitt","doi":"10.1007/978-3-031-69491-2_15","DOIUrl":"https://doi.org/10.1007/978-3-031-69491-2_15","url":null,"abstract":"Schizophrenia is a major mental disorder that affects approximately 0.5% of the population worldwide. Persistent negative symptoms and cognitive impairments associated with schizophrenia (CIAS) are key features of the disorder and primary predictors of long-term disability. At the neurochemical level, both CIAS and negative symptoms are potentially attributable to dysfunction or dysregulation of N-methyl-D-aspartate receptor (NMDAR)-mediated neurotransmission within cortical and subcortical brain regions. At present, there are no approved treatments for either CIAS or persistent negative symptoms. Development of novel treatments, moreover, is limited by the lack of biomarkers that can be used translationally across preclinical and early-stage clinical investigation. The present chapter describes the use of mismatch negativity (MMN) as a pharmacodynamic/response (PD/R) biomarker for early-stage clinical investigation of NMDAR targeted therapies for schizophrenia. MMN indexes dysfunction of early auditory processing (EAP) in schizophrenia. In humans, deficits in MMN generation contribute hierarchically to impaired cognition and functional outcome. Across humans, rodents, and primates, MMN has been linked to impaired NMDAR function and resultant disturbances in excitatory/inhibitory (E/I) balance involving interactions between glutamatergic (excitatory) pyramidal and GABAeric (inhibitory) local circuit neurons. In early-stage clinical trials, MMN has shown sensitivity to the acute effects of novel pharmacological treatments. These findings support use of MMN as a pharmacodynamic/response biomarker to support preclinical drug discovery and early-stage proof-of-mechanisms studies in schizophrenia and other related neuropsychiatric disorders.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"40 ","pages":"411-451"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered Sleep Oscillations as Neurophysiological Biomarkers of Schizophrenia. 作为精神分裂症神经生理学生物标志物的睡眠振荡改变

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-69491-2_13

Ahmad Mayeli, Francesco L Donati, Fabio Ferrarelli

{"title":"Altered Sleep Oscillations as Neurophysiological Biomarkers of Schizophrenia.","authors":"Ahmad Mayeli, Francesco L Donati, Fabio Ferrarelli","doi":"10.1007/978-3-031-69491-2_13","DOIUrl":"https://doi.org/10.1007/978-3-031-69491-2_13","url":null,"abstract":"Sleep spindles and slow waves are the two main oscillatory activities occurring during nonrapid eye movement (NREM) sleep. Here, we will first describe the electrophysiological characteristics of these sleep oscillations along with the neurophysiological and molecular mechanisms underlying their generation and synchronization in the healthy brain. We will then review the extant evidence of deficits in sleep spindles and, to a lesser extent, slow waves, including in slow wave-spindle coupling, in patients with Schizophrenia (SCZ) across the course of the disorder, from at-risk to chronic stages. Next, we will discuss how these sleep oscillatory deficits point to defects in neuronal circuits within the thalamocortical network as well as to alterations in molecular neurotransmission implicating the GABAergic and glutamatergic systems in SCZ. Finally, after explaining how spindle and slow waves may represent neurophysiological biomarkers with predictive, diagnostic, and prognostic potential, we will present novel pharmacological and neuromodulatory interventions aimed at restoring sleep oscillatory deficits in SCZ, which in turn may serve as target engagement biomarkers to ameliorate the clinical symptoms and the quality of life of individuals affected by this devastating brain disorder.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"40 ","pages":"351-383"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory Biomarkers of Neuropsychiatric Disorders in Nonhuman Primates. 非人灵长类神经精神疾病的听觉生物标志物

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-69491-2_9

Monica N O'Connell, Annamaria Barczak

{"title":"Auditory Biomarkers of Neuropsychiatric Disorders in Nonhuman Primates.","authors":"Monica N O'Connell, Annamaria Barczak","doi":"10.1007/978-3-031-69491-2_9","DOIUrl":"https://doi.org/10.1007/978-3-031-69491-2_9","url":null,"abstract":"Animal models of neuropsychiatric disorders with appropriate biomarkers can greatly inform the neurobiological basis of disorder-related deficits of cognitive and/or sensory processes. Given the genetic, physiologic, and behavioral similarities between humans and nonhuman primates (NHPs), NHP studies are monumentally important for preclinical translational research. Capitalizing on the NHP's similarities with human systems provides one of the best opportunities to gain detailed insight into the mechanisms underlying disorder-related symptoms and to accumulate a foundation of information for the development of therapeutic interventions. Here, we discuss how results from NHP studies have provided insight into the generation and modulation of select auditory biomarkers of schizophrenia including auditory steady-state responses and mismatch negativity. Since neuro-oscillatory activity has been shown to be relatively preserved across species, we highlight how incorporating the analysis of local and network-level oscillations from multiple nodes across different pathways involved in auditory processing has been used to further the precision of translational comparisons across species.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"40 ","pages":"219-234"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational and Translational Fractal-Based Analysis in the Translational Neurosciences: An Overview. 转化神经科学中基于分形的计算和转化分析：概述。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-47606-8_39

Antonio Di Ieva

引用次数: 0

Computational Fractal-Based Analysis of Brain Tumor Microvascular Networks. 基于计算分形的脑肿瘤微血管网络分析

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-47606-8_27

Antonio Di Ieva, Omar S Al-Kadi

{"title":"Computational Fractal-Based Analysis of Brain Tumor Microvascular Networks.","authors":"Antonio Di Ieva, Omar S Al-Kadi","doi":"10.1007/978-3-031-47606-8_27","DOIUrl":"10.1007/978-3-031-47606-8_27","url":null,"abstract":"Brain parenchyma microvasculature is set in disarray in the presence of tumors, and malignant brain tumors are among the most vascularized neoplasms in humans. As microvessels can be easily identified in histologic specimens, quantification of microvascularity can be used alone or in combination with other histological features to increase the understanding of the dynamic behavior, diagnosis, and prognosis of brain tumors. Different brain tumors, and even subtypes of the same tumor, show specific microvascular patterns, as a kind of \"microvascular fingerprint,\" which is particular to each histotype. Reliable morphometric parameters are required for the qualitative and quantitative characterization of the neoplastic angioarchitecture, although the lack of standardization of a technique able to quantify the microvascular patterns in an objective way has limited the \"morphometric approach\" in neuro-oncology.In this chapter, we focus on the importance of computational-based morphometrics, for the objective description of tumoral microvascular fingerprinting. By also introducing the concept of \"angio-space,\" which is the tumoral space occupied by the microvessels, we here present fractal analysis as the most reliable computational tool able to offer objective parameters for the description of the microvascular networks.The spectrum of different angioarchitectural configurations can be quantified by means of Euclidean and fractal-based parameters in a multiparametric analysis, aimed to offer surrogate biomarkers of cancer. Such parameters are here described from the methodological point of view (i.e., feature extraction) as well as from the clinical perspective (i.e., relation to underlying physiology), in order to offer new computational parameters to the clinicians with the final goal of improving diagnostic and prognostic power of patients affected by brain tumors.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"36 ","pages":"525-544"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fractal Electronics for Stimulating and Sensing Neural Networks: Enhanced Electrical, Optical, and Cell Interaction Properties. 用于刺激和传感神经网络的分形电子学：增强电气、光学和细胞交互特性。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-47606-8_43

S Moslehi, C Rowland, J H Smith, W J Watterson, W Griffiths, R D Montgomery, S Philliber, C A Marlow, M-T Perez, R P Taylor

{"title":"Fractal Electronics for Stimulating and Sensing Neural Networks: Enhanced Electrical, Optical, and Cell Interaction Properties.","authors":"S Moslehi, C Rowland, J H Smith, W J Watterson, W Griffiths, R D Montgomery, S Philliber, C A Marlow, M-T Perez, R P Taylor","doi":"10.1007/978-3-031-47606-8_43","DOIUrl":"10.1007/978-3-031-47606-8_43","url":null,"abstract":"Imagine a world in which damaged parts of the body - an arm, an eye, and ultimately a region of the brain - can be replaced by artificial implants capable of restoring or even enhancing human performance. The associated improvements in the quality of human life would revolutionize the medical world and produce sweeping changes across society. In this chapter, we discuss several approaches to the fabrication of fractal electronics designed to interface with neural networks. We consider two fundamental functions - stimulating electrical signals in the neural networks and sensing the location of the signals as they pass through the network. Using experiments and simulations, we discuss the favorable electrical performances that arise from adopting fractal rather than traditional Euclidean architectures. We also demonstrate how the fractal architecture induces favorable physical interactions with the cells they interact with, including the ability to direct the growth of neurons and glia to specific regions of the neural-electronic interface.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"36 ","pages":"849-875"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene Expression at the Tripartite Synapse: Bridging the Gap Between Neurons and Astrocytes. 三方突触的基因表达：弥合神经元与星形胶质细胞之间的鸿沟

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-64839-7_5

Gillian Imrie, Madison B Gray, Vishnuvasan Raghuraman, Isabella Farhy-Tselnicker

{"title":"Gene Expression at the Tripartite Synapse: Bridging the Gap Between Neurons and Astrocytes.","authors":"Gillian Imrie, Madison B Gray, Vishnuvasan Raghuraman, Isabella Farhy-Tselnicker","doi":"10.1007/978-3-031-64839-7_5","DOIUrl":"10.1007/978-3-031-64839-7_5","url":null,"abstract":"Astrocytes, a major class of glial cells, are an important element at the synapse where they engage in bidirectional crosstalk with neurons to regulate numerous aspects of neurotransmission, circuit function, and behavior. Mutations in synapse-related genes expressed in both neurons and astrocytes are central factors in a vast number of neurological disorders, making the proteins that they encode prominent targets for therapeutic intervention. Yet, while the roles of many of these synaptic proteins in neurons are well established, the functions of the same proteins in astrocytes are largely unknown. This gap in knowledge must be addressed to refine therapeutic approaches. In this chapter, we integrate multiomic meta-analysis and a comprehensive overview of current literature to show that astrocytes express an astounding number of genes that overlap with the neuronal and synaptic transcriptomes. Further, we highlight recent reports that characterize the expression patterns and potential novel roles of these genes in astrocytes in both physiological and pathological conditions, underscoring the importance of considering both cell types when investigating the function and regulation of synaptic proteins.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"39 ","pages":"95-136"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracranial Pressure and Its Related Parameters in the Management of Severe Pediatric Traumatic Brain Injury. 严重小儿创伤性脑损伤治疗中的颅内压及其相关参数。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-69832-3_1

Vincent Y Wang

引用次数: 0

Modulatory Processes in Craniofacial Pain States. 颅面疼痛状态的调节过程

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-45493-6_6

Barry J Sessle

{"title":"Modulatory Processes in Craniofacial Pain States.","authors":"Barry J Sessle","doi":"10.1007/978-3-031-45493-6_6","DOIUrl":"10.1007/978-3-031-45493-6_6","url":null,"abstract":"Pain is a common symptom associated with many disorders affecting the craniofacial tissues that include the teeth and their supporting structures, the jaw, face and tongue muscles, and the temporomandibular joint. Most acute craniofacial pain states are easily recognized and readily treated, but chronic craniofacial pain states (e.g., temporomandibular disorders [TMD], trigeminal neuropathies, and some headaches) may be especially challenging to manage successfully. This chapter provides an overview of the processes that underlie craniofacial pain, with a focus on the pain-modulatory mechanisms operating in craniofacial tissues and in the central nervous system (CNS), including the role of endogenous chemical processes such as those involving opioids. The chapter outlines in particular findings from preclinical studies that have provided substantial information about the neural as well as nonneural (e.g., glial) processes involved in the initiation, transmission, and modulation of nociceptive signals in the trigeminal system, and also draws attention to their clinical correlates. The increased understanding gained from these preclinical studies of how nociceptive signals can be modulated will contribute to improvements in presently available therapeutic approaches to manage craniofacial pain as well as to the development of novel analgesic approaches.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"35 ","pages":"107-124"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0